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Conversion in Medical Technology

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... Ltd. in Houston, TX. "In this study, the conversion of VYVANSE to its active form was not affected ... form by the body's natural metabolism. This conversion takes place minimally in the gastrointestinal ... studies have demonstrated that the conversion of VYVANSE to active medication is unlikely to be ...

Merck Serono Announces Initiation of the ORACLE MS Trial to Evaluate Cladribine Tablets in Patients at Risk of Developing Multiple Sclerosis

... of Cladribine Tablets in Preventing conversion to Definite Multiple Sclerosis in Addition to the ... and safety of Cladribine tablets in preventing conversion to definite multiple sclerosis." "As a leader ... endpoint of the ORACLE MS trial is time to conversion to MS, according to the McDonald criteria. Other ...

Circulation Publishes Data Showing KYNAPID(TM) (Vernakalant Hydrochloride) Injection Rapidly Converted Short-Duration Atrial Fibrillation to Sinus Rhythm

... In the study, known as the Atrial arrhythmia conversion Trial (ACT I), the primary efficacy analysis ... who received KYNAPID demonstrated the highest conversion rate (62.1%) compared with 4.9% with placebo. The median time to conversion to sinus rhythm for the 75 patients receiving ...

Study Shows Vernakalant Hydrochloride is Effective in Conversion to Normal Heart Rhythm in Atrial Fibrillation Patients Following Cardiac Surgery

... agent vernakalant hydrochloride increased conversion to normal heart rhythm (sinus rhythm, or SR) ... surgeries." Study Results The Atrial arrhythmia conversion Trial or ACT II was a randomized, double-bind, ... the percentage of patients with treatment-induced conversion of AF/atrial flutter to SR for at least ...

New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy

... pediatric patients as young as 2 years and 2) for conversion to monotherapy in adults with partial ... established 1) as initial monotherapy, 2) for conversion to monotherapy from AEDs other ... primidone, or valproate, 3) for simultaneous conversion to monotherapy from two or more concomitant AEDs. ...

Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset

... agent vernakalant hydrochloride increased conversion to normal heart rhythm (sinus rhythm, or SR) ... The study, referred to as the atrial arrhythmia conversion trial or ACT I, was a prospective, randomized, ... was the percentage of patients demonstrating conversion to SR for at least one minute within 90 minutes ...

DURECT Reports Positive Phase IIb Data from TRANSDU(TM)-Sufentanil Clinical Program

... to stable pain control and into the maintenance period (see above), the conversion ratios from oral morphine equivalents at baseline to TRANSDUR-Sufentanil ... Phase III program (including the dose titration regimens and dose conversion ratios expected to be utilized in the Phase III program) and regulatory ...

Merck Serono Completes Enrollment in the REFLEX Trial of Rebif(R) in Patients at Risk of Developing Multiple Sclerosis

... the therapeutic benefit of Rebif(R) (interferon beta-1a) on the time to conversion to multiple sclerosis (MS) in people with a first clinical event ... three times a week. The primary endpoint of the REFLEX trial is time to conversion to MS, according to the McDonald criteria. Further endpoints include time ...

Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's

... of BACE1 in combination with other biomarker candidates for predicting the conversion from MCI to Alzheimer's. The additional candidates were abnormal brain ... (a genetic risk factor for Alzheimer's) were the strongest predictors of conversion to Alzheimer's, after controlling for age and gender. The classification ...

Alliance Pharmaceutical Corp. Announces Approval of Proposed Actions at Annual Shareholders Meeting

... indebtedness have agreed to convert such debt into common stock at a conversion price of $0.17 per share. The material conditions to such conversion are: (i) that the company effect a reverse stock split in a ratio of ten ...

Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference

... - Data Support Intravenous to Subcutaneous conversion - SAN DIEGO, April 16 /PRNewswire-FirstCall/ -- Halozyme ... absorb bisphosphonates, it could prevent local irritation and facilitate conversion from intravenous infusion to a more convenient subcutaneous route of ...

Alseres Pharmaceuticals, Inc. to Address a Congressional Briefing on Paralysis Research and the Spinal Cord Injury Community at 'Working 2 Walk' in Washington, DC, April 13-15, 2008

... thoracic and cervical patients approximately four times greater than the conversion rate for patients in a comparable historical study who did not receive ... with cervical injuries, the interim efficacy data also suggest that the conversion rate was dose-dependent. The Congressional briefing, sponsored by ...

