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Carotid in Medical Technology

Vascular Surgeons Agree: Case Rehearsal Improves Outcomes

... Using an Endovascular Simulator Prior to carotid Artery Stenting Sean J Hislop, MD, Joseph H ... To determine whether a patient's specific carotid anatomy can be modeled using CTA on an ... Methods: Patients underwent CTA of the arch and carotid circulation. Simbionix (Cleveland, OH and Lod, ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

... doses tested (p<0.001). The second trial, the carotid endarterectomy (CEA) trial, missed its primary ... is a surgical procedure to remove plaque from the carotid artery to increase blood flow to the brain and to ... reduction in macrophages in the plaque tissue in carotid arteries of patients treated with 100mg VIA-2291 ...

VIA Pharmaceuticals Completes Patient Visits in Phase 2 Carotid Endarterectomy (CEA) Trial

... has completed the last patient visit in its carotid endarterectomy (CEA) study. The excised carotid plaque tissue will be analyzed to ... attack and stroke. "Analyzing the carotid plaque collected in the CEA trial is a ...

VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial

... that it has completed patient enrollment in its carotid endarterectomy (CEA) study, the first of three ... inflammation by analyzing plaque removed from the carotid arteries of patients treated with VIA-2291 or ... a surgical procedure to remove plaque from the carotid artery to increase blood flow to the brain in ...

New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease

... calcium) 40 mg slowed the progression of carotid intima-media thickness (CIMT) in four patient ... when compared with placebo, slows progression of carotid atherosclerosis in subjects at relatively low ... (p Ultrasound assessments were made at 12 carotid artery sites at baseline and every 6 months up to ...

ActivBiotics to Present Results of Pivotal Study in the Treatment of Peripheral Arterial Disease at AHA Meeting

... completed in separate Phase II study in carotid Atherosclerosis LEXINGTON, Mass., Oct. 24 ... Evaluation of Short-Term Rifalazil Treatment on carotid Atherosclerosis and Intima Media Thickness) is ... history of atherosclerosis and image-detectable carotid disease. This study will use the ...

Boston Scientific Carotid Artery Stenting Trials Produce Positive Three-Year Results

... three-year results from its CABERNET and BEACH carotid artery stenting clinical trials. The studies ... embolic protection for patients at high risk for carotid endarterectomy (CEA), the surgical treatment for carotid artery disease. The three-year CABERNET and BEACH ...

Boston Scientific to Release Broad Range of Clinical Trial Data Reinforcing Safety and Efficacy of Taxus(R) Coronary Stent Systems at TCT 2007

... October 23 -- CABERNET & BEACH Trial Results on carotid Stenting. At 4:00 p.m., three-year follow-up ... safety and efficacy of the Company's NexStent(R) carotid Stent System and FilterWire EZ(TM) Embolic ... outcomes of the Company's Monorail(R) carotid WALLSTENT(R) Endoprosthesis in conjunction ...

Boston Scientific Begins Clinical Trial for Next-Generation Nitinol Stent to Treat Iliac Artery Disease

... offers physicians a range of peripheral stent indications, including the carotid Wallstent(R) Endoprosthesis for carotid artery disease and the Express(R) SD Stent for renal artery disease. ...

Abbott Advances Its Revolutionary Fully Bioabsorbable Drug Eluting Stent With Initiation of Next Phase of Clinical Trial

... research program includes clinical trials in peripheral artery disease, carotid artery disease, and coronary artery disease. Key products in the vascular ... Stent System; the EMBOSHIELD NAV6(TM) Embolic Protection System for carotid stenting; and the XIENCE PRIME(TM) Everolimus Eluting Coronary Stent ...

VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial

... VIA will report top-line data from the ACS trial, as well as the Phase 2 carotid endarterectomy trial (CEA), concurrent with the company's data ... in this trial is ongoing and endpoints in this study include reduction in carotid plaque inflammation following dosing with VIA-2291 as measured ...

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

... to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry ... In the current study, the iNOS reduced restenosis by 56 percent in the carotid arteries of treated rats, as compared with control animals. Although ...

Zetia Does Not Reduce Carotid Plaque Size When Added to Zocor

... alone. However, the researchers found that "the average thickness of the carotid artery plaque increased by 0.0111 of a millimeter in patients taking ... He also said that "one should not confuse the very, very small increase in carotid plaque dimension with a risk of cardiovascular events, as this event data ...

