proliferation

UV Radiation induces Melanoma

...osure to sunlight." It is feared that this rapid proliferation increases the chance that DNA damaged cells will reproduce and take hold, producing a tumour. Melanoma accounts for roughly 10% of reported cases of skin cancer and can spread rapidly throughout the body, forming secondary tumours in the liver, lungs...

Combination therapy to treat breast cancer

...that they interact with one another to ensure cell proliferation and survival. Trastuzumab and ZD1839 have been spe...king together, trastuzumab and ZD1839 reduced cell proliferation by 70 per cent. The findings suggest that simultaneous inhibition of the action of both growth fact...

New treatment for Rheumatoid Arthritis

...ients with rheumatoid arthritis (RA), in which the proliferation of new blood vessels plays an important role in the disease. Researchers in United States believe if endostatin can inhibit angiogenesis in cancer patients, it should be considered as a treatment therapy for RA as well. In a new study, researchers ...

Missing Protein In Cancer Development

... many human tumors have too many centrosomes. This proliferation of centrosomes may be key in the progression of breast, prostate and colon tumors. However there are other factors involved in this process. What is identified an just an regulator....

New Hair in 15 Days Could Now Be A Possibility Say Researchers

... cells, triggering a highly coordinated program of proliferation followed by expansion into the multiple differentiated cell types that comprise the mature, growing hair follicle. In contrast to the effects of transient and regulated beta-catenin activation, prolonged activation of ?-catenin leads to uncontrolled ...

Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids

...e range of functions including cell communication, proliferation and development as well as the metabolism of proteins, nucleic acids and carbohydrates. Studies in the past have identified only three of the 124 genes to be linked with ALL resistance. Thus researchers say the genes uncovered in their recent study ...

Artificially made protein to inhibit angiogenesis

...n cancer called melanoma, reduced the blood vessel proliferation by up to two third of its growth. The protein is all set to stop vascular endothelial growth factor (VEGF) where it is produced. The new protein with its amino acid tail will stop the VEGF from leaving the site of production inside the cell, thereby ...

Virus that does not cause disease can kill cancer cells

...known to suppress cancer by decreasing cancer cell proliferation rates and arresting the growth of the cancer cells. Reference: Penn State University, news release, June 2005...

Understanding Chronic Infections May Help in Developing Therapeutic Vaccines

...ic vaccination, or a cytokine that might boost the proliferation or survival of responding cells. While Wherry's primary interest is in chronic infection, he notes that research in this area should inform the design of better therapeutic cancer vaccines as well because many of the deficiencies in immune response a...

The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs

...with new strategies// and technologies to curb the proliferation of counterfeit drugs in the market. Deputy direc...s are trying to bring in novel features to prevent proliferation of duplicated drugs with new package designs such as child resistant closure and tamper evidence pac...

Compounds Found In The Vegetable Broccoli Could Have Anti-Cancer Properties

...wth of cancer cells. The isothiocyanates decreased proliferation in all three-cell lines. The strongest effect was on the most aggressive of these lines – human invasive transitional cell carcinoma. The glucosinolates had no such effect, hence researchers are now investigating the mechanism for this anti-cancer ...

Chocolate To Combat Cancer: So Indulge!

...ting and deactivating the proteins involved in the proliferation of malignant cells (vol. 4, no. 4, pp. 537-46).Biting into the bar of chocolates is anyone’s delight. Chocolate with its various forms is a darling of one and all. Some time back lot of talk was towards its health harms, but today lot of research pro...

Encephalitis Death Toll In U.P. Crosses 200 Mark.

..."Yes, we had decided to launch a drive against the proliferation of pigs in residential areas; but then local legislators have come in the way to pressurise the administration to defer its plan," a district official told on condition of anonymity. "Who doesn't know that the presence of pigs is a major source of ...

Role Of Estrogen In Breast-Cancer

...the levels of N-CoR, it can promote the associated proliferation and progression of breast cancer, as the balance of co-activators and co-repressors involved in normal gene transcription is altered. The findings may have sweeping implications. For one, the mechanisms at play could explain at least some of the mi...

Pigs Population A Major Threat To Encephalitis Ravaged UP

...ed to be at the root of the virtual epidemic. The proliferation of pigs has made matters // worse as the animal is known to be the biggest host for the encephalitis virus, carried across to human beings by mosquitoes. Uttar Pradesh officials do not even have any official statistics on pigs or piggeries. "They c...

