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Blind in Medical Technology

Gene Therapy Provides Vision to People who Were Nearly Blind

... partial vision to patients who were nearly blind from a condition known as Leber congenital ... effectiveness in younger children who were born blind from LCA. The investigators believe the treatment ... RPE65 gene in 1993. In 2000, the first dog born blind from LCA, a Briard named Lancelot, was ...

Phase III Data Demonstrate Efficacy and Tolerability of Carisbamate as an Adjunctive Therapy for Partial Onset Seizures

... endpoints were median percent reduction in seizure frequency in the double blind phase compared to the baseline phase, and the proportion of patients with 50% or greater reduction in POS frequency during the 12-week double blind phase. Carisbamate was well tolerated, with minimal central ...

Pharmacopeia's First-in-Class Investigational Therapy PS433540 Achieves Statistically Significant Reductions in Blood Pressure in Hypertensive Patients

... men and women with Stage I and Stage II hypertension entered into a single blind placebo run-in period for 3-4 weeks, after which 114 were randomized to receive double blind study medication for four weeks. At the time of the database lock, 108 ...

Diagnostic Center for Disease: Prostate Biopsy Spreads Prostate Cancer Cells

... cancer to avoid a biopsy procedure. This is a quantum leap from the blind biopsy approach enabling the potential savings of millions of dollars to ... want to avoid an unnecessary prostate biopsy now have an alternative to a blind biopsy," states Ronald Wheeler, M.D., the Medical Director at the center. ...

R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023

... the next step, single and 5-day repeated applications of RK-023 preparation to the scalp were conducted by a randomized, placebo-controlled, double blind method to evaluate the safety and pharmacokinetics of the drug. In the single-dose study, 2 ml of RK-023 preparation was applied to the vertex region ...

When It Comes to Natural Remedies for Hormonal Balance, the Proof Is in the Clinical Research

... the body's ability to balance (either increase or decrease) levels of its own hormones. Passing stringent pharmacology, toxicology and double blind placebo controlled clinical trials for health and safety, Femmenessence is as safe and side effect-free as your own hormones have been throughout ...

No Causality Found Between Black Cohosh and Liver Problems

... MD, presented at the American College of Obstetricians and Gynecologists Annual Clinical Meeting in Chicago results of a placebo-controlled, double blind study. He concluded that the isopropanolic black cohosh extract (Remifemin(R)) has no effects on liver function. These findings are in agreement with ...

Oramed Pharmaceuticals Announces Launch of Phase 2B Clinical Trials in South Africa of its Oral Insulin Capsule

... it will test its first indication for ORMD-0801 on a large group of volunteers for the duration of six weeks. This six week randomized, double blind placebo controlled study will be performed in three locations in Cape Town. The principle investigators of the study will be renowned South African ...

Lions Eye Institute for Transplant & Research, Inc. Launches Multi-Million Dollar, State-of-the-Art Research Institute that Will Advance the Study of Blinding Eye Diseases

... Mission "Our stated mission is to set new standards for ocular research that will improve visual outcomes and quality of life for those who are blind or visually impaired," says Jason K. Woody, Executive Director and CEO of LEITR. "We intend to be the new pioneers of ocular research." About ...

QRxPharma Successfully Completes Comparative Study for Dual-Opioid(TM) Pain Therapy

... "From these data, we are confident that our upcoming Phase 3 Combination Rule study will prove successful." In this randomized, double blind study of 197 patients at 6 US clinical research sites, MoxDuo(TM) IR was compared to morphine and oxycodone in managing acute pain during the first ...

The Quigley Corporation Licenses Naturally Derived Compound For Scar Improvement; License Requires Payments Totaling $1.1 Million To The Quigley Corporation Over A Five Year Period For Exclusive Ownership

... skin care market is not a focus of The Quigley Corporation. The patented QR-340 formulation had demonstrated potential consumer benefits in a double blind clinical trial, (Press Release, April 18, 2005, http://www.quigleyco.com/news/nr/041805.php ), and a decision was made to realize a return on the ...

New Research Suggests Platelet 'Stickiness' May be the Single Most Important Risk Factor in Patients Treated with Coronary Stents - Findings May be Applicable to Anyone with Vascular Disease

... event," said Dr. Gurbel. "The platelet aggregation of each patient needs to be precisely measured to determine how well the drug is working. The blind administration of anti-platelet drugs without confirming a good response, in our opinion, will soon be reaching an end." Click here for a recent ...

Two New Studies in the New England Journal of Medicine Show Malaria Vaccine Candidate Advancing in Africa

... JJ, Aide P, Renom M, et al. Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomized controlled phase I/IIb trial. Lancet 2007 Nov 3;370(9598):1543-51. Epub 2007 Oct 18. ...

Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin

... accessed November 24, 2008. (6) Sahakian V., et al. Vitamin B6 Is Effective Therapy for Nausea and Vomiting of Pregnancy: A Randomized, Double blind Placebo-Controlled Study. Obstetrics & Gynecology, 1991; 78(1): 33-36. (7) Dietary Supplement Fact Sheet: Vitamin B6. Office of Dietary ...