Micromet Announces Presentation of Five Posters Related to Its Proprietary BiTE Antibody Platform at Annual Meeting of American Association for Cancer Research

... delivered to mice (abstract no. 2131). A third poster describes the conversion of the commercial antibodies trastuzumab and cetuximab (Genentech's and ... Abstract No. 2131 (board #6, April 14, 2008) Lutterbuese, R. et al. conversion of Cetuximab and Trastuzumab into T Cell-engaging BiTE Antibodies Creates ...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

... No. APB 14-1 (FSP 14-1) for its 2 5/8% convertible notes, which required Isis to assign a value to its convertible debt without considering the conversion feature. As a result, Isis is recording its convertible debt at a discount, which Isis is amortizing over the expected life of the debt as ...

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

... Pittsburgh Life Sciences Greenhouse, Innovation Works (Pittsburgh), and several individual investors. The round included both new investments and the conversion of existing convertible notes. "This investment facilitates the advancement of our existing lead molecules towards a major milestone," said ...

Gen-Probe and DiagnoCure Amend Collaboration Agreement Surrounding PCA3-Based Prostate Cancer Tests

... and may be exchanged for common shares on a one-for-one basis. DiagnoCure has the option to redeem the preferred shares or to require their conversion into common shares in certain circumstances. As part of its investment in DiagnoCure, Gen-Probe will receive a liquidation preference in certain ...

Recent Study Demonstrated VYVANSE(R) (lisdexamfetamine dimesylate) CII Provided Improvements in Behavior, Inattention, and Math Test Scores from 1.5 Hours up to 13 Hours following Administration in Children with ADHD

... in which d-amphetamine is covalently bonded to l-lysine, and after oral ingestion it is converted to pharmacologically active d-amphetamine. The conversion of VYVANSE to d-amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in GI transit times. Additional ...

Study Published in Journal of Clinical Psychiatry Showed Once-Daily VYVANSE(R) (lisdexamfetamine dimesylate) Significantly Improved ADHD Symptoms in One of the Largest Controlled Stimulant Trials in Adults with ADHD

... in which d-amphetamine is covalently bonded to l-lysine, and after oral ingestion it is converted to pharmacologically active d-amphetamine. The conversion of VYVANSE to d-amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in normal GI transit times. ...

New Data Presented at WCTRIMS* Supports the Importance of Early and Sustained Treatment with Betaseron(R)

... outcomes. It demonstrated that initiating Betaseron treatment early in the disease reduced the risk of negative long-term outcomes, including conversion to secondary progressive multiple sclerosis (SPMS), reaching a confirmed EDSS of 6.0 or the use of a wheelchair. The study also found that the longer ...

MTV and SpinVox Partner to Launch First Ever Integrated Voice Powered Cause-Related Social Networking Campaign 'Stand By What You Say'

... managed service provider any network or service can rapidly and cost-effectively implement SpinVox. At the heart of SpinVox is its Voice Message conversion System(TM) (VMCS), which works by combining state-of-the-art speech technologies with a live-learning language process. VMCS is being rolled-out ...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

... may have escaped the prostate. Mostaghel and colleagues feel the most promising drug targets will be inhibitors of CYP17 enzymes, which disrupt the conversion of progesterone to testosterone precursors, as well as inhibitors of enzymes that perform subsequent steps in testosterone production: AKR1C3 and ...

Alseres Pharmaceuticals Enters Agreement to Amend Cethrin(R) License to Lower Milestone Payments and Royalty Rates

... demonstrated an improvement in their impairment level on the American Spinal Injury Association scale that was approximately 400% greater than the conversion rate for patients in a comparable historical study who did not receive Cethrin. When analyzed as a subset, patients with cervical (neck) injuries who ...

Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies

... which has shown clinical responses in relapsed and refractory non-Hodgkin's lymphoma patients." Reference (1) Lutterbuese, R. et al. conversion of Cetuximab and Trastuzumab into T Cell-engaging BiTE Antibodies Creates Novel Drug Candidates with Superior Anti-tumor Activity. Annual ...

Most Back Pain Could Be Cured Without Surgery or Drugs if Doctors Treated Muscles - Not the Spine - Says Leading Pain Specialist

... pain and headaches, says Dr. Marcus, who has found muscle involvement in over 75 percent of his chronic back pain patients. Dr. Marcus credits his conversion from helping patients live with their pain to actually curing them to Dr. Hans Kraus, the legendary physical medicine and rehabilitation specialist. ...

Novavax Reports Fourth Quarter and 2007 Year-End Financial Results

... cash and short term investment balances in 2007. The relatively small change for the full year of $0.1 million in 2007 versus 2006 was due to the conversion of $7.0 million of long term debt into equity in 2006, thereby lowering interest expense, partially offset by lower interest income due to lower cash ...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

... dissociates very slowly, thereby preventing the degradation of GLP-1 at the site of action. Unbound ARI-2243 then undergoes a unique non-enzymatic conversion as it passes through the gut and into systemic circulation, which limits the exposure of the active species to unwanted targets, such as DPP 8 and 9. ...