Novel protein found to enhance effect of Vitamin E and suppress prostate cancer

...nces the retention of Vitamin E // that limits the proliferation of cancer cells. The researchers of the present study are the first to describe the role of a protein known as alpha tocopherol associated protein or TAP in prostate cancer. Expression levels of TAP are significantly lower in prostate cancer than i...

Study Offers Insights Into Treatment Of Rheumatoid Arthritis

...amed lymph node. Two proteins, known as APRIL (A proliferation inducing ligand) and BlyS (B-lymphocyte stimulator) that are hypothesized to help B-lymphocytes survive and differentiate are the targets of new experimental drugs currently in early phase clinical trials. The researchers implanted human tissue fro...

Chronic Myelogenous Leukemia (CML) Has An Answer Now!

...veloped resistance to the drug. In these patients, proliferation of white blood cells continues, leading the disease to the final (acute stage) called the blast crisis, where immature white blood cells infiltrate the blood and bone marrow. Clinicians know the signs and symptoms of the different stages of CML, but...

Link Between Hepatitis C And Liver Cancer Unraveled By Scientists

...king out this ‘tumor suppressor’ and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer”, according to Dr. Stanley M. Lemon, senior author of the paper. Nearly 85% of liver cancers in the United States occur in Hepatitis C affected individuals. In addition, a more t...

Molecular Flaw Detected in Aggressive Breast Cancers

...s is a "growth switch", which unleashes a virulent proliferation of cancer cells. "The development of cancer drugs like Gleevec and Iressa have shown that it is possible to block the action of kinases," said Sicinski, "so we hope that these findings will stimulate interest in developing drugs to block CDK4 as a ta...

Combination growth factors for Stem cell proliferation

...ination growth factors have been very effective in proliferation in the laboratory conditions the researchers have to see the effect of this proliferation in humans. The result of the work has been published in the Journal Nature Medicine....

Effectiveness Of Drug-Releasing Coronary Stents

...ntimal [a new layer of cells on the inner surface] proliferation suppression to translate into significantly different rates of binary restenosis or adverse clinical events,” the authors suggested. ...

Women With Fewer Periods Have Low Risk Of Gynecological Cancer

...onth, which means a greater chance of error in the proliferation process of abnormal cells,' he says. In our society, girls menstruate earlier and women have more periods before giving birth. Women from traditional societies however breastfeed for extended times, often conceive soon after their menses return, ...

Ovarian Cancer Research Faces Funds Crunch

...nd participants in an effort to raise $50,000. The proliferation of such events and of the selling of colored ribbons (silver for ovarian cancer) point to the urgent need to make up the serious shortfall in government and philanthropic funding for cancer research. Though Australian scientists are leading the wor...

Mouse Models To Determine The Cause Of Aggressive Leukemia

...7. It is produced in the bone marrow enhancing the proliferation of cultured leukemic cells removed from the mice and made the cells resistant to imatinib’s growth inhibitory effects. It binds to receptors on the surface of lymphocytes, which triggers the activity of the JAK kinases. This later stimulates cell gro...

PI-103 Effective against Brain Cancer

...o be a safe and effective inhibitor of cancer cell proliferation in mice with the human tumors, the scientists found. The glioma research is being published online May 15 by the journal Cancer Cell. A description of the strategy used to identify the molecular level action of the inhibitors was published online ...

New Research May Be Useful for Developing Drugs for HIV and Cancer

...paper, the HIV NCp7 protein is responsible for the proliferation of the HIV virus. If researchers can inhibit the action of this zinc finger protein, they can stop the spread of the virus. 'When we target specific viruses with drugs, over time patients can become resistant to treatment and the drug becomes ineff...

Green Tea Reduces the Risk of Cardiovascular Disease and Cancer

...atelet aggregation, regulates lipids, and promotes proliferation and migration of smooth muscle cells, which are all factors in reducing cardiovascular disease, he said. Sumpio said other reports show that EGCG prevents growth of certain tumors. Tea, according to studies, also can improve gastrointestinal functi...

Functional Differences In Estrogen Receptor Could Be A Therapeutic Target

...trogens and anti-estrogens can both stimulate cell proliferation through membrane-associated hER-?36. 'By identifying and cloning a novel form of the human estrogen receptor, our studies suggest that hER-?36 may have a greater potential to signal estrogen stimulated membrane responses than hER-a66,' Deuel said. ...

Hantavirus Scare Grips U.S

...n field days for the scurrying mouse. Infact mouse proliferation has been on the rise, //and citizens fear the deadly Hantavirus, fallout of poor hygiene in mice habitats. Some of the initial symptoms of Hantavirus pulmonary syndrome could be fever, muscle aches, nausea, cough and abdominal pain, which surface o...

