Receptor in Medical News

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

... injectable gonadotropin-releasing hormone (GnRH) receptor antagonist indicated for patients with advanced ... injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug ... the treatment of advanced prostate cancer. As a receptor antagonist, FIRMAGON reversibly binds to the GnRH ...

Advanced targeted therapies effective as first-line treatment for lung cancer

... OUTCOMES OF PATIENTS WITH EPIDERMAL GROWTH FACTOR receptor (EGFR) MUTATIONS IN IPASS (IRESSATM PAN ASIA ... (ABSTRACT # B9.5) An epidermal growth factor receptor (EGFR) is a protein found on the surface of cells ... a protein called the epidermal growth factor receptor (EGFR). EGFR, which helps cells divide, is found ...

QuatRx Announces Further Positive Phase 3 Results For Ophena(TM) (Ospemifene Tablets) in Postmenopausal Vaginal Atrophy

... for Ophena(TM) , a new SERM (selective estrogen receptor modulator) for the treatment of the symptoms of ... program. Fispemifene is a new selective estrogen receptor antagonist that is in Phase 2 studies as an oral ... in men. Sobetirome, a novel, selective thyroid receptor beta agonist, is in Phase 1 as a potential ...

Colon capsule endoscopy diagnoses 64 percent of total polyps detected by conventional colonoscopy

... images per second. The pictures are recorded by a receptor which enables them to be downloaded subsequently ... passing through the intestine are recorded in the receptor which has to be attached to the patient that same ... That evening the person being examined takes the receptor to the medical services who download the images ...

Eliminating Cell Receptor Prevents Infections in Animal Study

... mice genetically engineered to lack a particular receptor in heart and pancreas cells, the study team ... process. In this case, we confirmed that this receptor really is involved in the disease." The ... , focused on the coxsackievirus and adenovirus receptor (CAR), which Bergelson discovered in 1997. He ...

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

... antiplatelet drug elinogrel, a P2Y(12) ADP receptor antagonist currently in Phase II clinical ... & Co., Inc., and elinogrel, its P2Y(12) ADP receptor antagonist and potential competitor for Plavix* ... cancer and inflammatory diseases; a thromboxane receptor antagonist, which is an aspirin replacement ...

JNCI news brief: Breast cancer hormone receptor status and risk of a second primary tumor

... Women with hormone receptor (HR) negative first tumors have twice as much ... to analyze whether a first tumor's estrogen receptor and progesterone receptor content and the age or race of the woman has ...

Variants of 'umami' taste receptor contribute to our individualized flavor worlds

... Monell Center confirm that the T1R1-T1R3 taste receptor plays a role in human umami (amino acid) taste. ... that variations in the genes that code for this receptor correspond to individual variation in sensitivity ... that combine to form the G-protein coupled receptor T1R1-T1R3. Comparing DNA structure to the ...

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

... NBI-56418), of the gonadotropin-releasing hormone receptor into clinical studies. Elagolix, the most ... antagonist of the corticotrophin-releasing factor receptor as the first-in-class compound advanced into ... agonists and antagonists for the melanocortin-4 receptor for eating disorders. Dr. Chen has ...

Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer

... required the activation of a latent adhesion receptor (known as integrin 51). ... cancer because this newly appreciated estrogen receptor is not promoting estrogen-dependent growth but ... that GPR30 represents yet another estrogen receptor with biological significance for breast cancer ...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

... making them more likely to bind to the IGF-1 receptor which is known to be involved in promoting tumor ... insulin analogs have been tested for IGF-1 receptor binding in the early research phase and only ... for further development(3). Studies on receptor binding and cell growth together show that ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry therefore ... a novel adenoviral vector that binds to the EphA2 receptor (EphA2R). This receptor is highly expressed in several solid tumors ...

Defeating nicotine's double role in lung cancer

... this finding may be due to the reduced number of receptor binding sites on normal cells as opposed to ... that cancer cells with the greatest number of receptor binding sites seemed to respond with the greatest ... nicotine may promote lung cancer yet nicotine receptor antagonists may offer treatment options for ...

World first: Chinese scientists create pig stem cells

... because the swine flu virus needs to bind with a receptor on the cell membrane of the pig to enter the cells and proliferate, we could knock out this receptor in the pig via gene targeting in the pig induced pluripotent stem cell. If the receptor is missing, the virus will not infect the pig." ...

