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Dendritic in Medical Technology

Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy

... The study entitled "Phase II Trial of dendritic Cells Loaded with Antigens from Self-Renewing, ... a total of up to eight injections. The patient's dendritic cells were obtained from their peripheral blood ... (64 vs. 31 months, p=.016). Eight patients in the dendritic cell vaccine study experienced remarkable ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... vaccines can activate and cause human immature dendritic cells from blood monocyte cells to become dendritic cells that secrete the IL-12 cytokine. The dendritic cells that result initiate a protective cell ...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

... Talactoferrin is a novel targeted dendritic cell recruiter and activator (DCRA) being studied ... mediates its anti-cancer activity by targeting dendritic cells which play an important role in activating ... talactoferrin induces the recruitment of immature dendritic cells to the GALT and promotes their maturation. ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

... Peregrine's PS-Targeting Antibodies Stimulate dendritic Cell Maturation, Inflammatory Cytokine and ... antibody PGN632 to promote the maturation of dendritic cells, important antigen-presenting cells of the ... system. In the in vitro studies, immature dendritic cells cultured in the presence of PGN632 ...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... on Molecular and Cellular Biology Conference on dendritic Cells, March 29-April 3, 2009 in Banff, Alberta. ... on March 30th entitled MAb-Enhanced, Human dendritic Cell-Mediated Adaptive Immune Response to B. ... can enhance the killing of anthrax by human dendritic cells. Dr. Cross remarked, "These latest ...

Update of Long-Term Data on Brain Cancer Patients Receiving DCVax(R)-Brain Continues to Show Striking Improvements in Delay of Disease and Survival

... surgery as part of the current standard of care. dendritic cells drawn from a sample of the patient's blood ... weeks apart and then months apart. These dendritic cells are then able to mobilize the immune system ... The Company has two broad platform technologies: dendritic cell-based vaccines and therapeutic antibodies. ...

Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain

... surgery as part of the current Standard of Care. dendritic cells drawn from a sample of the patient's blood ... and "educated." These activated and "educated" dendritic cells are injected back into the patient, in a ... several weeks apart and then months apart. These dendritic cells are then able to mobilize the immune system ...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

... About Talactoferrin Alfa Talactoferrin, a novel dendritic cell recruiter and activator (DCRA), is a unique ... in the body. It acts through a novel mechanism of dendritic cell recruitment and activation. Following oral ... Patches, where it recruits circulating immature dendritic cells bearing tumor antigens to the GALT ...

Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma

... - Phase II Trial Shows Increase in Mature dendritic Cells - WAYNE, N.J., June 30 ... of 65 months and increased mature dendritic cells in high-risk melanoma patients. dendritic cells are special antigen-presenting cells that ...

Oral Talactoferrin Alfa Improves Overall Survival in Patients With Refractory Non-Small Cell Lung Cancer: Final Phase 2 Study Results Presented at the 8th Annual Targeted Therapies for the Treatment Of Lung Cancer Meeting

... About Talactoferrin Alfa Talactoferrin, a novel dendritic cell activator (DCA), is a unique recombinant ... in the body. It acts through a novel mechanism of dendritic cell recruitment and activation. Following oral ... Patches, where it recruits circulating immature dendritic cells bearing tumor antigens to the GALT ...

Phase I and Phase I/II DCVax(R)-Brain Data Continues to Show Significantly Improved Survival Rates for Brain Cancer Patients

... DCVax(R)-Brain is made up of the patient's own dendritic cells that have been "educated" to recognize and ... surgery as part of the current Standard of Care. dendritic cells drawn from a sample of the patient's blood ... and "educated." These activated and "educated" dendritic cells are injected back into the patient, in a ...

Northwest Biotherapeutics Conducting Ovarian Cancer Clinical Trial With DCVax(R)-L at University of Pennsylvania

... for cancer, which is made from a patient's own dendritic cells (the master cells which initiate and manage ... biomarkers are then loaded onto the patient's own dendritic cells (the master cells responsible for ... The Company has two broad platform technologies: dendritic cell-based vaccines, and therapeutic antibodies. ...

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

... collaborators) and Affitech demonstrated in in vitro studies that immature dendritic cells cultured in the presence of PGN632 exhibited a significant increase ... in the expression of cell-surface molecules that are indicative of mature dendritic cells and that assist in antigen presentation functions, as well as in ...

