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Activation in Medical Technology

Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II

... C3 inhibitor, which shuts down the complement activation cascade that could otherwise lead to local ... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens of ... through the membrane attack complex (MAC). activation of the complement system is an important part of ...

Stress-Related Disorders Affect Brain's Processing of Memory

... processed by the hippocampus, showed abnormal activation in the patients with stress-related disorders ... with stress-related disorders showed greater activation in the hippocampus, suggesting that insufficient activation of the prefrontal cortex could be the basis for ...

Potentia Pharmaceuticals Announces Positive Safety Data and Study Expansion in Phase I Trial for Lead Drug Candidate POT-4

... inhibitor, which shuts down the complement activation cascade that could otherwise lead to ... the Complement System and POT-4 Complement activation is an inflammatory process involving dozens ... through the membrane attack complex (MAC). activation of the complement system is an important part of ...

Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged

... by exerting stabilization effects, not by activation of the gene. This new finding throws a scientific cloud over the use of Sirtuin1 gene activation tests as a measure of resveratrol activity. ... has since abandoned the Sirtuin1 gene activation test as a measure of dietary supplement activity. ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... and homeostasis. For example, bile acid activation of FXR results in a decrease in serum triglyceride levels. -- The activation of TGR5 by bile acids increases energy ... These effects have been attributed primarily to activation of FXR. Additionally, mice that lack FXR have ...

DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin

... crossover study compared the effects on platelet activation and bleeding time of DG041 alone and in ... to substantially inhibit EP3 mediated platelet activation that is not being addressed by current therapy. ... inhibit platelet aggregation as well as platelet activation mediated specifically through ...

Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta

... Meeting, showed that in breast cancer cells the activation of GADD45 gene via the estrogen receptor beta ... of breast cancer cells by increasing GADD45. The activation of this gene blocks the activation of important genes that stimulate the growth ...

New Clinical Data Further Supports Chromium Picolinate's Role in Enhancing Brain Activity in Older Adults

... chromium picolinate exhibited greater brain activation while engaged in a cognitively demanding task," ... for a 12-week period might affect brain activation under working memory task demands in 13 older ... receiving chromium picolinate exhibited greater activation in right thalamic, right temporal, right ...

CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License

... of the innate inflammatory response to bacterial infection. CD14 triggers activation of the innate immune response to bacterial components including ... receptor (TLR) pathway. Lung inflammation in response to innate immune activation through the TLR pathway is a primary factor in the early pathogenesis of ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... retinal detachment. In addition, we show that Palomid 529 also reduces the activation of glial cells and subsequently slows the formation of subretinal scar ... is considered a major therapeutic target in several different diseases. activation and subsequent deregulation of this signaling pathway, via direct or ...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

... PCI-32765 has the remarkable ability to selectively inhibit human B-cell activation without effecting T cells. Strong preclinical validation of Btk as a ... Also many lymphomas are caused by uncontrolled growth of B-cells where activation of the B-cell receptor and Btk signaling are thought to play important ...

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

... is the most potent activator of platelets. Drugs that block platelet activation by other mechanisms, such as the thromboxane- or ADP-mediated pathways, ... clinical benefit through inhibition of this thrombin-mediated platelet activation without the liability of increased bleeding (when added to standard of ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... author of the study. "At the center of cellular reprogramming lies the activation of the transcription factors Oct4, Sox2, and nanog. These core factors ... relies on maternal factors in the egg, further development requires activation of the embryonic genome to ensure correct progression of the cell cycle. ...

Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol

... in a similar position or exhibit a similar function. Does Sirtuin1 activation prolong human life? The idea that activation of a single gene -- Sirtuin1 -- may prolong human life, has faced a ...

Swedish in Seattle to Study Connections Between Preeclampsia and Migraine

... project, titled "A Prospective Cohort Study of Migraines, Platelet activation and Preeclampsia," will be conducted by Dr. Williams and her ... prenatal exams, in part, to evaluate the role of platelet aggregation and activation in preeclampsia," said Dr. Williams. "We're trying to go way beyond asking ...

Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis

... and selective inverse agonist of the 5-HT2A serotonin receptor. Serotonin activation of the 5-HT2A receptor on platelets and vascular smooth muscle is thought ... associated with other anti-platelet agents while preventing the robust activation of platelets needed to cause thrombosis. In a Phase 1a clinical trial, ...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

... pathway to temperature regulation, are mediated selectively by the activation of estrogen receptor beta. MF101 demonstrated this selective regulation." ... and uterine cancers is associated with estrogen receptor alpha (ER-a) activation and that estrogen receptor beta (ER-b) blocks the growth promoting effects ...

Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma

... quarter of calendar 2008." Btk is a critical enzyme involved in B-cell activation and mast cell function, and inhibition of its function may be useful in ... Most lymphomas are caused by uncontrolled growth of B-cells where activation of the B-cell receptor and Btk signaling are thought to play important ...

New AMITIZA 8 mcg Phase III Studies Demonstrated Overall Symptom Improvement in Adult Women with Irritable Bowel Syndrome with Constipation (IBS-C)

... 4:30pm-4:45pm PDT Pre-Clinical Data T1876 Lubiprostone activation of Cl- Poster; Tuesday, Currents Does Not Involve ... siRNA Eliminates Poster; Tuesday, Lubiprostone activation of Cl- May 20, 2008 from Currents in T84 Cells ...

Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting

... refractory prostate cancer (HRPC) demonstrating dose-dependent T-cell activation and clinical activity of ipilimumab, an investigational anti-CTLA-4 ... refractory prostate cancer: dose-dependent induction of CD8+ T cell activation and clinical responses" (Abstract #2539) Preliminary data from an ...

Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach

... via TLR3" Mark E. Kleinman, et. al., and Molecules and Cells(2) "Immune activation by siRNA/Liposome Complexes in Mice is Sequence-Independent: Lack of a ... shown to both avoid immune responses (published data demonstrates lack of activation of interferon-alpha and IL-12) and induce RNAi-mediated gene silencing as ...

Arena Pharmaceuticals Announces Positive Phase 1a Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis and Initiates Phase 1b Clinical Trial

... inverse agonist, or inhibitor, of the 5-HT2A serotonin receptor. Serotonin activation of the 5-HT2A receptor on platelets and vascular smooth muscle is thought ... associated with other anti-platelet agents while preventing the robust activation of platelets needed to cause thrombosis. APD791 demonstrated improved ...

'Brain Signature' for Cigarette Cravings Identified

... cravings in smokers who are deprived of nicotine are linked with increased activation in specific regions of the brain. Using a novel method of measuring brain ... unprovoked cravings to smoke are associated with increased activation in brain regions important in attention, behavioral control, memory, and ...

NicOx Announces TOPIGEN Initiates Phase 2 Proof of Concept Study in COPD for TPI 1020

... effective than budesonide at inhibiting the infiltration and subsequent activation of neutrophils in the lungs. Additional secondary outcome measures will ... effective than budesonide at inhibiting the infiltration and subsequent activation of neutrophils in the lungs. Additional secondary endpoints will follow ...

SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients

... is the most potent activator of platelets. Drugs that block platelet activation by other mechanisms, such as the thromboxane- or ADP-mediated pathways, ... clinical benefit through inhibition of this thrombin-mediated platelet activation without the liability of increased bleeding (when added to standard of ...

EntreMed Shows Increased Survival With MKC-1 in Preclinical Renal Cell Cancer Model

... (Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ) activation of the oncogenic kinase Akt and the mTOR pathway are known to be adverse ... marked sensitivity to MKC-1. MKC-1 inhibited both Akt and mTOR pathway activation in vitro, and was further evaluated in a preclinical model consisting of a ...