Alseres Pharmaceuticals Concludes Enrollment in the Cethrin(R) Phase I/IIa Clinical Trial in Acute Spinal Cord Injury

... of Neurotrauma. When subjects with cervical injuries who were treated with Cethrin were analyzed separately, about 46% of the subjects exhibited a conversion rate from ASIA A to ASIA B or better. Moreover, about 18% of subjects overall and 38% of subjects with cervical injuries improved to ASIA C or better ...

Solvay Pharmaceuticals, Inc. Responds to Advisory Committee Recommendation for Further Study of Tedisamil to Treat Atrial Fibrillation

... to fully address the questions raised by members of the Cardio-Renal Advisory Committee in its meeting to consider tedisamil as a treatment for rapid conversion of recent onset atrial fibrillation to normal sinus rhythm (NSR). The Committee voted against approval of tedisamil, at this time, requesting that ...

Clinical Data Presented on OrthoGlide(R) Medial Knee Implant

... either a unicompartmental knee or TKR. Nine OrthoGlide patients enrolled (10.2%) were converted, which is comparable to the 9% unicompartmental knee conversion rate at two years post-operative. Also important is the fact that only one patient out of 350 total implants (includes study and non-study patients) ...

Emisphere Technologies, Inc. Announces 2007 Third Quarter Financial Results

... - 11,890 - Operating income (loss) 3,453 (8,691) (13,191) (18,727) Other income and (expense): Beneficial conversion of convertible security - - - (12,215) Investment and other income 188 466 ...

Pivotal MIRCERA(R) Study First to Convert Dialysis Patients From Frequent Dosing Directly to Once Every Two Weeks or Once Every Four Weeks

... MIRCERA(R), administered up to once every four weeks(1) The MAXIMA study is the first randomized, comparative study to investigate the direct conversion of dialysis patients with chronic kidney disease from treatment with erythropoiesis-stimulating agents (ESA) given one to three times a week to IV ...

Alseres Pharmaceuticals' Announces Expansion of the Cethrin(R) Acute Spinal Cord Injury (SCI) Phase I/IIA Clinical Trial

... that Cethrin treated patients experience a frequency of post-treatment conversions from ASIA A to ASIA B or greater which is up to four times the conversion rate seen with the standard of care reported in the literature (6.7%, Burns et al., J. Neurotrauma, 2003). When subgroups of patients treated with ...

Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years

... AVODART, the first and only dual 5ARI for the treatment of enlarged prostate, inhibits both the type I and type II isoenzymes responsible for the conversion of testosterone into dihydrotestosterone (DHT). DHT is the primary male hormone responsible for the enlargement of the prostate. AVODART provides the ...

Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate

... one share of common stock. 13,842,590 of the Units were purchased for cash, with the balance of 9,962,961 Units issued in consideration for the conversion of all of the Company's $10.544 million in outstanding bridge loan indebtedness. Net cash proceeds to the Company, after expenses relating to closing ...

Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results

... 8,642 19,851 16,951 Operating loss (9,542) (3,422) (16,644) (10,035) Other (expense) and income: Beneficial conversion of convertible security - - - (12,215) Investment and other income 482 294 797 ...

New Data Shows Once a Day Lamictal XR is Effective in Treating Patients with Partial Seizures

... of age and older with epilepsy. The open label, conversion study consisted of a 2 week base line phase ... patients as young as 2 years and 2) for conversion to monotherapy in adults with partial seizures ... established 1) as initial monotherapy, 2) for conversion to monotherapy from AEDs other than ...

Cardiome And Astellas Announce Positive Results From ACT 2 Trial

... patients dosed with vernakalant (iv) experienced conversion to normal heart rhythm within 90 minutes, as ... of dosing. "We are delighted to see a 47% conversion rate in post-operative atrial fibrillation ... drug being evaluated for the acute conversion of atrial fibrillation (AF). Positive top-line ...

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

... million (approximately EUR 157 million or USD 204 million) from private placements of equity securities and two convertible loans including the conversion premiums. We have had total revenues, principally from milestone payments, of CHF 57.7 million (approximately EUR 37 million or USD 44 million). The ...

Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension

... million (approximately EUR 157 million or USD 204 million) from private placements of equity securities and two convertible loans including the conversion premiums. We have had total revenues, principally from milestone payments, of CHF 57.7 million (approximately EUR 37 million or USD 44 million). The ...
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