NeoVista Unveils 18-month Data on Novel Wet AMD Therapy at Retina Society Meeting

... delivered concomitantly with the FDA-approved anti-VEGF therapy Lucentis(R) (ranibizumab) versus Lucentis alone. "The Royal National Institute of blind People (RNIB) welcomes the results of the Phase II study for NeoVista's therapy, which may increase the treatment options for people with wet AMD," ...

Five-Year Data Confirm That Early Treatment with Betaseron(R) at First Sign of Disease Can Delay Progression to MS

... typical MRI findings were randomized to receive either 250 micrograms of Betaseron every other day or placebo as a subcutaneous injection in a double blind fashion for a maximum of two years. The study was designed to encompass a representative population of patients with the earliest signs of MS, ...

Headache Specialists Convene in Boston For 50th Annual American Headache Society Meeting

... the head and pushing a button twice, sending a very brief magnetic field pulse into the brain. The 16-site multicenter, randomized, double blind study is the first rigorous test of the magnetic stimulation device. -- STIMULATING THERAPY THAT HITS A NERVE: Early Research Shows New ...

Peptimmune Initiates Phase Ib Study of PI-2301 in Multiple Sclerosis Patients and Presentation at BIO 2008

... of the immune system and thereby controlling the pathogenic autoimmune response observed in some diseases. In a Phase I single ascending dose, double blind placebo controlled randomized study, all doses of PI-2301 were safe and well tolerated, and no serious adverse events were observed. ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... are swiftly moving forward to the next stage of clinical development with our ongoing Phase 2 clinical trials. We expect to have data from our double blind Phase 2 clinical trial (SB-509-601) available in the fourth quarter of this year." About SB-509 SB-509 is an injectable formulation of a plasmid ...

Vion Pharmaceuticals to Present Clinical Data on Cloretazine(R) (VNP40101M) at the ASCO(R) Annual Meeting

... at the 2008 American Society of Clinical Oncology (ASCO(R)) Annual Meeting in Chicago, Illinois. The poster (Abstract #7051) entitled "A double blind placebo-controlled randomized phase III study of high-dose continuous infusion cytosine arabinoside (araC) with or without VNP40101M in patients with ...

ATHENA Clinical Results with Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress

... for congestive heart failure. There was a similar rate of study drug discontinuation between the 2 study groups. ATHENA, was the largest double blind randomized study in patients with atrial fibrillation, and conducted in more than 550 sites in 37 countries and enrolled a total of 4,628 patients. ...

ATHENA Clinical Results for Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress

... the risk of death, an increased risk of stroke and cardiovascular complications, including congestive heart failure. ATHENA, was the largest double blind randomised study in patients with atrial fibrillation, and conducted in more than 550 sites in 37 countries and enrolled a total of 4,628 patients. ...

RAD001 More Than Doubles Time Without Tumor Growth After Failure of Standard Treatment in Patients With Advanced Kidney Cancer

... lesions (223 and 107 in RAD001 and placebo arms, respectively), tumor shrinkage was observed in 50% of patients receiving RAD001 during the double- blind portion of the study versus 8% of patients receiving placebo. Quality of life measurements taken throughout the study showed no significant ...

Landmark ATHENA Study Findings With Multaq(R) (dronedarone) Shows 24% Reduction In Cardiovascular Hospitalization or Death in Patients With Atrial Fibrillation

... death or 30% cardiovascular death, dronedarone may become an appropriate treatment option for atrial fibrillation." ATHENA, the largest double blind randomized study in patients with atrial fibrillation, was conducted in more than 550 sites in 37 countries and enrolled a total of 4,628 patients. ...

Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration

... In wet AMD, new blood vessels grow beneath the retina and leak blood and fluid. This leakage causes disruption and dysfunction of the retina creating blind spots in central vision, and it can account for blindness in wet AMD patients. Wet AMD is the leading cause of blindness for people over the age of ...

Peptimmune Completes Phase I Study with a Novel Peptide Copolymer for the Treatment of Multiple Sclerosis

... PI-2301, a novel peptide copolymer for the treatment of multiple sclerosis and other autoimmune diseases. The Phase I single ascending dose, double blind placebo controlled randomized study involved 56 healthy volunteers who received the drug in eight escalating dose cohorts. All doses were safe and ...

Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy

... oral mTOR inhibitor everolimus as a treatment option for patients with metastatic RCC who have failed prior targeted therapy. The randomized, double- blind multi-center Phase III study compared everolimus to placebo. Patients in the study were randomized according to Memorial Sloan- Kettering Cancer ...

Horizon Therapeutics Completes Enrollment in Phase 3 Trials for Lead Product Candidate HZT-501

... in decreasing NSAID-associated ulcers." In addition, a phase 3 follow-on safety study HZ-CA-304 is underway. The trial is a multi-center, double blind trial that will enroll approximately 200 patients who have participated in the 301 or 303 phase 3 trials. Study participants will continue to receive ...