Nventa Presents Findings on Proprietary Toll-like Receptor 3 (TLR3) Agonist, Poly-ICR, at World Vaccine Congress

... significant cytokine and chemokine production; -- Poly-ICR matures dendritic cells, known as "the teachers of the immune system". In addition to ... novel and potent immunomodulator works with the immune system to induce dendritic cell maturation, along with a broad range of inflammatory cytokines ...

Study Supports Possible Use of Leukine(R) as a Potential Adjuvant Therapy for High-Risk Melanoma Patients

... by Leukine and IL-2 (p=.8), and there was no increase in the number of dendritic cells during or after Leukine administration in the 11 patients who donated blood for dendritic cell counts. About Leukine(R) Leukine(R) (sargramostim) is a growth ...

IDM Pharma Announces Updated Phase 2 UVIDEM(R) Results Showing Durable Disease Control and Tolerability in Advanced Melanoma Patients

... and the incidence and severity of adverse events of a multivalent dendritic cell-based vaccine (UVIDEM) in patients with in-transit or low volume ... marketing rights to UVIDEM in melanoma. UVIDEM consists of mature dendritic cells loaded with lysates from melanoma tumor cell lines. UVIDEM is ...

VioQuest Pharmaceuticals Completes Enrollment of Phase I Trial of Lenocta(TM)

... Chief Scientific Officer, stated, "The increased function in T, NK, and dendritic cell populations at a dose that is well tolerated is exactly what we had ... the body's immune system, through improved cytokine signaling, T-cell and dendritic cell functions indicate that Lenocta(TM) has potentials as an anti-cancer ...

BioInformatics, LLC New Report - Capitalizing on New Opportunities for Stem Cell Products, Now Available

... increasing interest over the next couple of years. By 2011, osteogenic cells in particular, but also endothelial, cardiomyocytes, chondrocytes, and dendritic cells are projected to be differentiated states as common as hematopoeitic and epithelial cells. These findings have implications for product ...

Doctors Urge Precaution to Shield Against Swine Flu

... NK cell activity in people with low NK cell function, improving the coordination of many aspects of immune response, including the interaction of dendritic macrophage cells, T-cells and B-cells, resulting in improved health. The benefit of AHCC's NK Cell supporting effect, and its role in defense ...

Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells

... Medical University in Osaka, Japan has shown that AHCC (Active Hexose Correlated Compound) enhances immune function by increasing the number of dendritic cells (DCs). DCs are a key part of the immune system responsible for presenting foreign substances to other immune system cells. The study was ...

Nventa Develops Proprietary Vaccine Adjuvant

... and prophylactic areas of immunotherapy and vaccine development. This novel and potent immunomodulator works with the immune system to induce dendritic cell maturation, along with a broad range of inflammatory cytokines and chemokines, to facilitate the prevention and treatment of infectious diseases ...

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

... tumor necrosis and tumor infiltrating lymphocytes (TILs) were observed within the tumors. Characterization of the recruited TILs showed CD35+ dendritic cells, CD8+ killer T cells, and CD138+ plasma B cells, with lesser amounts of CD68+ macrophages and CD20+ B cells, suggesting a relatively mature or ...

Quantum Immunologics, Inc. and the South Alabama Medical Science Foundation Announce an Early Clinical Evaluation of a Novel Immuno-therapeutic Vaccine for Treating Advanced Human Breast Carcinomas

... local oncology centers in and around Mobile, Alabama. The investigators will collect from each patient's blood a white blood cell population called dendritic Cells (DC). These cells are then exposed in vitro to replicated iLRP, cultured, and reintroduced into the patient via subdermal injection. The hope ...

Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis

... of Xigris(R), treatment for severe sepsis remains an area of significant unmet medical need. About Talactoferrin Alfa Talactoferrin, a novel dendritic cell recruiter and activator (DCRA), is a unique recombinant form of human lactoferrin, an important immunomodulatory protein. Talactoferrin is an ...

Genetic Immunity Presents Clinical Data on DermaVir Patch Immune Therapy at 15th Annual Conference on Retroviruses and Opportunistic Infections

... of HIV antigens, allowing a broad immune response. DermaPrep is a topical administration device by which NanoComp is delivered specifically into the dendritic cells. Contacts: The Ruth Group Investors Sara Ephraim +1-646-536-7002 sephraim@theruthgroup.com Media Janine McCargo +1-646-536-7033 ...

New Patent Awarded for Antigen-Sparing Vaccines that Elicit Robust Immunity

... together with antigens from specific pathogens. Studies in animals demonstrate these vaccines easily penetrate the mucous membrane, where dendritic cells rapidly engulf the antigen and present it to the immune system. This rapid awakening of the immune system via the intranasal route negates the ...

Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma

... Celldex's proprietary technology platform uses fully human monoclonal antibodies administered directly to patients to target and stimulate dendritic cells - key cells within the immune system. The Company is headquartered in Phillipsburg, New Jersey. On October 22, 2007, Celldex and AVANT ...

Celldex Therapeutics Announces Orphan Drug Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma Multiforme

... Celldex's proprietary technology platform uses fully human monoclonal antibodies administered directly to patients to target and stimulate dendritic cells - key cells within the immune system. The Company is headquartered in Phillipsburg, New Jersey. On October 22, 2007, Celldex and AVANT ...

VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor

... demonstrated pharmacodynamic activity in some solid tumors as demonstrated by increases in the activities of natural killer cells, CD8 and type II dendritic cells. About Lenocta Lenocta, a pentavalent antimonial originally used for the treatment of the parasitic disease leishmaniasis, is an inhibitor ...

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

... present within B cells, which secrete high levels of interferon-alpha and contribute to disease severity. TLR8 is expressed in monocytes and other dendritic cells, which are thought to produce proinflammatory cytokines, which further contribute to disease process. Other studies have indicated that ...

IDM Pharma Announces UVIDEM(R) and EP-2101 Data Presentations at 2007 ASCO Annual Meeting

... responses in patients with malignant melanoma treated with a dendritic cell-based vaccine. Preliminary report from a multi-institutional ... marketing rights to UVIDEM in melanoma. UVIDEM consists of mature dendritic cells loaded with lysates from melanoma tumor cell lines. UVIDEM is ...

IDM Pharma Presents Preliminary Results from Phase II UVIDEM Melanoma Vaccine Clinical Trial

... clinical and immunological activities and the safety of a multivalent dendritic cell-based vaccine in patients with in-transit or low volume metastatic ... marketing rights to UVIDEM in melanoma. UVIDEM consists of mature dendritic cells loaded with lysates from melanoma tumor cell lines. UVIDEM is ...

MaxCyte and Medinet to Present at the 13th Annual Meeting of the International Society for Cellular Therapy (ISCT) in Sydney, Australia

... "Electroloading of mature dendritic cells with tumor lysate triggers robust antigen-specific CTL response" ... cGMP compliant manufacturing process and the resulting production of dendritic cell (DC) vaccines with enhanced potency as demonstrated by higher ...

Anadys Reports Preclinical Data Showing ANA773 Promotes Anti-Tumor Activity of Natural Killer Cells

... other immune cells. NK cells are activated by diverse signals, including type I interferons. Large amounts of type I IFN are produced by plasmacytoid dendritic cells (pDCs) upon engagement of the pattern recognition receptor TLR7. The natural ligand for TLR7 is single stranded RNA, although a variety of ...

Data Presented at AACR Meeting Show Peregrine's Bavituximab Equivalent Can Generate Curative Immune Responses as Part of a Vaccine-Like Regimen in Preclinical Models of Aggressive Brain Cancer

... system. In these studies, the animals receiving 2aG4-treated irradiated cells showed increased antigen presentation of PS positive tumor cells by dendritic cells, as well as an increase in the number of cytotoxic T cells enabling the animals' immune systems to attack the tumor cells directly. These ...

MedImmune Publishes New Data in Nature Immunology Demonstrating The Role HMGB1 May Play in Systemic Autoimmune Diseases

... by HMGB1 and RAGE," contains data showing that HMGB1 is a key component of DNA-immune complexes that stimulate activation of B cells and plasmacytoid dendritic cells (pDCs) via the toll-like receptor 9 pathway (TLR9). Both B cells and pDCs are associated with immune system disorders such as lupus. The data ...

Argos Therapeutics Presents Immunosuppression Data for Soluble CD83 at the American Society of Transplantation Congress 2007

... using the Company's "Arcelis" technology, trains the immune system to recognize and attack the disease. Argos' scientific leadership in RNA-loaded dendritic cells and advanced manufacturing processes provide a platform to tackle virtually all forms of cancers and infectious ....

Introgen and Clinical Collaborators to Report New Results with Advanced-Stage Cancer Therapies at Upcoming Medical Meetings

... -- Final results of a phase II trial of patients with extensive stage small cell lung cancer (ES-SCLC) immunized with wild type -p53 transduced dendritic cells after first-line chemotherapy, Abstract #3012: Poster presentation on Sun., June 3, from 2:00 - 6:00 p.m. in room S102a at McCormick Place, by ...
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