Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults
... been shown to involve the modulation of sodium channel
activity in the nervous system. Sodium channels ... for Vimpat(R) is thought to reduce this sodium channel
over-activity by enhancing the longer lasting ... a different action compared with current sodium channel
blocking drugs. This action then regulates the ...
New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure
... not adequately controlled with any calcium channel
blocker or any angiotensin receptor blocker ... acute myocardial infarction on starting calcium channel
blocker therapy or at the time of dosage ... Congestive Heart Failure
In general, calcium channel
blockers should be used with caution in patients ...
Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia
... which targets TRPM8 (a transmembrane cation channel
protein), to treat benign prostatic hyperplasia ... (#1408), "Preclinical Evaluation of the TRPM8 Ion channel
Agonist D-3263 for Benign Prostatic Hyperplasia" ... in-house discovery efforts. It is an ion channel
that is triggered by cold temperatures and ...
Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer
... designed to target TRPM8 (a transmembrane cation channel
protein) in cancer cells and induce cell death. ... in-house discovery efforts. It is an ion channel
that is triggered by cold temperatures and ... including D3263 that activate the TRPM8 ion channel
and induce cell death.
Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment
... study of
leconotide, an investigative calcium channel
blocker, shows it has the
potential to be safe, ... as has been seen in studies
of other calcium channel
blockers used for treating pain. It was ... the rodents were given injections of two
blockers (leconotide or ziconotide) alone and in ...
/C O R R E C T I O N -- Prof Terje Pedersen, SEAS Study Principal Investigator & Head of Steering Committee/
... Satellite: AB1 12.5 Deg West Txp: B6 Lower, channel
2 DL: 11152.700 V symbol rate 5.632 FEC 3/4
... Galaxy 11 @ 91 degrees west KU Band: Txp 13, channel
A DL: 11946.5 H SYMBOL RATE 5.632 FEC 3/4
... Satellite: AB1 12.5 Deg West Txp: B6 Lower, channel
2 DL: 11152.700 V symbol rate 5.632 FEC 3/4
Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic Hyperplasia
... which targets Trp-p8 (a transmembrane cation channel
known as Trp-M8), to treat benign ... discovery efforts. It is an ion channel
that is triggered by cold
temperatures and ... molecule
agonists that activate the Trp-p8 ion channel
and induce cell death. The
lead molecule, D-3263, ...
Parion Sciences Announces Phase I Clinical Results for Novel Dry Mouth Treatment
... a Phase I clinical
safety study of a novel sodium channel
blocker, P-552-02, as a topical
therapy for dry ... other potential indications."
Epithelial sodium channel
blockers, such as P-552-02, are ... utilizing Parion's expertise in
epithelial sodium channel
blockers. Parion was founded based on ...
Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells
... suggested that a
therapy designed to block this channel
might have a beneficial effect on
the progression of the disease.
Senicapoc, a known Gardos channel
blocker, works by limiting solute and
water loss, ... provide further evidence that
blocking the Gardos channel
reduces dehydration of the sickle ...
Award-Winning Medicine Wheel Returns to the Cyclorama at the Boston Center for the Arts on Dec. 1 for 24-hour Vigil Recognizing World AIDS Day
... Water bearers from Fort Point channel
to the Cyclorama mark 16th Annual
... copper buckets filled
with water from Fort Point channel
in South Boston into The Boston Center
for the ... people will make short
processions to Fort Point channel
and back to the Boston Center for the
Arts, where ...
Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM)
... combination of two
antihypertensives, the calcium channel
blocker, amlodipine and the
angiotensin receptor ... amlodipine, the number one prescribed calcium channel
blocker (CCB) on
the market, and olmesartan ... acute myocardial infarction on starting calcium channel
blocker therapy. In studies of ACE inhibitors in ...
Essentialis Meets Primary Endpoint in Phase 2b Trial of DCCR for Treatment of Hypertriglyceridemia and is Granted Extensive Patent Coverage in the US
... of a US patent covering DCCR. The patent entitled "Salts of potassium ATP channel
openers and uses thereof" contains claims to salts of diazoxide - ... DCCR, diazoxide choline controlled release, is an ATP-dependent potassium channel
agonist with potential utility in several cardiovascular and metabolic ...
PTC Announces Data Showing That PTC124 Causes Statistically Significant Improvements in Chloride Channel Function in Cystic Fibrosis Patients
... drug PTC124 caused statistically significant improvements
in the chloride channel
function of children with cystic fibrosis (CF)
caused by a particular ... protein. PTC124
also induced significantly improved CFTR-mediated chloride channel
as measured by nasal potential difference, with 40 percent of ...
