Getting More From Whole-Transcript Microarrays

... that researchers could get information about differential splicing from the Gene platform in certain ... authors acknowledge that the ability to detect differential splicing depends on various factors, including ... about adjacent poorly fitting probes to calculate differential expression in the Gene arrays and showed that it ...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

... identification of a stable dose of PROMACTA, perform CBC with WBC differential monthly. If the patient develops new or worsening morphological ... therapy. Prior to the initiation of PROMACTA, examine the peripheral blood differential to establish the extent of red and white blood cell abnormalities. Obtain ...

FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder

... identification of a stable dose of PROMACTA, perform CBC with WBC differential monthly. If the patient develops new or worsening morphological ... therapy. Prior to the initiation of PROMACTA, examine the peripheral blood differential to establish the extent of red and white blood cell abnormalities. Obtain ...

New Clinical Studies Confirm Mauna Kea Technologies' Cellvizio(R) GI in Range of Procedures

... results were reported in a study evaluating Cellvizio(R) GI in the differential diagnosis of indeterminate biliary strictures (Abstract PS-W- 24). Standard approaches to making this differential diagnosis have certain limitations, which may be overcome by Cellvizio(R) ...

Genaera Corporation Provides Highlights of Positive Phase 1 Trodusquemine (MSI-1436) Data from the North American Association for the Study of Obesity Annual Meeting

... is a Protein Tyrosine Phosphatase 1B Inhibitor that Causes differential Weight Loss," provides additional positive data and confirms the high ... loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction ...

Genaera Corporation Presents Preclinical Trodusquemine (MSI-1436) Data at the North American Association for the Study of Obesity Annual Meeting

... "Trodusquemine is a Protein Tyrosine Phosphatase 1B Inhibitor that Causes differential Weight Loss," will be presented today from 9:00 a.m. to 2:30 p.m., Central ... loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction ...

Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program

... disorders with an emphasis on Alzheimer's disease. The Institute's Memory Clinic also offers comprehensive cognitive and medical assessment toward differential diagnosis of Alzheimer's disease and offers treatments and disease management options once the diagnostic evaluation is complete. For more ...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

... or if platelet counts 500,000 mm3, Leukine administration should be interrupted or the dose reduced by half. Twice weekly monitoring of CBC with differential should be performed. Leukine therapy should be discontinued if disease progression is detected during treatment. For more information about ...

Prometheus and Rosetta Genomics Announce License and Collaboration Agreement

... differentiate mesothelioma, a cancer connected to asbestos exposure, from other carcinomas in the lung and pleura, a medically and legally important differential diagnosis. As mesothelioma patients require specific treatment regimens, an accurate diagnosis is critical. Currently there is no single diagnostic ...

Genaera Presents Preliminary Phase 1b Data for Trodusquemine (MSI-1436)

... in four primary outcomes used to evaluate type 2 diabetes, including: A 9.5% decrease in fasting blood glucose with a resulting 17% differential compared to placebo subjects in the same cohort; A 7% decrease in the area under the curve during the oral glucose tolerance test; An ...

Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease

... with an emphasis on Alzheimer's disease. The Roskamp Institute's Memory Centers also offer comprehensive cognitive and medical assessment toward differential diagnosis of Alzheimer's disease and offers treatments and disease management options once the diagnostic evaluation is complete. For more ...

Study Shows EUFLEXXA(R) Patients Report Significant Improvements in Osteoarthritis of the Knee Pain over a Six Month Period

... device, for use with its fertility treatments. Other products include: ACTHREL(R) (corticorelin ovine triflutate for injection) for the differential diagnosis of Cushing's syndrome; DESMOPRESSIN ACETATE in injectable and rhinal tube forms for the treatment of diabetes insipidus and primary ...

Nationwide Survey Shows Infertility Patients Prefer ENDOMETRIN(R) Compared With Other Progesterone Supplements

... for the relief of discomfort of the lower urinary tract. Other products include: ACTHREL(R) (corticorelin ovine triflutate for injection) for the differential diagnosis of Cushing's syndrome; and DESMOPRESSIN ACETATE in injectable and rhinal tube forms for the treatment of diabetes insipidus and primary ...

