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Absorption in Medical Technology

Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Supplementation

... characteristics Eligen(R) B12 absorption time was 30 minutes - Public Conference Call to ... B12 formulation avoids the normal specialized absorption process that limits absorption of Vitamin B12 from current formulations. "By ...

Halozyme Therapeutics Announces Phase I Clinical Trial Results Demonstrating that the Combination of Recombinant Human Hyaluronidase (rHuPH20) With Humulin R(R) and with Humalog(R) Yields Faster, More Physiologic Insulin Kinetics and Better Predictability

... include: -- Significantly faster systemic absorption of each insulin, starting with the first ... use as an adjuvant to increase the dispersion and absorption of other injected drugs. Halozyme plans to ... drug delivery platform designed to increase the absorption and dispersion of biologics. Its key ...

Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated

... Welchol, including reductions in glucose absorption and effects on glucose metabolism via nuclear ... TG levels >300 mg/dL. Welchol may decrease the absorption of fat-soluble vitamins A, D, E, and K. Patients ... Welchol reduces gastrointestinal absorption of some drugs. Drugs with a known interaction ...

Research Team Clones Genes Responsible for Amino Acid Absorption

... ways to block substances that interfere with absorption of nutrients in patients with inflammatory bowel ... And most important, we have shown how the absorption of this important nutrient is affected in IBD." ... ones such as how fat, glucose, salt and glutamine absorption is affected," he said. "The next step would be to ...

Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference

... whether increasing the dispersion and absorption of bisphosphonates in the skin and subcutaneous ... enzyme that increases the dispersion and systemic absorption of locally injected drugs by temporarily ... drug delivery platform designed to increase the absorption and dispersion of biologics. Its key partnerships ...

Emisphere Announces Second Study Demonstrating Dramatic Increases in Absorption of Oral B12 Using eligen(R) Technology at Lower Doses

... its proprietary eligen(R) technology enhances the absorption of oral B12 at considerably lower doses than ... The data showed that the rate of absorption of B12 administered with eligen(R) increased ... alone. Confirming the original study, overall absorption of B12 using eligen(R) technology was 18 times ...

Baxter Presents Latest Clinical Trial Results of GAMMAGARD LIQUID Administered Subcutaneously

... (rHuPH20), which facilitates dispersion and absorption of subcutaneously injected solutions. The ... drugs, Enhanze Technology may facilitate the absorption and dispersion of these drugs by ... drug delivery platform designed to increase the absorption and dispersion of biologics. In addition, the ...

Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex

... use as a spreading agent to increase the absorption and dispersion of other injected drugs and for ... is indicated as an adjuvant to increase the absorption and dispersion of other injected drugs, as an ... Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist ...

Access Pharmaceuticals Demonstrates Ability to Significantly Reduce Glucose Levels in Pre-clinical Testing of Cobalamin(TM) Oral Insulin

... Cobalamin, which is based upon the body's natural absorption of vitamin B12 in the gastrointestinal tract, ... an attached or encapsulated drug. The vitamin B12 absorption mechanism transfers the macrostructure from the gut to blood, facilitating the absorption of drugs that otherwise could not be delivered ...

Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study

... effects and may act by increasing nutrient absorption at low-doses while higher doses of GLP-2 may have ... that lower doses of GLP-2 can enhance nutrient absorption through enhancement of mechanisms promoting ... and significantly increased intestinal absorption and body weight in parenteral-nutrition-dependent ...

Oramed Pharmaceuticals Completes Proof of Concept Study of Insulin Suppository

... formulations. The insulin suppositories showed rapid insulin absorption and reactive glucose lowering effect. The suppositories were well ... control of seizures, or antipyresis. Suppositories also provide rapid absorption and have the advantage of being relatively painless. "This proof of ...

Halozyme Therapeutics Begins Phase 1 Clinical Trial of Bisphosphonate Administered With rHuPH20 Enzyme

... Technology is a novel drug delivery platform designed to increase the absorption and dispersion of biologics. Its key partnerships are with Roche to apply ... fertilization, and HYLENEX, for use as an adjuvant to increase the absorption and dispersion of other injected drugs and fluids. HYLENEX is partnered ...

