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ANTIGEN in Medical Technology

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

... protein component known as the anthrax Protective antigen (PA) of the lethal and edema toxin complexes ... - a second generation recombinant protective antigen (rPA) anthrax vaccine Valortim(R) - a ... agents RypVax(TM) - a recombinant dual antigen vaccine for plague A third generation rPA ...

PharmAthene Submits SparVax(TM) Regulatory Strategy to FDA

... a next generation recombinant protective antigen anthrax vaccine. The FDA submission is in ... - a second generation recombinant protective antigen (rPA) anthrax vaccine Third generation ... agents RypVax(TM) - a recombinant dual antigen vaccine for plague For more ...

Human Genome Sciences Submits Biologics License Application to FDA for ABthrax(TM)

... infection at the cellular level. After protective antigen and the anthrax toxins are produced by the bacteria, protective antigen binds to the anthrax toxin receptor on cell ... Raxibacumab blocks the binding of protective antigen to cell surfaces and prevents the anthrax toxins ...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... protein component known as the anthrax Protective antigen (PA) of the lethal toxin complex produced by the ... - a second generation recombinant protective antigen (rPA) anthrax vaccine Valortim(R) - a ... agents RypVax(TM) - a recombinant dual antigen vaccine for plague A third generation rPA ...

Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile

... antibody to Bacillus anthracis protective antigen that was discovered and developed by HGS, using ... Technology. Research has shown that protective antigen is the key facilitator in the progression of ... at the cellular level. After protective antigen and the anthrax toxins are produced by the ...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

... to assess anthrax bacteremia and protective antigen in blood. Samples were analyzed for protective ... protein component known as the anthrax protective antigen of the lethal toxin complex produced by the ... is designed to target anthrax protective antigen and protect the cells from damage by the anthrax ...

Inverness Medical Innovations Receives USDA Licensure of the BinaxNOW(R) Avian Influenza Virus Type A Antigen Test Kit

... the BinaxNOW(R) Avian Influenza Virus Type A antigen Test Kit. Test results are available in 15 ... manufacturer to have two versions of their rapid antigen test kit for influenza: one USDA licensed for ... FDA cleared for human use. The BinaxNOW AI antigen Test is an easy-to-use, ...

Interim Phase 1/2 Data of Ipilimumab in Prostate Cancer Presented at American Society of Clinical Oncology Annual Meeting

... of 33) experienced decreases in prostate-specific antigen (PSA) serum levels of over 50 percent, ... further exploration of the ability of tumor antigen release by radiotherapy to serve as an ... to CTLA-4 (cytotoxic T lymphocyte-associated antigen 4), a molecule on T-cells that plays a critical ...

Quantum Immunologics, Inc. and the South Alabama Medical Science Foundation Announce an Early Clinical Evaluation of a Novel Immuno-therapeutic Vaccine for Treating Advanced Human Breast Carcinomas

... This immunizing protein, called the Oncofetal antigen (OFA) or immature Laminin Receptor Protein (iLRP), is a universal cancer antigen or protein expressed in all human cancer types ... will then recognize iLRP as a foreign protein or antigen on cancer cells and, when reintroduced into the ...

Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival

... as the increase of CD54 molecules expressed on antigen Presenting Cells [APC] after incubation with the PROVENGE antigen Delivery Cassette(TM)) and the number of ... cancer. The Company applies its expertise in antigen identification, engineering and cell processing ...

New Patent Awarded for Antigen-Sparing Vaccines that Elicit Robust Immunity

... they will be able to reduce vaccine antigen quantities to a fraction of what current vaccines ... with whole virus or a recombinant protein antigen and apply it to the naso-pharynx, the ... where dendritic cells rapidly engulf the antigen and present it to the immune system. This rapid ...

New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies

... infection at the cellular level. After protective antigen and the anthrax toxins are produced by the bacteria, protective antigen binds to the anthrax toxin receptor on ... cells. ABthrax blocks the binding of protective antigen to cell surfaces and prevents the anthrax toxins ...

GeoVax Labs, Inc. Comments on Discontinuance of Merck's HIV Vaccine Trial

... protective anti-AIDS vaccine responses. Pulses of antigen from the GeoVax vaccines elicit T cell responses ... provide more prolonged AIDS virus antigen exposure than the GeoVax poxvirus vectors. Prolonged antigen exposure affects the state of elicited T cells ...

GlaxoSmithKline Receives New HHS Order for H5N1 Bulk Antigen. First North American Clinical Trials with GSK's Candidate Pre-pandemic Flu Vaccine to Start.

... has placed another order to purchase bulk H5N1 antigen for the US national stockpile of pre-pandemic ... 22.5 million doses of 15 mcg H5N1 bulk vaccine antigen from the U.S. Department of Health and Human ... to the 5 million doses of H5N1 clade 2 bulk antigen at 15 mcg HA/dose ordered in November 2006. The ...

Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis

... of repeat biopsies more accurately than traditional prostate-specific antigen (PSA) testing.(5) Gen-Probe's PROGENSA(R) PCA3 assay, which has been ... Alexandre de la Taille, et al. (2) AUA poster #2127, "Prostate cancer antigen 3 (PCA3) shows significant association to prostate cancer volume but ...

PharmAthene to Host a Conference Call and Webcast on Wednesday, April 29th at 4:30 PM to Provide an Update on the SparVax(TM) rPA Anthrax Vaccine Program

... SparVax(TM) - a second generation recombinant protective antigen (rPA) anthrax vaccine Third generation rPA anthrax vaccine ... exposure to chemical nerve agents RypVax(TM) - a recombinant dual antigen vaccine for plague For more information about ...

New Body of Research Suggests Statin Use Benefits Multiple Areas of Urologic Health

... Abstract 574: Associations between statin use and prostate-specific antigen levels and prostate cancer diagnosis Statin use may be associated with ... biopsy, prostate cancer and exceeding age-specific prostate-specific antigen thresholds. Statin use may also prevent the development of prostate ....

Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy

... with 96.4 percent for leuprolide. In addition, prostate-specific antigen (PSA) levels were lowered by 64 percent two weeks after administration of ... levels.(3) Degarelix also reduces levels of prostate-specific antigen (PSA). Unlike luteinizing hormone-releasing hormone (LHRH) agonists, such ...

Leader in Prostate Health Urges Prostate Cancer Screening in Face of Contradicting Data

... the founder and chairman of the PCEC. "Since the Prostate-Specific antigen test was made available, we have seen a decrease in deaths attributed to ... there is already a wealth of research that shows the Prostate-Specific antigen (PSA) test as a valuable tool to assist in the diagnosis of prostate ...

Freezing Prostate Cancer Does a Man's Body Good

... over the past 12 years, including testing the levels of prostate-specific antigen (PSA) in the blood. Of those patients, 112 (93 percent) had no evidence of ... used to categorize the risk include the results of the prostate-specific antigen (PSA) blood test (which looks for a protein produced by the prostate gland ...

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

... pandemic influenza DNA vaccine induced T-cell responses against the H5 antigen in 75% to 100% of evaluable subjects in the various cohorts. T-cell ... Antibody and/or T-cell responses against the matching H5 antigen and the conserved NP and M2 antigens were detected in a majority of ...

Dendreon Presents Integrated Analysis of Clinical Data from NEUVENGE Trials at Chemotherapy Foundation Symposium

... T cell proliferative stimulation index in response to the immunizing antigen increased from 1.3 at baseline to 19.7 at Week 4 (p = 0.0002), 19.4 at ... of novel therapeutics. The Company applies its expertise in antigen identification, engineering and cell processing to produce active cellular ...

PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)

... include: -- SparVax(TM) - a second generation recombinant protective antigen (rPA) anthrax vaccine -- Third generation rPA anthrax vaccine -- ... exposure to chemical nerve agents -- RypVax(TM) - a recombinant dual antigen vaccine for plague For more information about PharmAthene, please visit ...

Intercell Announces Initiation of Further Phase II Clinical Trial of V710 an Investigational Vaccine to Prevent S. aureus Infection

... Intercell has embarked on a large scale, comprehensive and multi-target antigen identification program to contribute to vaccine efforts in this field. Besides Merck's S. aureus vaccine, based on an antigen identified by Intercell, Intercell is developing a vaccine against ...

Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer

... has discovered that the biomarker called prostate specific membrane antigen (PSMA), abundantly present in cancer cells of patients with advanced ... response to therapy. The discovery, titled "Prostate specific membrane antigen associates with anaphase promoting complex and induces chromosomal ...

The New England Journal of Medicine Publishes Study Investigating the Safety and Efficacy of Baxter's Cell-Based Pandemic, Avian Flu Vaccine

... avian flu vaccine is derived from the H5N1 strain A/Vietnam/1203/2004. Its antigen composition and structure are identical to the actual virus circulating in ... against divergent H5N1 strains. The trial tested four different antigen concentrations ranging from 3.75 micrograms to 30 micrograms; 7.5 ...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

... on the expression of the tumor antigens. MAGE-A3 is a tumor-specific antigen that is expressed in a large variety of cancers, including Melanoma, ... of the MAGE-A3 gene has been observed in testicular cells but without antigen presentation capabilities. MAGE-A3 protein has been in-licensed by GSK ...

Trubion Announces Initiation of Phase I/II Clinical Trial of TRU-015 for the Treatment of B-Cell Non-Hodgkin's Lymphoma

... Pharmaceuticals are developing SMIP therapeutics directed to CD20, an antigen present on B cells. Trubion's SMIP drug candidates represent a novel class ... assembly technology. Trubion's current product candidates bind to specific antigen targets on a cell's surface that have been clinically validated as ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand Epitope antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses that ...

