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situ in Medical News

Story ideas from molecular & cellular proteomics

... and colleagues established a technique called in situ proximity ligation assay (in situ PLA) to reveal protein-protein interactions in ... the detected proteins is lower. Article: In situ Detection of Phosphorylated Platelet-derived ...

New microchip technology performs 1,000 chemical reactions at once

... invisible to the eye. The chemical reactions were performed using in situ click chemistry, a technique often used to identify potential drug ... as well. "The precious enzyme molecules required for a single in situ click reaction in a traditional lab now can be split into hundreds of ...

Caltech chemists say antibody surrogates are just a 'click' away

... reagent still worked," says Agnew. The technique makes use of the "in situ click chemistry" method, introduced by Sharpless in 2001, in which ... do not bind to the protein all that well; the trick is to repeat the in situ screen several times, and the binding improves with every iteration," ...

HPV Data May Aid Vaccine's Effectiveness

... Epidemiology and End Results registry and identified 1,213 cases of in situ cervical cancer diagnosed between 1980 and 1999, as well as 808 cases of ... and HPV45 DNA in 6.1 percent. HPV16 DNA was found in 56.3 percent of in situ cervical cancers, HPV31 DNA in 12.6 percent, and HPV33 DNA in 8 percent. ...

Human papillomavirus genotype distribution in New Mexico cervical cancers

... Epidemiology, and End Results registry to identify 1,213 cases of in situ cervical cancer diagnosed between 1985 and 1999 and 808 cases of invasive ... DNA was found in 13.1 percent, and HPV45 DNA in 6.1 percent. In the in situ cervical cancer samples, HPV16 DNA was detected in 56.3 percent of cases, ...

LSUHSC public health contributes to estimate of HPV-related cancers

... which the LSUHSC public health faculty are co-authors are Incidence of in situ and invasive vulvar cancer in the US, 1998-2003 (p 2865-2872), Descriptive ... of cervical cancer have an increased risk of developing subsequent in situ (non-invasive) cancers of the vagina and vulva, as well as invasive ...

Early Breast Cancer No More Likely to Return in Young Women

... with a common form of early-stage breast cancer called ductal carcinoma in situ (DCIS) are no more likely to have recurrences than older women with the ... from the duct to other breast tissues, however. About 62,000 cases of in situ cancer are diagnosed each year, according to the American Cancer Society. ...

Cancer research highlights

... COMPUTER ANALYSIS FOR DIAGNOSING BREAST CANCER ... Ductal carcinoma in situ (DCIS), the development of cancer cells within the milk ducts of breast ... COMPUTER ANALYSIS FOR DIAGNOSING BREAST CANCER Ductal carcinoma in situ (DCIS), the development of cancer cells within the milk ducts of breast ...

Bioniche Presents Pre-Clinical Research at Two International Conferences

... "Quantification of chromosomal aberrations by multiprobe fluorescence in situ hybridization profile (FISH) of 9 human bladder cancer cell lines commonly ... University of Miami, Miami, Florida, U.S.A. Using fluorescence in situ hybridization (FISH), the chromosomal status of bladder cancer cell lines ...

Scientists identify 'gatekeepers' of breast cancer transition to invasive disease

... that progresses into localized carcinoma, called ductal carcinoma in situ (DCIS); invasive carcinoma; and eventually, metastatic disease. DCIS is ... signals. Thus, myoepithelial cells can be considered gatekeepers of the in situ to invasive carcinoma transition; understanding the pathways that regulate ...

China Medical Technologies Completed the Development of Prostate Cancer FISH Reagent

... cancer-specific molecular diagnostic test based on the Fluorescent in situ Hybridization ("FISH") technology. The Company expects to launch the Kit ... using Enhanced Chemiluminescence (ECLIA) technology and Fluorescent in situ Hybridization (FISH) technology, to detect and monitor various diseases ...

Precancerous Breast Lesions Cause Unnecessary Worry

... In most cases, ductal carcinoma in situ will not spread, researchers say TUESDAY, Feb. 12 (HealthDay ... diagnosed with a precancerous breast lesion known as ductal carcinoma in situ (DCIS) are highly anxious about their prognosis, even though they face a ...

Play it Straight with Swine Flu, AA Travel Insurance Advises

... Travel insurance would cover treatment overseas and the costs of repatriation once you've recovered. As the Government recommends that you remain in situ until you have recovered, you would probably not be repatriated until all symptoms of swine flu have cleared but again, you must contact and have ...