Halozyme Therapeutics Announces Roche Begins Phase 1 Clinical Trial and Selects Fourth Exclusive Biologic Target

... Technology is a novel drug delivery platform designed to increase the absorption and dispersion of biologics. Its key partnerships are with Roche to apply ... fertilization, and HYLENEX, for use as an adjuvant to increase the absorption and dispersion of other injected drugs and fluids. HYLENEX is partnered ...

Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models

... Technology is a novel drug delivery platform designed to increase the absorption and dispersion of biologics. Its key partnerships are with Roche to apply ... fertilization, and HYLENEX, for use as an adjuvant to increase the absorption and dispersion of other injected drugs and fluids. HYLENEX is partnered ...

Halozyme Therapeutics Announces That Chemophase Meets Primary Endpoint in Phase I/IIa Clinical Trial

... Technology is a novel drug delivery platform designed to increase the absorption and dispersion of biologics. Its key partnerships are with Roche to apply ... fertilization, and HYLENEX, for use as an adjuvant to increase the absorption and dispersion of other injected drugs and fluids. HYLENEX is partnered ...

New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder

... treating patients with TG levels >300 mg/dL. Welchol may decrease the absorption of fat-soluble vitamins A, D, E, and K. Patients on vitamin supplements ... dysphagia and swallowing disorders. Welchol reduces gastrointestinal absorption of some drugs. Drugs with a known interaction with colesevelam ...

Data Presented at the American Academy of Neurology Show XP13512/GSK1838262 Significantly Improved Symptoms of Moderate-to-Severe Primary Restless Legs Syndrome

... in healthy volunteers compared with commercially-available gabapentin. absorption of commercially-available gabapentin is limited to a narrow region in the ... saturation occurs, additional gabapentin can not be absorbed. In addition, absorption rates can vary from patient to patient. In contrast, studies with both the ...

Phosphagenics Initiates U.S. Clinical Trials for Its Topical Retinoic Acid

... of pre-clinical studies that demonstrated both an increase in dermal absorption of retinoic acid when formulated with Phosphagenics' proprietary drug ... million annually. "A new formulation with the ability to deliver greater absorption of retinoic acid, reduce irritation and dryness and limit systemic ...

Photo: Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes

... patients with TG levels >300 mg/dL. Welchol may decrease the absorption of fat-soluble vitamins A, D, E, and K. Patients on vitamin supplements ... dysphagia and swallowing disorders. Welchol reduces gastrointestinal absorption of some drugs. Drugs with a known interaction with colesevelam ...

Promising Cystic Fibrosis Compound on Track for Development

... lung damage. A common condition in CF patients is the excessive absorption of sodium by affected cells, such as those lining the lungs, compounded by ... 680 try to remediate this condition by decreasing the CF cell's excessive absorption of sodium. Gilead's commitment ensures that Parion 680 will be developed ...

R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023

... blood was measured, the level was below the quantification limit as in the case of the single-dose study. As described above, percutaneous absorption of the drug was not high even after continuous application in the morning and at night for 5 days, suggesting hardly any safety problem. ...

Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW

... disease is an immune-mediated digestive disease that is triggered by the consumption of gluten and damages the small intestine, interfering with the absorption of nutrients from food. Gluten is a protein found in grains such as wheat, barley and rye. Symptoms of celiac disease will vary significantly from ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... inhibitor on the amphetamine pharmacokinetics of VYVANSE and ADDERALL XR and further supports that, as a prodrug, VYVANSE does not rely on pH for its absorption or conversion." Heartburn is a common problem affecting millions of Americans. Prilosec OTC and other proton pump inhibitors reduce the ...

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

... warfarin may need to be monitored for increases in INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts, and digoxin). Concomitant use of ...

ViroPharma Submits Comments on Vancocin(R) Draft Bioequivalence Guidance

... When faced with a safety issue identified in Vancocin's labeling and by its own 2008 advisory committee - the potential for systemic absorption of the drug at toxic levels and the need for pharmacokinetic (PK) testing to address that safety issue - OGD again turned away from patients with ....

New, Published GELNIQUE Data Show Efficacy, Convenience and Excellent Tolerability

... that showering one hour or later, or the application of sunscreen 30 minutes before or after GELNIQUE application did not significantly alter the absorption of the drug. For full prescribing information, please visit www.gelnique.com . About Watson Pharmaceuticals, Inc. Watson ...

