Newly Published Phase III Study Shows Arzoxifene Significantly Increased Bone Mineral Density
... arzoxifene, dosed at 20 mg/day, decreased biochemical
markers of bone turnover, and showed a neutral ...
Arzoxifene significantly decreased biochemical
marker of bone resorption C-terminal ... percent, placebo 3.79 percent; p<0.001); and biochemical
marker of bone formation serum N-terminal ...
Parasites That Live Inside Cells Use Loophole to Thwart Immune System
... nitric oxide production by subverting the biochemical
by immune cells called macrophages ... to develop drugs to block such pathogens' biochemical
restoring nitric oxide production and ... in macrophages. The
researchers also traced the biochemical
mechanism by which the organisms
Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART
... treatment period in the
and virological response of clevudine therapy ... Clevudine monotherapy showed rapid viral and biochemical
chronic hepatitis B patients with ... viral suppression and significant biochemical
patients with cirrhosis.
New Body of Research Suggests Statin Use Benefits Multiple Areas of Urologic Health
Abstract 1598: Statin medication use and the risk of biochemical
recurrence following radical prostatectomy: results from the SEARCH database
Statin use may be associated with a reduction in the risk of biochemical
recurrence following prostatectomy.
Abstract 574: Associations ...
SAFC Biosciences(R) and Vivalis Collaborate to Optimize Cell Culture Media for Vaccines Production
... cell culture products and services for biopharmaceutical manufacturing, biochemical
production and the manufacturing of complex, multi-step organic synthesis ... is a leading Life Science and High Technology company. Its chemical and biochemical
products and kits are used in scientific research, including genomic and ...
Scientists Discover Why Teeth Form in a Single Row
... While the study was in mice, past studies have shown that the involved biochemical
players are active in humans as well.
"This finding was exciting ... researchers said. Thanks to the work of Jiang and others, some of the biochemical
pathways involved in cleft lip/cleft palate development are now ...
BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease
... The secondary objective was to evaluate changes in physiological
markers of endothelial function which underlie some key
aspects of SCD. ... is a naturally
occurring enzyme cofactor that is required for numerous biochemical
physiologic processes, including the synthesis of nitric oxide (NO). ...
Anavex presents neuroprotective effects of Anavex 1-41 at the International Conference on Alzheimer's Disease 2008
... with the goal of
preventing neurodegenerative action of disturbed biochemical
About Anavex Life Sciences Corp.
Anavex Life ... sigma receptors, which are involved in the
modulation of multiple cellular biochemical
ANAVEX's SIGMACEPTOR(TM)-N program involves the ...
Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
... visit http://www.compozrzfn.com/ .
About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical
and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of ...
Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets
... molecule or mechanism of interest is a true drug target. While researchers have continued to identify novel targets in recent years through genetic, biochemical
and epidemiological studies, a lack of funding for validation studies has long been a major roadblock to the efficient translation of these ...
CRi Oosight(TM) Instrument Crucial in IVF Breakthrough Demonstrating a Correlation Between Non-Invasive Egg Metrics and Pregnancy
... CRi helps scientists and clinicians extract new disease-specific information from biological samples in the physiological, morphological, and biochemical
context of intact tissues and organisms. CRi's award-winning innovations are being recognized for their novel and groundbreaking capabilities in ...
Blanchette Rockefeller Neurosciences Institute and Inverness Medical Innovations to Develop Commercial Test to Detect Early Alzheimer's Disease
... recognized cure and is difficult to diagnose. In fact, doctors can only definitely diagnose the illness at autopsy and there is currently no approved biochemical
test to diagnose it. Finding a cure for AD is one of the central missions of the Blanchette Rockefeller Neurosciences Institute. In 2005, the cost to ...
Lilly Advances Second Alzheimer's Disease Treatment Candidate Into Late-Stage Testing by Launching Two Global Trials
... bathing, and using the telephone. Secondary objectives of the trials include different clinical benefits as measured by several brain-scanning and biochemical
biomarkers and ratings scales, and quality of life impact.
"Current therapies available to treat Alzheimer's disease may help with symptoms, ...
Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition
... acid linked to cognitive function. This finding, the researchers report, warrants further research into how the low fatty acid levels may trigger biochemical
changes in the brain linked to autism.
