Vectors in Medical News

JCI table of contents: March 23, 2009

... cause of leukemia is thought to be that the viral vectors used to carry the therapeutic gene into cells ... The authors therefore conclude that SIN viral vectors should be the preferred choice in future gene ... TITLE: The genotoxic potential of retroviral vectors is strongly modulated by vector design and ...

ALS TDI and Asklepios to Develop New Therapeutic Delivery Options for Treating Lou Gehrig's Disease

... Collaboration to evaluate gene delivery vectors for ALS CAMBRIDGE, Mass. and CHAPEL HILL, ... aimed at developing a panel of viral vectors that could be used to deliver therapeutics based ... custom constructed Biological Nano Particle (BNP) vectors are designed using proprietary technology ...

In blood vessel stents, innovative materials allow better control, delivery of gene therapy

... that can bind to a variety of gene therapy vectors and can be custom-designed for controlled local ... allows us to increase the dosage of gene therapy vectors delivered, and we can tune the materials for ... one molecule thick, containing adenovirus vectors that delivered genes that successfully inhibited ...

Freeze-dried tendon implants prove effective in early studies

... drugs, growth factors or gene therapy vectors to drive healing and reduce swelling. ... into the graft site, a solution of gene therapy vectors that directed the recipients cells to accept the ... human cells and insert their own DNA. Viral vectors retain this ability, but have been harnessed to ...

Converting adult somatic cells to pluripotent stem cells using a single virus

... Stem Cells . Prior research studies have required multiple retroviral vectors for reprogramming -- steps that depended on four different viruses to ... Medicine in the Gastroenterology Section, achieved was combining the four vectors into a single "stem cell cassette" containing all four genes. The ...

Vaccine and drug research aimed at ticks and mosquitoes to prevent disease transmission

... only be able to stop disease transmission, but also prematurely kill the vectors carrying these diseases; such vectors include ticks, sand flies and mosquitoes the insects responsible for most ...

Indiana University to host national biorepository for gene therapy

... Center at the IU School of Medicine, which provided gene therapy vectors for use in clinical trials. Indiana University continues to provide gene therapy vectors under contracts with the National Cancer Institute and the National Heart ...

Summit VetPharm Announces Grand Prize and March Winner in its 'Great Vectra 3D(TM)' $125,000 Giveaway

... a new broad-spectrum topical that effectively protects dogs against three vectors -- fleas, ticks, and mosquitoes. Dr. Leonard graduated from VA-MD ... topical with dinotefuran, effectively protects dogs against three vectors -- fleas, ticks, and mosquitoes. Vectra(TM) for Cats & Kittens and ...

Amsterdam Molecular Therapeutics Initiates Program for Late Stage Liver Cirrhosis and Reports Strong Progress in AMT-011 With Trial Fully Recruited and European and US Submission On Track for First Half of 2008

... with, or even reverse fibrosis and achieve a long term effect. AAV vectors constitute the gene therapy platform of choice of Amsterdam Molecular ... a mainstay of clinical medicine. Using adeno-associated viral (AAV) vectors as the delivery vehicle of choice for therapeutic genes, the company has ...

Repellents between dusk and bedtime make insecticide-treated bednets more effective

... of reducing morbidity and mortality from malaria in Africa, where local vectors bite indoors, late at night. Insect repellents were also known to reduce ... should not be used as the only means of treating malaria in areas where vectors feed mainly in the evening. Use of an insect repellent can significantly ...

Penn Veterinary Medicine report new strategy to create genetically modified animals

... induced cryptorchid donor testes that were then exposed in vitro to AAV vectors carrying a green fluorescent protein transgene and transplanted to germ ... with developmental abnormalities. The use of retroviral or lentiviral vectors has been reported in rodents, but it requires that animals be handled and ...

100+ Nurses to Rally in SF Wed. to Demand Stronger Swine Flu Safety Protections: California Hospitals Remain Unprepared Despite First Nurse Death

... Burger, RN. "If hospitals do not take urgent precautions to reverse this lack of preparation, we may see our health care facilities become vectors for infections. That is especially worrisome for hospital patients who already have compromised immune systems, and our nurses who may be unable to ...

Researchers develop the first climate-based model to predict Dengue fever outbreaks

... and infectious disease, which addresses increasing concerns that global warming, will exacerbate certain diseases like Dengue Fever and allow the vectors to spread to more temperate areas. The findings of this study were published earlier this year in the Institute of Physics journal Environmental ...

