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Asymptomatic in Medical Technology

MADIT-CRT Trial Meets Primary Endpoint

... CRT-Ds slow the progression of heart failure in asymptomatic and mildly symptomatic patients NATICK, ... defibrillators (ICDs). High risk(1), asymptomatic or mildly symptomatic, New York Heart Association ... the degree of symptoms or functional limits, from asymptomatic to bed ridden. (3) Trials include MADIT, ...

Exelixis Reports XL647 Clinical Data at AACR-NCI-EORTC Conference

... and dysgeusia, fatigue, rash, and clinically asymptomatic QTc prolongation. In phase 1, a total of ten ... (DLTs) were observed. Two events of clinically asymptomatic Grade 3 QTc prolongation occurred in two of four ... 2 diarrhea, rash, fatigue, and nausea. Clinically asymptomatic QTc prolongation was also observed. About the ...

Virtual Colonoscopies Show Value for Some Patients, But Polyps Will Be Missed

... polyps and cancer that would have been detected by colonoscopy. For asymptomatic high-risk patients and symptomatic patients, the percentage of patients ... cancers. No firm conclusions could be drawn regarding the proportion of asymptomatic high-risk patients with important polyps that would be identified by CT ...

Screening for Ischemia in Asymptomatic Patients With Type 2 Diabetes: Five- Year Outcomes in the DIAD Study

... the first manifestation of CAD. Data from the Detection of Ischemia in asymptomatic Diabetics (DIAD) Study, presented today at the American Society of Nuclear ... and ACE-inhibitors. "Systematic screening cannot be recommended in asymptomatic patients with diabetes," commented Dr. Wackers. "However, targeted ...

New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens

... or withdrawal of consent.(1) Three patients in the combination arm had an asymptomatic decrease (greater than or equal to 20 percent) in left ventricular ... of patients experienced adverse events of Grade 1 or 2. Two Grade 2 asymptomatic left ventricular ejection fraction decreases, one Grade 3 gastrointestinal ...

New NIH-Funded Study Shows Masimo Rainbow SET(R) May Help Clinicians Assess Oxygenation in Children With Sickle Cell Disease

... using the Masimo Radical-7 Pulse CO-Oximeter with invasive blood draws and laboratory analysis of carboxyhemoglobin and methemoglobin in 38 asymptomatic children (2-18 years of age) with sickle cell disease. The researchers found SpCO (with a bias of 0.1% and precision of +/- 2.2%) and SpMet (with a ...

Prostate Cancer Immunotherapy Significantly Prolongs Survival in Men With Advanced Prostate Cancer

... More than 500 patients were enrolled in the IMPACT trial, a multi-center, randomized, double-blind, placebo-controlled study evaluating men with asymptomatic or minimally symptomatic, metastatic, androgen-independent prostate cancer. The primary endpoint was overall survival. Researchers are ...

Data Presented at AUA Demonstrate PROVENGE Significantly Prolongs Survival for Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study

... P rostate A deno C arcinoma T reatment) was a 512-patient, multi-center, randomized, double-blind, placebo-controlled study evaluating men with asymptomatic or minimally symptomatic, metastatic, androgen-independent prostate cancer, and the primary endpoint was overall survival. In addition to the ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... treated. Cirrhosis of the liver resulting from chronic HCV infection is the leading indication for liver transplantation in the U.S. Due to the asymptomatic nature of HCV infection, it often goes undetected for up to 20 years following initial infection. Each year, 8,000 to 10,000 people in the U.S. die ...

American Lung Association Study to be Published in the 'New England Journal of Medicine' Finds Prescription Heartburn Medication Does Not Control Asthma Symptoms as Previously Thought

... from PPI treatment. Serious adverse events were fewer with esomeprazole than placebo (11 vs. 17). Conclusion: Despite a high prevalence of asymptomatic GER in patients with poorly controlled asthma, treatment with proton pump inhibitors does not improve control. Silent GER is not a likely cause of ...

Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer

... to provide detailed information on the safety and therapeutic efficacy of different doses of Alpharadin in HRPC patients, both symptomatic and asymptomatic for bone metastases, as well as evaluating its ability to relieve pain caused by bone metastases in symptomatic patients. In all three phase II ...

ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients

... treated. Cirrhosis of the liver resulting from chronic HCV infection is the leading indication for liver transplantation in the U.S. Due to the asymptomatic nature of HCV infection, it often goes undetected for up to 20 years following initial infection. Each year, 8,000 to 10,000 people in the U.S. die ...