Researchers Use Magnetism to Target Cells to Animal Arteries

... into steel stents, small metal scaffolds that had been inserted into the carotid arteries of rats. The uniform magnetic field created "magnetic gradients," ... animals were alive. After introducing stainless steel stents into rats' carotid arteries, Levy's team used magnetic fields to steer the cells into the ...

Study Results Show That Minimally Invasive Therapy is Successful for Over Two-Thirds of Stroke Patients Treated Outside the Standard Eight-Hour Window

... of neurointerventional surgery. Our practitioners specialize in minimally invasive and endovascular procedures to treat stroke, aneurysms, carotid stenosis and spine fractures. Over the past two decades, our physicians have made numerous contributions to the neurosciences including: advancing ...

Neurointerventionists Expand Research to Quality of Life in Aneurysm Patients Following Minimally Invasive Coiling Treatment

... of neurointerventional surgery. Our practitioners specialize in minimally invasive and endovascular procedures to treat stroke, aneurysms, carotid stenosis and spine fractures. Over the past two decades, our physicians have made numerous contributions to the neurosciences including: advancing ...

VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease

... VIA-2291's potent inhibition of leukotrienes, lowering of hsCRP, and the potential for plaque stabilization as demonstrated by reduction in carotid plaque inflammation and non-calcified coronary plaque volume. We believe this compound is now ready for testing in a broad outcome Phase 3 trial that ...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

... disease (CVD) risk (defined by total cardiovascular events: the composite of cardiovascular death, myocardial infarction, stroke, and coronary and carotid revascularization) in patients with type 2 diabetes and atherogenic dyslipidemia, that is, the combination of high triglyceride (2.3 mmol/L-200mg/dL ...

MGuard(TM) Coronary Stent System Approved in Israel

... generation drug eluting stents. InspireMD intends to pursue applications of this technology both for bare metal and drug eluting stents in coronary, carotid and peripheral artery procedures. For further information visit http://www.inspire-md.com Contact: Jonina Ohayon Marketing ...

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

... includes annual TCD screening for children with normal TCD results (indicated by a cerebral blood-flow velocity of less than 170 cm/s in the internal carotid and middle cerebral arteries), repeat screening every three to six months in children with conditional TCD results (between 170 and 199 cm/s), and ...

VIA Pharmaceuticals Announces Conference Call and Webcast to Discuss VIA-2291 Phase 2 Data Presentations at AHA

... disease, announced today that it will hold a conference call and webcast to discuss results of the VIA-2291 Phase 2 acute coronary syndrome (ACS) and carotid endarterectomy (CEA) trials presented at the American Heart Association (AHA) Scientific Sessions 2008 on Sunday, November 9. The conference call and ...

VIA Pharmaceuticals to Present at American Heart Association Scientific Sessions 2008

... and Strategies: First in Man Title: Three Months of Treatment with 5-Lipoxygenase Inhibitor VIA- 2291 in Patients Scheduled for Elective carotid Endarterectomy Surgery Presented by: Tilmann M Brotz, Ph.D., Vice President of Pre-Clinical Research and Development, VIA Pharmaceuticals ...

Blueberry-Supplemented Diet Shows Promise in Lowering Cholesterol in Animal Trials

... of LDL similar to humans and are susceptible to diet-induced vascular disease. Pigs can also develop atherosclerotic plaques in the aorta and carotid artery, and have a similar blood pressure and heart rate as humans. The Antioxidant Power of Blueberries The antioxidant activity of blueberries ...

VIA Pharmaceuticals Completes Enrollment in Phase 2 Acute Coronary Syndrome (ACS) Trial

... with VIA-2291 or placebo. Enrollment in the third Phase 2 clinical trial, the FDG-PET Trial, is ongoing. Endpoints in this study include reduction in carotid plaque inflammation following dosing with VIA- 2291 as measured with state-of-the-art FDG-PET imaging technology, as well as assessment of standard ...

New Data Showed ACTOS(R) (pioglitazone HCl) Prevented Progression of Atherosclerotic Plaque Volume in Patients With Type 2 Diabetes

... patients with type 2 diabetes, all from the Chicago area. The primary goal was to compare the effects of ACTOS versus glimepiride, a sulfonylurea, on carotid intima-media thickness (CIMT), defined as the thickness of the inner lining of a patient's neck arteries. CIMT is an established surrogate marker of ...

