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Antibiotics in Medical Technology

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

... to its unique mode of action, which allows the antibiotics to penetrate into the bacteria, ... cepacia is almost always multi-resistant to antibiotics and this, in conjunction with the poor prognosis ... - has developed mechanisms to eliminate antibiotics once they have entered the cell. ...

Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis

... eye drops. Regular innovation to develop newer antibiotics is required because over time antibiotics may encounter increasing bacterial resistance. ... the same or better efficacy than currently used antibiotics without contributing to the growing rise of ...

Rib-X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R&D Directions 100 Great Investigational Drugs of 2009

... focused on the discovery and development of novel antibiotics for the treatment of antibiotic-resistant ... synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ... engine has yielded several distinctive new antibiotics that can be used for the treatment of either ...

Novexel's NXL104/ceftazidime Combination Commences Second Phase II Clinical Trial in Hospital Patients With Complicated Intra-Abdominal Infections (cIAIs)

... problem of microbial resistance to beta lactam antibiotics (penicillins, cephalosporins, carbopenems) ... focused on the discovery and development of novel antibiotics designed to overcome the significant global ... The ever increasing resistance to marketed antibiotics has led to a clear need for novel drugs that are ...

Early Switch from IV to Oral Meds Is Effective for Children with Acute Bone Infection

... from intravenous (IV) antibiotic delivery to oral antibiotics is just as effective as continuing the IV ... patients suggesting that early transition to oral antibiotics was safe and effective," said study leader ... The traditional treatment has been to supply antibiotics through a central venous catheter over a four- to ...

Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile

... a new way to address the anthrax threat. While antibiotics can kill the anthrax bacteria, they are not ... in their blood, and it may be too late for antibiotics alone to be effective. "We are delighted to ... is a key finding given the important role that antibiotics are expected to continue to play in the treatment ...

Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin

... development and commercialization of novel antibiotics for the treatment of antibiotic-resistant ... synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ... engine has yielded several distinctive new antibiotics that can be used for the treatment of either ...

Novexel's NXL104/ceftazidime Combination Commences Phase II Clinical Trial in Hospital Patients With Complicated Urinary Tract Infections

... problem of microbial resistance to beta lactam antibiotics (penicillins, cephalosporins, carbopenems) ... focused on the discovery and development of novel antibiotics designed to overcome the significant global ... The ever increasing resistance to marketed antibiotics has led to a clear need for novel drugs that ...

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Next Generation Oxazolidinone at 2008 ICAAC/IDSA Joint Meeting

... development and commercialization of novel antibiotics for the treatment of antibiotic-resistant ... and improve the utility of this class of antibiotics relative to the only other oxazolidinone marketed ... synthesis. Many known, commercially valuable antibiotics exert their effects by binding to the bacterial ...

Paratek Reports Positive Phase 2 Clinical Data on its New Antibiotic PTK 0796 in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

... Officer of Paratek Pharmaceuticals, stated, "New antibiotics are critically needed as multi-drug resistance ... program." PTK 0796 represents a new class of antibiotics that has shown potent, broad-spectrum activity ... techniques, AMCs were evolved from tetracycline antibiotics as potential agents to combat ...

Rib-X Pharmaceuticals, Inc. Announces Recent and Upcoming Presentations at Scientific Conferences

... focused on the discovery and development of novel antibiotics for the treatment of antibiotic-resistant ... "Using Structure-Based Discovery to Define Novel antibiotics Targeting the 50S Ribosomal Subunit." RX-04 is ... synthesis. Many known, commercially valuable antibiotics bind to the ribosome, including those used to ...

Bad News to Bad Bugs: Northern Antibiotics Develops Novel Polymyxins With Reduced Toxicity

... Martti Vaara, CEO and co-founder of Northern antibiotics Ltd. "The need for well-tolerated antibiotics that are active against multidrug-resistant ... strains start to spread." About Northern antibiotics Ltd. Founded in 2003 and headquartered in ...

Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community- Associated Methicillin Resistant Staphylococcus Aureus (CA-MRSA)

... is a pathogen that is not killed by many of the antibiotics doctors most commonly prescribe for the treatment ... treatments is increasing the demand for new antibiotics that can overcome this resistance. We believe ... more clinical failures, there is a need for new antibiotics with unique mechanisms of action that can ...

June 2008 Mayo Clinic Women's HealthSource Highlights Shingles Vaccine for Pain Prevention, Tips to Avoid Antibiotic Resistant Infections, and Benefits of Broad Genetic Testing

... MRSA in case you need a special antibiotic. Use antibiotics appropriately: When you take antibiotics, take ... even when you start feeling better. Don't demand antibiotics for viral illnesses; antibiotics don't work with viruses. Taking too ...

Forest Laboratories Announces Positive Results from Phase III Clinical Studies of Ceftaroline for the Treatment of Complicated Skin and Skin Structure Infections

... recognize the urgent need for new broad-spectrum antibiotics such as ceftaroline to treat the growing number ... most frequently prescribed class of antibiotics in the world. Ceftaroline is also being studied ... A comparison of available and investigational antibiotics for complicated skin infections and ...

Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia

... known hypersensitivity to tetracycline class antibiotics -- Glycylcycline class antibiotics are structurally similar to tetracycline class antibiotics and may have similar adverse effects. Such ...

Pew Commission Says Industrial Scale Farm Animal Production Poses 'Unacceptable' Risks to Public Health, Environment

... to lack of oxygen. IFAP runoff also carries antibiotics and hormones, pesticides, and heavy metals. antibiotics are used to prevent and treat ... resistance to medically important antibiotics and other microbials. 2. Implement a disease ...

More Clinical Data Required to Support European Approval of CAP Indication for TYGACIL

... known hypersensitivity to tetracycline class antibiotics -- Glycylcycline class antibiotics are structurally similar to tetracycline class antibiotics and may have similar adverse effects. Such ...

Innocoll Announces Dosing of First Patient in US Phase 2 Clinical Trial to Investigate CollaRx(R) GENTAMICIN TOPICAL for the Treatment of Moderately Infected Diabetic Foot Ulcers

... antibiotics. Orally and parenterally administered antibiotics are often associated with systemic side effects ... (ischemia), which may render systemically acting antibiotics less effective. Infection can also spread to the ... Since there are currently no topical antibiotics on the market for infected diabetic foot ulcers, ...

Rib-X Pharmaceuticals Renews Collaborative Agreement with the Medical Research Council

... focused on the discovery and development of novel antibiotics for the treatment of antibiotic-resistant ... on an atomic level, of the binding properties of antibiotics to the 50S subunit of the ribosome." About ... synthesis. Many known, commercially valuable antibiotics bind to the ribosome, including those used to ...

New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies

... a new way to address the anthrax threat. While antibiotics can kill the Bacillis anthracis bacteria, ... is a key finding given the important role that antibiotics are expected to continue to play in the treatment ... those toxins have been released into the blood. antibiotics also may not be effective ...

Innocoll Announces Dosing of First Patient in US Phase 2 Clinical Trial to Investigate CollaRx(R) GENTAMICIN TOPICAL for the Treatment of Mildly Infected Diabetic Foot Ulcers

... Orally and parenterally administered antibiotics are often associated with systemic side effects ... which may render systemically acting antibiotics less effective. Infection can also spread to the ... tissue. Currently, there are no topically applied antibiotics marketed in the US that are specifically ...

Paratek Pharmaceuticals Announces the Close of $40 Million Private Placement to Finance Programs to Combat MRSA Infections

... Paratek has designed two broad- spectrum antibiotics that have been shown to work against susceptible ... broad-spectrum antibiotic and narrow-spectrum antibiotics to treat acne and C. ... pneumonia (HAP) and to enhance the activity of antibiotics against resistant bacteria, and since they do ...

