Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

... alpha, and examined the effects on structural, functional, and behavioral expression of synaptic memory. In the K42R brain, tetanus-induced long-term potentiation (LTP), a proposed cellular mechanism of memory, and sustained postsynaptic spine enlargement, a structural basis for LTP, were both impaired, whereas ...

Cancer-causing virus associated with higher risk of new HIV infection

... cell cancer. This study points to another important means by which HPV infection may be associated with morbidity and mortality, i.e., through potentiation of HIV infection. A direct role for HPV in this process will need to be confirmed in additional studies, and additional studies will be needed to ...

What Moms Learned May Be Passed to Offspring

... short period of time unlocks an otherwise dormant biochemical and control mechanism that boosts a cellular process in nerve cells called long-term potentiation (LTP), which is believed to be involved in learning and memory. "This is the first study to demonstrate an inheritance of a change in a signaling ...

Cocaine addiction linked to voluntary drug use and cellular memory, UCSF study shows

... as the ventral tegmental area (VTA). In rats that self-administered cocaine, the increase in neuronal communication called long-term synaptic potentiation (LTP) was similar to those that had self-administered food or sucrose, but with a critical distinction. The increase in LTP due to cocaine persisted ...

Hebrew University research on octopuses sheds light on memory

... that an area in the octopus brain that was known to be important for learning and memory showed a robust, activity-dependent, long-term synaptic potentiation (LTP) a process which is strikingly similar to that discovered in vertebrate brains. This LTP process accelerates the transformation of ...

Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy

... of Hematology, which appeared online May 27. Further, Grant said that the interaction between these agents may occur at multiple levels, including potentiation of Bcr/Abl inhibition as well as enhanced disruption of aurora kinase and mitosis. In addition, the group demonstrated that vorinostat-mediated ...

Pain receptor in brain may be linked to learning and memory

... lasting changes in the connections between neurons. These changes in the brain and the related process of neural reorganization known as long-term potentiation are believed to be the cellular basis for memory making. Weve known that TRPV1 receptors are in the brain, but this is some of the first evidence ...

Brain Cells More Powerful Than You Think

... Svoboda said, so that long-term electrical activation ("potentiation") of one synapse didn't directly affect a neighboring synapse. Long-term potentiation is, in essence, the key cellular step in how the brain lays down memory. However, computer models had suggested that activation at one synapse ...

Southern Research Institute's Neurodegenerative Disease Drug Discovery Program Receives National Institute of Mental Health Funding

... indications that the NF-kB signaling system plays a role in neuronal resilience and in the changes induced by cellular learning such as long term potentiation and depression. Several reports have shown that knocking out NF-kB activity in the brain causes sensitization to toxic stimuli, such as beta-amyloid, ...

Memory Loss Linked to Cognitive Disorders

... memory thus linking memory loss to cognitive disorders. Earlier studies have established that a physiological effect known as long-term potentiation (LTP) encodes everyday forms of memory. In neuroscience, LTP is an increase in the strength of a chemical synapse that lasts from minutes to ...

Enriching Environment Stimulates Neurons: Hope For Fragile X Syndrome

... Importantly, they found that increased stimulation of neurons in the mice, which enhanced calcium signaling, could restore normal long-term potentiation and neuronal plasticity. There have been reports that Fragile X patients can still learn and memorize information but need more repetition ...

How Morphine Affects Memory

... long-term potentiation, even after 24 hrs of the drug in the animal’s body, when the crucial effect is thought to have faded out. Long-term potentiation or LTP assists with information storage in the brain, and connections between neurons called synapses are strengthened with repeated stimulation. ...

Researchers Investigate Molecular Basis of Memory

... information from news. In other words a cell remembers an event as an unusually strong and long-lasting signal. This phenomenon called long-term potentiation (LTP) is thought to underpin learning and memory and its molecular basis is being investigated intensively. "It is difficult to study a dynamic ...

Eating Strawberries may boost memory

... stored in the brain by strengthening connections between neurons. "We wanted to find out whether we could detect any effects of fisetin on long-term potentiation and the formation of memories in animals," Maher recalls. Since the hippocampus plays an important role in establishing new memories, Maher, and ...