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toxicity in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... of total cumulative dose Cardiac toxicity may also occur at lower cumulative doses (400 ... or AIDS-related Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil ... In patients with multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil ...

Hamner Institutes and UNC Launch International Drug Safety Institute

... in vitro assays, starting with evaluating liver toxicity and expanding into cardiovascular and kidney drug ... cause of acute liver failure in the U.S., liver toxicity is also the major reason global regulatory ... a study in patients who have experienced liver toxicity as a result of taking drugs to treat ....

BioTech Medical Well-Positioned to Immediately Respond to Swine Flu Emergency with SDC-Based SpectraSan 24 Disinfectant

... currently on the market, while maintaining lower toxicity ratings. Based on the EPA toxicity ratings from Category I (high toxicity) down to ... (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver ...

Metametrix Announces New Toxic Effects Profiles to Help Combat Growing Concerns About Toxicity and Health

... exposure to environmental toxins and pollutants, toxicity is becoming a major concern to overall health. ... for their patient treatment plans." These toxicity tests are beneficial for patients who have been ... "Finding the burden and removing the sources of toxicity are the critical steps in the road to recovery of ...

Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer

... currently on the market, while maintaining lower toxicity ratings. Based on the EPA toxicity ratings from Category I (high toxicity) down to ... (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver ...

Genstruct and Gene Logic Collaborate on Systems Toxicology

... its state-of-the-art methodology and expertise in toxicity mechanisms, Genstruct will apply its Causal ... to create network models that fully capture the toxicity potential of any compound. "We are excited ... complex and poorly understood mechanisms of toxicity such as idiosyncratic drug-induced liver injury ...

Research increases possibilities of personalizing treatment of infant osteosarcoma

... resistance to a specific treatment and a greater toxicity of the pharmaceutical drug in some child patients ... of these variants are associated with different toxicity of the pharmaceutical drug and, accordingly, ... taken effect, given that, otherwise, significant toxicity could be caused. As a result of the research, ...

BioTech Medical LLC Launches Leading Edge 'Powered by SDC' Disinfectant Products

... currently on the market, while maintaining lower toxicity ratings. Based on the EPA toxicity ratings from Category I (high toxicity) down to ... (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver ...

Pre-emptive treatment helped curtail skin toxicity with panitumumab

... were randomized to receive pre-emptive skin toxicity treatment initiated 24 hours prior to the first ... six, or reactive skin treatment after the skin toxicity developed. The skin treatment included ... the median time to first grade 2 or higher skin toxicity in the reactive skin treatment group. "This ...

Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials'

... use the phase I trial to evaluate a drug's toxicity and tolerability, Dr. Von Hoff advocates that it ... for a phase I approach that looks beyond toxicity and gleans meaningful efficacy data, creating a ... looking at the phase I typically sees it as a toxicity trial, not a therapeutic trial, because of course ...

Proton therapy may reduce serious side effect of lung cancer treatment

... of a serious side effect called bone marrow toxicity than patients who receive chemotherapy and ... risk of a serious side effect called bone marrow toxicity that can lead to delayed or missed treatments, ... had a significant reduction in bone marrow toxicity compared to patients who received IMRT and ...

Nanoparticles + light = dead tumor cells

... tissues from being affected by the treatment, the toxicity of the quantum dot-Photofrin conjugate is only ... healthy tissues. As a result, Yang says, "the toxicity of the drug is substantially lower in the lower ... compared to radiation alone, but with minimal toxicity to nearby cells. ...

US Drug Watchdog Expands Its National Investigation Into The Drug Called Digitek, And Would Like To Talk To Possible Victims

... Digitek tablet poses a serious risk of digitalis toxicity in those patients suffering from renal failure. Digitalis toxicity can cause nausea, vomiting, diarrhea, dizziness, ... can also occur. Patients suffering digitalis toxicity can also experience decreased urine output and ...

Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer

... Myelosuppression is usually the dose-limiting toxicity with ALIMTA therapy. Contraindication ALIMTA ... folic acid and vitamin B12 died of drug-related toxicity following administration of ALIMTA alone. ... hematologic counts or maximum nonhematologic toxicity from the preceding cycle of therapy. Modify or ...