Oh, My Aching Back: Give Me a Shot of Ozone

... invasive surgical diskectomy puts you on a path where you may be left with too little disk. Taking out a protruding disk may lose the shock absorption that naturally resides between them in the spine," said Murphy, who predicts this procedure will become standard in the United States within the next ...

Studies Show Combination Laser Therapy Effective At Clearing Acne, Reducing Oil Production

... topical methyl-aminolevulinic acid (MAL) with either PDT or red light. Dr. Alexiades-Armenakas noted that MAL may have better specialized absorption into acne cysts than ALA, but - for reasons not entirely known at this point - it has not yet been found to improve oily skin. "Although early ...

Emerging Therapies Could Help Ease The Chronic Symptoms of Atopic Dermatitis For Adults and Children

... and eczema is born with problems with the function of their outer layer of skin, which can cause the skin to be drier and more prone to the absorption of irritants, microbes and allergens that can penetrate the skin and cause adverse reactions. Fortunately, this new understanding is leading to new ...

Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin

... Pregnant women may experience improved comfort with CitraNatal Assure. CitraNatal Assure contains calcium citrate, a source known for proven absorption and no gas production to help ease GI discomfort during pregnancy, a gentle dual-iron formulation of carbonyl iron and ferrous gluconate for gentle ...

RHEI Pharmaceuticals Announces the Initiation of the Final Clinical Study for Approval of Tibozole in China

... therapies. Tibozole, a locally active azole derivative in a patented slow release mucoadhesive system, will be a welcome alternative when systemic absorption could create issues in patients." About Oral Candidiasis Oral candidiasis, which is sometimes called thrush, is a fungal infection of ...

PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)

... of compounds known as organophosphate (OP) agents. OP nerve agents, such as sarin gas, soman, tabun or VX, enter the blood stream via inhalation or absorption through the skin. The nerve agents travel in the circulatory system to the brain and muscles causing the nerves to become over-stimulated which lead ...

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... bowel syndrome with constipation, chronic constipation, and other functional gastrointestinal disorders; and novel, next-generation cholesterol absorption inhibitors for the treatment of hypercholesterolemia. Ironwood also has a growing pipeline of additional drug candidates in earlier stages of ...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

... bowel syndrome with constipation, chronic constipation, and other functional gastrointestinal disorders; and novel, next-generation cholesterol absorption inhibitors for the treatment of hypercholesterolemia. Ironwood also has a growing pipeline of additional drug candidates in earlier stages of ...

Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3

... bowel syndrome with constipation, chronic constipation, and other functional gastrointestinal disorders; and novel, next-generation cholesterol absorption inhibitors for the treatment of hypercholesterolemia. Ironwood also has a growing pipeline of additional drug candidates in earlier stages of ...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

... of compounds known as organophosphate (OP) agents. OP nerve agents, such as sarin gas, soman, tabun or VX, enter the blood stream via inhalation or absorption through the skin. The nerve agents travel in the circulatory system to the brain and muscles causing the nerves to become over-stimulated which leads ...

Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients

... dosing. All doses achieved plasma drug concentrations predicted to display substantial antiviral activity based on preclinical results. Additionally, absorption was enhanced when ANA598 was taken with food, indicating that it should not be necessary to take ANA598 on an empty stomach in order to achieve ...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

... bowel syndrome with constipation, chronic constipation, and other functional gastrointestinal disorders; and novel, next-generation cholesterol absorption inhibitors for the treatment of hypercholesterolemia. Ironwood also has a growing pipeline of additional drug candidates in earlier stages of ...

Alexza's AZ-004 (Staccato(R) Loxapine) Phase 3 Trial Meets Primary Endpoint of Treating Acute Agitation in Schizophrenic Patients

... that the ability to provide loxapine via our Staccato technology, thus combining a drug with a well-established mechanism of action with rapid absorption and patient self-administration, makes AZ-004 a potentially important new drug candidate for treating acute agitation." "The clinical data we have ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... Metabolic Diseases NEW YORK, Aug. 7 /PRNewswire/ -- Historically, bile acids have been recognized primarily as natural detergents that regulate the absorption of dietary lipids and cholesterol homeostasis. However, recent research advances provide evidence that bile acids have broader systemic ...
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