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Bone in Medical Technology

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... protein) analog -- significantly increased bone mineral density (BMD) at the lumbar spine and ... evaluate the effect of three doses of BA058 on bone formation markers and on lumbar spine and femoral ... by BA058's superior efficacy in building new bone rapidly, particularly at the femoral neck, since ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... an intravenous (IV) infusion in the treatment of bone metastases in 1,776 advanced cancer patients with ... with advanced prostate cancer, next year." bone metastases, the spread of tumors to the bone, are ... the growing cancer cells weaken and destroy the bone around the tumor. This damage can result in a ...

British Woman Celebrates a Year of Living Cancer-Free

... treatments, including chemotherapy and a bone marrow transplant, failed to keep her in ... and multiplied. Within a month, a study of her bone marrow -- the site affected by the type of ... AML, abnormal white blood cells accumulate in the bone marrow and impede the production of normal blood ...

Economy is Driving Many Osteoporotic Women to Retire Later - But Their Ability to Work May Be Undermined by Sub-Optimal Management of Their Disease

... disease today are not optimally managing their bone health," said Chad Deal, M.D., Head, Center for Osteoporosis and Metabolic bone Disease, Cleveland Clinic Foundation. "I have ... important for women to be passionate about their bone health given their desire and need to remain ...

Schering-Plough Announces U.S. Filing of Mometasone Furoate/Formoterol Fumarate Combination for the Maintenance Treatment of Asthma

... long time may have an increased risk of decreased bone mass, which can affect bone strength. Patients who are at increased risk of decreased bone mass should be monitored. Inhaled ...

Prospective Clinical Advantages of Trabecular Metal(TM) Technology Highlighted in Comparative Study

... , found significant reductions in acetabular bone loss adjacent to the Trabecular Metal device ... component, and a significant relative increase in bone mineral density (BMD) after total hip ... over the course of 6 to 9 years and compared bone loss around highly porous Trabecular Metal cups ...

ASMANEX(R) (Mometasone Furoate Dry Powder Inhaler) Now Approved in Japan for the Treatment of Bronchial Asthma in Adult Patients

... long time may have an increased risk of decreased bone mass, which can affect bone strength. Patients who are at increased risk of decreased bone mass should be monitored. Inhaled steroids, ...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

... Zometa(R) (zoledronic acid) in the treatment of bone metastases in 2,049 patients with advanced breast ... can reduce or delay the serious complications of bone metastases in breast cancer patients better than ... the importance of the RANK Ligand pathway in bone disease, and offer the promise of improved care ...

Neurocrine Biosciences Presents Elagolix Data

... without inducing severe hot flashes or excessive bone resorption as determined by n-telopeptide. ... the study was to assess the impact of elagolix on bone mineral density using dual energy x-ray ... The results showed that elagolix had no long-term bone risk during or after treatment. "We are ...

UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients

... from stem cells, as an alternative treatment to bone marrow transplants for hematological ... cord blood stem cells instead of a traditional bone marrow transplant opens tremendous ... with diseases like leukemia and lymphoma." bone marrow transplantation is a life-saving treatment ...

ThermoGenesis Announces National Institute of Health Grant

... can be used to deploy placental stem cells in bone repair and regenerative medicine applications. ... effect in orthopedic applications, such as bone repair and generation." Engle said the Company's ... MXP are used to prepare cell concentrates from bone marrow. The Res-Q Platform is also being studied ...

Research: Popular Diabetes Medications Associated with Increase in Bone Fractures

... experienced a 43 percent higher incidence of bone fracture than type 2 diabetes patients not taking ... both medications equally increase the risk of bone fracture. In addition, the study showed that ... since they are already at higher risk for a bone fracture given the nature of their disease and ...

Three Surgeons in East Texas Are Successfully Integrating a Novel Stem Cell Procedure for Spine Surgeries

... own body. During surgeries for the neck and back, bone marrow is extracted from the hip through a small ... autograft being the gold standard. Autologous bone graft is likely traumatic and time-consuming. My ... invasive system to utilize a patient's autologous bone marrow, which science has shown to contain high ...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

... following allogeneic and autologous bone marrow transplantation (BMT), peripheral blood ... in patients undergoing PBSC transplantation and bone marrow transplantation failure or engraftment ... in patients with excessive leukemic blasts in bone marrow or peripheral blood (10 percent), in ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... follow-up is needed to determine the risk of bone fracture associated with long-term use of Femara. ... nausea, tiredness, other heart-related events and bone fractures. Other less commonly reported side ... events, muscle pain, osteoporosis, arthritis and bone fracture. In the metastatic cancer setting, ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... by enhancing HSC proliferation and homing to the bone marrow. "The mission of Fate Therapeutics is ... mediate the cells' ability to home to the bone marrow and eventually repopulate the patient's ... with HSCs from any source, including from bone marrow and peripheral blood. FT1050 was ...