Repeated Liver Cell Proliferation, a Cause for Liver Cancer

...to cell death; if activated briefly, it stimulates proliferation of pre-malignant and cancerous tumor cells," said ...se to liver injury, as well as what stimulates the proliferation of surviving hepatocytes," said Karin. "Since we previously knew that JNK activity is required for n...

Pomegranate Juice Remedy for Prostate Cancer

... they started drinking pomegranate juice. The cell proliferation rate in these patients decreased by 12 %. On the whole pomegranate juice has other good qualities such as anti-inflammatory effects and high levels of antioxidants. Dr Hiley added that further research would give us an idea about the uses and the wi...

Menin Gene Mutation made Insulin Secreting Cells to Proliferate

...proliferation-suppressing function resulted in the proliferation of pancreatic islet cells, which again affected bl... develop mostly benign tumors or hyperplasia (over proliferation of cells) in several endocrine organs, such as parathyroids and pancreatic islet cells. Normally, th...

Significant Advance in Treatment of Breast Cancer Reported

...r cells. "This important study suggests that the proliferation and survival of breast tumor cells from one third of the patients in our study depended on proteins that were activated by farnesyltransferase," said Dr. Said Sebti, coauthor of the study and associate director of the Moffitt Research Institute in Ta...

BJP Seeks Tougher Laws Against Pre-Natal Sex Tests

...id both men and women were equally responsible for proliferation of female foeticide in the country. "Parents who kill their unborn babies because of their gender and doctors who assist them in such acts should be treated as murderers. There should be tougher laws against both pre-natal sex detection and female f...

Stem cells help in the understanding of drug-resistant, recurrent tumors

...s potential to maintain the ability to inhibit the proliferation of these cells, MIS may play a role in these new therapeutic approaches," Donahoe says. "We intend to keep searching for stem-like cells in patient tumor samples and to study their responsiveness to both chemotherapeutic agents and to novel agents sp...

"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart

... overactive BCR-ABL, in turn, drives the excessive proliferation of white blood cells that is the hallmark of CML. According to Dr. Force, 10 patients taking Gleevec at the University of Texas’ M.D. Anderson Cancer Center in Houston developed fairly severe heart failure, with no prior symptoms. Because physician...

Endometriosis Could be Treated with Iron Therapy

... help cause these lesions to grow by promoting the proliferation of their epithelial (lining) cells. The study reve... their harmful effects on the body can reduce cell proliferation in the lesions. Research leader Jacques Donnez, head of the department of gynecology at the Cathol...

Treatment of Endometriosis in the Pipeline

... show that increase iron results in the growth and proliferation of the lesion. The study results are published in the journal Human Reproduction. The researchers also suggest that the harmful effects of the metal (iron) ion can be reduced by treating the patient with iron chelaters. Scientists suggest that exce...

Drug Denial may Leave Several Thousands Blind

...rmation. But excessive VEGF in the eye can cause a proliferation of blood vessels and leakage of fluids. These are the characteristics of wet AMD. Macugen targets this particular protein. A course of three injections when given over 18-weeks, costs ￡1,542.According to Steve Winyard, head of research for the Roya...

'Blimp1' Gene Linked To Oily Skin

...clues to how stem cells can control the balance of proliferation and differentiation in tissues." Source: Eurekalert...

Studies Find Connection Between Acid Reflux And Esophageal Cancer

...id exposure to increased ROS production, increased proliferation and decreased apoptosis may provide a number of potentially useful therapeutic targets," the authors write. Source: EurekAlert...

Estrens For Osteoporosis Might Have Adverse effects

...ncreased in size. Furthermore, estrens induced the proliferation of human breast cancer cells. This study indicates that estrens might not be the sought after estrogen-like molecules that improve bone strength but do not cause cancer, and has important implications for their clinical development. In an accompany...

Breakthrough In The Identity Of Compounds That Encourage Stem Cell Growth

... play a role in inflammation and are regulators of proliferation of several cell types. When stem cells isolated from the brains of mouse embryos were exposed to LTB4 they proliferated and differentiated, giving rise to additional stem cells and to differentiated neurons with limited or absent capacity to divide. ...

Gene May Regulate Cellular Aging

...degree seen in aging.According to Sharpless, islet proliferation persisted in p16INK4a -deficient animals as they aged, 'almost as if they were younger animals.' In mice with an excess of p16INK4a, 'islet cells aged prematurely; they stopped dividing early.''This suggests that if we could attenuate p16INK4a expres...