Discovery in amber reveals ancient biology of termites

... George Poinar, an Oregon State University researcher and international expert on life forms found in amber. It was just published in Parasites and vectors , a professional journal. This particular termite was probably flying around while mating in a wet, humid tropical forest in what is now Myanmar ...

American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research

... Cells Prevent the Development of Regulatory T Cells Novel Insights into the Pathogenesis Chronic Allograft Vasculopathy Novel Viral vectors as a Tool to Study Liver Physiology and Pathophysiology The American Transplant Congress 2009 (ATC), sponsored by the ASTS and the ...

SecureWorks, Inc. Launches Managed Web Application Firewall Service

... that organizations may have. Imperva is a market leading Web application firewall provider. "Web applications are one of the fastest growing vectors of Internet attacks," said Corey Merchant, vice president of product management at SecureWorks. "Analyzing the attack data from over 2,000 clients, ...

iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

... Dr. Yamanaka's group reported for the first time a virus-free method for inducing pluripotency in differentiated cells by using a pair of plasmid vectors to introduce the four iPS genes into embryonic mouse fibroblasts as part of CiRA's efforts to establish safe and efficient methods to generate iPS ...

New Protocols Demonstrate Dramatic Improvement in Thermage Efficacy and Safety

... size of the treatment tips and adding charges to the tips, thus allowing additional passes and decreasing treatment times. Additionally, treatment vectors were added to the protocol to produce tension lines for added soft tissue lift. In 2007, a paper was published in the peer reviewed journal, ...

Medical imaging developers can speed time to market, improve performance, and lower development costs with TI's new embedded processor software toolkit

... to other architectures. Full test benches provide assurance of module functionality while aiding in evaluation and development. Custom test vectors can easily be added to check functional and cycle performance for any input. Full documentation of each optimized module provides coding ...

TB vaccine developed at McMaster University in Canada

... E. Fitzhenry Vector Laboratory of the Institute of Molecular Medicine and Health on campus, Canada's first university laboratory certified to provide vectors (delivery agents) for use in clinical trials in humans. Most of the pre-clinical testing of the vaccine was undertaken at McMaster. The phase 1 ...

Decoding short-term memory with fMRI

... these activation patterns." Increases in blood flow, as seen with fMRI, are measured in voxels -- small units displayed in a 3-D grid. Different vectors of the grid, corresponding to neurons, respond as subjects view and store their chosen memories. Based on patterns of activity in an individual's ...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

... Pikaard and his colleagues' work may have implications for applied medical research. For instance, gene therapy procedures sometimes use retroviral vectors as a way of introducing a foreign gene to replace a function impaired by disease. Often this foreign gene, called a transgene, restores the missing ...

CRSTI and Medical City Hospital Dallas Currently Recruiting For a Phase 2 Clinical Trial of MYDICAR(R) for Advanced Heart Failure

... The data are consistent with safety established for other AAV vectors, which has been demonstrated in clinical studies of more than 500 patients. AAV vectors are the product of decades of research focused on the safety of gene transfer agents, and are derived from components of a non-replicating, ...

AVMA: Veterinarians Need to Be Included in Proposition 2 Implementation

... engage in more species-typical behaviors, but it also increases the hens' risks of illness and injury because it increases their exposure to disease vectors and predators," explains Dr. Gail Golab, head of the AVMA's Animal Welfare Division. Dr. Golab says the AVMA can help California producers protect ...

ALS Therapy Development Institute Awarded $1M Grant

... said Dr. Steve Perrin, Chief Scientific Officer at ALS TDI. The grant will support research designed to identify and develop gene specific viral vectors at ALS TDI, including in vitro validation and the development of sufficient vector stocks to conduct full in vivo validation projects. Support from ...

Safety study indicates gene therapy for blindness improves vision

... Byrne, M.D., Ph.D., a professor of molecular genetics and microbiology and director of UF's Powell Gene Therapy Center, which manufactured the viral vectors used in the study. "Improvements in someone's medical condition are ultimately what we are after." LCA2 affects about 2,000 people in the United ...

Lumension Security Launches Interactive Office Game To Educate IT Professionals On 10 Most Common Security Risks Within The Workplace

... Brice stated: "Today's technology and business environment is highly dynamic. With the evolution of new, sophisticated attacks that use multiple vectors to penetrate the security infrastructure combined with increasing insider risks, enterprises are challenged with constantly evolving their security ...

