Telomere in Medical News

Multivitamins Might Prolong Life

... corresponds to about 9.8 years less age-related telomere shortening, the researchers noted. Vitamins C ... Chen said. But, whether the vitamins preserved telomere length or actually lengthened life is not clear, ... a healthy lifestyle," he said. "Although shorter telomere length has been linked to higher mortality and ...

RevGenetics Releases Its New Science-Based Telomere Health Supplement Formulation for DNA and Chromosome Health

... helps slow and repair some of the natural telomere DNA shortening that happens as we age MIAMI, ... update and release of its latest science-based telomere health supplements , Astral Fruit. To ... at a recent study entitled: "Proteins induced by telomere dysfunction and DNA damage represent biomarkers ...

First sister study results reinforce the importance of healthy living

... that cap the ends of a person's chromosomes. telomere length is one of the many measures being looked ... women who were obese for a long time had reduced telomere length. The researchers looked at the ... measures of current and past body size and telomere length in 647 women enrolled in the Sister Study. ...

Enhanced skin cancer risk linked to defects in cellular aging controls

... (DMM), dmm.biologists.org , describes how telomere dysfunction in skin cells can lead to increased ... the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma ... This study establishes a link between telomere dysfunction, cancer progression and the ...

The 2009 Leibniz Prize: Eleven new scientific discoverers

... division. Rudolph has studied this process of telomere shortening and its effects in numerous ... is in the enzyme telomerase, which inhibits the telomere shortening, thus allowing cells to divide more ... models and mutants, Rudolph was able to show that telomere shortening ultimately leads to a shorter lifespan ...

Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging

... is a revolutionary technology that is based on telomere biology. Telomeres are part of your DNA. They are ... an opportunity to slow or potentially reverse telomere shortening-hence technically making ... 64, recipient of TA-65. The emerging science of telomere biology is changing the way science and society ...

Sedentary Lifestyle Accelerates Aging

... Overall, the study participants had an average telomere loss of 21 nucleotides (structural units) per ... active. "Such a relationship between leukocyte telomere length and physical activity remained significant ... wrote. "The mean difference in leukocyte telomere length between the most active [who performed an ...

Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under

... telomeres raises the possibility of one day using telomere length as a biomarker of cancer or an early ... between colon cancer patients and increased telomere shortening is exciting because, if validated, it ... treatment strategies. For example, we know that telomere length can be repaired, so we want to look ...

Advances in drug screening: building a better haystack for the needles of tomorrow

... of molecular compounds for the ability to disrupt telomere maintenance. Through their screening process, the ... that keep the DNA from fraying at the ends. The telomere consists of a short repeated segment of six DNA ... below a critical threshold. In cancers, the telomere structures are maintained but they require ...

New telomere discovery could help explain why cancer cells never stop dividing

... may provide a new avenue of attack for stopping telomere renewal in cancer cells. Inside the cell ... from getting scrambled when cells divide. The telomere is like a cellular clock, because every time a cell divides, the telomere shortens. After a cell has grown and divided a ...

Study gives clues to how adrenal cancer forms

... a higher risk of mutating into cancer. But, a new study finds, if the telomere becomes dysfunctional at any point regardless of shortening it can ... causing scrambled genes and mutations. "P53 mutation together with telomere dysfunction may be the basis for the genomic changes we see in adrenal ...

KLRI Releases 3rd Annual Report On Year's Top Longevity Research Findings

... as the cap on a pen prevents ink from leaking. With time, however, the telomere shrinks. The shorter the telomere, the worse the cell functions and the ... that, in addition to age, being overweight or obese can wreak havoc on telomere length even in your twenties, thanks to insulin resistance. Physical ...

Other highlights in the Jan. 8 JNCI

... Human tumor viruses employ a variety of strategies for maintaining telomere length, which assist in the growth and survival of tumor cells. ... ways that human tumor viruses regulate these enzymes in order to maintain telomere stability and promote tumor cell survival and proliferation. The ...

Wistar Institute team finds key target of aging regulator

... accumulation of the acetylation mark along with disrupted histone organization at telomeres. Deacetylation of H4K16 by Sir2 and consequent telomere stability play a major role in maintaining long lifespan in yeast. Since sirtuins deacetylate many different proteins, these results clarify a key ...

Smoking May Harm the Egg, Embryo

... development was dependent on the length of exposure, the team noted. But even embryos exposed to smoke for as little as four days showed reduced telomere length in cells and decreased blastocyst development, suggesting that embryos may be more sensitive to smoke-induced oxidative stress than eggs, the ...

Secrets of Telomerase Revealed

... "It's extremely exciting," said Skordalakes. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication." Skordalakes plans to further investigate the active region of telomerase and search for new potential cancer therapies. More ...