Vitamin D May Cut Pancreatic Cancer Risk by Nearly Half

...active form. Other studies have shown an anti-cell proliferation effect of 1,25-dihydroxyvitamin D, potentially inhibiting tumor cells. “In concert with laboratory results suggesting anti-tumor effects of Vitamin D, our results point to a possible role for Vitamin D in the prevention and possible reduction in mo...

Genetic Link To High Blood Pressure

...of the smooth muscle cells. They do not affect the proliferation of the cells, and the thickening of the walls of b...in the cell, and, ultimately, more contraction and proliferation of smooth muscle cells," she said. The transcription factor that binds the mutated gene more easil...

A.Q. Khan Discharged from Hospital after Successful Prostate Surgery

...anuary 2004 after admitting he was involved in the proliferation of nuclear weapons technology. Source-IANS...

Genetic susceptibility in viral encephalitis

...y resulted in high rates of herpes simplex virus-1 proliferation and cell death. Assuming these findings extend to neurons, they provide a plausible mechanism for herpes simplex encephalitis. "We and our colleagues have identified recessive UNC-93B deficiency as a genetic etiology of herpes simplex encephalitis ...

Mouse Gene With Gene Stutter Will Help Leukemia Research

...th the mutation lived longer than normal. Rapid proliferation and unusually long life are features of cancer cel...Three Hox genes could be involved in the increased proliferation of the progenitor cells. An analysis showed that of the three, the HoxA9 gene was overactive. Its pr...

NACO Inaugurates 37 Additional HIV Treatment Centers

...ion, nevertheless are powerful enough to check the proliferation of the virus. The therapy also helps in cutting down the number of opportunistic infections that will positively enhance the quality of life as well as extend the life of the patient....

Antibiotic Inhibits Cancer Gene Activity

...s responsible for turning on genes needed for cell proliferation and turning off genes that block proliferation. Uncontrolled proliferation is characteristic of cancer cells. The researchers developed a new screening system, based on a na...

Antiretroviral Drugs: A Shot in the Arm to Fight Malaria?

...rapine (Viramune) in thereapies did not hamper the proliferation of the malarial parasite. According to researchers, the life of the parasite is entirely dependent on the protease enzymes released by the plasmodium species, which may form the basis for the development of a new variety of anti-malarial drugs. Fu...

Rescuing Injured Hearts by Enhancing Regeneration

...ng only the p38 MAP kinase inhibitor had increased proliferation of cardiomyocytes, but no longer had improved hear...ctional improvement, but did not show as much cell proliferation as those receiving the p38 MAP kinase inhibitor. Rats receiving both agents had the greatest improve...

Gene Involved In Common Birth Defect Also Regulates Skin Biology

...lysis of the mice revealed that IRF6 regulates the proliferation and differentiation of keratinocytes -- the main c...he epidermis. The researchers also showed abnormal proliferation of keratinocytes in one of the remaining two layers and failure of these cells to die off or differe...

Yet Another Reason not to Smoke

...esearchers also noted that there was less cellular proliferation in the rats' surgically repaired shoulders and decreased collagen production, leading to inferior healing. "When you have an injury and a repair, new cells come in and start to facilitate healing," Galatz says. "When the new cells arrive, they make ...

Cigarette Smoking Impedes Tendon-to-Bone Healing

...esearchers also noted that there was less cellular proliferation in the rats' surgically repaired shoulders and decreased collagen production, leading to inferior healing. "When you have an injury and a repair, new cells come in and start to facilitate healing," Galatz says. "When the new cells arrive, they make...

Artificial Liver from Cord Blood Stem cells

...babies. These stem cells were subjected to rapid proliferation by placing in a “bioreactor” developed by NASA. These cells were then induced to convert into liver tissue by the addition of certain hormones and chemicals. This was the first time that liver tissue had been generated from cord blood stem cells, u...

Garlic compound may help treat cancer

...nosulphur compounds. Many of these can inhibit the proliferation whereas some of them can induce apoptosis (a form of programmed cell death) in cancer cells, Karunagaran said. The main clue from the present invention is that a composition comprising a garlic organosulphur compound together with an anti-cancer ag...

Anti-Cancer Drug Shows Early Promise in Pulmonary Hypertension

...he chemical signals that can trigger both cellular proliferation and new blood vessel growth, Gomberg-Maitland and colleagues suspected it might slow the growth and thickening of the pulmonary artery walls. To test this theory they treated rats at high risk for pulmonary hypertension with sorafenib. The research...