For Most, Good Oral Care Does More Than Antibiotics to Prevent Dental-Related Heart Problems, Reports the Harvard Heart Letter

... might flood the bloodstream with bacteria. The antibiotics were supposed to prevent infective endocarditis, ... routine oral care and recommends pre-procedure antibiotics for only some people, reports the October 2007 ... so, no large trials have tested whether taking antibiotics before dental work actually prevents ....

Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria

... drug candidate, oritavancin, to that of other antibiotics against a variety of susceptible and resistant ... of oritavancin when combined with other antibiotics against S. aureus and enterococci of different ... in vitro in combination as it synergizes with antibiotics of different classes against gram-positive ...

Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models

... surgical intervention. There are currently no antibiotics approved to treat osteomyelitis, which has ... to generate molecules that deliver the antibiotics directly to the bone, targeting the site of ... on developing and commercializing innovative antibiotics to treat serious infections in the hospital and ...

Promising Data from Paratek Pharmaceuticals' MAR Inhibitor Program Presented in 'Late Breaker' Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... and develop resistance to a broad range of antibiotics and other toxic substances. MAR inhibitors ... also developing community-targeted broad-spectrum antibiotics and narrow-spectrum antibiotics to treat acne and C. difficile ...

Boston University Biomedical Engineers Find Chink in Bacteria's Armor

... Find Could Lead to More Effective antibiotics Against 'Superbugs' BOSTON, Sept. 6 ... Currently, three classes of bactericidal antibiotics are used to target different bacterial functions: ... free radical overload appears to help current antibiotics do their job, but is not always enough to kill ...

DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux

... - Need for antibiotics Eliminated in 87 Percent of Patients, New Study ... DEFLUX also eliminated the need for prophylactic antibiotics in 87 percent of patients. VUR, a malformation of ... DEFLUX also eliminated the need for prophylactic antibiotics in 87 percent of patients. Of the 13 patients ...

Novexel to Present Four Posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases in Helsinki

... pharmaceutical company focused on the discovery and development of novel antibiotics designed to overcome the significant global problem of microbial resistance. The ever increasing resistance to marketed antibiotics has led to a clear need for novel drugs that are active against multi-drug ...

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

... cases, death. CDI typically develops from the use of broad-spectrum antibiotics that disrupt normal gastrointestinal (gut) flora, allowing C. difficile ... About Fidaxomicin Fidaxomicin is the first in a new class of antibiotics called macrocyclics, which inhibit the bacterial enzyme RNA polymerase, ...

NovaBay(R) Pharmaceuticals Enters into Agreement to Broaden Intellectual Property Estate and Expand Clinical Opportunities for Its Aganocide(R) Compounds

... compounds may deliver the same or better efficacy than currently used antibiotics without contributing to the growing rise of bacterial resistance. In ... to be effective against bacteria in biofilm, which render most antibiotics ineffective. These compounds have a potentially broad therapeutic index ...

Elusys' Anthrax Anti-Toxin, Anthim(TM), Enters Second Phase I Clinical Study

... for people infected with anthrax in a bioterrorism emergency." Currently antibiotics represent the only therapeutic option for anthrax infection. antibiotics target the bacteria, but can still fail to prevent death from the damaging ...

NovaBay Pharmaceuticals Announces Lead Anti-infective Product Candidate, NVC-422, Shown to be Effective in Treating Topical Fungal Infection

... NVC-422 may deliver the same or better efficacy as currently used antibiotics without contributing to the growing rise of bacterial resistance. The ... infections such as acne, nail fungus and topical viral infections, where antibiotics are not effective. Advancing NVC-422 into Phase II clinical trials ...

British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection

... as the dominant strain in outbreaks and, worryingly, there are only two antibiotics which are still effective against them. There is a very real danger that ... biology of C.difficile and MRSA that will assist efforts to develop new antibiotics and better diagnostic tests to identify these pathogens. During the ...

Mpex Pharmaceuticals Announces Initiation of a Phase 2 Clinical Trial of Aerosol MP-376 in COPD

... formulations, PK/PD strategies and novel potentiating agents with proven antibiotics to overcome or directly inhibit the molecular mechanisms in bacteria ... found in many gram-negative bacterial pathogens. Bacterial efflux of antibiotics is a leading source of multi-drug resistance, particularly in ...

Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections

... Idaho. "With rates of MRSA increasing and effectiveness of some current antibiotics declining, it is important to identify effective alternative treatments ... protocol violation was use of additional systemic or topical prohibited antibiotics or high-dose steroids registered as clinical failures. The causative ...

Novexel to Present Five Posters at the Joint Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Disease Society of America (ICAAC/IDSA) Meeting

... pharmaceutical company focused on the discovery and development of novel antibiotics designed to overcome the significant global problem of microbial resistance. The ever increasing resistance to marketed antibiotics has led to a clear need for novel drugs that are active against multi-drug ...

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

... formulations, PK/PD strategies and novel potentiating agents with proven antibiotics to overcome or directly inhibit the molecular mechanisms in bacteria ... found in many gram-negative bacterial pathogens. Bacterial efflux of antibiotics is a leading source of multi-drug resistance, particularly in ...

Rapid Test for Pathogens Developed By K-State Researchers Could Be Used to Detect Diseases Used By Bioterrorists

... five common serotypes of E. coli, and resistance to the 45 most common antibiotics used to treat human and animal illnesses caused by these pathogens. When ... the doctor how many different kinds of pathogens are in a sample and which antibiotics won't work, all in a shorter time frame. The test's efficiencies also ...
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(Date:4/23/2014)... of Public Health-Bloomington has bolstered the link between red ... association between heme iron, found only in meat, and ... that heme iron consumption increased the risk for coronary ... found between nonheme iron, which is in plant and ... study was published online ahead of print in the ...
(Date:4/23/2014)... Toronto Scarborough research shows that male black widow spiders ... a rare example of mate preference by male spiders. ... Emily MacLeod and Maydianne Andrade, a professor in UTSC,s ... studies and the wild that males overwhelmingly chose to ... black widows can tell whether a potential mate is ...
(Date:4/23/2014)... of an accurate group decision increases with the abundance ... collective faces a variety of factors as often ... report that smaller groups actually tend to make more ... on only certain pieces of information. , The findings ... collective intelligence, or the "wisdom of crowds," wherein individual ...
Breaking Biology News(10 mins):Study: Iron consumption can increase risk for heart disease 2Picky male black widow spiders prefer well-fed virgins 2Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
(Date:4/23/2014)... Ind. - Purdue University researchers have developed a way ... cell by using tiny gold particles with tails of ... of agricultural and biological engineering, used gold nanoparticles to ... as BRCA1 messenger RNA splice variants, which can indicate ... of these mRNA splice variants in a cell can ...
(Date:4/23/2014)... April 23, 2014Men whose testosterone falls below normal levels ... be overweight and have heart disease and type 2 ... testosterone-deficient men for further testing and possible treatment is ... Health , a peer-reviewed publication from Mary Ann Liebert, ... Journal of Men,s Health website at ...
(Date:4/23/2014)... of probiotics, antioxidants and other nutritional compounds, more and ... is getting in on the action. But legitimate skepticism ... industry is responding with clinical research to shore up ... Chemical & Engineering News (C&EN), the weekly news ... Bomgardner, a senior editor at C&EN, writes that about ...
(Date:4/23/2014)... researcher from the Cancer Science Institute of Singapore (CSI ... the cancer specific stem cell which causes gastric cancer. ... drugs for the treatment of this disease and other ... Dr Chan Shing Leng, Research Assistant Professor at CSI ... variant of a cell surface protein, CD44v8-10, marks gastric ...
(Date:4/23/2014)... prevent the depletion of self-control, according to research published ... Association for Psychological Science. , Self-control can be difficult ... attention on a boring textbook are hard things to ... difficulty: Exerting self-control for a long period seems to ... tasks. , "It is as if self-control is a ...
Breaking Medicine News(10 mins):Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:ADHD drug may help preserve our self-control resources 2
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