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Calcium in Medical Technology

Neuroscience Researcher Has Positive Message for International Alzheimer's Awareness Week, July 6 - 12: 'Even Though World Economy is Declining, Alzheimer's Research is Advancing'

... a suspected link between unregulated, excessive calcium levels within the neurons and the occurrence of ... simple as devising a process to remove the excess calcium ions from calcium-overloaded neurons and thereby ... function could be improved by lowering neuronal calcium concentrations. "We asked 83 healthy ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... Corporation presented today Phase 1 data from the calcium Up-Regulation by Percutaneous Administration of ... the return toward normal intracellular calcium cycling and contractility in some of the heart ... York, developed MYDICAR for restoring the SERCA2a calcium transporter in heart failure and validated the ...

Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy

... Phase 1/2 calcium Upregulation by Percutaneous Administration ... cells, which results in abnormal intracellular calcium cycling and poor contractility," said Zsebo. "Our ... advanced heart failure, SERCA2a, which regulates calcium cycling and contractility in heart muscle cells. ...

New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure

... on the market(12), which inhibits the entrance of calcium into the blood vessel walls, with olmesartan ... for patients not adequately controlled with any calcium channel blocker or any angiotensin receptor ... angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage ...

New Data for Abbott's TRILIPIX(R) (fenofibric acid) in Combination with Rosuvastatin Calcium Shows Improvement on Key Lipids for Cholesterol Management

... with the most commonly used doses of rosuvastatin calcium (5 mg, 10 mg, 20 mg) in patients with mixed ... capsules in combination with rosuvastatin calcium met all of the study's primary endpoints. TRILIPIX 135 mg in combination with rosuvastatin calcium 5 mg significantly improved HDL cholesterol and ...

Galderma Announces Interim Data Relating to Sequential Treatment Regimen of Clobex(R) Spray Followed by Vectical(TM) Ointment in Managing Plaque Psoriasis

... patients with known or suspected disturbances in calcium homeostasis, who are taking calcium or Vitamin D supplements, or who are on medications known to increase serum calcium levels, such as thiazide diuretics. If ...

Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment

... study of leconotide, an investigative calcium channel blocker, shows it has the potential to be ... to treat neuropathic pain, was selective for calcium channels involved with pain and it did not act on other calcium channels to cause side effects, as has been seen ...

Roxane Laboratories, Inc. Updated Launch of Calcium Acetate Capsules, 667mg

... Last week, Roxane Laboratories, Inc. launched its calcium acetate capsules, 667mg. Since the October ... tremendous demand. Roxane Laboratories' calcium acetate capsules, 667mg are the only AB rated ... million(1). Full prescribing information for calcium acetate capsules, 667mg is available on the ...

FDA Broadens US Indication for Once-Yearly Reclast(R) as Only Osteoporosis Treatment Approved for Prevention of Fractures After a Hip Fracture

... means a single treatment, along with daily calcium and vitamin D supplements, helps protect against ... should tell their doctor if they have low blood calcium or cannot take calcium and vitamin D, had surgery involving the neck or ...

Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids

... should tell their doctor if they have low blood calcium or cannot take calcium and vitamin D, had surgery involving the neck or ... especially important for them to take 1500 mg of calcium and 800 IU of vitamin D daily, particularly ...

Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis

... needle is used to aspirate, or withdraw, the calcium residue. Recovery time is about an hour. ... when untreated calcifications break up, the calcium is not extracted but spreads along the tendon and ... fluid sac that helps lubricate the tendon. calcium buildup in the tendon and bursa can cause ...

Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease

... Phase 2a study of MEM 1003, a neuronal L-type calcium channel modulator, in Alzheimer's disease. The ... About MEM 1003 MEM 1003 is a neuronal L-type calcium channel modulator that Memory Pharmaceuticals is ... of Alzheimer's disease. By blocking L-type calcium channels, MEM 1003 may regulate the flow of ...

Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM)

... a fixed combination of two antihypertensives, the calcium channel blocker, amlodipine and the angiotensin ... amlodipine, the number one prescribed calcium channel blocker (CCB) on the market, and ... angina or acute myocardial infarction on starting calcium channel blocker therapy. In studies of ACE ...

Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease

... inhibition of bone loss and reduction of calcium levels, Velcura has chosen Myeloma as its lead indication, as the bone fragility, bone pain, high calcium levels and eventual kidney involvement present ... bone destruction, bone pain, anemia, high calcium levels and kidney dysfunction. The incidence of ...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... peptide by activating different signaling responses--PTH regulates calcium homeostasis and bone resorption by acting primarily on target cells in ... highlighting differing therapeutic effects of the two peptide types on calcium and bone metabolism. About BA058 BA058 is Radius' novel analog ...

Astrocytes Help Separate Man From Mouse

... laser system to look at their activity by measuring the amount of calcium inside the cells. Her team has discovered what might be called the secret ... astrocytes and has made a series of startling discoveries. Astrocytes use calcium to send signals to the neurons, and the neurons respond; neurons and ...

