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Colorectal in Medical Technology

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... of patients with KRAS wild-type metastatic colorectal cancer (mCRC). "We believe that these ... an important advance for patients with metastatic colorectal cancer," said Roger M. Perlmutter, M.D., Ph.D., ... combination with chemotherapy for M etastatic colorectal cancer to determine E fficacy) enrolled 1,183 ...

ARUP Laboratories Applauds FDA's Decision on the Value of KRAS-Mutation Testing in Colorectal Cancer

... that, "retrospective analyses of metastatic colorectal cancer trials have not shown a treatment benefit ... the drugs is not recommended for the treatment of colorectal cancer patients with these mutations. ... technical bulletin, " KRAS Mutation Detection in colorectal Cancer; For Determining Mutational Status that ...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

... Thiarabine Achieves High Cure Rate in a colorectal Cancer Model DALLAS, June 4 ... than achieved by either agent alone. In one colorectal cancer model, 66% of mice were cured of their ... cures were observed in several models including colorectal cancer and leukemia. The combination of agents ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... in a poster during the Gastrointestinal Cancer -- colorectal session at the 45th Annual Meeting of the ... this program forward in patients with advanced colorectal cancer." Mr. Bentsur added, "We wish to thank ... Cancer Society, not counting skin cancers, colorectal cancer is the third most common cancer diagnosed ...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... in a poster during the Gastrointestinal Cancer - colorectal session at the 45th Annual Meeting of the ... this program forward in patients with advanced colorectal cancer." Mr. Bentsur added, "We wish to thank ... Cancer Society, not counting skin cancers, colorectal cancer is the third most common cancer diagnosed ...

Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

... to Oxaliplatin for First-Line Treatment of colorectal Cancer - - Poniard Management Team to Host ... 2 trial of picoplatin in patients with metastatic colorectal cancer (CRC). The new data demonstrated that ... is the current standard of care for metastatic colorectal cancer, but is associated with severe neuropathy ...

Poniard Pharmaceuticals Reports First Quarter 2009 Financial Results and Provides a Corporate Update

... "Given the Phase 2 proof-of-concept data in our colorectal and prostate cancer clinical trials that will be ... SPEAR trial continue. colorectal Cancer In April, final data from a ... study of picoplatin in patients with metastatic colorectal cancer (CRC) was presented at the American ...

Poniard Pharmaceuticals to Present New Data from Phase 2 Clinical Trials of Picoplatin in Multiple Tumor Types at the 45th Annual Meeting of the American Society of Clinical Oncology

... Survival Data to be Presented for Phase 2 colorectal and Prostate Trials - - Company to Hold ... plus 5-FU/leucovorin in patients with metastatic colorectal cancer (CRC). Both presentations will ... options and a poor prognosis. About colorectal Cancer CRC is the third most common cancer in ...

Gen-Probe and DiagnoCure Amend Collaboration Agreement Surrounding PCA3-Based Prostate Cancer Tests

... Inc., launched in 2008 the Previstage(TM) GCC colorectal Cancer Staging Test, the first GCC-based molecular test for the management of colorectal cancer. A major study published in the February ... GCC is the strongest independent predictor of colorectal cancer recurrence in patients considered low risk ...

Clinical Genomics Continues Progress in Developing Biomarker Portfolio for Colorectal Cancer Testing

... biomarkers associated with early onset of colorectal cancer. Clinical Genomics was awarded ... as an aid in detecting precancerous and cancerous colorectal tumors in conjunction with other clinical ... that show promise as aids in detection of both colorectal cancer and precancerous adenomas. "Quest ...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

... T cells to eliminate EpCAM-expressing human colorectal cancer stem cells in cell culture and in animal ... highly active against KRAS-and BRAF-mutated human colorectal cancer cell lines. Recent clinical studies have ... Vectibix. These patients make up more than 40% of colorectal cancer patients. "Micromet ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... highly active against KRAS-and BRAF-mutated human colorectal cancer cell lines(1). Recent clinical studies ... and panitumumab(3,4) are not active in colorectal cancer patients with tumor cells harboring ... These two populations make up more than 40% of colorectal cancer patients. Micromet's researchers ...

Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients

... (MT201) for the treatment of patients with colorectal cancer (CRC) after complete resection of liver ... survival rate at one year. "The relapse of colorectal cancer patients with liver metastases still ... is a cancer target which is highly expressed in colorectal cancer, and targeted therapies such as ...

Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update

... from our ongoing Phase 2 picoplatin studies in colorectal and prostate cancers, and securing a commercial ... clinical trials. colorectal Cancer: In January 2009, the Company presented ... leucovorin (FOLPI) in patients with metastatic colorectal cancer (CRC) at the ASCO 2009 Gastrointestinal ...

Virtual Colonoscopies Show Value for Some Patients, But Polyps Will Be Missed

... procedures as a diagnostic method for detecting colorectal cancer and precancerous growths. Research ... of patients correctly identified as having colorectal polyps or cancer may be too low to be useful. ... at the regular recommended intervals for colorectal cancer screening. Nine studies ECRI ...

