Transporter in Medical News

Raptor Pharmaceuticals to Collaborate with Roche on Therapeutic Delivery Across Blood-Brain Barrier

... with Raptor's proprietary NeuroTrans(TM) BBB transporter platform. Under terms of the agreement, Roche ... has resulted in an intensive search for "BBB transporter molecules" that could be attached to these ... the development of Raptor's NeuroTrans(TM) BBB transporter molecules, in conjunction with Roche's ...

Transporter could help breast cancer cells commit suicide

... cancer. Tumor cells are smart; they silence the transporter to avoid death. No transporter means no pyruvate is getting into the cells." ... will try to force cancer cells to express the transporter and open the door for pyruvate. ...

2 Genes Implicated in Autism

... susceptibility genes -- PTEN and the serotonin transporter gene -- had more severe symptoms than mice with ... with a mutation in PTEN alone or in the serotonin transporter gene alone had brains that were larger than ... with mutations in both PTEN and the serotonin transporter gene had more severe symptoms. "We found that ...

New Approach Keeps Tumor Cells From Refueling

... which lactic acid enters oxygenated cells -- a transporter protein called MCT1 (monocarboxylate transporter 1). "The same transporter is present in the muscle where it helps to clear ...

PET scans help identify mechanism underlying seasonal mood changes

... tomography (PET) scan to assess serotonin transporter binding potential value, an index of serotonin transporter density. The higher the binding potential value, ... and winter or spring and summer. "Serotonin transporter binding potential values were significantly ...

New method to overcome multiple drug resistant diseases developed by Stanford researchers

... as other mammalian bodies. Using such a common transporter to ferry a potent medication inside a resistant ... of bonding a medication to an arginine-rich transporter to slip it past the cellular sentries could, in ... as well as other types of cancer. The arginine transporter manages to avoid ejection by slipping through the ...

DIA And FDA To Host Two Important Critical Path Workshops

... 15 -16; Bethesda, MD) and the Critical Path transporter Workshop (October 2-3; North Bethesda, MD). ... [Critical Path transporter Workshop] (October 2-3; North Bethesda, MD). ... [Critical Path transporter Workshop] will be held in collaboration with ...

Research shines spotlight on a key player in the dance of chromosomes

... The question is whether CENP-E acts like a transporter or like an anchor, Selvin said. A transporter moves things around the cell, whereas an anchor ... Selvin said. That is, we showed that it is a transporter in vitro, hauling around a little bead. Now we ...

Sticky blood protein yields clues to autism

... associates with and regulates the serotonin transporter (SERT), a protein that controls serotonin ... found that integrin beta3 can put the serotonin transporter into high gear, said Blakely. Notably, Edwin ... but rather we believe that the brains serotonin transporter may be controlled by integrin proteins in a very ...

New cataract gene discovered

... for the molecule that is carried by this new transporter across the membrane has now begun. The ... assume that defects in this newly discovered transporter may also be a cause of age-related cataract. ... gene. Understanding the exact function of this transporter may open new venues for non-surgical treatment of ...

Genetic difference predicts antidepressant response

... certain variants in the gene for a protective transporter protein that pumps drugs and other substances out ... rates, said the researchers, is that protective transporter proteins pump such substances as drugs and some ... the researchers explored the function of one such transporter protein, called P-gp, in preventing the entry of ...

Developing a modular, nanoparticle drug delivery system

... molecules. She has also discovered a molecular transporter that, when attached to the nanosponge, carries it ... cell nucleus. They figured out how to attach this transporter to her nanoparticle and showed that the transporter can pull the nanoparticle after it into cellular ...

UVA researchers uncover gene's role in severity of drinking

... than others. A UVA team has found strong evidence that the serotonin transporter gene, SLC6A4, plays a significant role in influencing drinking intensity ... sequence variations, or single nucleotide polymorphisms, of the serotonin transporter gene with the levels of drinking intensity among 275 alcohol-dependent ...

Lactic acid found to fuel tumors

... machinery could be used by tumor cells. "We discovered that a transporter protein of muscle origin, MCT1, was also present in respiring tumor ... it does not need to enter into cells at all it merely needs to block the transporter molecule that moves the lactose, which is outside of the cells. "This ...