VioQuest Pharmaceuticals Completes Enrollment of Phase I Trial of Lenocta(TM)

... of regulating the growth and proliferation of cancer cells involves activation of cellular pathways, especially protein tyrosine kinase pathways and in ... targeted drug candidates in clinical development: VQD-002 which inhibits activation of Akt that is seen at abnormally high levels in breast, ovarian, ...

Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation

... new therapies may be developed to prevent inappropriate platelet activation and reduce the risk of adverse cardiovascular events," Dr Podrez said. ... (easily activated) with abnormal cholesterol levels. Excessive platelet activation can lead to blood clot formation and blockage of vital blood vessels ...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... signals instruct the cancer cell to reproduce and metastasize, leading to cancer progression. Anti-EGFR antibody therapies work by blocking the activation of EGFR, thereby inhibiting downstream events that lead to malignant signaling. However, it is hypothesized that in patients whose tumors harbor a ...

Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930

... 0930, a small molecule activator of AMPK (adenosine monophosphate activated protein kinase) for the treatment of diabetes and metabolic diseases. activation of AMPK has been shown to lower fasting blood glucose levels and improve glucose disposal following a glucose challenge, two key goals in the ...

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

... action. TELINTRA has a novel mechanism of action that inhibits a target enzyme called glutathione S- transferase P1-1 which in turn facilitates the activation of JNK kinase, a key regulator of cellular growth and differentiation of blood. TELINTRA has been shown to stimulate normal multilineage ...

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

... that could put them in the at-risk population. "We've been aware that certain antidepressants, known as CYP2D6 inhibitor drugs, block the activation of tamoxifen chemically, but this evidence shows that these drugs are putting women in New Jersey and across the nation at a much higher risk for ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... of finalizing late-stage protocols for Perifosine in the treatment of Multiple Myeloma and Metastatic Colon Cancer. STUDY RATIONALE: activation of the PI3K/AKT pathway has been associated with poor prognosis, or proliferation, in several pediatric tumors such as neuroblastoma, glioblastoma, ...

New Bisphenol A Study Is of Very Limited Relevance to Human Health

... Health Sciences (NIEHS). The study, "Neonatal bisphenol A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin releasing hormone neurons," was funded by NIEHS and published online June 17 by the journal Biology of Reproduction. The study was ...

New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer

... included Celexa(R) (citalopram), Lexapro(R) (escitalopram) and Luvox(R) (fluvoxamine). "We've known that these CYP2D6 inhibitor drugs block the activation of tamoxifen chemically, but this is the first time there's evidence that these drugs are putting women at a much higher risk for recurrent breast ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... the types of inflammatory reactions observed in trials involving adenoviral vectors, which are known to induce acute inflammation of tissues due to activation of the body's immune system. Patients with heart failure may assess eligibility to participate in the CUPID trial and download a patient ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... trial of FT1050, a small molecule Stem Cell Modulator (SCM) designed to increase hematopoietic stem cell (HSC) number and function through its activation of key pathways that guide cell fate. The study, which is being conducted at the Dana-Farber Cancer Institute in Boston, Massachusetts, will ...

Theranostics Health Announces Involvement with Major Academic Medical Center in Study Funded by Susan G. Komen for the Cure(R)

... for each of her patients afflicted with breast cancer. Theranostics Health will use its pathway mapping platform to measure signaling pathway activation in hundreds of key signaling proteins directly from randomly obtained periareolar breast fine-needle aspiration to assess individual response to ...

Mutant Genes in High-Risk Childhood Leukemias Identified

... M.D., chairman of the COG ALL committee and a co-senior author of the study. "What's more, in test tube studies, we found that drugs blocking the activation of the mutant JAK kinases prevented uncontrolled growth suggesting that drugs that target JAK proteins might be effective in this subtype of ALL." ...

Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial

... heart failure and bone loss. "Our drug development program focuses on a different molecular target," said Colca. "We believe that selective activation of the novel mitochondrial target will produce a significantly improved safety profile for individuals with type 2 diabetes. If the results of this ...
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