regulator

Liver transplant oversight urged

...ing donors, some doctors are proposing an external regulator be appointed to certify hospital units to do the s...t Denver's University of Colorado said an external regulator should carry out the task of certifying such units. They also urged adoption of uniform medical crit...

Developing HIV fighter

...ts of the virus that make the protein as well as a regulator protein. According to Sharp, in both cases we were able to show that these small RNAs in cells would inhibit the infection by HIV,'' in laboratory work.The RNA interference process is a very new development in biological science and is quite excitin...

Regeneration of muscle

...s argue that these results establish Pax7 as a key regulator of muscle cell differentiation in specific populations of adult stem cells during muscle tissue regeneration in mice. If therapeutic strategies that activate Pax7 in adult stem cells can turn them into muscle cells, effectively replenishing injured o...

Oily Fish Is Set To Cure Arthritis

...lvins are called resolving E1 and these are potent regulator of inflammatory conditions in mice. When human beings were tested for the effects of omega-3 fatty acids combination with aspirin, resolving E1 is found to be the receptor that inhibits inflammatory responses. A team of professionals did the resear...

An answer to obesity: weight control protein

...Our findings reveal SH2-B as an important positive regulator of leptin sensitivity inside cells of the brain region known as the hypothalamus," said senior author of the study, Liangyou Rui. The hypothalamus is a key area in the central nervous system that integrates neuronal, hormonal, and nutrient-related si...

An Answer To Obesity: Weight Control Protein

...Our findings reveal SH2-B as an important positive regulator of leptin sensitivity inside cells of the brain region known as the hypothalamus," said senior author of the study, Liangyou Rui. The hypothalamus is a key area in the central nervous system that integrates neuronal, hormonal, and nutrient-related si...

Sugar Helps Control Cell Division

...t a deceptively simple sugar is in fact a critical regulator of cells' natural life cycle.// The discovery reveals that, when disturbed, this process could contribute to cancer or other diseases by failing to properly control the steps and timing of cell division, the researchers say. The sugar, known as O-...

A Component In Milk May Help Control Inflammatory Diseases

...group of fatty acids found in milk, //is a natural regulator of the COX-2 protein, which plays a significant role in inflammatory disease such as arthritis and cancer, according to a study published by University of Wisconsin-Madison researchers. "It's clear from previous research that conjugated linoleic aci...

Food Habits Could Change Your Genes

...hanges. We think diet may have a role to play as a regulator in genes. "Ultimately one would want to chose diets that would give you the most beneficial pattern of DNA methylation in the gut. But it is too early to say that we know the dietary strategy to do that. "Genes regulate all the processes in the b...

A Step Towards Unraveling The Schizophrenia And Depression Mystery

..., researchers have discovered that DISC1 acts as a regulator for PDE4B, creating a 'pathway' between the two genes. "It is now clear that the DISC1 gene plays an important role in the risk of developing schizophrenia or bipolar affective disorder. The new genetic link we have made to PDE4B and how that links...

US Regulator Sees No Link Between Tamiflu And Japan Deaths

...fects, reports AFP. But the powerful US medicines regulator found unanimously that there was no 'causal link between pediatric deaths and neuropsychiatric adverse events and Tamiflu,' an FDA statement said after a hearing of its paediatric safety panel. Roche said it 'intends to work with the FDA to change t...

Scientists Identify Gene Responsible For Depression

...n called p11, a protein previously identified as a regulator of the localization of several proteins on the cell's surface. They analyzed tissue from a mouse model of depression as well as post-mortem tissue from depressed human patients, and found decreased levels of p11 protein in both cases. On the other...

Helicobacter pylori effectively killed by Sodium nitrite

...lled the cystic fibrosis transmembrane conductance regulator (CFTR). Affecting the airways and many other vital organs and processes, cystic fibrosis is chronic, progressive and ultimately fatal, mostly as a result of respiratory failure. The good news is that Dr. Hassett and his colleagues found that about...

A breather for worried parents: rules laid down for junk food child ads

...les to govern child ads for junk foods. This media regulator has ruled out a total TV advertising ban, but is launching// a 10-week consultation on guidelines restricting the adverts. This follows government’s White Paper on public health which said children should not be encouraged to eat too many foods hig...

FDA Warns VaxGen On Anthrax Vaccine

...ade on the basis of only a handful of studies. The regulator also threatened legal action against the company unless it stops "disseminate truthful, non-misleading, and complete information" about the vaccine. Paul Laland, a VaxGen spokesman, said, "Based on our internal assessment and research of industry st...

