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Autoimmune in Medical Technology

Lupus Research Institute Highly Encouraged by Benlysta(TM) Trial Results

... more worldwide, who suffer from this devastating autoimmune illness." "This is a major advance for ... diseases, is a chronic and potentially fatal autoimmune disorder that affects more than 1.5 million ... scientific solutions to the complex and dangerous autoimmune disease of lupus. Founded by families and shaped ...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... to potentially treat other T-cell mediated autoimmune diseases." About Teplizumab Teplizumab, ... About Type 1 Diabetes Type 1 diabetes is an autoimmune disease in which the body's immune system attacks ... and delivery to patients of novel biologics for autoimmune disorders, cancer and infectious diseases. Since ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... for the Treatment of Inflammatory and autoimmune Disorders SOUTH SAN FRANCISCO, Calif., June ... of this target for therapeutic intervention in autoimmune diseases. However, a specific form of the ... of the production of cytokines associated with autoimmune inflammation, without affecting proteasome ...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... used non-obese diabetic (NOD) mouse model of autoimmune diabetes. Tolerx researchers conducted ... novel anti-CD3 monoclonal antibody, in new onset autoimmune type 1 diabetes patients. About the ... patients, age 18 to 35, with newly diagnosed autoimmune type 1 diabetes. DEFEND is being conducted at ...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... for the treatment of cancer, inflammation and autoimmune diseases, announced that the German Multicenter ... for the treatment of cancer, inflammation and autoimmune diseases. Its product development pipeline ... in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

... for the treatment of cancer, inflammation and autoimmune diseases, last week presented an update from an ... for the treatment of cancer, inflammation and autoimmune diseases. Its product development pipeline ... in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Corgenix, Tulane Announce Award of NIH Grant Extending Hemorrhagic Fever Virus Product Development Program

... with Corgenix and Tulane in this grant are autoimmune Technologies, LLC, Vybion, Inc. and various ... public health and tropical medicine. About autoimmune Technologies, LLC autoimmune Technologies (New Orleans, La.) is a privately ...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

... for the treatment of cancer, inflammation and autoimmune diseases, today held an R&D Day for investors ... for the treatment of cancer, inflammation and autoimmune diseases. The Company's novel antibody technology ... applications in the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... for the treatment of cancer, inflammation and autoimmune diseases, yesterday presented non-clinical data ... for the treatment of cancer, inflammation and autoimmune diseases. The Company's novel antibody technology ... applications in the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy

... (LPMs), for the treatment of inflammatory and autoimmune diseases. CCL2-LPM selectively targets activated ... and/or maintain a variety of inflammatory and autoimmune disorders. The CCL2-CCR2 chemokine ... nephropathy, as well as a variety of other autoimmune and inflammatory conditions. CCL2-LPM is designed ...

Micromet Receives Milestone Payment for Filing of the First Clinical Trial Application for MT203

... for the treatment of cancer, inflammation and autoimmune diseases, today announced the filing of the first ... for the treatment of various inflammatory and autoimmune diseases. Preclinical studies support development ... for the treatment of cancer, inflammation and autoimmune diseases. The Company's novel antibody technology ...

Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients

... for the treatment of cancer, inflammation and autoimmune diseases, today announced the commencement of a ... for the treatment of cancer, inflammation and autoimmune diseases. The Company's novel antibody technology ... applications in the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.

... preclinical testing (PCI-45261) targeting autoimmune and allergic indications; and an HDAC-8 inhibitor (PCI-34051) for autoimmune and cancer indications. Motexafin gadolinium ... treat serious unmet medical needs in oncology and autoimmune diseases. Its deep and broad pipeline includes ...

Micromet Expands Committed Equity Financing Facility to $75 Million

... for the treatment of cancer, inflammation and autoimmune diseases, today announced that it has entered ... for the treatment of cancer, inflammation and autoimmune diseases. The Company uses its proprietary ... applications in the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

... PEGINTRON or any other component of the product, autoimmune hepatitis, and hepatic decompensation (Child-Pugh ... to INTRON A or any component of the product, autoimmune hepatitis, and decompensated liver disease. ... colitis, development or exacerbation of autoimmune disorders including thyroiditis, RA, systemic ...

Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells

... the treatment of cancer, inflammation and autoimmune diseases, presented data from a preclinical ... for the treatment of cancer, inflammation and autoimmune diseases. Four of its antibodies are currently in ... in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Diamyd(R) Study Published in Prestigious New England Journal of Medicine

... the mechanism of action: Type 1 diabetes is an autoimmune disease in which the body's own immune system ... decisive in counteracting the course of autoimmune diseases. About the Phase II study: The Phase ... of pharmaceuticals for treatment of autoimmune diabetes and its complications. The company's ...

Peptimmune Announces Grant of United States Patent for PI-2301 Peptide Copolymer for Multiple Sclerosis

... PI-2301 peptide copolymer for the treatment of autoimmune diseases. PI-2301 is currently in a Phase Ib ... for the treatment of multiple sclerosis and other autoimmune diseases." PI-2301 is a second-generation ... system and thereby controlling the pathogenic autoimmune response observed in some diseases. In a Phase I ...

Micromet and Nycomed Begin Formal Preclinical Safety Studies for Antibody MT203 for Inflammatory and Autoimmune Diseases

... for the treatment of various inflammatory and autoimmune diseases. Preclinical studies support MT203's ... for the treatment of cancer, inflammation and autoimmune diseases. Four of its antibodies are currently in ... in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

Peptimmune Initiates Phase Ib Study of PI-2301 in Multiple Sclerosis Patients and Presentation at BIO 2008

... of any immunomodulator in patients suffering from autoimmune diseases," stated Thomas P. Mathers, President ... system and thereby controlling the pathogenic autoimmune response observed in some diseases. In a Phase I ... as Crohn's disease, rheumatoid arthritis, and autoimmune uveitis. Peptimmune has put in place high-quality ...

Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus

... of SLE." SLE is a chronic, life-threatening autoimmune disease. It is estimated that approximately 1.5 ... against infection. In lupus and certain other autoimmune diseases, elevated levels of BLyS are believed to ... can reduce autoantibody levels and help control autoimmune disease activity. About Human Genome Sciences ...

Peptimmune Presents Early Clinical Data at European Neurological Society and Federation of Clinical Immunology Societies Meetings

... of the immune system to control the pathogenic autoimmune response in certain diseases. PI-2301 has ... has also shown efficacy in pre-clinical models of autoimmune diseases where immune modulation may be ... such as Crohn's disease, rheumatoid arthritis and autoimmune uveitis. Peptimmune has also introduced ...

Micromet's BiTE Antibody Blinatumomab (MT103/MEDI-538) Demonstrates Durable Responses in Patients with Relapsed Non-Hodgkin's Lymphoma

... the treatment of cancer, inflammation and autoimmune diseases, today presented an update of an ongoing ... for the treatment of cancer, inflammation and autoimmune diseases. Four of its antibodies are currently in ... in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, ...

St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity

... switch; a discovery that hints at how autoimmune disease may develop late in life MEMPHIS, ... function, including avoiding autoimmunity. In autoimmune disease, rather than attacking invading microbes, ... lupus. "Among the many mysteries surrounding autoimmune diseases is why they can sometimes take decades ...

Trubion Initiates Phase 1/2 Study of TRU-016 in CLL, Announces Next-Generation Product Candidate for RA and Provides Product Pipeline Update

... under development for the treatment of autoimmune and inflammatory diseases. Trubion and Wyeth are ... and helping us establish category leadership in autoimmune and inflammatory diseases." TRU-015 and SBI-087 ... protein therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer. The ...

Peptimmune Completes Phase I Study with a Novel Peptide Copolymer for the Treatment of Multiple Sclerosis

... for the treatment of multiple sclerosis and other autoimmune diseases. The Phase I single ascending dose, ... of the immune system to control the pathogenic autoimmune response in certain diseases. PI-2301 has been ... has also shown efficacy in pre-clinical models of autoimmune diseases where immune modulation may be ...

Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis

... of Inflamed Skin Lesions Caused by Chronic autoimmune Disease ABBOTT PARK, Ill., Jan. 18 ... moderate to severe chronic plaque psoriasis, an autoimmune disease characterized by skin lesions that are ... Psoriasis is a serious, sometimes painful autoimmune disease resulting in inflamed, scaly, red skin ...