Another Study Links Fluoride to Bone Cancer

... Research (April 2009). Osteosarcoma, a rare bone cancer, occurs mostly in children and young ... had osteosarcoma, group two had non-osteosarcoma bone tumors, and group three had musculo-skeletal ... Jersey.(3) More studies link fluoride to bone and other cancers but are downplayed or ignored ...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

... including cartilage and different zones of the bone such as bone marrow, calcified bone and importantly, the growth plate. Our ...

Newly Published Phase III Study Shows Arzoxifene Significantly Increased Bone Mineral Density

... increased lumbar spine and total hip bone mineral density (BMD) in postmenopausal women with normal or low bone mass, versus placebo. In addition, ... at 20 mg/day, decreased biochemical markers of bone turnover, and showed a neutral effect on the ...

Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack

... Mesenchymal Stem Cells Accelerate bone Marrow Stem Cell Mobilization via Paracrine ... to massive stem cell mobilization from the bone marrow and their increased homing in the injured ... receptor 4 (found on these stem cells in the bone marrow but reduced after ex vivo expansion) with ...

Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis

... Also Showed Arzoxifene Significantly Suppressed bone Turnover Markers versus Raloxifene in ... (SERM), was superior to raloxifene at increasing bone mineral density (BMD) in the lumbar spine, total hip and femoral neck, and at suppressing bone turnover as assessed by serum markers ...

Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps

... to treat the painful effects of metastatic bone disease by injecting bone cement to support weakened bones -- provides ... be severely affected when they have metastatic bone disease. Normal daily activities can become ...

Staying One Step Ahead of Osteoporosis

... New studies show key steps to preventing bone loss focus on early screening and treatment ... ) also contributes to an estimated 1.5 million bone fractures in the United States annually. ... ( http://www.aaos.org/ ), new steps to manage bone health and increase communication, will ...

Comparative Study Shows Significant Bone In-growth and Advanced Clinical Outcomes Using Zimmer's Trabecular Metal(TM) Technology

... debris and maximize the area available for bone in-growth. Further, the researchers observed a ... biomaterial whose cellular architecture resembles bone and approximates its physical and mechanical ... configuration is conducive to more normal bone formation ...

Children and Orthopaedic Surgical Emergencies

... Fractures and infections of the bone are among most serious injuries to children ... musculoskeletal conditions in children include bone and joint infections, a hip problem known as ... in the bloodstream, which settle into the child's bone or joint and within days can lead to: ...

Applying Clinical Findings to the Practice of Medicine

... of my research is that connecting tendon to bone is like connecting rope to cement," stated Dr. ... Studies on Molecular Mechanisms Underlying bone and Cartilage Disorders." This research ... of this research may have the power to stop these bone and cartilage conditions before beginning. ...

American Academy Of Orthopaedic Surgeons 2009 Annual Meeting 'Highlights and Hot Topics'

... of abuse were treated at the emergency room for bone trauma at a younger age (12 months) than those ... and tendons that hold the top of the upper arm bone in place, appear to create an increased risk for ... to correct spinal deformity, followed with bone paste injections, are shown to add improved ...

Bone Biologics Announces Significant Milestone for Spinal Fusion Surgery Using Recombinant Protein and Demineralized Bone Matrix

... THOUSAND OAKS, Calif., Feb. 24 /PRNewswire/ -- bone Biologics, Inc. announced today that it has ... trials validating the efficacy of the proprietary bone growth regeneration UCB-1 (NELL-1) protein in ... is currently preparing Pre-IDE studies. bone Biologics has been developing the protein as a ...

IlluminOss Medical Announces First Human Case Utilizing a Unique, New, Minimally Invasive Technology for Fracture Repair is Performed at Medical Hospital del Trabajadar in Santiago, Chile

... Procedure Utilizing IlluminOss(TM) Photodynamic bone Stabilization System SANTIAGO, Chile, Feb. ... utilizing the innovative IlluminOss Photodynamic bone Stabilization System for orthopedic surgery. The IlluminOss Photodynamic bone Stabilization System was used on a 21 year old ...