The team found that levels of docosahexanoic acid and total omega-3 fatty acids were significantly lower ...
Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy
... tumor response as measured by PSA suppression.
"Intermittent androgen deprivation therapy is a commonly employed treatment for men with biochemical
failure, however it needs to be evaluated in a randomized clinical trial," says Dr. E. David Crawford, Head Urologic Oncology, University of ...
BARC Central Laboratory Joins Alzheimer's Association Research Roundtable
... As a Sponsor, BARC will be participating in the Roundtable presentations and related subcommittee meetings, with particular focus on the evolution of biochemical
biomarkers as prognostic and diagnostic indicators.
A biomarker is a substance or characteristic that can be objectively measured and evaluated ...
Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)
... to comprise the high affinity copper binding site in the beta amyloid protein. Professor Hong's findings provide the missing link to explain the biochemical
significance of these earlier findings, from which we gain additional insight into the mechanism of action of our drug candidate. OXIGON(TM) is ...
TissueGene Announces Regulatory Allowance to Initiate Phase IIa Study of TG-C in South Korea for Osteoarthritis of the Knee
... www.TissueGene.com .
About Kolon Life Science, Inc.
Kolon Life Science, Inc. (KLS), a subsidiary company of Kolon, is a leading biochemical
company in Korea focused on research and discovery in the life sciences. In 2006, Kolon established KLS by merging TissueGene Asia Co., Ltd with ...
Lenetix Launches Screening Study of New Down Syndrome Test
... Down syndrome is routinely offered to patients in the
first and/or second trimester of pregnancy. These evaluations rely on indirect
ultrasound and biochemical
exams, which are of imperfect accuracy. Patients
deemed "at risk" by these tests are generally referred for genetic counseling
and amniocentesis or ...
St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment
... which are representative of the array of antileukemic medications used to treat lymphoblastic leukemia. Pharmacokinetics comprises the various biochemical
fates of a drug in the body--absorption, distribution throughout the body, breakdown and excretion. In almost all cases, gene variation predicting ...
Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease
... Discovery in Neurology with Dr. Michael Wolfe and Dr. Ross Stein from 2002-2003. Dr. Bakshi has a Ph.D. in Bioorganic Chemistry from the Center for biochemical
Technology, New Delhi, and a Master of Science in Organic Chemistry and Bachelor of Science in Chemistry from the University of Delhi, New Delhi.
A Window Into Parkinson's Disease
... genes instead of one at a time, so things
should clear a thousand times faster," says Greengard.
The novel TRAP tool will also help study the biochemical
Alzheimer's, Huntington's and other neurological diseases.
About The Michael Stern Parkinson's Research ...
Lilly Announces Initiation of Second Global Phase III Trial of Investigational Alzheimer's Disease Compound
... bathing, and using the telephone. A number of
optional biomarker substudies will be available to patients that will
utilize brain-scanning and biochemical
techniques to detect markers of
Alzheimer's disease is a progressive neurodegenerative condition that
is the most common cause ...
St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins
... cullin-RING into a kind of molecular valet that can
then attach a different accessory (ubiquitin) onto other proteins to foster
the myriad of biochemical
reactions that enable life.
"The ubiquitination machinery is critical for the cell's proteins to be
able to function as necessary in a given ...
MicroRNA First Disclosed by Rosetta Genomics may Increase Efficacy of Imatinib (Gleevec(R)(1)) in Glioblastoma
... to be
launched later this year."
In the study, "MIR-451 and Imatinib Mesylate Inhibit the Growth of
Glioblastoma Stem Cells", published online in biochemical
Research Communications, scientists demonstrated that overexpressing
miR-451 in-vitro caused inhibition of GBM cell growth. In ...
St. Jude Study Finds Treatment With New Drug Might Make Tumor Cells More Sensitive to Therapy
... Jude researchers demonstrated in the laboratory that a molecule
called CP466722 rapidly blocks the ATM protein's ability to orchestrate a
series of biochemical
events that culminate in the repair of DNA damaged by
irradiation. The molecule exerted its effect in small quantities, and its
effects rapidly ended ...
The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC
... function and flexibility of trans-membrane proteins," says
Anders Aberg, CSO at Sidec.