Two-Year Follow-Up Data Demonstrates Preservation of Adequate Mitral Valve Area in Patients Treated with the MitraClip(R) System

... analyzed for the 96 patients in the study population who received the MitraClip(R) device. All patients were either symptomatic (91 percent) or if asymptomatic had evidence of left ventricular dysfunction. Transthoracic echocardiography was performed at baseline, pre-discharge, one year and two year ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

... liver enzymes in the low dose VIA-2291 treated group (10 percent) and placebo (2 percent), not seen in the higher dose drug-treated groups; and asymptomatic >/= 1.5x lipase elevations that were more common in VIA-2291 treated patients. In the CEA study, common AEs (>7 percent) included fever, diarrhea ...

Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers

... treated. Cirrhosis of the liver resulting from chronic HCV infection is the leading indication for liver transplantation in the U.S. Due to the asymptomatic nature of HCV infection, it often goes undetected for up to 20 years following initial infection. Each year, 8,000 to 10,000 people in the U.S. die ...

Vermillion Renews Strategic Alliance Agreement With Quest Diagnostics, Inc.

... a 90% cure rate following surgery and/or chemotherapy if detected in stage 1. About Peripheral Artery Disease (PAD) PAD, a serious but often asymptomatic disorder affecting some eight to 12 million Americans, is caused by the buildup of fat and cholesterol, or plaque, in the peripheral arteries, ...

Cepheid Announces CE IVD Release of First On-Demand Test for van A/van B Genes Most Associated With Hospital-Acquired VRE Infection

... and unnecessary use of antibiotics -- leading to dramatically higher costs for healthcare institutions. Healthcare workers, after contact with asymptomatic colonized patients, may spread VRE to other patients within hospitals. VRE can also be spread directly to people after contacting surfaces that are ...

Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients

... treated. Cirrhosis of the liver resulting from chronic HCV infection is the leading indication for liver transplantation in the U.S. Due to the asymptomatic nature of HCV infection, it often goes undetected for up to 20 years following initial infection. Each year, 8,000 to 10,000 people in the U.S. die ...

ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options

... large colorectal adenomas (polyps most likely to become cancerous) or cancers 10 mm or larger that were detected by colonoscopy in 9 out of 10 asymptomatic patients. The study also showed that CT colonography had a lower sensitivity for smaller colorectal lesions of 6 to 9 mm in size. Researchers also ...

New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease

... ten specific DNA mutations related to mitochondrial disease. The study's findings establish that the incidence of new mutations and the frequency of asymptomatic carriers are not rare and emphasize the importance of developing new approaches to prevent transmission. ...

Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598

... liver failure. Cirrhosis of the liver resulting from chronic HCV infection is the leading indication for liver transplantation in the U.S. Due to the asymptomatic nature of HCV infection, it often goes undetected for up to 20 years following initial infection. Each year, 8,000 to 10,000 people in the U.S. die ...

New Data Show TORISEL Improves Progression-Free Survival for Patients With Relapsed/Refractory Mantle Cell Lymphoma

... of infections, including opportunistic infections. Cases of interstitial lung disease, some resulting in death, have occurred. Some patients were asymptomatic and others presented with symptoms. Some patients required discontinuation of TORISEL and/or treatment with corticosteroids and/or antibiotics. ...

New Analyses Presented at ASCO Reaffirmed Efficacy and Safety of TORISEL in Patients With Advanced Kidney Cancer

... of infections, including opportunistic infections. Cases of interstitial lung disease, some resulting in death, have occurred. Some patients were asymptomatic and others presented with symptoms. Some patients required discontinuation of TORISEL and/or treatment with corticosteroids and/or antibiotics. ...

Wyeth Initiates INTORACT -- A New Clinical Trial to Examine TORISEL Plus Avastin for First-Line Treatment of Advanced Kidney Cancer

... of infections, including opportunistic infections. Cases of interstitial lung disease, some resulting in death, have occurred. Some patients were asymptomatic and others presented with symptoms. Some patients required discontinuation of TORISEL and/or treatment with corticosteroids and/or antibiotics. Cases ...

Antipodean Pharmaceuticals Announces Completion of Phase 2 Study of Lead Compound MitoQ(R)

... in the United States have chronic Hepatitis C infections; however, the true prevalence may be underestimated, since newly infected people usually are asymptomatic for many years. HCV infection is the leading cause of cirrhosis, hepatocellular carcinoma, and liver failure. Current treatment strategies focus on ...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

... U.S. in 2007 resulting in approximately 15,000 deaths. About half of all ovarian cancers occur in post-menopausal women. Ovarian cancer is frequently asymptomatic in the early stages. As a result, ovarian cancer is often not diagnosed until stage III or IV, where 5-year survival rates decline to 10-20%. Current ...

Interim Analysis Supports Continuation of Cell Genesys' VITAL-1 Phase 3 Clinical Trial of GVAX Immunotherapy for Prostate Cancer

... to Taxotere(R) (docetaxel) chemotherapy plus prednisone in hormone refractory prostate cancer (HRPC) patients with metastatic disease who are asymptomatic with respect to cancer- related pain. The primary endpoint of the trial is an improvement in survival. VITAL-1 was initiated in July 2004 and ...