JCI online early table of contents: Nov. 6, 2008

... copies of the gene SLC36A2, which is normally responsible for making a transporter protein that helps kidney cells reabsorp protein building blocks. ... as functional as the normal protein. In these people, mutations in other transporter proteins were detected, leading the authors to conclude that mutations in ...

Gene Variations May Predict Antidepressant Response

... researchers at the Mayo Clinic have found that variations in the serotonin transporter gene could help select which patients should try this drug, one of the ... (GENE) Unit. Mrazek and his colleagues looked at the serotonin transporter gene, SLC6A4, in about 2,000 individuals. White patients who had two ...

JCI online early table of contents: March 3, 2008

... HEMATOLOGY: Role for the serotonin transporter in platelet aggregation New data, generated by Randy Blakely and ... TITLE: Interactions between integrin alpha-IIb/beta-3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans ...

Deafness and seizures result when mysterious protein deleted in mice

... to lack the transporter. The effect was dramatic. Mice lacking the transporter are completely deaf from birth, says the senior author of the study, ... auditory input, or signal, into glutamate release, express VGLUT3, and the transporter contributes to the release of glutamate onto the first neuron in the ...

Genetics May Determine Antidepressants' Effectiveness

... Psychiatry in Munich found that 11 variants in the gene for a protective transporter protein called P-gp, which removes drugs and other substances from the ... by P-gp, indicating that the antidepressants were "substrates" of the transporter protein. Next, the team analyzed 443 people on antidepressants for ...

Isis Adds New Drug to Its Development Pipeline: ISIS 388626 Targeting SGLT2 for the Treatment of Type 2 Diabetes

... it has added a new diabetes drug targeting the sodium dependent glucose transporter type 2 (SGLT2) to its development pipeline. ISIS 388626, a generation ... program." ABOUT SGLT2 AND ISIS 388626 The sodium dependent glucose transporter type 2 (SGLT2) is substantially responsible for glucose re-absorption in ...

Inflammation may trigger Alzheimer's disease, Saint Louis University findings suggest

... The blood-brain barrier is a system of cells that regulates the exchange of substances between the brain and the blood. The blood-brain barrier transporter known as LRP is the pump that removes amyloid beta protein from the brain and into the bloodstream. "LRP malfunctions like a stop light stuck on ...

Hormones May Affect Neurological Disease Risk

... researchers at the University of Texas Medical Branch. They found that a number of estrogens acting through their receptors affect the dopamine transporter (DAT). Dopamine is a neurotransmitter in the brain that plays an important role in normal functioning of the central nervous system. "The ...

Breakthrough in combating the side effects of quinine

... revealed that strains of yeast unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external sources, and thus die if tryptophan ...

Animal model for schizophrenia identifies a novel approach for treating cognitive impairments

... line of research are just beginning to be tested in patients. For example, several pharmaceutical companies are studying drugs that block the glycine transporter (GlyT1) and thereby raise synaptic glycine levels. A new study in Biological Psychiatry , published by Elsevier, by Dr. Kenji Hashimoto and ...

Capsules encapsulated

... requires transport systems that can encapsulate medications and other substances and release them in a controlled fashion at the right moment. The transporter must be able to interact with the surroundings in order to receive the signal to unload its cargo. A team led by Frank Caruso at the University of ...

Protein Might Mute Effects of Methamphetamine

... cells tied to Parkinson's disease might also help fight drug addiction, according to a newly published study. The protein -- organic cation transporter 3, or oct3 -- normally guides molecules in and out of cells, but it seems to lead the toxic brain chemical MPP+ straight to brain cells, where it ...

Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder

... laboratory at the University of Toronto and Hospital for Sick Kids. The studies found significant associations between glutamate receptor and transporter genes and abnormal brain volumes in brain regions implicated in OCD such as the thalamus ('grand central station' in the brain), caudate nucleus ...