ASCO Study Confirms Importance of Histology in Treatment of Non-Small Cell Lung Cancer With ALIMTA (pemetrexed for injection)

... folic acid and dexamethasone. No significant toxicity differences were identified between the two trial ... Myelosuppression is usually the dose-limiting toxicity with ALIMTA therapy. Contraindication ALIMTA ... folic acid and vitamin B12 died of drug-related toxicity following administration of ALIMTA alone. ...

Potential viral therapy weapon for difficult cancers is safe and effective in study

... of the treatments potential safety, specifically toxicity to nerve tissues. Most research of oncolytic ... with a single-gene mutation would retain neural toxicity to the recipient. Dr. Cripe and his colleagues addressed the neural toxicity question in part by injecting normal human liver, ...

U.S. Seeks to Limit Animal Testing of Toxic Chemicals

... Health, and the U.S. National Toxicology Program, toxicity tests will start being done using human cells in ... we might be able to do a better job of predicting toxicity by using these cell-based tests, but we don't ... issue of the journal Science . Historically, toxicity has been determined by injecting chemicals into ...

Elan Pharmaceuticals Joins GeneGo's MetaTox Consortium

... in the MetaDiscovery(TM) platform with toxicity ontologies, developing "knowledge-based" ... descriptors), manual reconstruction of toxicity pathways in human and relevant preclinical model ... drugs still fail in clinical trials due to human toxicity unseen in pre-clinical safety assessment", said ...

Advanced targeted therapies effective as first-line treatment for lung cancer

... disease does not worsen) than those receiving chemo. Also, high-grade toxicity was less common in the gefitinib group than in the chemotherapy group. ... survival outcome along with high overall response rate and better toxicity profile suggests that gefitinib might be a reasonable first-line therapy ...

Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting

... marrow function. There have been rare reports of serious kidney or liver toxicity with GEMZAR treatment, sometimes fatal. Serious lung toxicity has also been reported, sometimes fatal. If you think you are pregnant, ...

Camp High Harbour Response to Flu Outbreak Includes SpectraSan 24 Disinfectant

... faster than traditional disinfectants on the market. It has the lowest toxicity rating assigned by the EPA, is non-corrosive, non-flammable, and is ... while currently being the only registered disinfectant assigned the lowest toxicity rating (IV) by the EPA. SpectraSan 24 is intended for use on hard ...

Pluronic L-81 is a potential anti-diabetic drug?

... and adipocyte volume of the db /db mice were assessed after treatment. toxicity of L-81 was also evaluated. To understand the molecular mechanism, HepG2 ... of plasma cholesterol and triglyceride. With the effective dosage, little toxicity was observed. Treatment on HepG2 cells with L-81 not only inhibited apoB ...

Report: Asbestos Litigation Disaster for Investors Could Be Repeated With Nanotechnology Unless SEC and FASB Close Eight Major Loopholes Now Preventing Honest Disclosures

... them into commerce, much less effort has been devoted to assessing their toxicity and developing governance systems for them. IEHN's new report identifies ... size and surface area of nanoparticles may result in dramatically enhanced toxicity and harm to living organisms. Evaluation of the impact on human health ...

'Cannabis alters human DNA' -- new study

... is illegal in many countries. "There have been many studies on the toxicity of tobacco smoke. It is known that tobacco smoke contains 4000 chemicals ... smoke would have the same effect. Our research has focused on the toxicity of acetaldehyde, which is present in both tobacco and cannabis." The ...

Aethlon Medical Releases Shareholder Letter to Discuss the Treatment of Hepatitis-C Virus (HCV)

... The challenge facing these candidates is the effect of stacking new drug toxicity on top of established SOC toxicity, which is known to trigger fatigue, ... Many patients fail SOC therapy because they are unable to endure the toxicity of the 24-48 week regimen on its own. Based on clinical data, Telaprevir, ...

Poniard Pharmaceuticals Announces Positive Efficacy and Safety Data From Phase 2 Clinical Trial of Picoplatin in Men With Metastatic Prostate Cancer

... results suggest that hematologic events are severe but manageable. Kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) are less severe than is commonly observed with other ...

FDA's Hydroxycut Recall Highlights the Need for Stem Cell Innovations' ACTIVTox Human Liver Testing

... -- Stem Cell Innovations' (Pink Sheets: SCLL) ACTIVTox(R) human liver toxicity tests are the only products on the market using a standardized human liver ... Company's ACTIVTox system is a human liver based model for high throughput toxicity testing. Stem Cell Innovations proprietary, human pluripotent stem cells, ...