National Study Presented at ACG 2008 Confirms New Device Functions Like 'Rear-View Mirror' to Provide Improved View of the Colon
... Calif., this
innovative new device is passed through the instrument channel
standard colonoscope. As it emerges from the channel
and extends beyond the
tip of the colonoscope, the device automatically ...
Azor(TM) Reduces Blood Pressure in Difficult to Treat Special Populations
... or severity of angina
or acute myocardial infarction on starting calcium channel
or at the time of dosage increase.
Congestive Heart Failure
In general, calcium channel
blockers should be used with caution in
patients with heart failure.
Ranolazine Shortens QT Interval and Improves Cardiac Relaxation in Study of Patients With Genetic Sodium Channel Disorder
... called LQT3, which is caused by a genetic mutation in the late
and can be associated with heart rhythm problems, including
sudden death. ... "Since individuals with LQT3 syndrome have a defect in the specific
where ranolazine has its activity, it makes sense that we
are seeing ...
PTC Therapeutics Announces Publication of Preclinical Data in PNAS
... functional protein. Patients with CF lack the
CFTR protein, a chloride channel
that maintains proper hydration of
epithelial cells in the lung, pancreas, ... to be delivered to the proper cellular location, and to
induce chloride channel
function. Collectively, these results indicate that
this new approach may ...
ReachMD Broadcasts First-of-its-Kind Physician Peer-Peer Discussion on ENHANCE Trial
... through multiple channels throughout the day:
-- Satellite Radio - XM channel
157, beginning at 1:30 p.m. EST
-- Online Simulcast - ... information and communication to
medical professionals. The ReachMD XM channel
is a new and innovative media
vehicle that continues to deliver on this ...
Lilly and Glenmark Pharmaceuticals Announce License Agreement
... 16% to 17% About TRPV1 TRPV1 is a member of the TRPV family of ion channel
proteins. It is
expressed in human pain pathways and in sensory neurons ... Research on TRPV1 supports the potential for
antagonists of this ion channel
to be effective in various pain conditions.
The goal of the partnership is ...
Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease
... placebo-controlled Phase 2a study
of MEM 1003, a neuronal L-type calcium channel
modulator, in Alzheimer's
disease. The trial enrolled 183 subjects with ... the fourth quarter. About MEM 1003 MEM 1003 is a neuronal L-type calcium channel
modulator that Memory
Pharmaceuticals is developing for the treatment of ...
Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)
... prescribed for chronic pain management. Lubiprostone, a chloride channel
activator developed by Sucampo
Pharmaceuticals, is currently approved for ... effects of these analgesics. Lubiprostone, as a locally acting
activator, is being studied to evaluate if it may directly
counteract this ...
FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents
6. Wang M, Arnsten AF, Brennan A, et al. Ã¿Â±2A-adrenoceptors strengthen
working memory networks by inhibiting cAMP-HCN channel
prefrontal cortex. Cell. 2007;129:397-410.
7. Arnsten AF, Li BM. Neurobiology of executive functions: catecholamine
influences on ...
Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease
... Cognition Therapeutics was founded on small molecule chemical libraries licensed from co-founder Dr. Gilbert Rishton at California State University channel
Islands and proprietary screening strategies established by co-founder and Chief Science Officer Dr. Susan Catalano. After initial investment and ...
Pivotal Data Show Bronchial Thermoplasty Can Improve Quality of Life and Reduce Asthma Attacks and Emergency Room Visits for Adults with Severe Asthma
... Delivered by the Alair System
Bronchial thermoplasty is a non-drug procedure for asthma. The treatment is performed through the working channel
of a standard flexible bronchoscope that is introduced through a patient's nose or mouth, and into their lungs. The tip of the small diameter ...
Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results
... of five years. Patients with hypertension were also treated at the investigator's discretion with diuretics, alpha- or beta-blockers or calcium channel
antagonists to achieve a target BP of <130/80. Patients requiring treatment with an ARB or ACEi were withdrawn from the study.
About the ...
Clinician Reports Fast Healing of Intractable Wounds Using MEDIHONEY(R)
... wide variety of common wounds, abrasions, and minor burns. As announced previously, these dressings are expected to be in the US retail distribution channel
Additional clinical abstracts on the use of MEDIHONEY presented at the SAWC include:
Active Leptospermum ...
BARC Central Laboratory Joins Alzheimer's Association Research Roundtable
... dermatology and immunology. BARC performs more than 2,000 assays, including molecular diagnostics and genomics, and serves as a technology transfer channel
by developing and clinically validating new laboratory tests on a global, multi-site GCP-certified platform for pharmaceutical and biotechnology ...