First Molecular Tem-PCR Test to Identify Multiple Forms of Staph and MRSA Obtains CLIA Certificate

... (CLIA) certificate* for its proprietary licensed testing process, Target Enriched Multiplex Polymerase Chain Reaction (Tem-PCR). This molecular differential diagnostic technology is the first Tem- PCR test introduced to the clinical market which is able to identify multiple pathogens, both viral and ...

Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma

... or if platelet counts 500,000 mm(3), Leukine administration should be interrupted or the dose reduced by half. Twice weekly monitoring of CBC with differential should be performed. Leukine therapy should be discontinued if disease progression is detected during treatment. About Bayer HealthCare ...

Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease

... Results from a national prospective registry. Ann Intern Med 1991; 115: 343-349. 6. Barst RJ, McGoon M, Torbicki A et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43(Suppl S): 40S-47S Actelion Ltd Actelion Ltd is a ...

Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs

... that are activated by SERMs but not by estrogens used in hormone therapy. The identification of these elements, coupled with the understanding of the differential regulation in various tissues, provides a new platform for the discovery of estrogenic drugs with SERM-like profiles." The study was conducted by ...

DURABLE Clinical Trial Results Show GlycoMark is Key Test for Managing Patients with Diabetes

... Does serum 1,5-AG establish a relationship between improvements in HbA1c and postprandial glucose excursions? Supportive evidence utilizing the differential effects between biphasic insulin aspart 30 and insulin glargine. Reference: Diabetic Medicine 2008 (Alan Moses) About GlycoMark GlycoMark is an ...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

... with immunosuppressant therapies and impairment of immune function. In immunosuppressed patients, physicians should consider PML in the differential diagnosis in patients reporting neurological symptoms and consultation with a neurologist should be considered as clinically indicated. ...

Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function

... with immunosuppressant therapies and impairment of immune function. In immunosuppressed patients, physicians should consider PML in the differential diagnosis in patients reporting neurological symptoms and consultation with a neurologist should be considered as clinically indicated. ...

Genomic Health Announces Results of Initial Studies to Develop Predictive Tests for Targeted Therapies

... predicted benefit from treatment with docetaxel (Taxotere), a type of taxane commonly used for breast cancer therapy. A genomic classifier predicting differential benefit was identified and, if validated through additional studies, might be useful in defining differential benefit of docetaxel. "We continue to ...

GlaxoSmithKline Announces New Drug Application and Phase III Results for Rezonic(TM)/Zunrisa(TM) (Casopitant)

... Chemotherapy-Induced Nausea and Emesis after Modern Antiemetics: Perception versus Reality. Cancer. 2004;100,10 :2261-2268. (7) Hesketh PJ, et Al. differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists. Eur J ...

Sarasota's Roskamp Institute Highlights Positive Japanese Data that Validates its Ongoing Alzheimer's Disease Research

... addictions with an emphasis on Alzheimer's disease. The Institute's Memory Clinics also offer comprehensive cognitive and medical assessment toward differential diagnosis of Alzheimer's disease and offers treatments and disease management options once the diagnostic evaluation is complete. For more ...

Cost-Effectiveness Study Supports Use of EUFLEXXA(TM) by Rheumatologists for Pain Relief in Patients with Knee Osteoarthritis

... device, for use with its fertility treatments. Other products include ACTHREL(R) (corticorelin ovine triflutate for injection) for the differential diagnosis of Cushing's syndrome and DESMOPRESSIN ACETATE in injectable and rhinal tube forms for the treatment of diabetes insipidus and primary ...

Genaera Corporation Presents Phase 1 Data for Trodusquemine (MSI-1436) at the North American Association for the Study of Obesity Annual Meeting

... to overcome metabolic readjustment, which often limits sustained weight loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction of lean mass), and improves glucose tolerance via inhibition of a unique ...

Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer

... to 4mg of dexamethasone administered orally twice a day. Monitoring: Monitor prior to each dose for complete blood cell count, including a differential white cell count and platelet count. Absolute neutrophil count should be > or = 1,500 cells/mm(cubed) and platelets > or = 100,000 cells/mm(cubed). ...

CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia

... in AML cells from patients treated with belinostat. Evaluation of the genes regulating proliferation and apoptosis (programmed cell death) and the differential gene expression in AML cells obtained both prior to and following treatment with belinostat will also be performed. The trial is being led by Dr. ...

Georgia Reproductive Specialists Participates in Largest-Ever In Vitro Fertilization Clinical Trial in the World

... hyaluronic acid for pain from osteoarthritis in the knee. Other products include ACTHREL(R) (corticorelin ovine triflutate for injection) for the differential diagnosis of Cushing's syndrome and DESMOPRESSIN ACETATE in injectable and rhinal tube forms for the treatment of diabetes insipidus and primary ...

Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session

... "Trodusquemine is a Multiple Pathway Inhibitor that Causes differential Weight Loss, Reduces Adiposity, and Improves Plasma Insulin and Leptin ... demonstrating that trodusquemine suppresses appetite and causes differential weight loss in a mouse model of diet-induced obesity (DIO). Data presented ...

Hematology Analyzers Simple, Sophisticated Technology Serving All Patients

... cell counter models, improving the accuracy of the automated WBC differential count and enabling further classification of atypical or immature cells. ... of the specificity of the cell-surface marker labels, the automated cell differential maximizes accuracy in hematology analysis. A variety of other ...

Diobex Announces Successful Completion of Phase 2a Trial Of DIO-902, a Novel Cortisol Synthesis Inhibitor for Type 2 Diabetes

... the co-administration of DIO-902 with the most commonly used doses of atorvastatin. This study also provided clinical evidence of a significant differential effect of DIO-902 and racemic ketoconazole on the metabolism of atorvastatin, thereby reducing the potential for toxicity. DIO-902 has been proven to ...

Ferring Reports on ENDOMETRIN Presentations at Pacific Coast Reproductive Society Annual Meeting

... hyaluronic acid for pain from osteoarthritis in the knee. Other products include ACTHREL(R) (corticorelin ovine triflutate for injection) for the differential diagnosis of Cushing's syndrome and DESMOPRESSIN ACETATE in injectable and rhinal tube forms for the treatment of diabetes insipidus and primary ...

Genaera to Present Preclinical Data on Trodusquemine for the Treatment of Obesity at the American Diabetes Association 67th Scientific Sessions

... 67th Scientific Sessions, June 22 to 25 in Chicago. The abstract, # 1801-P, is titled, "Trodusquemine is a Multiple Pathway Inhibitor that Causes differential Weight Loss, Reduces Adiposity, and Improves Plasma Insulin and Leptin Levels." The poster will be available from Saturday, June 23 through Monday, ...

The Past, Present and Future of HLA Typing

... specific oligonucleotide probes to HLA loci amplified by the polymerase chain reaction (PCR), or by using PCR to amplify the HLA DNA directly through differential primer extension. One of the most commonly employed strategies in HLA DNA typing is to first amplify a given HLA locus, then hybridize it with ...

Controlling the Spread of Healthcare Associated Methicillin Resistant Staphylococcus aureus Requires Active Surveillance

... is projected for launching in the UK in the second quarter of 2005. BBL CHROMagar MRSA (BD Diagnostics), utilizes culture on a selective and differential medium. The nasal swab specimen is directly inoculated to the plate for streaking and the plates are incubated for 24 to 48 hours. The agar permits ...

Rapid Whole Blood Testing for Infectious Mononucleosis Antibodies

... secondary to acute lymphadenopathy, anemia and ruptured spleen. Therefore, accurate diagnosis and prompt treatment of complications is important. differential diagnosis of IM is also useful in ruling out other mononucleosis-like illnesses induced by cytomegalovirus, adenovirus, or Toxoplasma gondii. ...