JCI online early table of contents: April 6, 2009

... mice, they showed that HIF-2-alpha (but not HIF-1-alpha) helped maintain iron levels in the intestine by regulating expression of the primary iron transporter gene. Furthermore, mice lacking HIF-2-alpha displayed low levels of iron in the blood and liver. The authors therefore conclude that strategies ...

Institute for Neurodegenerative Disorders Deploys OpenClinica EDC solution for Large Parkinson's Study

... (PARS). PARS is a clinical study to develop a pre-motor Parkinson disease (PD) cohort using a combination of olfactory testing and dopamine transporter imaging to detect those at risk for PD. This ambitious project will recruit up to 15,000 study subjects from throughout the US who will participate ...

'Fasting Signal' Offers Clues to Insulin Resistance in the Obese

... in fat cells in obese mice encourages insulin resistance by lowering the production of a hormone called adiponectin and the insulin-sensitive glucose transporter 4 (GLUT4). Obese mice genetically altered to lack CREB in fat cells became more sensitive to insulin and were also protected from the development ...

Gene Variant Tied to Severity of Drinking

... heavily dependent on alcohol than are others. University of Virginia Health System researchers linked the DNA sequencing of the SLC6A4 serotonin transporter gene to how many drinks a day people receiving help for alcohol dependency used to have. Serotonin, a brain chemical, previously had been found to ...

DRE Veterinary Unveils Line of Surgical and Exam Tables

... and can purchase DRE VSE 2250 Series tables with an optional waste push-thru flap in the cabinet door. The DRE VSE 2300 battery-pack multipurpose transporter provides extra versatility and is great for emergency surgery, treatment and preparatory procedures. It lifts up to 450 pounds, is constructed of ...

Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes

... Stephan Herzig, head of the Research Group "Molecular Metabolic Control" at the German Cancer Research Center, and his team have now shown that lipid transporter LSR (lipolysis-stimulated lipoprotein receptor) appears to be responsible for this. LSR, a molecule found in the bowel and primarily in the liver, is ...

GEN Reports on Strategies to Overcome Blood-Brain Barrier

... small molecule drugs across the BBB involves targeting endogenous nutrient transporters. These transporters are members of the solute carrier (SLC) transporter superfamily. Transport of small molecules across the BBB by these membrane proteins is known as carrier-mediated transport (CMT). In order to ...

Neurocrine Biosciences Reports Fourth Quarter and Year-End 2008 Results

... results of these studies should allow urocortin 2 to be infused for periods up to two weeks in duration in humans. Vesicular Monoamine transporter 2 Inhibitor (VMAT2 ) VMAT2 is a protein concentrated in the human brain that is essential for the transmission of nerve impulses between ...

Penn study finds link between Parkinson's disease genes and manganese poisoning

... the team set out to find the function of YPK9. Study co-first author, postdoctoral fellow Alessandra Chesi, PhD, discovered that YPK9 encodes a metal transporter protein. "Its sequence looks like other proteins that we know transport metals," says Chesi. She deleted the YPK9 gene from yeast and the cells ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, and organic cationic transporter (OCT). Digoxin: Sitagliptin had a minimal effect on the pharmacokinetics of digoxin. Following administration of 0.25mg digoxin concomitantly ...

Completely novel action of insulin unveiled

... known as Myo1c, which in turn performs a critical role in glucose uptake." Insulin controls glucose uptake into our fat cells by moving glucose transporter proteins from inside the cell to the surface membrane so that they can pump glucose into the cell. Myo1c aids in this process by helping the ...

Glutamate: Too much of a good thing in schizophrenia?

... in the November 1st issue of Biological Psychiatry , reinforces this point with new data about the impact of deleting the gene for the glutamate transporter EAAT1. EAAT1, implicated in schizophrenia, plays a critical role in inactivating glutamate by removing it from the synaptic and extracellular ....

Brain's Serotonin May Explain Seasonal Mood Changes

... of Toronto had 88 healthy people undergo a positron emission tomography (PET) scan to assess serotonin binding potential, which indicates serotonin transporter density. The higher the serotonin binding potential, the less serotonin that is circulating in the brain. To study seasonal fluctuations of ...