Amgen Highlights Data to Be Presented at ASCO

... Final STEPP results of prophylactic versus reactive skin toxicity (ST) treatment (tx) for panitumumab (pmab)-related ST in patients (pts) ... toxicities that are grade 3 or higher or are considered intolerable. If toxicity does not improve to less than or equal to grade 2 within 1 month, ...

Glutamate Identified As Predictor of Disease Progression in Multiple Sclerosis

... multiple sclerosis patients. The study is the first to measure glutamate toxicity in the brain over time and suggests an improved method for tracking the ... is the first time that we have had the ability to measure glutamate toxicity in the brain in real time, which gives us a marker for monitoring disease ...

Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Oral Picoplatin Demonstrating Bioavailability

... date suggest manageable hematologic adverse events with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with other platinum chemotherapy ...

Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology

... date suggest manageable hematologic adverse events with less severe kidney toxicity (nephrotoxicity) and nerve toxicity (neurotoxicity) than is commonly observed with other platinum chemotherapy ...

Star Scientific Reports on Filing Patent Application for Zero-Nitrosamine Tobacco Curing Process, Product Development by Rock Creek Pharmaceuticals

... dietary supplement products. Contracts for initial benchtop and animal toxicity testing have been entered into by Rock Creek. Additional toxicity testing is expected to begin in the next few months. If those testing ...

Caraco Pharmaceutical Laboratories, Ltd. Announces a Nationwide Voluntary Recall of All Lots of Digoxin Tablets Due to Size Variability

... and the existence of higher than labeled dose may pose a risk of digoxin toxicity in patients with renal failure. Digoxin toxicity can cause nausea, vomiting, dizziness, low blood pressure, cardiac ...

Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference

... Francisco. "The XF96 Analyzer has revolutionized the way we approach toxicity screening," said Yvonne Will of Pfizer's Compound Safety Prediction Group, who spoke about mitochondrial toxicity at the conference and one of the first users of the XF96. "Since getting ...

PURE Bioscience Announces Brazilian Regulatory Approval for SDC-Based Hospital-Grade Disinfectants

... challenges, including Staph (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver dihydrogen citrate-based ... competitors in the marketplace because of its superior efficacy, reduced toxicity and the inability of bacteria to form a resistance to it. PURE is ...

Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate

... study, a 9-week repeated dose study in normal mice, was designed to assess toxicity following long-term administration of twice-weekly therapeutic doses (1.5 ... major organs was conducted by an independent pathologist and revealed no toxicity attributable to SNS-01. Richard Dondero, Senesco's Vice President of ...

Penn study finds link between Parkinson's disease genes and manganese poisoning

... Gitler. "It was one of the genes that could rescue alpha-synuclein toxicity from our yeast screen. That was the big Eureka! and completely unexpected. ... causes of Parkinson's. How does PARK9 protect against alpha-synuclein toxicity and how does PARK9 help prevent manganese poisoning? This is what we will ...

Treatment with the Zevalin(R) Therapeutic Regimen as Sole Therapy Produces 83 Percent Complete Response Rate in Mucosa-Associated Lymphoid Tissue (MALT) Orbital Lymphoma

... standard of therapy for MALT lymphoma, which may result in lower ocular toxicity than EBRT and equivalent or better disease control," noted Jack Singer, ... associated with pre-administration of rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow involvement prior to Zevalin ...

Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.

... following the successful completion of Good Laboratory Practices (GLP) toxicity studies. AM211 is an oral, selective antagonist of the receptor DP2 ... we have a structurally distinct backup compound, AM461, about to enter GLP toxicity studies." "Amira is establishing a track record of rapid and ...

PURE Bioscience Reports First Quarter Results

... challenges, including Staph (MRSA). PURE's proprietary high efficacy/low toxicity bioscience technologies, including its silver dihydrogen citrate-based ... competitors in the marketplace because of its superior efficacy, reduced toxicity and the inability of bacteria to form a resistance to it. PURE is ...
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(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
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(Date:11/18/2014)... -- The Secure Identity & Biometrics Association (SIBA) and ... formation of The Airport Entry and Exit Working ... Biometric Entry and Exit Solutions Framework for Airports ... BORDERPOL, the international non-profit organization that works directly ... border security, traveler and migration systems. ...
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