Oncolytics Biotech Inc. Announces Start of Patient Enrolment in Translational Clinical Trial Investigating REOLYSIN(R) in Patients with Metastatic Colorectal Cancer

... of REOLYSIN(R) in patients with metastatic colorectal cancer prior to surgical resection of liver ... advance of their scheduled operations to remove colorectal cancer deposits metastatic to the liver. Patients ... patients include those with histologically proven colorectal cancer, planned for potentially curative surgical ...

Chemoembolization Improving as Liver Cancer Treatment

... in Tampa, Fla., included 25 patients who had colorectal cancer that had spread to the liver and 11 with ... a type of chemotherapeutic agent, while 13 of the colorectal patients received doxorubicin-emitting beads and ... patients and 10 of the 13 (77 percent) of the colorectal patients were alive after two years. Conversely, ...

New Overall Survival Study Results Confirm Oral Xeloda(R) plus Oxaliplatin (XELOX) is Comparable to FOLFOX-4 for the First-Line Treatment of Advanced Colorectal Cancer

... the first-line treatment of advanced (metastatic) colorectal cancer. In the study, patients receiving ... to FOLFOX-4 for the treatment of advanced colorectal cancer, while providing the added flexibility of ... of patients with this insidious disease." colorectal cancer is the third most common cancer in the ...

ASGE Urges Patients to Seek a Qualified Endoscopist Before Undergoing a Colonoscopy for Colorectal Cancer

... rates, but raises concerns about detection of colorectal cancer on the right side of the colon ... is associated with lower death rates from colorectal cancer, however, the procedure missed lesions ... Endoscopy (ASGE), representing the specialists in colorectal cancer screening, recommends that patients seek ...

Poniard Pharmaceuticals Announces Management Changes and Focus on Development and Commercialization of Picoplatin

... Phase 2 data in ongoing clinical trials in colorectal and prostate cancer," said Jerry McMahon, ... of picoplatin in the treatment of lung, colorectal and prostate cancers." About Poniard ... cell lung cancer and Phase 2 trials in metastatic colorectal and hormone-refractory prostate cancers, as well ...

National Study Presented at ACG 2008 Confirms New Device Functions Like 'Rear-View Mirror' to Provide Improved View of the Colon

... cases of colon cancer arise from adenomas." colorectal cancer is the second greatest cause of cancer ... His major research interests have been in colorectal disease, and in particular, colorectal cancer screening and the technical performance ...

ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options

... small polyps. CT colonography is one of several colorectal cancer screening options. The American Society ... far too few people undergo screening for colorectal cancer. Any advances that result in increased ... that CT colonography identified large colorectal adenomas (polyps most likely to become cancerous) ...

Video: Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy

... of clinical practice as a primary option for colorectal cancer screening. We hope that this additional, ... M.D., of the Mayo Clinic in Scottsdale, Ariz. colorectal cancer is the third most frequently diagnosed ... continue to see a decline in the incidence of colorectal cancer," said NCI Director John E. Niederhuber, ....

Despite Advances in the Accuracy of CT Colonography in Detecting Polyps, Digestive Health Experts Urge Patients to Consider Risks and Realities

... in detecting large pre-cancerous polyps and colorectal cancers, coordinated by the American College of ... several important issues for the public about colorectal cancer screening using a CT scan of the abdomen: ... issued a Multi-Society Task Force Guideline on colorectal Cancer which stated a preference for tests which ...

August 2008 Mayo Clinic Women's HealthSource Highlights Avoiding Blood Pressure Increase at Menopause, Healthful Benefits of Dark Chocolate and Scheduling a Colorectal Exam

... to $4 each. Most Important Choice -- Schedule a colorectal Exam More options are available for colon ... That misperception could be deadly. colorectal cancer is the third-leading cause of cancer ... that begins in either organ may be called colorectal or colon cancer. For people age 50 and older, or ...

Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer

... and the United Kingdom, found that metastatic colorectal cancer patients with fewer than three circulating ... measurements of CTCs for patients with metastatic colorectal cancer beginning a new therapy can provide ... and Overall Survival in Patients with Metastatic colorectal Cancer," which summarizes data from a prospective ...

Avastin(R) Shows Unprecedented Benefits in Colorectal Cancer Patients, Irrespective of K-Ras Gene Mutation

... improves survival in patients with metastatic colorectal cancer regardless of whether they have mutation ... is active for patients with metastatic colorectal cancer with both K-Ras wild type and mutant ... in more than 800 previously untreated metastatic colorectal cancer patients. In the study Avastin was ...

New Data Demonstrates 5-FU Personalized Chemotherapy Management (PCM(R)) Assay Provides Similar Performance to More Complicated Liquid Chromatography-Mass Spectrometry (LC-MS/MS)

... 5-FU is a cornerstone treatment regimen for colorectal cancer; the third leading cause of cancer deaths ... results of a Phase III randomized study of colorectal cancer patients who were dosed with 5-FU based on ... manage dosing of blood thinning drugs. About colorectal Cancer ...