Colon capsule endoscopy diagnoses 64 percent of total polyps detected by conventional colonoscopy

... moreover, conventional colonoscopy enables the undertaking of a diagnosis of the colon as well as practicing therapeutic procedures, such as the in situ extirpation of polyps during exploration or the obtaining of a biopsy when required. Capsule endoscopy of the colon explores the large intestine ...

NeoGenomics Enters into Strategic Supply Agreement with Abbott for Development of a Melanoma Cancer Test

... with Abbott (NYSE: ABT ). The Agreement provides for Abbott to supply materials for NeoGenomics to develop its own FISH (fluorescence in situ hybridization)-based test for the diagnosis of melanoma. In a separate transaction, Abbott has also acquired 9.6% of NeoGenomics common stock for ...

Orlando Regional Medical Center (ORMC) Implements PNA FISH(R) Tests to Help Provide Better Care for Patients with Bloodstream Infections

... information, visit www.myormc.com About PNA FISH(R) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. ...

More Mammograms May Mean More 'Harmless' Cancers

... New South Wales, Australia; Sweden; and parts of Norway. They found an estimated overdiagnosis rate of 52 percent for all cancers, including in situ malignancies, which have not spread, and an overdiagnosis rate of 35 percent for invasive breast cancer. The study also detected a jump in incidence ...

Exiqon Announces 2009 North American Grant Award Winners

... complete product line for microRNA investigation, including products for RNA isolation, Microarray analysis, qRT-PCR analysis, Northern Blotting, In situ Hybridization, and Knockdown studies. Exiqon also offers microRNA profiling services for both microarray and qRT-PCR analysis, complete with full ...

New Tests Spot Tough-to-Detect Cancers Sooner

... is then performed to look for abnormally shaped cells, a search repeated with the additional use of digital image analysis and fluorescence in situ hybridization (FISH). The latter procedure uses colored probes visible with a fluorescence microscope to seek abnormal cells. In the study, ...

Memorial University Medical Center (MUMC) Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections

... appropriate therapy and save patient lives. About PNA FISH(R) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. ...

Mayo Clinic finds new pathology tests double sensitivity to detect bile duct and pancreatic cancers

... an endoscopic procedure, and cell brushings were taken. Brushings were then analyzed by routine cytology, digital image analysis and fluorescence in situ hybridization (FISH) to determine the various tests' effectiveness and sensitivity in detecting and diagnosing cancer. While traditional cytology ...

AdvanDx Receives FDA 510(k) Clearance for GBS PNA FISH(R) for Rapid Detection of Group B Strep from Lim Broths

... and their newborns," Johansen added. About PNA FISH(R) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. ...

Exiqon Announces New Grant Program for MicroRNA Research

... complete product line for microRNA investigation, including products for RNA isolation, Microarray analysis, qRT-PCR analysis, Northern Blotting, In situ Hybridization, and Knockdown studies. Exiqon also offers microRNA profiling services for both microarray and qRT-PCR analysis, complete with full ...

ConvaTec Launches New AQUACEL(R) Ag Dressing with Strengthening Fiber

... on contact with wound fluid to provide a moist wound healing environment, help manage exudate, help protect the periwound skin(5) and reduce pain in situ and on removal.(6,7,8) With the inclusion of ionic silver, AQUACEL(R) Ag dressing provides on demand antimicrobial activity, as demonstrated in ...

A feasible, simple and convenient model for study of rectal carcinoma

... the implantation of the VX2 cell strain into the muscle, kidney, lung, pleural, ossature, and mammary gland of rabbit in order to produce an in situ tumor model that mimics the human condition for research of possible treatments. The implantation technique using VX2 cells which included implanting ...

New universal breast cancer marker predicts recurrence and clinical outcome

... & Therapy, the researchers also found that the loss of stromal caveolin-1 in ER-positive non-invasive breast cancers called ductal carcinoma in situ (DCIS) serves as a biomarker for progression to invasive breast cancer. "This marker was highly predictive of development of invasive breast ...

Novel gene predicts local recurrence in early onset breast cancer

... proper structures. In addition, the researchers used immunohistochemical staining to examine DEAR1 expression in 14 samples of ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the corresponding invasive cancer from the same patient. They found that DEAR1 ...