Say no to smoking: passive smokers may develop diabetes

...d affect the pancreas, which makes the blood sugar regulator insulin. Professor Thomas Houston of the Birmingham Veterans Affairs Medical Centre in Alabama led the researchers and divided their subjects into smokers, former smokers, passive smokers and those never exposed to smoke. Thereafter, subjects were t...

The ABC Of Photoreceptors In The Eye

...tudy also looked at the role played by of the gene regulator NRL. This particular substance was known to be vital for the development of rods, which are the light-sensing elements in retina. The details of the study appear in the March 7 issue of the Proceedings of the National Academy of Sciences (PNAS). Ana...

Experts From India, US To Discuss On Bioethics In Research

...uirements by Indian and international research and regulator agencies, a US Embassy statement said here today. "Research on human volunteers to evaluate and eventually licence products for prevention, treatment or management of disease has become an area of intense interest in India and around the world. T...

Research Identifies Osteoporosis Controlling Protein

...s Runx2, a transcription factor that is the master regulator of osteoblast differentiation, which activates key bone formation genes. By removing Shn3 or WWP1, Runx2 doesnt degrade, which leads to increased bone mass. The authors believe that targeting Shn3 and WWP1 for drug discovery is an exciting prospect...

Serotonin the Answer for Anti-Obesity Treatment

... Neuron, also reinforces the role of serotonin – a regulator of emotions, mood and sleep – in affecting the brain's melanocortin system, a key molecular pathway that controls body weight. "The more we understand about the pathways and the way serotonergic drugs regulate body weight, the more it one day might l...

Study Shows Tomosyn Plays an Important Role in Learning and Memory

...aid Richmond. ‘This suggests tomosyn is a negative regulator of release. In other words, it dampens down the system, regulating the efficiency and strength of the synapse.’ Because the nematode C. elegans uses proteins in its nervous system comparable to those in humans, Richmond suspects that forthcoming expe...

Role Of MicroRNAs In Angiogenesis Researched

...eamed up with Dang to identify MYC as an important regulator of microRNAs. The new collaboration between the Thomas-Tikhonenko and Mendell laboratories identified a missing link between MYC and thrombospondin, which indeed turned out to be a microRNA cluster designated miR-17-92. In the key experiment the rese...

Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified

... protein cystic fibrosis transmembrane conductance regulator (CFTR). People with cystic fibrosis do not have enough CFTR for their cells to work normally because their bodies quickly destroy the mutant protein. "Most cases of CF are caused by the inability of faulty CFTR to get in the correct shape, which l...

Model of Internal Clocks Reveals How Jet Lag Disrupts the System

... have to conquer—and our clock is a very important regulator at a basic level— medications to target the clock may be counter-productive if they affect future oscillatory behavior,” she says. “Instead, take a stopover if you are traveling for more than 6 hours—relax for a day and then continue. Understand and ...

Discrepancy in salt content on food labels

... decrease of iodised salt intake. Transtasman food regulator Food Standards Australia New Zealand intends to require iodised salt to be used in baked cereal products. Responding to the test results, Green Party spokeswoman Sue Kedgley said: "Look, if it was 2 per cent over, who would care? But 50 per cent ...

Parents Support Junk Food Ad Ban

...es to eat unhealthy foods." The UK communications regulator Ofcom is holding a consultation on the proposal and is due to make an announcement in autumn. A spokesman revealed that if Ofcom passes the regulations, they would come into effect early next year. "We are going through all the consultation responses...

New Tool for Understanding Estrogen-Fueled Breast Cancer

...erated by the cells' estrogen receptor, the master regulator of cell growth in the most common form of breast cancer. The map, which includes thousands of such control regions, provides scientists with a new tool for understanding how genes are regulated, and may eventually help doctors match patients with tre...

Scientists Make World Breakthrough

... a chaperone protein called BiP, which is a master regulator of ER function. Disrupting this crucially important chaperone has inevitably fatal consequences for a wide range of cell types.” As well as learning how the toxin works, the scientists have also determined its three-dimensional structure, which wil...

‘Aricept’ drug gives an Alzheimer’s patient reason to smle

...xtend the reach of Alzheimer’s drugs, the NHS drug regulator has disallowed// the use of the drug during the preliminary stages of the disease. When John, aged 77, showed initial symptoms of Alzheimer’s, doctors had recommended the benefit of one of the controversial drugs, ‘Aricept’ in retarding the advance...