Leading Vaccine Expert Joins IAVI

... to accelerate the development of an effective AIDS vaccine. IAVI created its AIDS Vaccine Development Laboratory to systematically test novel vaccine vectors and promising antigens that will ultimately form the foundation of the next generation of AIDS vaccine candidates. Dr. Hassell will work to ensure ...

World AIDS Vaccine Day 2008

... T-cell immunity to mop up any rogue cells that do become infected. AIDS vaccine researchers are focused on both of these approaches, designing new vectors to carry the vaccine inserts, including some that replicate in the mucosal surfaces where HIV often enters the body. Experts are also collaborating ...

Geneticists at the American Museum of Natural History trace the evolution of St. Louis encephalitis

... strains happened about 116 years ago. St. Louis encephalitis is a perfect storm between infected bird hosts coming into a new area and the mosquito vectors transferring the virus to humans, says Perkins. It is the North American version of West Nile. St. Louis encephalitis is currently found ...

Summit VetPharm Announces New Distributor Partnership with Webster Veterinary

... animals. Vectra 3D(TM), a broad-spectrum topical with dinotefuran, a third-generation neonicotinoid, effectively protects dogs against three vectors -- fleas, ticks, and mosquitoes, even in regions experiencing resistance issues. Vectra(TM) for Cats & Kittens and Vectra(TM) for Cats feature a ...

Cancer researchers receive NIH grant to advance brain tumor therapies from lab to clinical trials

... MD, PhD, associate professor in the departments of Neurological Surgery and Surgery at the University of Pittsburgh School of Medicine Viral vectors (a modified herpes virus) to kill tumor cells while leaving other cells intact Joseph C. Glorioso III, PhD, chair of the Department of Microbiology ...

Boston Trial to Test New HIV/AIDS Vaccine

... FRIDAY, April 11 (HealthDay News) -- A new HIV/AIDS vaccine designed to overcome the problem of preexisting immunity to common vaccine vectors is being tested in an early clinical trial at Brigham and Women's Hospital in Boston. Preexisting immunity is believed to be a major problem in ...

Summit VetPharm Announces Second Winner in Its 'Great Vectra 3D(TM)' $125,000 Giveaway

... of Summit VetPharm's introductory sales incentive program for Vectra 3D, a new broad-spectrum topical that effectively protects dogs against three vectors -- fleas, ticks, and mosquitoes. All four winners of the contest will be flown to New York City in May 2008 for an all-expense- paid awards ceremony ...

Scientists shine new light on inflammatory diseases

... involved in a University of Pennsylvania gene therapy experiment that used an adenovirus to deliver the gene died. Host response to adenoviral vectors is dependant on both IRF1 and TNF. What we have described is that TNF has both pathogenic affectsit helps to sustain some of these inflammatory ...

Summit VetPharm Announces First Winner in its 'Great Vectra 3D(TM)' $125,000 Giveaway

... of Summit VetPharm's introductory sales incentive program for Vectra 3D, a new broad-spectrum topical that effectively protects dogs against three vectors -- fleas, ticks, and mosquitoes. All four winners of the contest will be flown to New York City in May 2008 for an all-expense- paid awards ceremony ...

U.S. Food Safety: Home-Grown Problems Abound

... represents victims of food poisoning. "As soon as you have manure on the ground, and you have birds and wild animals and water, you have all these vectors for transferring bacteria to fresh fruits and vegetables." And, most of the time, Clark added, produce is not subjected to the "kill step" ...

Protein power: Researchers trigger insulin production in diabetic mice

... research team was one of three groups that discovered Pdx1 and identified it as an important regulator of pancreas development, said using viruses as vectors for gene therapy in humans can pose problems because of the bodys immune reaction to them. He heralded the UF findings and said the idea of using a ...

Lymphatic vessel and lymph node function are restored with growth factor treatment

... nodes in patients in response to metastatic breast cancer. They found that treatment of lymph node-excised mice with adenoviral VEGF-C gene transfer vectors induced robust growth of the lymphatic capillaries, which gradually underwent an intrinsic remodeling, differentiation and maturation program into ...

Sumitomo Corporation Appoints New Chairman to U.S. Animal Healthcare Company Summit VetPharm, LLC

... topical combining Dinotefuran with a pyrethroid and an insect growth regulator (IGR) in a formula that effectively protects dogs against three vectors - fleas, ticks, and mosquitoes. The company's studies show that Vectra 3D delivers efficacy of at least 30 days. Vectra 3D's new insecticide is ...