Novel gene predicts local recurrence in early-onset breast cancer

... proper structures. In addition, the researchers used immunohistochemical staining to examine DEAR1 expression in 14 samples of ductal carcinoma in situ (precancerous abnormalities) with adjacent normal epithelium and in the corresponding invasive cancer from the same patient. They found that DEAR1 ...

AdvanDx Receives FDA 510(k) Clearance for EK/P. aeruginosa PNA FISH(R)

... appropriate therapy and save patient lives. About PNA FISH(R) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. ...

K-State professor awarded $1.48 million to study LASIK complictions

... difference in the connective tissue of normal corneas compared to those that have been cut during LASIK. LASIK, which stands for laser-assisted in situ keratomileusis, is a surgery using a laser to reshape the cornea as an alternative to wearing glasses or contact lens. During the procedure a ...

Mayo Clinic researcher says improved detection of bladder tumors reduces cancer recurrence

... the 278 patients randomized to blue light. There was also a 46 percent increase in detection of high-risk bladder cancers known as carcinoma in situ (CIS), using the blue-light technique, Dr. Mynderse says. The researchers then looked at 402 patients with Ta/T1 tumors who completed the study, ...

ConvaTec and HemCon Announce Co-Promotion Agreement

... gel on contact with wound fluid to provide a moist wound healing environment, manage exudate, protect the periwound skin(1) and reduce pain in situ and on removal.(2),(3),(4) In addition, AQUACEL(R) Ag dressing provides the broad-spectrum antimicrobial properties of ionic silver, which kills a ...

More women with early stage breast cancer choosing double mastectomies

... to have both breasts surgically removed. The rate of contralateral prophylactic mastectomy (CPM) surgery among U.S. women with ductal carcinoma in situ (DCIS) increased by 188 percent between 1998 and 2005, according to Todd Tuttle, M.D., lead researcher on this study. Tuttle is associate ...

More women with early-stage breast cancer choosing double mastectomies

... to have both breasts surgically removed. The rate of contralateral prophylactic mastectomy (CPM) surgery among U.S. women with ductal carcinoma in situ (DCIS) increased by 188 percent between 1998 and 2005, according to Todd Tuttle, M.D., lead researcher on this study. Tuttle is associate ...

Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS

... biology, MIT. "In contrast, tumor development in the HIM model proceeds through defined histological stages of hyperplasia, from ductal carcinoma in situ (DCIS) to invasive carcinoma. Moreover, HIM tumors display characteristic responses to a targeted therapy known to be effective in humans, ...

I-Therapeutix Announces First Commercial Use of I-ZIP(R) Adherent Ocular Bandage for Clear Corneal Cataract Incisions

... 90% water that can be applied to cornea, sclera and conjunctiva. The hydrogel bandage is applied as a liquid which then polymerizes in situ , forming a soft, adherent, protective barrier over the ocular incision. I-ZIP Bandage is intended to remain on the ocular surface during the normal ...

PGD Technology Offers More Than Designer Babies

... genetic markers located near the mutation of interest can be used to identify affected embryos. Using a technique known as Fluorescent In situ Hybridization (FISH), PGD can also be used to count the chromosomes in the cell removed from an embryo. A normal cell has a complement of 23 pairs ...

BioMosaics' Glypican-3 Antibody (clone 1G12) Validated at PhenoPath Laboratories for Immunohistochemical Detection of Liver Cancer

... Laboratories. PhenoPath Laboratories is a state-of-the-art reference pathology laboratory providing diagnostic immunohistochemistry (IHC), in situ hybridization (ISH), flow cytometry, and other molecular pathology services to pathologists throughout the United States. "We are pleased that ...

Mercy Integrated Labs Implements PNA FISH(R) Tests to Help Clinicians Provide Best Care for Patients With Bloodstream Infections

... information regarding Mercy Health Partners. About PNA FISH(R) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. ...

Breast-Specific Gamma Imaging (BSGI) Uncovers Additional Breast Cancer in Newly Diagnosed Breast Cancer Patients

... lobular carcinoma, 32 ductal carcinoma in situ, and 17 mixtures of invasive ductal carcinoma, invasive lobular carcinoma, or ductal carcinoma in situ and other) were reviewed. Twenty-five patients (18.1%) had a positive BSGI study for cancer at a site other than their known cancer, or more ...
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