Powerful Antacids Raise Chances of Fracture

... called proton pump inhibitors and histamine-2 receptor antagonists relieve stomach acid, but also appear ... Prevacid and Nexium, while common histamine-2 receptor antagonists include Pepcid, Tagamet and Zantac. ... had a fracture if they were taking histamine-2 receptor antagonists, Corley found. People taking less ...

Aragon Pharmaceuticals Announces $8 Million Series A Financing

... through the creation of a new class of nuclear receptor targeting drugs, thereby opening the door to a ... and Development, who has worked in the nuclear receptor drug discovery field for 20 years and brought ... resistance by creating a new approach to hormone receptor therapy." "Aragon will build off the work ...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

... "It is clear that signaling by the androgen receptor is paramount for not only the initiation but also ... halt the potentially deadly increase in androgen receptor expression, the MCG research team has found. ... they found a reciprocal relationship: androgen receptor expression is low when βarrestin2 expression ...

Amgen Highlights Data to Be Presented at ASCO

... (AMG 655), a molecule designed to target death receptor 5 (DR5) to induce apoptosis selectively in cancer ... antagonist of type 1 insulin-like growth factor receptor (IGF-1R) Lead Author: McCaffery I ... of patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal carcinoma ...

Video: FDA approves Exforge HCT(R) - the Only High Blood Pressure Treatment to Combine Three Medications in a Single Pill

... a proven calcium channel blocker, angiotensin receptor blocker and diuretic (amlodipine, valsartan, ... prescribed calcium channel blocker, angiotensin receptor blocker, and diuretic in one pill, and is an ... classes: calcium channel blockers, angiotensin receptor blockers, and diuretics. The full blood pressure ...

Fixed Dosed Combination Agents and Novel Antihypertensives Are Expected to Face Tougher Formulary Restrictions

... Future Shifts in Tier Placement of Angiotensin II receptor Antagonists, Single Pill Fixed-Dose Combinations ... plans placing step restrictions on angiotensin II receptor antagonists is relatively stable, a growing ... Future Shifts in Tier Placement of Angiotensin II receptor Antagonists, Single Pill Fixed-Dose Combinations ...

New target for maintaining healthy blood pressure discovered

... and colleagues discovered that mice that lack the receptor for one type of prostaglandin have lower blood ... of Sciences . "Blocking this prostaglandin receptor may provide a strategy for controlling blood ... mutation in the low-density lipoprotein receptor gene. These manipulations effectively rendered ...

Researchers find drug that inhibits acute leukemia cell growth

... Center have discovered how to turn off a certain receptor that promotes the growth of leukemia cells. The ... (ASPHO). "There is a certain receptor we now know is expressed in acute myeloid leukemia (AML) cells called Tropomyosin receptor Kinase A (TRKA)," said Mauricio Ghisoli, M.D., ...

Colon cancer shuts down receptor that could shut it down

... discovered a reason why: roughage activates a receptor with cancer-killing potential. Researchers ... April issue of Cancer Research that the GPR109A receptor is activated by butyrate, a metabolite produced by fiber-eating bacteria in the colon. The receptor puts a double-whammy on cancer by sending signals ...

Drug shows activity in men with advanced prostate cancer

... cells have increased expression of the androgen receptor and that overexpression of this receptor may contribute to the progression of disease. ... tested various compounds to block the androgen receptor in CRPC cells. They chose to further evaluate the ...

Prune juice not necessary: New research should make bowel movements easier

... causes the bowels to pass waste, and the specific receptor needed to activate bowel clearance. Furthermore, ... of new laxatives. "We hope that the receptor identified by our study would be exploited more ... two groups of mice, focusing on a type of receptor also present on human nerves in the gut (a type ...

Team Regrows Neurons Controlling Movement in Rats

... The cells were re-programmed to produce a receptor for the growth factor. The genetically ... engineering only allowed the growth factor receptor to go part way down the axon. That's what we're ... on now -- trying to get the cell to send the receptor down all the way into the spinal cord," he said. ...

Cellular target may prove useful in treating deadly brain tumors

... Duke University researchers have identified a receptor on the surface of cells that may give them ... deadly type of brain cancer. The neurokinin 1 receptor (NK1R), which may be expressed in all human ... The researchers examined stimulation of the receptor NK1R in human glioblastoma cells growing in a ...

Astellas Launches Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia

... Arginine vasopressin (AVP) receptor antagonist now available in new premixed ... Astellas, Vaprisol, an arginine vasopressin (AVP) receptor antagonist, is the first and only approved drug ... with hyponatremia. Vaprisol is the first AVP receptor antagonist with a demonstrated safety profile and ...

