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Aspirin in Medical Technology

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

... seeking approval for a product combining low dose aspirin with esomeprazole magnesium for the risk ... for developing gastric ulcers.(1) Low-dose aspirin is the mainstay in the prevention of cardio- and ... and stroke.(2A,3A) However, even at low doses, aspirin is associated with a risk of peptic ulcers and ...

Corgenix AspirinWorks(R) Test Recognized in POLYCAP Study at ACC.09

... Test confirms antiplatelet effectiveness of aspirin in new super pill ORLANDO, Fla. and DENVER, ... (TIPS) to help determine patients' response to aspirin and/or statin therapy. The TIPS trial ... Trial results also showed that randomization to aspirin therapy resulted in a reduction in 11dTxB2, ...

New Aspirin Recommendation Can Help Prevent Heart Attacks & Strokes, Says Partnership for Prevention

... Force (USPSTF) underscores the value of regular aspirin use in preventing heart attacks and strokes among ... said today. The USPSTF found that regular aspirin use reduces first heart attacks in men and first ... the ages of 45 and 79 and to women 55 to 79. aspirin should be used when the benefits outweigh the ...

Task Force Recommends Using Aspirin to Prevent Cardiovascular Disease When the Benefits Outweigh the Harms

... bleeding -- before deciding whether to use aspirin to prevent heart attacks or strokes, according to ... recent meta-analysis of the risks and benefits of aspirin and found aspirin may have different benefits and harms in men and ...

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

... doses. "In this study, TRA, when given with aspirin and clopidogrel, was able to inhibit the ... placebo plus standard medical care (including aspirin and clopidogrel) or to TRA once daily plus ... placebo plus standard medical care (including aspirin or clopidogrel) or to TRA plus standard medical ...

Consensus Document Outlines Practical Steps for Reducing Gastrointestinal Risks of Antiplatelet and NSAID Use

... Healthcare System. Patients taking low-dose aspirin plus NSAIDs have a two- to four-fold increased ... require a prescription. The best-known NSAID is aspirin (which also acts as an antiplatelet agent). Other ... low-dose aspirin. Antiplatelet agents (usually aspirin plus clopidogrel) are also recommended for ...

PRoFESS(R) Results Announced at XVII European Stroke Conference

... 25mg / 200mg capsules combine a low dose of aspirin and extended-release dipyridamole to reduce the ... drug that has shown superiority to low-dose aspirin in a head-to-head trial for the prevention of ... 2, GI bleeding with AGGRENOX was comparable to aspirin (4.1% vs 3.2%) and the incidence of intracranial ...

New Data Show High Frequency of Medical Claims for Gastrointestinal Events by Patients on Antiplatelet Therapy

... patients taking clopidogrel in combination with aspirin or other non-steroidal anti-inflammatory ... 60 years of age. Information about concurrent aspirin use, which is common among patients with ... and ulcers in patients who take CGT-2168 and aspirin compared with patients who take clopidogrel and ...

Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium

... Data Suggests That Millions on aspirin Therapy Can Safely Take Aleve for Pain ... commercially sold as Aleve(R), was added to an aspirin therapy regimen, there was no change in ... can negate the intended cardiovascular benefit of aspirin therapy, an OTC dose of naproxen sodium did not ...

Addition of INTEGRILIN(R) (Eptifibatide) to Bivalirudin Plus Standard of Care Inhibits Platelet Aggregation in Patients Undergoing Elective Coronary Stenting

... in the absence of chronic clopidogrel therapy and aspirin (325 mg) and then randomized to either a ... in patients being treated with clopidogrel and aspirin at the time of elective percutaneous ... treatment (75 mg clopidogrel and 325 mg aspirin daily). Patients had serial assessment ...

Aspirin Named 8th World Wonder by Majority of Americans

... survey, 74 percent of Americans believe that aspirin should take its place alongside the other Wonders ... researchers continue to explore the role aspirin may have in the prevention of diseases such as ... the 110th anniversary of the discovery of aspirin Bayer HealthCare will donate 110,000 bottles ...

Heart Patients More Likely to Adopt Healthy Habits in 3-Year Program Led by Cardiac Rehabilitation Experts, Mayo Clinic Research Shows

... to within recommended levels. Of the 503 participants, compliance with aspirin usage was 91 percent; statin usage, 91 percent; beta-blocker usage, 78 ... pressure to less than 140 systolic and 90 diastolic -- Taking a daily aspirin to help prevent blood clots -- Quitting smoking "This suggests the ...

Daiichi Sankyo/Eli Lilly's Effient and Astrazeneca's Ticagrelor May Offer Advantages in the Treatment of Post-Myocardial Infarction

... only adenosine diphosphate receptor antagonist used in combination with aspirin (excluding the occasional use of ticlopidine [Roche/Sanofi-Aventis's ... agent that is as effective as Plavix/Iscover when it is added to aspirin but does not bring the higher risk of major bleeding." About the Report ...