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... in both chemotherapy-naive and post-chemotherapy CRPC patients across dose levels and endpoints, as evaluated by reductions in prostate specific antigen (PSA) levels, radiographic findings and circulating tumor cell (CTC) counts. New findings include the median time to PSA progression, which was ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... data on our expanding clinical experience with TRU-016 as it is accrued." TRU-016 is a humanized, SMIP protein therapeutic that targets the CD37 antigen and has shown potent anti-tumor activity in pre-clinical studies. Trubion initiated a Phase 1 / 2 clinical trial of TRU-016 in March 2008. The ...

Intercell AG Announces First Subject Enrolled in a Phase II Trial for the Further Development of Its Investigational Vaccine Enhancement Patch to Improve Pandemic Influenza Prevention in Collaboration With U.S. Department of Health and Human Services (HHS

... that this strategy may be used for other injectable vaccines which are already approved or in development where improved immunogenicity, decreased antigen doses, or fewer immunization visits are desired. About Intercell AG Intercell AG is an innovative biotechnology company that develops novel ...

Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis

... new possibilities for more effective treatments of these patients, says Dr. Lazaridis. Researchers also confirmed that the human leukocyte antigen (HLA) region of the genome is linked to primary biliary cirrhosis, an association which had been identified in previous research. "Although both the ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... procedure is often referred to as hematopoietic stem cell support. About Cord Blood Use in Hematopoietic Stem Cell Support Human leukocyte antigen (HLA) typing is used to match patients and donors. To assure the highest rate of success, patients receiving a bone marrow or peripheral blood ...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

... and pneumocystosis. Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized disease. antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. Empiric anti-fungal therapy should be considered in ...

BioCryst Provides Peramivir Update and Reports First Quarter 2009 Financial Results

... (United States) in 2008 - 2009. It enrolled 405 subjects 18 years of age or older with acute uncomplicated influenza confirmed by positive rapid antigen test, whose symptom duration was 36 hours or less. The primary analysis population consisted of patients with confirmed influenza A. Approximately ...

Study Results Present Paradigm Shift; REDUCE Trial Shows New Hope for the Risk Reduction of Prostate Cancer

... Scott Williams, Vice President, Men's Health Network commented, "We continually stress the importance for men to receive a baseline Prostate Specific antigen or PSA and physical exam of the prostate at age 40 and to engage in a continual dialogue with their physician about their individual risk and need ...

Data Presented at AUA Demonstrate PROVENGE Significantly Prolongs Survival for Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study

... cancer and transform lives through the discovery, development and commercialization of novel therapeutics. The Company applies its expertise in antigen identification, engineering and cell processing to produce active cellular immunotherapy product candidates designed to stimulate an immune response. ...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

... cancer and transform lives through the discovery, development and commercialization of novel therapeutics. The Company applies its expertise in antigen identification, engineering and cell processing to produce active cellular immunotherapy product candidates designed to stimulate an immune response. ...

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

... PGN632 also induced an increase in the expression of cell-surface molecules that are indicative of mature dendritic cells and that assist in antigen presentation functions, as well as in stimulating T-cell proliferation. "These results demonstrate the efficiency and robustness of ...
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(Date:4/17/2014)... a novel method to help kidney stone sufferers ... treatment possible., Kidney stones represent a major medical ... left untreated, apart from being particularly painful, they ... In many patients treated successfully, stone recurrence is ... approach to diagnosis and treatment needs to be ...
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(Date:4/17/2014)... Branch at Galveston are the first to recommend ... cancer should begin colorectal cancer screening earlier than ... a high incidence of secondary colorectal cancers among ... recommendations that the younger women in this group ... their initial cervical cancer diagnosis instead of waiting ...
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(Date:4/17/2014)... of Experimental Biology and Medicine a ... and Paul Kenis in the Institute of Genomic ... of Illinois Urbana-Champaign describe their recent work on ... variety of cell functions including energy metabolism, signaling, ... in regulating normal cellular behavior, redox status has ...
(Date:4/17/2014)... (April 17, 2014) Two recent papers by ... and colleagues may help scientists develop treatments or ... fever, Japanese encephalitis and other disease-causing flaviviruses. , ... and molecular genetics at the School of Medicine ... Hughes Medical Institute, and colleagues recently published articles ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... personnel who served in Iraq and Afghanistan and ... (TBI) were compared to military personnel without TBI ... in measures of overall disability, cognitive function, post-traumatic ... reported in an article in Journal of ... Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... many as 10 million older Americans suffer from depression, ... , However, new research a project that followed ... six years found that Internet use among the ... than 30 percent. , "That,s a very strong effect," ... telecommunication, information studies and media who led the project. ...
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