ImpactRx Tracks Decline in Zetia and Vytorin Prescribing

... difference between treatment groups on the primary endpoint: mean change in the intima-media thickness (IMT) measured at three sites in the carotid arteries. In the past week, primary care physicians' usage of Vytorin, the combination of Zetia and simvastatin, has declined from 15% of ...

VIA Pharmaceuticals Enrolls First Patient in Phase 2 Clinical Trial to Measure Impact of VIA-2291 to Reduce Vascular Inflammation

... was randomized to treatment at Massachusetts General Hospital in Boston. Mount Sinai Heart in New York City is also participating in the study. carotid Endarterectomy (CEA) Study VIA has enrolled approximately 40 patients in the CEA study as planned, and is expanding enrollment to gather additional ...

Data Presented at the American Heart Association Scientific Sessions 2007 Demonstrated Increased HDL with ACTOS(R) (pioglitazone HCl) Slowed the Progression of Carotid Intima-Media Thickness in Patients with Type 2 Diabetes

... Heart Association Scientific Sessions 2007 being held November 4 through 7, 2007 in Orlando, Florida. Results revealed that reduced progression of carotid intima-media thickness (CIMT), the thickness of the inner lining of a patient's carotid, with ACTOS was associated with increased HDL cholesterol and ...

New Study Proves That Minimally Invasive Aneurysm Treatment Yields Successful Long-Term Results

... from subarachnoid hemorrhage each year. ASITN members specialize in minimally invasive and endovascular procedures to treat stroke, aneurysms, carotid stenosis and spine fractures. Our physicians have made numerous contributions to the neurosciences including: advancing stroke treatment through ...

Abbott to Present New Data Across its Vascular Portfolio at the American College of Cardiology's 56th Annual Scientific Session

... data from two studies designed to confirm that carotid stenting can be performed with good results by ... settings in patients who are at high risk for carotid artery surgery. In addition, one-year follow-up ... later that day. EXACT and CAPTURE 2 carotid Clinical Trial 30-Day Results Late-Breaking ...

Two New Imaging Studies Show Higher Dose Lipitor Stopped the Progression of Atherosclerosis

... by coronary intravascular ultrasound (IVUS) or carotid B-Mode ultrasound. IVUS is a relatively new, ... artery wall over the length of the vessel. carotid ultrasound measures the thickness between the inner and middle layers of the carotid artery wall (IMT). All three trials had a run-in ...

First Study To Show Positive Benefit On Atherosclerosis For People With Early Signs Of Diseased Arteries

... a 0.0014 mm/yr decrease in the mean maximum carotid intima-media thickness – a marker of ... ORION (Outcome of Rosuvastatin Treatment on carotid Artery Atheroma: a Magnetic Resonance Imaging ... the change in the composition of plaques in the carotid artery wall. Forty-three (43) patients with ...

Two Abbott Studies Reaffirm Carotid Artery Stenting as a Safe and Effective Treatment to Reduce Risk of Stroke

... invasive treatment option for patients with carotid artery disease who may be at risk of experiencing ... are improving over time as the practice of carotid stenting increases." The primary endpoint of ... and/or death in patients treated with Abbott's carotid stent systems (1.8 percent in EXACT, 1.3 ...

Treating Heart Disease Risk Factors May Slow Alzheimer's Disease Progression

... or TIA Associated with Increased Risk of MCI carotid endarterectomy is performed when a major blood ... skills, and were asked if they had ever had a carotid endarterectomy or a stroke or TIA. 295 persons in ... an alternate explanation for our findings is that carotid artery surgery may be a marker for generalized ...

New Point-of-Care Methods to Measure Coronary and Cerebrovascular Risk

... protein also predict risk. More recently, carotid intima-media thickness (CIMT) and the brachial ... assessing the arteries. Direct assays such as carotid ultrasound, coronary angiography, computed ... thickness of the intimal and medial layers of the carotid artery walls. OLeary and coworkers (New Engl. J. ...

Boston Scientific Announces Schedule for EuroPcr 2007

... in patients with diabetes. Thursday, May 24 * Focus Session on carotid artery stenting. The Company will sponsor a focus session entitled "Clinical and technical considerations for daily carotid artery stenting practice," chaired by Nick Hopkins, M.D., from 2:00 ...
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