Flaws Reported in overview of US organ transplants

...ter in Las Vegas, but four years passed before the regulator performed its own inspection. Besides this the organization demonstrated a failure to investigate health maintenance organization Kaiser Permanente's new kidney program in San Francisco, in spite of the fact that statistics showed twice as many pat...

Key Gene Controlling Eye Lens Development Identified

...tly activating Pax6, a gene considered the “master regulator of eye development.” In the absence of Six3, Pax6 fails to coordinate the activity of a series of additional genes that cooperate to form the lens. A report on this work appears in the prepublication online issue of The EMBO Journal. Previously, th...

Effect Of Growth Factor Signals On Cancer Development

...lly produced human growth hormone, it is the major regulator of body growth during childhood. These hormones continue to have important health effects during adulthood, after growth is done. IGF-I is also of considerable interest to cancer researchers, because of mounting evidence that high levels of the pro...

How Blood Flow Dictates Gene Expression

...Now that Klf2 has been established as an important regulator of blood flow in live animals and is required for the development of a healthy cardiovascular system, the next step is to elucidate the role of Klf2 in normal adult blood vessels and in the pathogenesis of vascular diseases, such as atherosclerosis. ...

New Iron Regulation Discovery by Children's Hospital

...dimensional shapes when it combines with a protein regulator called IRP1. This discovery is incredibly important to researchers who design medications based on the specific characteristics of a disease. The study, featured in the December issue of Science, contains some significant surprises about the struct...

President Bush's AIDS-Fighting Program Fraught With Inconsistencies

...light by the audit. Joe Farinella, a well placed regulator at the U.S. Agency for International Development said, "It's not good enough for the auditors to hear from the mission that we did A, B and C but we can't prove it to you, or there's no documentation to prove that we did it." While accepting the mi...

Estrogen Curbs Appetite: Research

... According to their report, estrogen is a strong regulator of energy metabolism through the brain. They show that while the pathway of estrogen-induced intracellular signaling merges with that of leptin, estrogen's effect on feeding and obesity is independent from leptin or the leptin receptor. "Impaired e...

Estrogen Curbs Appetite In Same Way as the Hormone Leptin

... According to their report, estrogen is a strong regulator of energy metabolism through the brain. They show that while the pathway of estrogen-induced intracellular signaling merges with that of leptin, estrogen’s effect on feeding and obesity is independent from leptin or the leptin receptor. “Impaired ...

Much Room for Cancer Cure in a Mushroom, Scientists Promise

...nd of the year. There is no obvious reason for the regulator to say no - there are no side-effects - so it is just a matter of time as to when we go ahead with the trials...

Understanding Autoimmune Disease

...T cells are themselves controlled by a master gene regulator called Foxp3. Master gene regulators bind to specific genes and control their level of activity, which in turn affects the behavior of cells. In fact, when Foxp3 stops functioning, the body can no longer produce working regulatory T cells. When this ...

'Gateway' Gene Discovered for Brain Cancer

Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain de...t 'our findings identify this core transcriptional regulator as an important candidate for antitumor therapeutics.' While transcription factors are not generally...

Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism

...our experiments suggest that Dap1 acts as a common regulator of cytochrome P450s in mammals,” says Espenshade. Because Dap1 affects one particular P450 responsible for drug metabolism, Espenshade suspects that genetic variations in the genetic blueprint coding for Dap1 may provide clues to how and why diffe...

Women Will Be Paid to Donate Eggs for Science

...ty and Embryology Authority (HFEA), the government regulator of this highly sensitive area, is expected to approve the policy when it meets on Wednesday. At present, clinics are not allowed to accept eggs donated for scientific research unless they are a byproduct of either IVF treatment or sterilisation. Camp...

E.U. Panel Backs Novartis' Mock-up Pandemic Flu Vaccine

Europe's main medical regulator said it has adopted a positive opinion recommending the granting of a marketing authorization for Focetria, from Novartis //AG (NVS) Vaccines and Diagnostics unit. Focetria is a mock-up pandemic influenza vaccine, intended for the prevention of in...

Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down

...he researchers then looked at miRNA let-7, a known regulator of the Ras oncogene, and likewise found that high levels of this miRNA were associated with low Ras activity. They established a cause and effect relationship as before, by adding additional let-7 to untreated leukemia cells. “Overall,” Garzon ...

Excessive RAMP1 Protein may Cause Migraines

.... "We have shown that this RAMP protein is a key regulator for the action of CGRP," said Andrew Russo, Ph.D., UI professor of molecular physiology and biophysics. "Our study suggests that people who get migraines may have higher levels of RAMP1 than people who don't get migraines." RAMP1 is a normal, requi...