EnVivo and Mitsubishi Tanabe Enter License Agreement on EVP-6124 in Japan, Korea, Taiwan and Other Asian Countries

... is EnVivo's novel alpha-7 nicotinic acetylcholine receptor agonist currently in development for cognition ... EnVivo's alpha-7 nicotinic acetylcholine receptor agonists such as EVP-6124 in Japan, Korea, ... product is an alpha-7 nicotinic acetylcholine receptor agonist and is being tested in Phase 2a clinical ...

Arena Pharmaceuticals Announces Positive Lorcaserin Pivotal Phase 3 Obesity Trial Results: Meets All Primary Efficacy and Safety Endpoints

... first in a new class of selective serotonin 2C receptor agonists. The serotonin 2C receptor is located in areas of the brain involved in the ... such as the hypothalamus. Stimulation of this receptor is strongly associated with feeding behavior and ...

Medivation Receives FDA Permission to Initiate Phase 3 Trial of MDV3100 in Castration-Resistant Prostate Cancer

... Phase 3 trial of MDV3100, its novel androgen receptor antagonist, in patients with metastatic ... prognosis. Overexpression of the androgen receptor is believed to contribute to the progression of ... MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits ...

JCI online early table of contents: March 9, 2009

... the urogenital system in mice and identified two receptor protein tyrosine phosphatases (RPTPs), types S ... connection in mice is controlled by LAR-family receptor protein tyrosine phosphatases AUTHOR CONTACT: ... that a membrane-anchored form of the urokinase receptor known as MuPAR is present on a subset of HSPCs ...

Ferring Pharmaceuticals Announces Immediate Availability of Degarelix for the Treatment of Advanced Prostate Cancer

... injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug ... cancer can be treated with a direct-acting GnRH receptor antagonist inducing rapid reduction of ... injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved by the U.S. Food and Drug ...

Vitamin A signals offer clues to treating autoimmunity

... against many infectious agents since the calming receptor is known to respond to bacteria and viruses as ... The calming receptor, known as TLR2 (Toll-like receptor 2), uses vitamin A to transmit its signals, which ... need TLR2, since zymosan also activates another receptor called dectin-1, which sends out stimulatory ...

Researchers identify potential therapeutic target in osteosarcoma

... HOUSTON-A receptor known to be active in bone metastases, but ... found that the protein - interleukin-11 receptor alpha (IL-11Ra) - is highly expressed in primary ... directly to osteosarcoma cells by targeting the receptor with circulating particles that display a peptide ...

Chili Pepper Compound Can Bring Pain Relief

... receptors that sense both pain and heat. "The receptor acts like a gate to the neurons. When stimulated ... letting outside calcium enter the cells until the receptor shuts down, a process called desensitization," ... detect pain signal. "In other words, the receptor had not desensitized per se, but its ...

Technique May Let More Women Use Tamoxifen

... between cells that didn't express the estrogen receptor and a loss of expression of Wnt-5a, a key ... to a theory that Wnt-5a might regulate estrogen receptor levels and, in fact, this seemed to be the case. ... Wnt-5a signaling resulted in higher estrogen receptor levels in estrogen receptor-negative cells. ...

Arena Pharmaceuticals Announces Initiation by Merck of Phase 2 Clinical Trial of Niacin Receptor Agonist

... 2 clinical trial of an orally administered niacin receptor agonist drug candidate being developed by Merck ... to treat atherosclerosis. Agonists of the niacin receptor have the potential to regulate plasma lipid ... as well as potential efficacy, of the niacin receptor agonist in patients with dyslipidemia. "We ...

Shionogi Announces Positive Top-Line Efficacy Results from Year-Long Studies of Velneperit, a Novel NPY Y5 Receptor Antagonist Being Investigated for the Treatment of Obesity

... of velneperit, a novel neuropeptide Y (NPY) Y5 receptor antagonist also known as S-2367, each met their ... further demonstrate the potential for the NPY Y5 receptor as a target for obesity treatment. Shionogi ... of velneperit involves blocking the Y5 binding receptor for neuropeptide Y (NPY), a centrally acting ...

New test may help to ensure that dengue vaccines do no harm

... viral surface and escort the virus via the Fc/Fc receptor link to macrophages where the virus is destroyed. ... itself. In this scenario, the antibody's Fc/Fc receptor interaction has served only to deliver the virus ... a gene that directs for the building of an FC receptor on their surfaces. They also constructed a CV-1 ...