New Insight Into the Controls on a Go-To Enzyme

... the St. Jude Department of Immunology. Calpains are triggered by calcium flowing into the cell. This process induces the enzyme to snip apart many ... also showed how calpain changes its shape once it is activated by calcium and how this transformation renders it a target of calpastatin attachment ...

Azor(TM) Reduces Blood Pressure in Difficult to Treat Special Populations

... duration, or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage increase. Congestive Heart Failure In general, calcium channel blockers should be used with caution in patients with heart ...

Preventing Prostate Cancer and BPH: Prostate-Health Expert Available (National Men's Health Week Is June 9-15)

... factors that promote cell growth." -- A high-calcium diet, calcium supplements and antacids may increase the risk of advanced prostate ... aggressive cancer increases by more than 100 percent. High intake of calcium suppresses blood levels of the active form of vitamin D, a hormone ...

European Medicines Agency Adopts Positive Opinion for Ranolazine for Treatment of Chronic Angina

... to first-line antianginal therapies (such as beta-blockers and/or calcium antagonists)." The labeling reflects data from the MERLIN TIMI-36 and ... The labeling also notes that the ability of ranolazine to reduce calcium overload is expected to improve myocardial relaxation and decrease left ...

Clinical Update - Debio 0614 (Istaroxime) in Acute Heart Failure

... pump and restores the SERCA2 ATPase activity (Sarcoplasmic Reticulum calcium ATPase 2 activity). The combined mechanism of action allows for cytosolic calcium accumulation during systole (inotropic response), as well as rapid ...

Phase III Data Published for Once Monthly Dose of Risedronate to Treat Postmenopausal Osteoporosis

... the monthly or daily dosing regimens. All patients were supplemented with calcium and vitamin D. In the study, BMD was measured at the lumbar spine, total ... 150 mg monthly or risedronate 5 mg daily and received daily supplements of calcium (1,000 mg) and vitamin D (400-1000 IU). The primary efficacy objective of ...

September is National Pain Awareness Month

... the mechanism of action for PRIALT works by targeting and blocking N-type calcium channels on nerves in the spinal cord that ordinarily transmit pain ... IT morphine. PRIALT is in a class of non-opioid analgesics known as N-type calcium channel blockers. WARNING: Severe psychiatric symptoms and neurological ...

New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis

... oral Fosamax 70 mg for 12 months. They also received vitamin D and calcium supplements. The primary endpoints were the relative change (%) from ... recommended in patients with severe renal impairment. Adequate intake of calcium and Vitamin D is important in all patients. Rarely, patients have ...

First Osteoporosis Study in Hip Fracture Patients Finds Once-Yearly Reclast(R) Prevents Additional Fractures and Improves Survival

... therapy. All patients with Paget's disease should receive 1500 mg of calcium in divided doses and 800 IU of vitamin D daily, particularly in the two ... It is recommended that patients with postmenopausal osteoporosis take calcium and vitamin D supplements, if dietary intake is not sufficient. For more ...

Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis

... with Zometa. All patients with Paget's disease should receive 1500 mg of calcium in divided doses and 800 IU of vitamin D daily, particularly in the two ... It is recommended that patients with postmenopausal osteoporosis take calcium and vitamin D supplements, if dietary intake is not sufficient. For more ...

July 2009 Mayo Clinic Women's HealthSource Highlights Food Storage Safety, Energy Therapies and Vitamins and Minerals

... to sunshine. Yet, an increasing number of Americans are deficient in vitamin D. It's been well established that adequate vitamin D and calcium can prevent or slow osteoporosis and reduce bone fractures. New research highlights other potential benefits of vitamin D, including reducing the ...

St. Francis Surgeon Uses Tissue Regeneration Technology to Rebuild Patients' Heart Structures

... and remodels the tissue. In the past, tissue replacement has been limited by options for implantation. Animal tissue implants are subject to calcium deposition and hardening, due to the body's ability to recognize them as foreign. Synthetic material lacks the performance characteristics of tissue ...

New Study Shows that Prebiotics, as Used by Jackson GI Medical, Increases Lifespan by 33%

... long known from clinical research that oligofructose enriched inulin, the prebiotic in our Prebiotin family of products, enhances immunity, increases calcium absorption, decreases heart-unfriendly triglycerides and promotes digestive health," says Chronister. "This latest study strongly suggests that a ...

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

... an average of five years. Patients with hypertension were also treated at the investigator's discretion with diuretics, alpha- or beta-blockers or calcium channel antagonists to achieve a target BP of <130/80. Patients requiring treatment with an ARB or ACEi were withdrawn from the study. About ...

Newly Published Phase III Study Shows Arzoxifene Significantly Increased Bone Mineral Density

... 331 postmenopausal women with normal or low bone mass were randomized to receive arzoxifene 20 mg/day or placebo. All subjects received elemental calcium 500 mg/day. The study's primary endpoints were change in lumbar spine and total hip BMD, and endometrial safety measured by endometrial histology. ...