Lactococcus Strain may Offer End to Food Allergies

...i-inflammatory interleukin-10 (IL-10), a potential regulator for food tolerance. Writing in the Journal of Allergy and Clinical Immunology, Frossard reports that oral administration of this non-pathogenic strain effectively reduced food-induced anaphylaxis (severe allergic response) in mice and suppressed the...

'Pan'demonium Over Non -stick Pans

Sydney: An Australian regulator of industrial chemicals has suggested that we may not be able to stomach what pans out following the prolonged use of non-stick frying// pans and baking trays; intake of harmful toxins present in non-stick cookware, could penetrate into our system ca...

EU Considers Allowing Cloned Meat, Milk on Market

...ning for food production later this year. The US regulator has issued a consultation proposing to allow the product into the food chain without the need for labelling. An independent study in the US indicates that 60 per cent of Americans would not knowingly eat cloned meat. A 2002 EU survey found that Eur...

A Novel Treatment for KSHV-infected Lymphomas

...n targets the interaction of p53 with its negative regulator MDM2. This is based on a potent and selective small-molecule inhibitor of the p53–MDM2 interaction, the Nutlin-3a, originally discovered by Dr Lyubomir T Vassilev (Roche Research Center, Nutley, NJ., USA). Nutlin-3a has been suggested to be a potenti...

FDA Cites Challenges of Generic Biotech

A top drug regulator told lawmakers Monday it could be a decade or more before science is available to safely approve generic versions of biotech drugs // in the way the agency approves knockoffs of traditional drugs. Food and Drug Administration deputy commissioner Ja...

Master Regulatory Gene of Epithelial Stem Cells Identified

...reast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells. The findings also have implications for cancers of the s...

China Admits Fake Blood Protein Used in Drips

...y milk. Last month the country's top food and drug regulator was sentenced to death for taking bribes to approve medicines not properly tested for safety. And tainted Chinese toothpaste has been blamed for dozens of deaths in Panama. Anti-malarial drugs and pet food have also been found to contain contamina...

Blood Test may Help Signal Tumor's Remission, Return in Throat Cancer Patients

...cytokines is controlled by the same master switcha regulator protein known as nuclear factor kappa B (NF-kappaB)the researchers suggest that this protein may represent a new target for drug therapy. Drugs that help turn off NF-kappaB are currently being tested in clinical trials at NIH and elsewhere. The res...

Brain Inflammation A Friend for Alzheimer's Patients

...ester Medical Center shows that a key inflammatory regulator , a known villain when it comes to parsing out damage after a stroke and other brain injuries, seems to do the opposite in Alzheimers disease, protecting the brain and helping get rid of clumps of material known as plaques that are a hallmark of the ...

Global Heartbeat Control Suggests Therapy for Beating Heart Failure

...ptor known as ERR was known to scientists as a key regulator in the production of cellular power plants called mitochondria, the researchers explained. But whether ERR or related ERR receptors play a broader role in cardiac energetics and function remained an open question. These receptors are considered "orph...

Diabetes Drug Dramatically Boosts Potency of Platinum Chemotherapy

... a transcription factor that functions as a master regulator of fat development in the body, a function discovered in the Spiegelman lab in 1994. Spiegelman and others observed that certain PPAR-gamma-activating compounds, called PPAR-gamma ligands, caused cancer cells to stop growing and become more mature, o...

Master Regulatory Gene of Epithelial Stem Cells Identified

...reast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells. The findings also have implications for cancers of the s...

UK Doctors Demand Overhauling of Fertility Regulatory Authority

... High Court in London has ruled that the fertility regulator had unlawfully obtained warrants to search a clini...nt of Health to conduct a full investigation. "The regulator needs to be accountable, and to maintain the trust and confidence of the sector," said BFS chairman ...

New Genetic Studies Carried Out in Cancer Therapy

... Ceramide metabolism was identified as a critical regulator of sensitivity to a wide range of chemotherapeutic drugs. Although ceramide has been associated with apoptosis for some time, the mechanisms have not been well understood. In this study, decreased expression of a ceramide transport protein, COL4A3B...

EU Drug Regulator Highlights Depression Danger of Weight-loss Pill

The European drug regulator EMEA said Thursday it had maintained authorisation of weight-loss pill Acomplia in the European Union, but had ordered it to be withheld from people suffering from depression. A panel of experts from the US Food and Drug Administration concluded i...