Breast Cancer Patients May Have a New Treatment Option When Cancer Spreads

... looked at alternative -- injecting radioactive bone cement into the vertebral body -- with promising ... in the paper "Feasibility of Using Radioactive bone Cement to Treat Vertebral Metastases" during the ... procedure would also deliver a higher dose to the bone metastases and a lower dose to the spinal cord ...

ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients

... of current therapies, including suppression of bone marrow function. About maribavir ... or myelosuppression (a condition in which bone marrow activity is decreased, resulting in fewer ... their use is limited by toxicities, most notably bone marrow suppression and renal impairment. ...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

... the most widely prescribed drug for prevention of bone complications due to bone metastases, with more than 2.7 million patients ... benefit of this treatment in preventing bone complications in advanced cancers." The ...

Phase 1 Trial of Quadramet in Combination with Velcade Shows Positive Results

... medication that targets the bone, specifically bone cancer, and is used to treat pain caused by ... combination of radiotherapy, a drug that targets bone and bone marrow, with Velcade in order to determine ...

Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

... muscle spasms, nausea, contusion, diarrhoea, bone marrow disorder, influenza like illness, insomnia ... after cessation of treatment and increased bone marrow reticulin have been associated with ... associated with Nplate in clinical studies were bone marrow reticulin deposition and worsening ...

ThermoGenesis Announces MXP Involvement in New Regenerative Medicine Initiatives

... PROGRAMS INCLUDE bone MARROW CLINICAL TRIAL IN ITALY RANCHO ... MXP, which is used to concentrate stem cells from bone marrow, in an ongoing Phase II clinical trial ... of Naples in Italy to study the effect of bone marrow derived mononuclear cells on patients with ...

Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer

... Highlight the Potential of Alpharadin to Treat bone Metastases in Major Cancer Indications ... Alpharadin (radium-223) as a new treatment for bone metastases in patients with ... to be a first-choice treatment for bone metastases that frequently arise from a number of ...

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

... follow-up is needed to determine the risk of bone fracture associated with long-term use of Femara. ... nausea, tiredness, other heart-related events and bone fractures. Other less commonly reported side ... events, muscle pain, osteoporosis, arthritis and bone fracture. In the metastatic cancer ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. ... immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. Two ... leukemia, or B-CLL. Symptoms include fatigue, bone pain, excessive sweating, abnormal bruising, and ...

Dacogen(R) (decitabine for injection) Data Presented on a Phase II Clinical Trial in Elderly Patients with Acute Myeloid Leukemia (AML)

... the marrow, no evidence of disease outside of the bone marrow and absolute neutrophil and platelet ... is a rapidly progressing cancer of the blood and bone marrow characterized by an overgrowth of abnormal ... is associated with high toxicity, including bone marrow suppression and increased risk of ...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

... treatment due to AEs. bone marrow reticulin was present or increased in ... blood count that occurs secondary to bone marrow suppression, in MDS patients receiving ... treatment for MDS, with the exception of bone marrow transplantation, and roughly 70 percent of ...
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(Date:4/17/2014)... honored Clemson professor Rajendra Singh Thursday as a ... and expand solar deployment in the residential, commercial ... Banks Professor of Electrical and Computer Engineering and ... considered a local hero leading the charge across ... in solar power and driving policy changes at ...
(Date:4/17/2014)... honeybees in Europe, Asia and the United States are ... be impacting native honeybee populations at this time, according ... include including Nosema microsporidia and Varroa ... resilient to these invasive pests, which suggests to us ... Asia and the United States currently are not necessary ...
(Date:4/17/2014)... Researchers in France have hit on a novel ... receive the correct and most effective treatment possible., ... the western and developing world. If left untreated, ... to renal failure and other complications. In many ... problem. Clearly a more effective pathological approach to ...
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(Date:4/17/2014)... in the April issue of Immunity , Kevin ... Medical Research, says it,s time to take a fresh ... sepsis, which kills millions worldwide every year, including ... released into the bloodstream to fight an injury or ... for maintaining good health without inflammation, wounds and ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... Doctors who treat patients with a severe and ... an agonizing treatment decision. , The drug sirolimus ... relieve shortness of breath. But some patients eventually ... potentially fatal complications following transplantation. , "It,s a ... director of Loyola University Medical Center,s LAM Clinic ...
(Date:4/17/2014)... YORK, NY (April 16, 2014) The cause of ... a new study proposes that neurons may be mistaken ... immune system, similar to the way autoimmune diseases like ... the body,s cells. The study was published April 16, ... a new, and likely controversial, idea in Parkinson,s disease; ...
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
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