Cogentus Pharmaceuticals Begins Clinical Study to Confirm the Full Antiplatelet Benefit of New Combination Medicine CGT-2168

... Phase 3 trial that will evaluate the clinical benefits of CGT-2168 with aspirin compared to Plavix with aspirin. COGENT stands for the Clopidogrel and the ... in the Annals of Internal Medicines concluded that the antiplatelet drugs aspirin and clopidogrel are, respectively, the third and fourth most common causes ...

News from the American Heart Association

... to eight days. According to the update, clopidogrel should be added to aspirin in patients with STEMI regardless of whether they undergo reperfusion ... inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) - except aspirin - should stop taking them while being treated for a heart attack. NSAIDs ...

Cogentus to Launch Phase III Program of Novel Combination Product Designed to Reduce Bleeding Side Effect of Antiplatelet Therapy

... gastrointestinal bleeding and ulcers in patients who take CGT-2168 and aspirin compared with patients who take clopidogrel and aspirin. The vast majority ... However, treatment with antiplatelet medicines such as clopidogrel, aspirin or the frequent combination of the two is associated with ...

Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept)

... Additional DMARDs, non-steroidal anti-inflammatory drugs (NSAIDs), and aspirin were added and/or adjusted at the discretion of the investigator in the ... entered the long-term extensions study. Additional DMARDs, NSAIDs, and aspirin were added and/or adjusted at the discretion of the investigator in the ...

SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients

... will be randomized to either placebo plus standard medical care (including aspirin and clopidogrel) or to TRA once daily plus standard medical care. This ... demonstrate incremental benefit on top of standard antiplatelet (including aspirin and clopidogrel) and other antithrombotic therapies, with no ...

Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer

... or = 80 ml/min), high doses of NSAIDs (such as ibuprofen >1600 mg/day) and aspirin at higher dosage (> or = 1.3 g daily) may decrease pemetrexed elimination ... from 49 to 79 ml/min) should avoid taking NSAIDs (e.g., ibuprofen) or aspirin at higher dosage, for 2 days before, on the day of, and 2 days following ...

Schering-Plough Announces Results of the Early ACS Trial

... until 2 hours preoperative (maximum 120 hours). Patients without revascularization received an infusion of less than or equal to 96 hours. aspirin (162-325 mg orally or 150-500 mg intravenously) was required upon enrollment, followed by greater than or equal to 75 mg daily thereafter. ...

February 2009 Mayo Clinic Women's HealthSource Highlights Diabetes and Heart Disease, Going Vegetarian and Tinnitus

... something as simple as a buildup of wax blocking the ear canal. Some medications, certain antibiotics and cancer drugs can cause or worsen tinnitus. aspirin --- taken in excessive amounts --- can cause temporary ringing in the ears, too. The treatment depends on the root cause. But so far, there is ...

Daiichi Sankyo and Lilly Respond to Speculation on Status of Prasugrel New Drug Application

... Agency in February 2008. In the TRITON-TIMI 38 clinical trial of more than 13,000 patients, the primary measure showed that prasugrel taken with aspirin reduced the relative risk of the combined endpoint of cardiovascular death, non-fatal heart attacks or non-fatal stroke by 19 percent more than ...

Regado Biosciences Completes Patient Enrollment for Phase IIa Study of REG1 Anticoagulation System

... a multi-center, open-label, randomized clinical study, has enrolled a total of 26 patients. All patients were pretreated with clopidogrel and aspirin to inhibit platelet activity and were then randomized to receive either REG1 or unfractionated heparin. In patients treated with the REG1 System, ...

12-Month ATLANTA Trial Data Show Sustained Benefit of Catania(TM) Stent in Treatment of De Novo Coronary Lesions

... of 6.8 percent (five of 74 lesions analyzed at twelve months). Of note, all patients stopped dual anti-platelet therapy after 30 days, but continued aspirin (100 mg/d) throughout the 12-month period. The acute angiographic and procedural success rate in the ATLANTA Trial was 100 percent. Independent ...

Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008

... (PK-PD) study; Phase Ib, a drug dose-escalating study in subjects with stable coronary artery disease who were receiving aspirin with or without clopidogrel; and Phase Ic, a multiple exposure, dose-ranging study in 39 healthy volunteers. Top-line results from these three ...

Head-to-Head Study Showed Prasugrel Statistically Superior to Clopidogrel in Reducing Recurrent Cardiovascular Events

... recurrence of subsequent events assessment was part of the larger TRITON-TIMI 38 trial, the primary measure of which showed that prasugrel taken with aspirin reduced the relative risk of the combined endpoint of cardiovascular death, non-fatal heart attacks or non-fatal stroke by 19 percent more than ...