Advances in Science and Treatment of Pain Presented at 25th Annual American Academy of Pain Medicine Meeting January 28 - 31, 2009
... 10:00 AM HAST
Coral Ballroom Foyer, Hilton Hawaiian Village
Authors present Jan. 29 from 3:30-5 PM and Jan. 30 from 9-10 AM
Blockers Compared for Neuropathic Pain, Poster 181
Addictive Qualities of Cannabinoid Medication, Poster 193
Tramadol Outcomes, Poster 197
Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans
... the H5 plasmid plus separate plasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ion channel
protein (M2). The trivalent vaccine was designed to elicit a combination of T-cell and antibody responses against all three proteins. Both vaccines ...
Retigabine Significantly Reduces the Number of Seizures in Adults With Inadequately Controlled Partial-Onset Epilepsy
... doses of up to three AEDs.
Retigabine has a different mechanism of action than currently approved
AEDs. Retigabine is a neuronal potassium channel
opener, which helps control
neuronal excitability. In epilepsy patients, brain cells can become overly
excited, disrupting normal brain activity and ...
New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy
... are triggered via voltage-gated sodium channels in the nerve
Zebinix(TM) is a novel voltage-gated sodium channel
blocker that has
been designed to reduce the frequency of partial-onset seizures when used
in combination with other anti-epileptic drugs.
Stem Cell Regeneration Repairs Congenital Heart Defect
... heart failure
in a series of genetically altered mice. Specifically, the "knockout" of a
critical heart-protective protein known as the KATP channel
heart contractions and caused ventricular dilation or heart enlargement.
The condition, including poor survival, is typical of patients ...
Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network
... Center for Chemical Probe Discovery and Optimization
at Scripps Research Institute, Scripps Institute, San Diego, Calif.
-- Johns Hopkins Ion channel
Center, Johns Hopkins University,
-- NIH Chemical Genomics Center, NIH/NHGRI, Rockville, Md.
-- University of Kansas Specialized ...
Vical Announces Breakthrough for Pandemic Influenza DNA Vaccines With Preliminary Human Data
... the H5 plasmid plus
separate plasmids encoding consensus sequences of two highly conserved
influenza virus proteins: nucleoprotein (NP) and ion channel
The trivalent vaccine is designed to elicit a combination of T-cell and
antibody responses against all three proteins. Both vaccines ...
Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
... candidates," said
Nils Lonberg, Senior Vice President and Scientific Director at Medarex. "We
are uniquely structured to identify, optimize and channel
promising lead candidates into clinical development on a continual basis to
ensure the future growth and value of our pipeline."
CV Therapeutics Announces Archives of Internal Medicine Publication of Study Showing 20 Percent of Heart Attack Patients in Premier Registry Experienced Angina at One Year
... or weekly angina attacks.
The investigators reported that in patients with angina after one year,
87.9 percent were not taking calcium channel
blockers, 30.8 percent were
not taking beta blockers and 48.6 percent were not taking nitrates.
"After patients survive a heart attack, a primary ...
Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease
... pulmonary arterial hypertension. NEJM 2002; 346: 896-903 (BREATHE-1). 4. Sitbon O, Humbert M, Jais X et al. Long-term response to calcium channel
blockers in idiopathic pulmonary arterial hypertension. Circulation 2005; 111: 3105-3111 5. D'Alonzo GE, Barst RJ, Ayres SM et al. Survival in ...
HUYA Bioscience Int'l Announces Pre-IND Outcome for HBI-3000 - Promising Anti-Arrhythmia Compound Sourced From China
... significant unmet need. HUYA is
proud to lead the way in co-developing new and important drugs that may
HBI-3000 is a novel, multi-ion channel
blocker for the treatment of
atrial or ventricular arrhythmias. In April 2008, HUYA announced the
completion of three Phase I protocol studies of ...
New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering
... 11. Schiffrin EL, Deng LY. Structure and function of resistance arteries of hypertensive patients treated with a beta-blocker or a calcium channel
antagonist. J Hypertens 1996;14:1247-55 12. Schiffrin EL. Remodeling of resistance arteries in essential hypertension and effects of ...
JDSU WaveReady Receives Brocade Data Center Ready Status for Brocade-Based Storage Area Network (SAN) Infrastructures
... the reach of SANs. WaveReady multirate transponders support
FC100 (1.0625 Gbps), FC200 (2.125 Gbps), FC400 (4.25 Gbps), and 10GFC
(10.518 Gbps) Fibre channel
interfaces and, combined with amplifiers,
extend the reach of SAN services to over 175 Km. WaveReady offers a simple
and reliable transport solution ...