Saladax Biomedical's 5-FU Personalized Chemotherapy Management (PCM(R)) Assay CE Marked for Distribution in the EU

... has not been readily available. As a result, colorectal cancer patients receive chemotherapy based on ... cost-effective tool in the battle against colorectal cancer," said Erick Gamelin, M.D., Ph.D. director ... quality of life and treatment outcomes." About colorectal Cancer ...

ADVENTRX Announces CoFactor(R) Phase 2b Clinical Trial Overall Survival Results

... for the treatment of first-line metastatic colorectal cancer. Overall survival results in this study ... for the treatment of first line metastatic colorectal cancer later this month. Furthermore, the Company ... in patients with first line metastatic colorectal cancer. Three hundred patients were randomized ...

Orion Genomics Gains Exclusive Worldwide Rights to the IGF2 Gene for Colorectal Cancer Risk Testing Through Licensing Agreement With Johns Hopkins University

... products that identify patients at risk for colorectal cancer. The license is based on a suite of issued ... enable at-risk patients to undergo screening for colorectal cancer significantly earlier, allowing physicians ... Lakey, President and CEO of Orion Genomics. "Our colorectal cancer risk test has the potential to save lives ...

Anti-TGF-Beta Antisense AP 12009 Shows Very Good Safety and Tolerability in Systemic Treatment of Pancreatic Carcinoma, Malignant Melanoma and Colorectal Carcinoma

... of pancreatic carcinoma, malignant melanoma and colorectal carcinoma. AP 12009, administered intravenously, ... in Pancreatic Carcinoma, Malignant Melanoma, or colorectal Carcinoma", ASCO Annual Meeting, 2008, Abstract ... metastatic melanoma (stage III/IV), or advanced colorectal carcinoma (stage III/IV) repeatedly receive ...

Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)

... Oncogene Population in Patients with Advanced colorectal Cancer New Phase 2 Clinical Trials Will Evaluate ... The company will target newly-characterized colorectal cancer patients with K-Ras mutated gene status in its Phase 2 study in advanced colorectal cancer. In addition, NKTR-102 will be evaluated ...

New Eloxatin(R) (oxaliplatin injection) Prescribing Information in the U.S. Includes Six-Year Overall Survival Data

... including long-term adverse effects. About colorectal Cancer Stage II colorectal cancer indicates that the cancer has grown ... but has not spread to distant sites. Metastatic colorectal cancer means that the cancer has spread to other ...

Nearly 60 New Studies of Oral Xeloda(R) (capecitabine) Featured at the 44th American Society of Clinical Oncology Annual Meeting

... support clinical testing of this regimen in colorectal cancer patients. [See 2008 ASCO Proceedings I - ... enhances single agent & combination activity in a colorectal cancer xenograft model. (Lead Author: Kenneth ... cancer and adjuvant and metastatic colorectal cancer. Inactive in pill form, Xeloda is ...

Annual FIT Testing Detects Colorectal Cancer Two Years Earlier Than Colonoscopy Alone, Study of High-Risk Population Finds

... (CSP) for People at Increased Risk for colorectal Cancer" conducted at the Flinders Centre for ... individuals with a family or personal history of colorectal cancer or adenoma were entered into a CSP. In ... FIT cohort (n=14) and the non-FIT cohort (n=14), colorectal cancers in the FIT cohort were detected an ...

New Roche Data to be Presented at ASCO Offers Further Hope for Cancer Patients

... ultimately lead to death of cancer cells. colorectal cancer -- Avastin: The first presentation of ... to Avastin) in patients with metastatic colorectal cancer will be shared. -- Avastin: Impressive ... is now playing in patients with advanced colorectal cancer. The results of the studies are ...

Poniard to Present Clinical Data From Picoplatin Trials in Multiple Tumor Types at American Society of Clinical Oncology 2008 Annual Meeting

... Safety and Efficacy Clinical Data from Prostate, colorectal and Ovarian Cancers ... ongoing Phase 2 clinical trial of picoplatin in colorectal cancer (CRC) and updated data from its Phase 1 ... Hall A1, Poster #16A -- First-line Treatment of colorectal Cancer: Abstract #4100 First-line Phase 1b ...

Studies Point to Benefits of Personalized Chemotherapy Dose Management in Colorectal Cancer

... Can a blood test improve treatment outcomes for colorectal cancer patients? Recently published studies ... cancer. A Phase III randomized study of 208 colorectal cancer patients, by Erick Gamelin, M.D., Ph.D. ... test the level of 5-FU in the blood of our colorectal cancer patients and adjust their doses to achieve ...

Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting

... evaluate its safety and efficacy as a second-line colorectal cancer therapy in combination with cetuximab. ... with bevacizumab in a mouse model of human colorectal tumors" #5741: "NKTR-102, a novel ... used for the treatment of solid tumors, including colorectal and lung cancers. By applying Nektar's small ...
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