Researchers Gather to Address New Tools in Development for Breast Cancer Detection

... San Francisco Viruses in breast fluid as possible biomarkers for breast cancer David Gilley, PhD, and Hiromi Tanaka, PhD, Indiana University telomere dysfunction markers for breast cancer detection Bassem Haddad, MD, Georgetown University Improving the diagnostic power of ductal lavage for early ...

Evolution of human genome's 'guardian' gives people unique protections from DNA damage

... to test the combined effects of altering p53 and telomerase, the enzyme that controls the length and stability of repeating DNA sequences in the telomere region. Mouse models will continue to become progressively more powerful tools for studying human cancer and additional information about the p53 ...

A Little Wine, Sunlight Help Boost Women's Health

... low levels of inflammation, he explained. Sure enough, the data indicated that higher levels of circulating vitamin D was associated with longer telomere length. Women with the lowest concentration of vitamin C and highest concentration of C-reactive protein had telomeres short enough to indicate about ...

Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer

... Understanding how and why the cells change in some cases and not others has been a major challenge for investigators. Researchers compared telomere length and telomerase activity in biopsy specimens from 38 patients with GERD and 16 control patients. This new line of research suggests that the ...

New Genetic Biomarkers Could Predict Coronary Heart Disease

... and Type 2 diabetics which have shown that telomere shortening is greater as a person progresses from ... which could be the one of the reasons for telomere shortening and so an early indication of their ... be a predictor for CAD. In other words, telomere shortening in prediabetics could predict those ...

Got a Short Telomere-Watch Your Heart

... a new predictive marker for heart disease, the telomere or strand of DNA found at the ends of the ... 45 to 64. A study into the length of their telomere (sampled from white blood cells) found that a ... a higher risk of coronary heart diseases. telomere is currently known to be associated with ...

Osteoarthritis May be Sign of Faster “Biological Ageing

... the findings showed that white cell telomere lengths were associated with chronological age. ... the 160 people with hand osteoarthritis, the telomere length was significantly shorter than among those ... osteoarthritis were over 50, and the amount of telomere shortening was equivalent to that accrued over 11 ...

Gene That Might Be Responsible For Aging

... sample of families living in northern Belgium. telomere length was found to be similar between fathers ... daughters) was strongly correlated with similar telomere length between parents and children. Results also confirm telomere length is longer in women than in men. ...

Dotted All Over? - Count Yourself Lucky

... moles disappear with age Bataille's team looked at their relationship with telomere length, a good biological indicator of an individual's rate of ageing. ... of normal ageing, and this was estimated by looking at the average rate of telomere length loss per year. It was concluded that people with a lot of ...

Salk Scientists - Links Between Cancer and Aging

... a link to cancer predisposition, saying, 'These results indicate that the telomere dysfunction in Werner Syndrome cells is a major cause of genomic ... model for aging, and we show here a direct relation between aging, telomere loss, and cancer occurrence,' he says. 'I predict that cancer in older ...

Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer

... yet sure how it does it, we will continue to study how Rad9 influences the telomere structure," Pandita said. "We speculate that without Rad9, some of the ... SN, Roti Roti JL, Lieberman HB, Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase specific cell survival and homologous ...

Telomere Plays an Important Role in Ageing

... is associated with ageing. The study results were published in the journal Ageing Cell. The author said that there existed a seven-year difference in telomere loss between people of the same age, same body mass index, same smoking status, same exercise status who happen to be in a manual job or non-manual ...

Inactivation of Rad9 in Tumor Cells Would Be Advantageous In Cancer Therapy

... are structures at the ends of chromosomes which protects the chromosome from fusion or degradation. Rad9 proteins interact with proteins called telomere binding proteins. During the experiment if Rad9 in human cells were inactivated it resulted in damaging the chromosomes and caused end-to-end fusion ...

Link between Old Cells and Ageing probed

... sedivy lab for the presence of six bio markers, which mean the onset of cellular aging. The most important indicator for replicative senescence is telomere dysfunction that stops the division of cells. Infact, scientists did the hair splitting task of counting the cells with bio markers. Their finding ...

Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

... mutations in genes, but even in half-telomerase mice the disease is still present although the genetic basis gets obscured due to the inherited telomere length and not the gene. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says ...

Chromosome Ends Trigger DNA Damage Response For Telomere Protection

... Telomeres, the ends of linear chromosomes, represent a problem for the control of genome stability and the DNA damage machinery. An exposed telomere could readily be taken for a break and recognized as damage, and thus, have to be distinguished from DNA breaks that initiate a DNA damage ...