Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce

... (CSHL) has discovered new details about how a simian strain of the AIDS virus replicates. The findings ... led a team that studied a virulent strain of simian immune-deficiency (SIV) virus called SIVsm/mac, ... machineries in order to reproduce. HIV and its simian cousin SIV are members of a viral subspecies ...

AIDS-like Illness Found in African Chimps

... Park for nine years, watching what happened to those infected with a simian equivalent of HIV. Their findings appear in the July 23 issue of ... with the end stages of AIDS in humans. Chimps appear to transmit the simian equivalent of HIV just like humans, Hahn said: They spread it through sex. ...

Progression of SIV infection in monkeys raises

... The study, Acute Loss of Intestinal CD4+ T Cells is Not Predictive of simian Immunodeficiency Virus Virulence, challenges current thinking regarding ... to full-blown AIDS in humans, some non-human primates infected with simian immunodeficiency virus (SIV) do not develop AIDS after such a depletion. ...

Yerkes researchers propose ambitious new strategies for AIDS vaccine research

... believe conventional vaccine strategies should not be the only avenue explored in the development of an effective AIDS vaccine. Based on studying simian immunodeficiency viruses (SIVs) in African nonhuman primates, they propose an additional new approach to the AIDS vaccine research agenda in a ...

Vaccine Shields Monkeys From Simian Form of HIV

... hopes for the development of an AIDS vaccine that might actually work, researchers report they were able to protect monkeys against infection with simian immunodeficiency virus (SIV), the primate version of HIV. They did so by using a novel approach that delivered antibody-producing genes directly ...

New HIV Drug May Help Those Resistant to Therapy

... the drugs. In the study, researchers tested the effectiveness of a molecule called D-1mT and anti-retroviral therapy (ART) in macaque monkeys with simian immunodeficiency virus (SIV), which is similar to HIV in humans. After six days of treatment, only three of the macaques had detectable SIV levels, ...

OHSU vaccine research targets HIV in the slower, early stage of infection

... the spread of the virus." To determine whether they could proactively "educate" the immune system, scientists used a monkey model of AIDS - simian immunodeficiency virus (SIV) the monkey counterpart to HIV. They introduced an altered monkey form of cytomegalovirus (CMV) programmed to express ...

Possible AIDS Treatment Shows Promise in Monkeys

... In the new study, Amara and colleagues injected nine monkeys with an antibody that blocks a kind of "don't kill me" signal that cells infected with simian immunodeficiency virus (SIV) send to immune cells. When the SIV-infected cells emit the signal, "the killer cell thinks, 'You are not my enemy. ...

Hopes for AIDS Vaccine Still Alive Despite Setbacks

... led by pathologist David Watkins has successfully tested a vaccine that has provided monkeys with protection from up to 20 different strains of the simian equivalent of HIV, using only T-cell mediated immunity. Similar experiments have panned out well in pathologist Louis J. Picker's lab at the ...

World AIDS Vaccine Day 2008

... that can stimulate the production of these antibodies in humans. Finally, non-human primates immunized with a live, but weakened form of the simian equivalent of HIV are protected from infection. For safety reasons, we cannot immunize humans with weakened HIV, but scientists are actively studying ...

SIV infection of natural hosts provides new insights into HIV disease complexity

... of CD4 T-cells is considered to be a key determinant of AIDS disease. However, in natural hosts, like the sooty mangabey (an African monkey species), simian immunodeficiency virus (SIV) induced CD4 T-cell depletion can be comparable to that in humans, but the monkeys do not show clinical signs of AIDS. ...

Urban Monkeys Source Of Virus Infections

... about half of the macaques tested positive for simian foamy virus (SFV), a primate retrovirus that so ... in Asia. Two of the monkeys tested positive for simian retrovirus (SRV), which, though it has been shown ... virus exposures. One monkey tested positive for simian T-cell lymphotropic virus (STLV), which is ...

Viruses Can Cross Species Barrier

... Scientists believe that HIV, the virus that causes AIDS, started out as simian immunodeficiency virus (or SIV), and jumped to humans decades ago when ... who visit a monkey temple in Bali, Indonesia, will be infected with simian foamy virus (SFV) from a monkey bite. SFV is a primate retrovirus that so ...

