Protein plays key role in transmitting deadly malaria parasite
... the USF Global Health Infectious Diseases Research team found that the transmembrane protein MAEBL is required for the infective stage of the malaria parasite ... observed in the gut of the mosquitoes. The researchers concluded that the transmembrane form of MAEBL is essential for the parasite to enter the mosquitos ...Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer
... Endocrinology. This new study by Edward Filardo, MD, and his research team further supports earlier published work by the group that linked the transmembrane receptor, GPR30/GPER-1, to specific estrogen binding, rapid estrogen signaling and breast cancer metastasis. "What is exciting about this new work," ...Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening
... One in 29 Americans of Northern European Caucasian or Ashkenazi Jewish descent are symptomless carriers of the defective, or mutated, cystic fibrosis transmembrane regulator (CFTR) gene. A child whose parents are both carriers has a one in four chance of developing the disease. "Taken together, these three ...Hope for preventative treatment for cystic fibrosis lung disease
... of all symptoms of cystic fibrosis are defects at a certain locations in the genetic makeup a mutation in what is called the CFTR ("Cystic Fibrosis transmembrane Conductance Regulator" gene) leads to loss of salt and water and thus dehydration of the surfaces of the mucous membranes in the lungs, intestines, ...A new light on the anti-tumor mechanisms of Scutellaria barbata
... Further investigating the molecular mechanism behind ESB-induced apoptosis, cells treated with ESB underwent a rapid loss of mitochondrial transmembrane potential(delta psi m), release of mitochondrial cytochrome c into cytosol, induction of caspase-3 activity in a dose-dependent manner. This may ...Estrogen May Explain Why Women With Cystic Fibrosis Suffer More
... has narrowed, largely thanks to more aggressive infection treatment in women. People with cystic fibrosis have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which reduces the ability of chloride ions to travel across cell membranes, the researchers said. Chloride ...2 UCSF scientists recognized for transformative research
... molecules across the mitochondrial membranes is the foundation of the mitochondrial physiology and a lack of direct methods to study mitochondrial transmembrane transport is likely the most significant barrier to a better understanding of mitochondria," he adds. His goal is to develop a method for the ...NYP/Columbia physician-scientists present at ASCO 44th annual meeting
... of NewYork-Presbyterian, and professor of pediatrics, medicine and pathology at Columbia University College of Physicians and Surgeons The transmembrane receptor CD33 is expressed in as much as 90 percent of childhood acute myelogenous leukemia (AML). The investigators found that Gemtuzamab therapy ...A potential route for human tumor gene therapy
... The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in ...Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?
... by nano-HPLC tandem mass spectrometry analysis. The molecular weight of CKAP4-similar protein is 62.02 kDa, including one hydrophobic region, one transmembrane domain, five coiled coils, four glycosylation sites and forty-nine phosphorylation sites. CKAP4-similar protein has high homogeneity with Np63, and ...Study Points to New Treatments for Polycystic Kidney Disease
... for PKD. It's believed the accumulation of fluid in the cysts is related to chloride secretion, which is affected by the CFTR (cystic fibrosis transmembrane conductance regulator) gene, according to background information in a news release about the research. "The CFTR inhibitors could be the basis of ...Peptide discovered in scorpion venom may hold key to secretory diseases
... causes blockages that obstruct airways and glands. The lack of water flow stems from a problem in a chloride channel called the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In individuals with cystic fibrosis, the CFTR protein is mutated, often with one or more amino acids ...Gene plays 'Jekyll and Hyde' in brain cancer
... Bonnis group found when EGFR is mutated, STAT3 is an oncogene; with a PTEN mutation, STAT3 is a tumor suppressor. EGFR, in its normal state, is a transmembrane receptor, usually performing its functions at the cell surface, says Bonni. However, when its mutated, we find it in the cells nucleus interacting ...AMRI and Cystic Fibrosis Foundation Launch Major Research Collaboration
... screen its natural products-based libraries to find compounds that improve the function of the defective protein in CF, known as the Cystic Fibrosis transmembrane conductance Regulator (CFTR). AMRI will also conduct an integrated drug discovery program -- including chemistry and in vitro biology -- on ...Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane
... have designed peptides that are able to bind to specific regions of transmembrane proteins, using computer algorithms, and information from existing protein ... of closely related membrane proteins." The researchers targeted two transmembrane proteins called integrins that influence the behavior of platelets, small ...Novel Technology to Locate and Treat Tumors
... inserted across the membrane as an alpha-helix. Under normal tissue conditions of neutral pH, the water-soluble form is favored. At acidic pH, the transmembrane alpha-helix predominates. An earlier paper from the same groups shows that at low pH, pHLIP can move cell-impermeable molecules across a cell ...New Technology Reveals Proteins Responsible for Diseases
... cassette (ABC) transporters – proteins that, when impaired, can cause disease. One of the best known ABC transporters is the Cystic Fibrosis transmembrane Conductance Regulator (CFTR), which, when disabled by mutation, causes cystic fibrosis, a hereditary disease that results in progressive disability ...