Thrombosis Guidelines Emphasize Difficult Choices for Pregnant Women

... make decisions about thromboprophylaxis based on the individual patient's thrombosis risk. The guidelines continue to recommend against the use of aspirin alone as a means to prevent venous thromboembolism in any patient population because more effective methods are available. The guidelines are ...

New Study: Pine Bark Significantly Reduces Menstrual Pain

... which may reach incapacitating severity," said Dr. Nobutaka Suzuki, lead researcher of the study. "Non-steroid anti-inflammatory drugs (NSAID) like aspirin or ibuprofen provide temporary help against menstrual pain. Unfortunately, they are generally ineffective for resolving spasmodic events and ...

BioElectronics Announces Profitability Breakeven and Additional Clinical Trials

... pain to millions of people. To relieve the pain and inflammation, many have turned to non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen, but the science clearly shows these are often of limited benefit. We are very excited about working with this group leading lower ...

AstraZeneca Submits sNDA for NEXIUM(R) I.V. for Peptic Ulcer Bleed Indication

... 2003;98(7):1494-1499. Table 5. (9) Mose et al. Thirty-day mortality after peptic ulcer bleeding in hospitalized patients receiving low-dose aspirin at time of admission. Am J Geriatr Pharmacother 2006;4(3):244-50. (10) Barkun et al. The cost-effectiveness of high-dose oral proton pump ...

Data Show FLECTOR(R) Patch Yields Significant Pain Reduction for Acute Strains, Sprains and Contusions

... to diclofenac. FLECTOR(R) Patch should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients. Use the lowest effective dose for ...

St. Jude Finds 'Dancing' Hair Cells Are Key to Humans' Acute Hearing

... prestin's role in hearing Zuo and his colleagues may help scientists better understand the mechanisms of hearing loss. "For example, an overdose of aspirin causes a high-frequency hearing loss by inhibiting prestin's function," Zuo said. "Also, there is evidence that many cases of high-frequency hearing ...

Starting Flu Vaccination in August Could Help Protect Nearly 11 Million More Children During Scheduled Doctors' Visits

... gelatin or arginine or with life-threatening reactions to previous influenza vaccinations, and in children and adolescents receiving concomitant aspirin or aspirin-containing therapy. Do not administer FluMist to children less than two years of age due to an increased risk of hospitalization and ...

Drug Combo Could Lower Diabetes Complications and Costs

... Overall, giving an inexpensive drug combination consisting of generic glucose, cholesterol and blood pressure-lowering drugs along with low-dose aspirin to all people with diabetes would result in 7.3 million fewer serious complications over the next 30 years. Diabetes continues to increase at an ...

Treximet(TM) (Sumatriptan and Naproxen Sodium) Tablets Approved by FDA for Acute Treatment of Migraine

... is contraindicated in patients who have had allergic reactions to products containing naproxen. It is also contraindicated in patients in whom aspirin or other NSAIDs/analgesic drugs induce the syndrome of asthma, rhinitis, and nasal polyps. Both types of reactions have the potential of being fatal. ...

ISAR-REACT 3 Pits Bivalirudin vs. Unfractionated Heparin in PCI

... angioplasty or implantation of bare-metal stents, and for at least six months after implantation of drug-eluting stents. Patients continued to take aspirin indefinitely. The study will determine whether use of bivalirudin influences rates of bleeding during the initial hospitalization or the 30-day ...

Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel

... received either bare metal or drug-eluting stents CHICAGO, March 29 /PRNewswire-FirstCall/ -- The investigational antiplatelet drug prasugrel plus aspirin produced a marked and highly statistically significant reduction in the risk of coronary stent thrombosis (ST) - a major concern for physicians and ...

Accumetrics Announces $28.8 Million Financing and Initiation of Pivotal Clinical Trial

... said Anthony Arnerich, President and CEO, Arnerich Massena and Associates, Inc. Because millions of patients are prescribed Plavix(R) and aspirin to lower the risk of coronary heart disease worldwide, the need to tailor antiplatelet therapy and improve clinical outcome is significant. Under ...

FDA Approves Cymbalta(R) for Maintenance Treatment of Major Depressive Disorder

... should tell their doctor about all of their medicines, including those for migraine to avoid a potentially life-threatening condition, and NSAIDs, aspirin or blood thinners due to an increased risk of bleeding. They also should talk to their doctor about their alcohol consumption. Patients should ...

CHMP Recommends Expanded Use of Angiox(R) (Bivalirudin) in Europe for Patients With Acute Coronary Syndromes

... specifically patients with unstable angina (UA) or non-ST segment elevation myocardial infarction (NSTEMI). Angiox should be administered with aspirin and clopidogrel. Angiox is an anticoagulant currently approved in Europe for use in patients undergoing percutaneous coronary interventions (PCI), ...
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