Evolution of HIV from African Greek Monkeys

... may have swept across Africa more recently than previously thought . A new family tree for African green monkeys shows that an HIV-like virus, simian immunodeficiency virus, or SIV, first infected those monkeys after the lineage split into four species. The new research reveals the split happened ...

Monkey Virus Identical to HIV Endemic in Gorillas

... Wednesday. // Statistics have shown that around 40 million people worldwide are living with HIV/AIDS. Although monkeys in Africa infected with simian immunodeficiency virus (SIV) are said to be the source of two of the three strains of the virus in humans the source of the third has been unknown, ...

Chronic binge drinking can hasten HIV development

... in heavy drinking more than the population all together. Recent study reveals that constant heavy drinking can quicken the advancement of end-stage simian immunodeficiency virus (SIV) among rhesus macaques. The same may be the case in humans infected with HIV. The October issue of Alcoholism: Clinical & ...

NHGRI Aims To Sequence Primate Genomes

... neuroscience, behavioral biology, reproductive physiology, endocrinology and cardiovascular studies. In addition, because it can be infected with simian immunodeficiency virus, a close cousin to the human immunodeficiency virus (HIV), the rhesus is widely recognized as the best animal model for ...

The Deadly Evolution of SIV to HIV

... University of Ulm in Germany and Dr Beatrice Hahn of the University of Alabama at Birmingham. They said HIV descended from a chimpanzee virus called simian immunodeficiency virus (SIV). But in case of SIV the monkeys though were infected with the virus did not develop the disease. But so was not the ...

HIV Vaccine for Monkeys Increases Survival Rates

... the NIAID Vaccine Research Center (VRC), and the other by Mario Roederer, Ph.D., of the VRC. The researchers found that monkeys vaccinated against simian immunodeficiency virus (SIV) -- a close relative of HIV that causes an AIDS-like disease in monkeys -- and then exposed to the virus survived ...

Research on AIDS vaccine a wealth of information

... infection control in monkeys infected with the AIDS virus. As in previous studies, this new research found that among monkeys infected with the simian immunodeficiency virus (SIV) -- 24 of which were vaccinated and six of which were not -- the immunity generated by the vaccine controlled infection ...

Origin of HIV Traced To Wild Chimps

... sample collected// from the chimpanzee found from forest floors in Africa. They collected 599 fecal samples from 10 forest sites. They found that the simian immunodeficiency virus which affects the chimpanzees had a close resemblance to HIV-1, one of the strains affecting humans. The study’s lead ...

Malignant virus in polio vaccine combined to Cancer

... the time, the manufacturing process was considered safe. But in 1960, it was discovered that large batches of the vaccine were contaminated with the simian virus later named SV40. An estimated 90 million Americans received Salk vaccine injections and as many as 30 million were exposed to the virus. ...

Malignant Mesothelioma – A New Genetic Revelation

... in frequency throughout the world. The main causative agents for the development of Malignant mesothelioma is exposure to asbestos, recently a virus, simian virus 40 (SV40) is also found to be a causative agent for development of this tumor. Many people with malignant mesothelioma have worked or ...

Malignant Mesothelioma – A New Genetic Revelatio

... in frequency throughout the world. The main causative agents for the development of Malignant mesothelioma is exposure to asbestos, recently a virus, simian virus 40 (SV40) is also found to be a causative agent for development of this tumor. Many people with malignant mesothelioma have worked or ...

New Virus : A Threat In the Future?

... Scientists say there is a new virus called simian foamy virus (SFV) that can be transferred from primates to humans.// While it’s not clear what type of health effects SFV will have on humans, ...

HIV did not arise from polio vaccine

... always denied that any chimp cells were used in manufacturing its OPV. But the fact that mainstream researchers believe HIV arose from the related simian Immunodeficiency virus (SIV) in chimps has bolstered the idea that HIV was mistakenly unleashed through polio vaccination. The theory was first made ...