Surgex(TM) Becomes the First and Only BSCG (Banned Substance Control Group) Certified Product Which is Clinically Proven Effective in Sports Recovery and Performance

... dominated by products with no clinical proof of benefit, unsubstantiated claims, excess protein, stimulants, and banned substances. In double blind placebo controlled trials at the Rutgers University Human Performance Lab Surgex(TM) significantly outperformed leading competitive products by ...

Research Highlights Potential Benefits of Telemedicine in Treating Eye Disease

... million people in the United States, as many as one-third of whom are unaware of their illness. People with diabetes are 25 times more likely to go blind than people who do not have the disease. Early detection and treatment of diabetic retinopathy significantly increases the chances of avoiding vision ...

Morria Biopharmaceuticals Plc Initiates Phase I Clinical Study of MRX-4 in Allergic Rhinitis

... initiation of a Phase I tolerance study of MRX-4 in 16 patients suffering from allergic rhinitis (AR). The randomized, placebo-controlled, double blind clinical trial is the first of two modules focusing on safety for Morria's first human study in AR. MRX-4 is nasally administered as a single dose ...

Peptimmune Initiates Phase I Study With a Novel Peptide Copolymer for the Treatment of Multiple Sclerosis

... PI-2301, a novel peptide copolymer for the treatment of multiple sclerosis and other autoimmune diseases. The Phase I single ascending dose, double blind placebo controlled randomized study will involve 56 healthy male volunteers who will receive the drug in eight escalating dose cohorts. Following ...

Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)

... of non-small cell lung cancer. The ZODIAC (ZACTIMA in cOmbination with Docetaxel In non-smAll cell lung Cancer), trial is a randomised, double- blind study evaluating vandetanib 100mg in combination with docetaxel vs. docetaxel alone, in patients with locally advanced or metastatic NSCLC after ...

NicOx Reports TOPIGEN to Advance TPI-1020 Into Phase 2 for COPD Following Promising Clinical Results

... to the initiation of a new trial in this indication later this year." This trial was initiated in May 2006 and was a 21-day, multi-center, double blind trial in asthmatic smokers who were randomized to receive repeated and ascending doses of either inhaled TPI-1020 or budesonide, a conventional ...

A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol

... for marketing by the FDA, when used in combination with weekly doses of the chemotherapy drug, carboplatin. The trial will consist of two double blind treatment arms. Patients in one trial arm will receive weekly carboplatin and phenoxodiol. Patients in the other trial arm will also receive weekly ...

First Patient Enrolled in Europe in Ovature Phase III Ovarian Cancer Trial

... and there are 4 sites open in Australia. The total number of patients to be treated in this pivotal study is 470. The trial consists of two double blind treatment arms. Patients in one trial arm will receive weekly carboplatin and phenoxodiol. Patients in the other trial arm will also receive weekly ...

New Data Suggest Cymbalta(R) Reduced Pain in Fibromyalgia Patients With and Without Depression

... TA, et al. "Psychiatric status of patients with primary fibromyalgia, patients with rheumatoid arthritis, and subjects without pain: a blind comparison of DSM-III diagnoses." American Journal of Psychiatry 1991; 148:1721-1726. (2) Arnold LM, et al. "Comorbidity of fibromyalgia and ...

ORENCIA(R) (abatacept) Supplemental Biologics License Application for Juvenile Idiopathic Arthritis Accepted by FDA for Filing and Review

... all participants (6-17 years old) received ORENCIA and both clinical response and safety were assessed (Period A), a six-month randomized double- blind withdrawal phase in which responders received either ORENCIA or placebo and time to disease flare and safety were assessed (Period B), and an open- ...

Indevus Announces Presentation of Pagoclone Data at 47th Annual New Clinical Drug Evaluation Unit Meeting

... patients randomized to pagoclone in the double- blind phase, the mean reduction in percent syllables ... For patients receiving placebo during the double blind phase, 36% were rated as improved, ... total exposure), who had, during the double blind phase, experienced a mean reduction of 18% of ...
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(Date:7/29/2014)... Schools of Dentistry (UM SOD) and Medicine (UM ... a five-year $10.7 million grant award from the ... of the National Institutes of Health to study ... (STDs). The grant, which renews a previous $12 ... direction for the research by studying chlamydial and ...
(Date:7/29/2014)... ground breaking new book that brings together two of ... raise the profile of insect fossils through stunning photographs ... Penney and James E Jepson, details the incredible preservation ... setting the scene for what these remarkable fossils can ... even the future of our planet. Like the mosquito ...
(Date:7/28/2014)... new discovery of two additional coral communities showing signs of ... footprint of the 2010 spill in the Gulf of Mexico. ... Fisher, professor of biology at Penn State University. A paper ... corals in the Gulf of Mexico will be published during ... Edition of the journal Proceedings of the National Academy ...
Breaking Biology News(10 mins):University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Unique images bring fossil insects back to life 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2
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