USC Keck School of Medicine's Dr. Alan Epstein Receives Prestigious National Cancer Institute RAID Award for Breakthrough IL-2 Molecule Therapeutic

... and resulting side effects, especially that of capillary leak syndrome where leakage of fluid from the ... (hypotension), edema and multiple organ failure. capillary leak syndrome affects as many as 65% of patients ... an IL-2 analog that eliminates the side effect of capillary leak syndrome while retaining the cytokine and ...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... the change in the amount of kidney interstitial capillary GL-3, the substrate that accumulates in the cells ... the change in the amount of kidney interstitial capillary GL-3 as measured in kidney biopsies using ... baseline samples had detectable interstitial capillary GL-3 and that reductions were observed in 8 of ...

Bethesda-Based NHSi Wins $2M Grant for Blood Technology

... and more deformable red blood cells for better capillary perfusion, and extend by 50 percent or more the ... diminished capacity to deform and perfuse narrow capillary networks in tissues is believed to be a major ... blood cells by passing it through an artificial capillary network produced on a disposable microchip. This ...

ECLIPSE Data on Effects of Otsuka's Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients' Hemodynamics and Urine Output Featured in Heart Failure Society of America's Late Breaking Trials

... in ECLIPSE significantly changed the primary outcome variable, pulmonary capillary wedge pressure (PCWP), compared to placebo treatment (tolvaptan 15 mg ... about two aspects of lung and heart function: an estimate of the lung capillary pressure, which is the fluid pressure that plays a role in pulmonary ...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

... retention, pulmonary infiltrates or CHF; respiratory symptoms or disease; cardiac symptoms or disease; and renal or hepatic dysfunction. Edema, capillary leak syndrome, pleural and or/pericardial effusion, supraventricular tachycardia, sequestration of granulocytes in the pulmonary circulation and ...

Glycerin Proven to Improve Bruising and Swelling Caused By Trauma to Skin

... Glycerin, a humectant, attracts water and helps lubricate and hydrate the skin's cells. It is a thick, water-soluble liquid. Bruises occur when capillary blood vessels break and blood and fluids pool underneath the skin. Glycerin's hydrating properties enable the body to seal off the broken capillaries ...

CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License

... combined. It is diffuse heterogeneous lung injury characterized by hypoxemia, non-cardiogenic pulmonary edema, low lung compliance and widespread capillary leakage. ALI is caused by any stimulus of local or systemic inflammation and commonly occurs after acute insults to the body, such as trauma, severe ...

Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels

... Capillaries are the smallest blood vessels in the body and the site at which oxygen and nutrients are transferred from the blood to the tissues. A capillary is composed of an endothelial cell, which forms the lining of the small tube, and a pericyte, which wraps around the outside of the tube. Scientists ...

Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients

... is to assess hemodynamic effects of intravenous infusions of CD-NP in patients with heart failure. Key assessments include measurement of pulmonary capillary wedge pressure (PCWP), plasma cGMP, a secondary messenger of the target receptor, blood pressure, heart rate, serum potassium and renal function. ...

Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma

... retention, pulmonary infiltrates or CHF; respiratory symptoms or disease; cardiac symptoms or disease; and renal or hepatic dysfunction. Edema, capillary leak syndrome, pleural and or/pericardial effusion, supraventricular tachycardia, sequestration of granulocytes in the pulmonary circulation and ...

Study Shows Lantus(R) Helped People Living with Type 2 Diabetes Reach the ADA's Recommended Target for Blood Sugar Control

... treated with maximum doses of metformin and sulfonylurea for greater than or equal to 2 years. Lantus(R) was injected once-daily and titrated to capillary fasting blood glucose 70-100 mg/dL. In the lifestyle management arm, dietary and physical activity counseling recommended stable weight for people ...

Study Supports Possible Use of Leukine(R) as a Potential Adjuvant Therapy for High-Risk Melanoma Patients

... retention, pulmonary infiltrates or CHF; respiratory symptoms or disease; cardiac symptoms or disease; and renal or hepatic dysfunction. Edema, capillary leak syndrome, pleural and or/pericardial effusion, supraventricular tachycardia, sequestration of granulocytes in the pulmonary circulation and ...

Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients

... syndrome, and organ dysfunction. Clolar should be discontinued immediately in the event of clinically significant signs or symptoms of SIRS or capillary leak syndrome. The most common side effects seen after Clolar treatment, regardless of causality, were gastrointestinal tract symptoms, including ...

Clinical Update - Debio 0614 (Istaroxime) in Acute Heart Failure

... multicenter trial, 120 patients were admitted with worsening heart failure, with a left ventricular ejection fraction below 35% and a pulmonary capillary wedge pressure above 20 mmHg. In 30 patients who received three doses of Debio 0614 over six hours, a statistically significant decrease of ...

Genzyme Completes Enrollment in Pivotal, Phase 2 Clinical Trial of Clofarabine in Adult AML

... syndrome, and organ dysfunction. Clolar should be discontinued immediately in the event of clinically significant signs or symptoms of SIRS or capillary leak syndrome. The most common side effects seen after Clolar treatment, regardless of causality, were gastrointestinal tract symptoms, including ...

Scios Announces Results From Exploratory Nesiritide Study Providing Important New Renal and Mortality Safety Data with a Neutral Effect on the Primary Endpoint

... medical journals, NATRECOR(R) was shown to significantly reduce pulmonary capillary wedge pressure and improve patient-reported dyspnea, an important symptom ... In this population, the use of NATRECOR(R) reduced pulmonary capillary wedge pressure and improved patient reported dyspnea. For full Prescribing ...

Discovery Labs Presents Surfaxin and Aerosurf Data At the Pediatric Academic Societies' Annual Meeting

... KL-4 surfactant) delivered via the Chrysalis Technologies novel capillary aerosol generator device Data from previously conducted pre-clinical ... that combines precision-engineered KL-4 surfactant technology with the capillary aerosol generator technology. This integrated drug device system ...

Hemoglobin Testing at the Point of Care

... on its inner walls and the blood sample is drawn into the cavity by capillary action and spontaneously mixed with the reagents. The microcuvette is ... meter and single-use test strips, used in measuring total hemoglobin, from capillary or venous whole blood. The system is portable, easy to use and provides a ...

Prothrombin Time Comes in Small (CLIA-Waived) Packages

... electromagnetic field kinetics to determine PT. A single drop (10 l) of capillary or venous whole blood is applied to a test strip containing ... which also provides results in PT and INR within two minutes, using fresh capillary whole blood. The device features automatic self-testing and includes ...

Telik Announces Telcyta Clinical and Preclinical Presentations at AACR Meeting

... Glutathione Analog Prodrug, Exhibits Antiangiogenic Effects Including the Inhibition of Human Endothelial Cell Proliferation and capillary Tubule Formation In Vitro; Tuesday, April 17, 2007, 1:00 - 5:00 pm; Angiogenesis II: Novel Inhibitors; Abstract # 4622 Telik, ...

Ontak (denileukin diftitox) Achieves 49.1% Overall Response Rate in Phase III Trial of Cutaneous T-Cell Lymphoma (CTCL)

... of patients reporting serious adverse events (SAEs) was higher for ONTAK than for placebo. Drug-related SAEs in ONTAK-treated patients were capillary leak syndrome (4%), dehydration (4%), hypotension (3%), fever (3%), hypoalbuminemia (2%), skin disorder (2%), chest pain (2%), vascular fragility ...

Blood Gas Analysis: The Pros and Cons of Point-Of-Care Testing

... are collected from an artery, usually the radial artery in the wrist, but also can be taken from the brachial or femoral arteries. For infants, capillary blood may be taken from a heelstick. In addition to arterial sampling, blood gas panels can be ordered on blood drawn through a central venous line ...

Tight Glycemic Control in the ICU

... microcuvette, which serves as pipette, reaction vessel, and measuring cuvette. Approximately 5 l blood is drawn into the cuvette cavity by capillary action and spontaneously mixed with dried reagents on the inner walls. The cuvette is then placed into the analyzer, the absorbance is measured, and ...