Lexicon Files Investigational New Drug Application for LX2931 as a Potential Treatment for Rheumatoid Arthritis

... drug candidate for rheumatoid arthritis and other autoimmune conditions. The initial Phase 1 clinical trial of ... new therapy for rheumatoid arthritis and other autoimmune disorders," said Philip M. Brown, M.D., J.D., ... discovery pipeline." Rheumatoid arthritis is an autoimmune disorder characterized by stiffness, pain, ...

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

... for the treatment of SLE, and potentially other autoimmune diseases, such as rheumatoid arthritis (RA) and ... The therapeutic mechanism for HCQ in these autoimmune diseases had been unknown, until research ... Lupus Erythematosus (SLE)(1) SLE is a chronic autoimmune disease that affects nearly 500,000 Americans. ...

Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors

... diagnosis of multifactorial conditions such as autoimmune disease and allergy, enabling earlier treatment ... test can never provide a complete diagnosis. autoimmune diseases, allergies, cancers, and infectious ... expertise and semiconductor manufacture, OHSU for autoimmune and allergy expertise, and PSU for engineering of ...

Peptimmune Initiates Phase I Study With a Novel Peptide Copolymer for the Treatment of Multiple Sclerosis

... the treatment of multiple sclerosis and other autoimmune diseases. The Phase I single ascending dose, ... of the immune system to control the pathogenic autoimmune response in certain diseases. PI-2301 has been ... has also shown efficacy in pre-clinical models of autoimmune diseases where immune modulation may be ...

New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments

... and may be involved with other autoimmune diseases. The genetic link, described in the ... and wages an attack. Patients with lupus, also an autoimmune disease, have about double the risk compared to ... called on to wage battle against infection. In autoimmune diseases like rheumatoid arthritis, ...

Biopure Reports on Meeting with the FDA

... a Phase 2 randomized trial for the treatment of autoimmune hemolytic anemia and other forms of hemolytic ... to the FDA. A study protocol for the treatment of autoimmune hemolytic anemia and other forms of hemolytic ... that are requested from treating physicians. autoimmune hemolytic anemia is a group of disorders ...

MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus

... assess the ability of teplizumab to inhibit the autoimmune attack that destroys insulin-producing ... About Type 1 Diabetes Type 1 diabetes is an autoimmune disease in which the body's immune system attacks ... eliminate cancer cells, cells that contribute to autoimmune disorders, or those infected with certain ...

Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364

... has demonstrated activity in multiple animal models of inflammation and autoimmune disease, proof-of-concept studies that led to human clinical trials. An ... pharmaceutical company engaged in developing anti-inflammatory and autoimmune therapeutics. The Company is headquartered in King of Prussia (near ...

First Potential Lupus-Specific Treatment in Sight

... its primary endpoint. These results provide hope that this complex chronic autoimmune disease can be brought under control and that, eventually, a cure can be ... LFA website . About Lupus Lupus is an acute and chronic autoimmune disease in which the immune system is unbalanced, causing inflammation and ...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

... first line of defense against infection. In lupus and certain other autoimmune diseases, elevated levels of BLyS are believed to contribute to the ... Systemic lupus erythematosus (SLE) is a chronic, life-threatening autoimmune disease. Approximately five million people worldwide, including ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... a pipeline of novel protein therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer. The Company's mission is to develop ... includes CD20-directed SMIP therapeutics such as TRU-015 and SBI-087 for autoimmune and inflammatory diseases, developed under the Company's Wyeth ...

Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis

... adult Americans have been diagnosed with rheumatoid arthritis, a chronic autoimmune disease that develops when certain cells of the immune system ... and debilitating diseases, including cancer, inflammation, autoimmune disorders and infectious diseases. Medarex applies its UltiMAb(R) ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... necrolysis to interferon alpha or any other component of the product, autoimmune hepatitis, and hepatic decompensation (Child-Pugh score greater than 6 ... pancreatitis, gout, hyperglycemia, hyperthyroidism and hypothyroidism, autoimmune thrombocytopenia with or without purpura, rheumatoid arthritis, ...
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