The publication is available on-line in the journal biochemical
Biophysical Research Communications, August 7, 2008.
Sidec offers Protein ...
Volcano's VH(R) IVUS Technology Used in Imaging Study of GlaxoSmithKline's Novel Investigational Compound, Darapladib
"Current treatments for atherosclerosis include preventative lifestyle
modifications and the regulation of physiological and biochemical
factors such as blood pressure and lipid profile. VH(R) IVUS measures the
effects of investigational compounds on plaque composition. We believe ...
CRi Announces New Maestro(TM) EX In Vivo Imaging System with Improved Performance and an Affordable Price
... care. CRi technology helps extract
new disease-specific information from biological and clinical samples in
the physiological, morphological, and biochemical
context of intact tissues
With over 80 patents pending and issued, CRi's award-winning
innovations are being utilized around the ...
Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development
... with many conditions commonly associated with aging.
Edison believes that inherited mitochondrial diseases may be genetic
roadmaps to deciphering the biochemical
basis of metabolic control and
aging. Given CoQ10's known role in mitochondrial disease and aging, as well
as its redox activity, Edison's initial ...
Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery
... quality of mitochondria from tissues
difficult to work with, such as muscle and brain. We also will examine the
ability of the PCT SPS to facilitate biochemical
studies of mitochondrial
constituents that are often otherwise limited by solubility concerns. If
successful, this work would facilitate drug ...
Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
... the patients' blood and measuring insulin and glucose
levels to calculate HOMA-IR, an index of insulin resistance. Insulin
resistance is a major biochemical
defect in Type 2 diabetes and Metabolic
Syndrome. It is associated not only with the development of high blood
sugars but also with abnormalities in ...
Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation
... cell-based models to screen estrogens for effects on neurons.
This study demonstrated that changes in calcium levels in neurons, an
pathway to temperature regulation, are mediated
selectively by the activation of estrogen receptor beta. MF101 demonstrated
this selective ....
Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds
... of total HDL, HDL Large, total LDL, total IDL,
total VLDL, and non-HDL particles were determined using the ion mobility
technique and correlated with biochemical
measurements of calculated
triglycerides, HDL cholesterol, LDL cholesterol as well as plasma ApoA1 and
Results showed that the ion mobility ...
Cryoablation Is Focus of 17 Clinical Studies at American Urological Association Annual Meeting
... A wide-ranging review of the outcomes of cryoablation in 2,558 primary prostate cancer patients showed efficacy of cryoablation in terms of biochemical
survival and low morbidity. The average age of the patients, all part of the nationwide Cryo-On-Line Database (COLD) Registry, was 70 years ...
Omeros Announces Initiation of Patient Enrollment in OMS201 Phase 1 Study
... are combinations of therapeutic agents designed to act
simultaneously at multiple discrete targets to preemptively block the
molecular-signaling and biochemical
cascade caused by surgical trauma and
to provide clinical benefits both during and after surgery. The lead
product candidate in the ...
ESBATech's Lead Antibody Fragment Enters Clinical Development for Ophthalmic Indications
... into the clinic is a truly exciting time for the company. ESBA105
represents a new generation of antibody fragment therapeutics that have
properties over earlier classes of antibody
fragments, such as high stability, solubility and high monomeric content.
This allows us to deliver the ...
Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS
... microscope based technique, called protein
tomography, the structural rearrangement accompanying inhibition of
individual EGFr molecules was studied. biochemical
analyses showed that
HuMax-EGFr binds bivalently to the EGFr and, furthermore, was shown to
prevent receptor dimerization and to severely limit ...
Cardium's Innercool Therapies Unit Announces Publication of Positive Effects of Early and Rapid Hypothermia Following Heart Attack
... membrane may in turn cause
the release of more inflammatory substances that may turn on apoptosis, or
programmed cell death, involving a series of biochemical
events that lead
to a variety of cellular changes, including cell shrinkage, chromatin
condensation, and chromosomal DNA fragmentation. White blood ...
Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines
... these programs to enter the clinic later
Sigma-Aldrich is a leading Life Science and High Technology company.
and organic chemical products and kits are used in
scientific and genomic research, biotechnology, pharmaceutical development,
the diagnosis of ...