Wyeth's TORISEL Receives European Commission Approval for the Treatment of Advanced Kidney Cancer

... of infections, including opportunistic infections. Cases of interstitial lung disease, some resulting in death, have occurred. Some patients were asymptomatic and others presented with symptoms. Some patients required discontinuation of TORISEL and/or treatment with corticosteroids and/or antibiotics. ...

UPDATE: Nile Therapeutics Announces Positive Phase 1a Results of CD-NP, a Selective NPR-B Agonist in Clinical Development for the Treatment of Heart Failure

... to an orthostatic challenge, some subjects exhibited transient symptoms consistent with volume depletion and/or vasodilatation including dizziness, asymptomatic tachycardia and orthostatic hypotension. These events are indicative of a practical limit of pharmacologic activity in normal healthy subjects, and ...

Nile Therapeutics Announces Positive Phase 1a Results of CD-NP, a Selective NPR-B Agonist in Clinical Development for the Treatment of Heart Failure

... to an orthostatic challenge, some subjects exhibited transient symptoms consistent with volume depletion and/or vasodilatation including dizziness, asymptomatic tachycardia and orthostatic hypotension. These events are indicative of a practical limit of pharmacologic activity in normal healthy subjects, and ...

ACRIN Study Endorses Virtual Colonoscopy - Validation for Colon CAD Software Maker Medicsight plc

... a virtual image of the colon. This study, funded by the U.S. National Institutes of Health, was initiated in 2005 and has involved more than 2,500 asymptomatic patients aged 50 or over at 15 centres across the U.S. Patients were investigated using both procedures and the resulting CT images were read by a ...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

... where the blood pressure is chronically elevated. Although asymptomatic in nature and in itself rarely an acute problem, persistent hypertension ... This poor overall treatment success is mainly attributed to the asymptomatic nature of hypertension and the necessity for long-term treatment ...

New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility

... reduce VTE events rate. The primary efficacy endpoint was the incidence of asymptomatic deep-vein thrombosis (DVT), symptomatic DVT, symptomatic pulmonary ... with a reduction in symptomatic VTE by 73% (0.3% vs. 1.1%; p=0.0044) and asymptomatic proximal DVT by 34% (2.5% vs. 3.7%; p=0.0319). No statistically ...

West Nile Virus Screening and Diagnostics Technology Emerges In Step with North American Outbreak

... clinical symptoms. These observations explain the rationale for screening asymptomatic blood donors with nucleic acid-amplification tests (NAT) and the use of ... there have been screening failures because of low levels of viremia in asymptomatic donors and the use of mini-pools. The most recent guidelines for ...

First Study To Show Positive Benefit On Atherosclerosis For People With Early Signs Of Diseased Arteries

... included patients with established coronary artery disease and at a high risk of CHD events, and now with METEOR, which evaluated CRESTOR in asymptomatic subjects with early disease and at low CHD risk. “It’s exciting to see that by using rosuvastatin we can potentially slow or even stop ...

Scios Announces Results From Exploratory Nesiritide Study Providing Important New Renal and Mortality Safety Data with a Neutral Effect on the Primary Endpoint

... or discontinued. At the recommended dose of NATRECOR(R), the incidence of symptomatic hypotension (4%) was similar to that of IV nitroglycerin (5%). asymptomatic hypotension occurred in 8% of patients treated with either drug. In some cases, hypotension that occurs with NATRECOR(R) may be prolonged. The ...

Trichomoniasis: Most Common Curable STD in U.S. Affects 7.4 Million Annually

... sperm count and movement, increased risk of infertility, and chronic pain in the prostate or pelvic region. Because trich is generally asymptomatic or only mildly symptomatic, people often don't know they are infected. This lack of awareness often leads to a delay in seeking treatment, ...

The Lancet Publishes PREVAIL Study Results Showing Lovenox Superiority Over Unfractionated Heparin for Reducing the Risk of Venous ThromboEmbolism in Patients With Acute Ischemic Stroke

... Score (severe being greater than or equal to 14 and less severe less than 14). The primary efficacy endpoint was the composite of symptomatic or asymptomatic DVT, symptomatic or fatal PE during the treatment period. The primary safety endpoints included symptomatic intracranial bleeding, major extracranial ...

New Position Statement from The North American Menopause Society Addresses Use of Local Estrogen for Treatment of Vaginal Atrophy in Postmenopausal Women

... estrogen is used locally for vaginal atrophy. -- Data are insignificant to recommend annual surveillance of the endometrium (lining of uterus) in asymptomatic women using vaginal estrogen. -- Vaginal estrogen therapy should be continued for as long as symptoms that are distressing to the patient remain. ...
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