DaVita Abstracts Accepted Into National Kidney Foundation's 2009 Spring Symposium

... Binder Timing Authors: Mark A. Livingston DaVita Inc., Warren, MI -- Title: Mortality of 5-Year Time-Averaged Low Serum calcium <8.5 mg/dL in Subgroups of Hemodialysis (HD) Patients Authors: Jessica E Miller(1), Elani Streja(1), Csaba P Kovesdy(2), ...

Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis

... randomized to receive arzoxifene 20 mg/day (N= 158) or raloxifene hydrochloride 60 mg/day (N= 162). In addition, supplements containing 500 mg/day calcium and 400-600 IU/day vitamin D were provided. The study's primary endpoint was lumbar spine BMD. Secondary objectives included assessment of femoral ...

Parkinson's Disease Foundation Awards $300,000 in Bridge Funding for Innovative Research Projects

... studied, may share a common mechanism that contributes to the death of neurons. He hypothesizes that this mechanism may involve excess levels of calcium inside cells. If Dr. Surmeier's high risk approach is on target, he says it may be very easy to identify a treatment that could concurrently ease ...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

... in Reclast(R) (zoledronic acid). Patients being treated with Zometa should not be treated with Reclast. Patients should be administered an oral calcium supplement of 500 mg and a multiple vitamin containing 400 IU of vitamin D daily. Please see full Prescribing Information. Disclaimer ...

Evidence Lacking in Multivitamin Study of Women's Risk of Cancer, Heart Disease or Death, Says Natural Products Association

... claim. However, even a cursory visit to the FDA's Web site would have revealed that other nutrients and dietary ingredients, including the very calcium and vitamin D that they studied, also have FDA-authorized health claims." The FDA was granted the ability to approved or authorize claims explaining ...

February 2009 Mayo Clinic Women's HealthSource Highlights Diabetes and Heart Disease, Going Vegetarian and Tinnitus

... Calcium: Low-fat dairy and dark green vegetables such as collard greens, kale and broccoli are good sources of calcium. Tofu enriched with calcium and fortified yogurt and juices also are options. Vitamin B-12: This is found almost exclusively in animal products including milk, eggs and ...

Advances in Science and Treatment of Pain Presented at 25th Annual American Academy of Pain Medicine Meeting January 28 - 31, 2009

... 2009, 10:00 AM HAST Coral Ballroom Foyer, Hilton Hawaiian Village Authors present Jan. 29 from 3:30-5 PM and Jan. 30 from 9-10 AM calcium Channel Blockers Compared for Neuropathic Pain, Poster 181 Addictive Qualities of Cannabinoid Medication, Poster 193 Tramadol Outcomes, ...

Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin

... hemoglobin to carry oxygen to tissues(7). Pregnant women may experience improved comfort with CitraNatal Assure. CitraNatal Assure contains calcium citrate, a source known for proven absorption and no gas production to help ease GI discomfort during pregnancy, a gentle dual-iron formulation of ...

Retigabine Significantly Reduces the Number of Seizures in Adults With Inadequately Controlled Partial-Onset Epilepsy

... Neurology, New York University Medical Center and an investigator in the study. "Many of the currently available AEDs regulate sodium channels or calcium channels in the brain to help reduce seizures. Given the unmet medical need, it is hoped that medications with novel mechanisms of action, like ...
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(Date:11/18/2014)... 2014 The Parenteral Drug Association (PDA) today confirmed ... speak and at least seven more will participate in the ... Shoreham Hotel in Washington D.C. , Dec. ... significant support from the regulatory agencies in the ... in our effort to help advance the use of metrics ...
(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... yet progress in preventing and treating migratory cancer ... challenging to design drugs that work against metastasis," ... at Harvard Medical School. , "Unfortunately, many ... , Gujral and colleagues have now identified a ... how metastasis begins. Their findings may also inform ...
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(Date:11/26/2014)... (PRWEB) November 26, 2014 The family ... $100,000 to the Mesothelioma Applied Research Foundation (Meso Foundation), ... Meso Foundation’s Patient Travel Grant Program . The ... is to create grant partnerships with organizations that can ... , Mr. Schulze is the founder and chairman emeritus ...
(Date:11/26/2014)... November 26, 2014 The American ... the Association’s new director of meetings and conferences. ... annual meeting, special events and conferences. , ... this post,” said AAA Executive Director Ed Liebow. ... enthusiasm and energy. She was recognized in January ...
(Date:11/26/2014)... Washington, DC (PRWEB) November 26, 2014 ... Inc.’s (AIS) independently published The AIS Report on Blue ... Inc. and WellPoint, Inc. on the varied strategies the ... costs and improve compliance with treatments for sleep apnea, ... The sleep disorder, because it’s linked to increased rates ...
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