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Polymerase in Medical News

WaferGen's Chief Scientific Officer to Deliver Executive Talk at Malaysian Ministry of Science, Technology and Innovation's PCR Conference

... Innovation's (MOSTI) biotechnology conference on polymerase chain reaction (PCR). The conference will be held ... as the conference's feature event, will focus on polymerase chain reaction (PCR) and highlight the history of ... as the inventor of Thermus aquaticus (Taq) DNA polymerase for use in PCR. About WaferGen ...

International Scientists Secure Quality in Molecular Diagnostics

... Consensus Guideline Reached For Quantitative polymerase Chain Reaction SALT LAKE CITY, March 31 ... laboratory method called qPCR (or quantitative polymerase chain reaction) was published by a group of ... PCR (qPCR): qPCR is an extension of the polymerase chain reaction invented in 1986 by Kary Mullis, ...

Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results and Highlights

... has been reported for any other non-nucleoside polymerase inhibitor. And today we are reporting that we ... ANA598 is an investigational oral non-nucleoside polymerase inhibitor that Anadys is developing for the ... has been reported for any other non-nucleoside polymerase inhibitor in a monotherapy study. A number of ...

Scientists identify key roadblock to gene expression

... on top of the transcription start site, so RNA polymerase must contend with that nucleosome as soon as it ... then soon pauses at the first nucleosome the RNA polymerase encounters. "This pause is maintained until ... removal of the nucleosome and encourage the RNA polymerase to continue along its path," said key ...

Urine Test for Chlamydia Shown Effective in Men

... infection is diagnosed by nucleic acid amplification tests, such as the polymerase chain reaction. But these tests are expensive, technically complex and can ... fast and accurate results in women. The new study compared the test to the polymerase chain reaction test using urine samples from more than 1,200 men, ages 16 ...

New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report

... and Boceprevir II-7 Telaprevir and Boceprevir - A Comparison II-8 polymerase Inhibitors (PLIs) - Adding More Teeth to HCV Pipeline II-8 Viral Polymerases II-8 polymerase Inhibitor Drugs in Pipeline by Company, Category, and Development ...

Hepatitis C Virus Market Will Expand Dramatically From $2 Billion in 2008 to Nearly $7.7 Billion in 2013

... Tanabe's telaprevir and Schering-Plough's boceprevir as well as polymerase inhibitors such as Roche/Pharmasset's R-7128 and Pfizer's filibuvir -- ... C virus-specific antiviral agents, such as protease inhibitors and polymerase inhibitors," said Decision Resources Analyst Alexandra Makarova, M.D., ...

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

... mucosa, and colorectal cancer tissue. Quantitative methylation-specific polymerase chain reaction was used to examine NDRG4 promoter methylation as a ... tissue compared with noncancerous colon mucosa. A methylation-specific polymerase chain reaction assay for NDRG4 promoter methylation in stool identified ...

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

... in a multiple ascending dose trial with PSI-7851, a nucleotide analog polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection. ... 15- to 20-fold more potent than Pharmasset's first generation nucleoside polymerase inhibitor, R7128. In vitro studies of PSI-7851 have not shown evidence ...

In Hepatitis C Virus Treatment, Interviewed Experts Indicate That Telaprevir- and Boceprevir-Based Regimens Have Advantages Over Pegasys/Ribavirin in Sustained Virologic Response

... market. The new report entitled Hepatitis C Virus: Protease and polymerase Inhibitors on the Horizon to Revolutionize Treatment finds that a novel ... regimens." About the Report Hepatitis C Virus: Protease and polymerase Inhibitors on the Horizon to Revolutionize Treatment is a DecisionBase ...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

... IV and V), found only in plants, are actually specialized forms of RNA polymerase II, an essential enzyme of all eukaryotic organisms, including humans. ... in determining which genes get switched on and which get turned off. RNA polymerase II, for instance, is vital in the production of messenger RNAs that ...

Pharmasset to Webcast an Investor Event from the AASLD Meeting

... website (AASLD.org). R7128 "Antiviral Activity Of The HCV Nucleoside polymerase Inhibitor R7128 In HCV Genotype 2 And 3 Prior Non-Responders: Interim ... Abstract: LB10 "Potent Antiviral Response To The HCV Nucleoside polymerase Inhibitor R7128 For 28 Days With Peg-Ifn And Ribavirin: Subanalysis ...

Scientists Hot on Trail of New Antibiotics

... in DNA into RNA, which in turn directs the assembly of proteins. "RNA polymerase has a shape reminiscent of a crab claw, with two prominent pincer-like ... antibiotics. The researchers said that antibiotics targeting this RNA polymerase hinge cut treatment time down to as little as two weeks. More ...

WaferGen's SmartChip(TM) Real-Time PCR System to Begin Alpha Testing at University of Pittsburgh Medical School

... as the first whole genome, high throughput gene expression real-time polymerase chain reaction (PCR) platform and promises to deliver significant speed ... as the first whole genome, high throughput gene expression real-time polymerase chain reaction (PCR) platform and promises to deliver significant speed ...

Pharmasset Presents R7128 14-Day Monotherapy Study Results for the Treatment of Chronic Hepatitis C

... -Nucleoside polymerase inhibitor demonstrates >99% mean decrease in HCV RNA ... an orally administered prodrug of PSI-6130, a cytidine nucleoside analogue polymerase inhibitor of hepatitis C virus (HCV) that is being developed through ...

Toward a faster prenatal test for Down syndrome

... accurate results within two hours. The test is a variation of the famed polymerase chain reaction (PCR) the basis of the genetic engineering revolution ... of minute samples of DNA. Using a technique known as the digital polymerase chain reaction, Quake and Fan replicated DNA from two cultures of cells ...

Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium

... results from three studies that support the use of quantitative real-time polymerase chain reaction (RT-PCR), as performed in the Oncotype DX assay, for ... (IHC), Compared to a New Method, Quantitative Reverse polymerase Chain Reaction (RT-PCR) Presenter: Frederick L. Baehner, M.D. ...

New test for safer biomedical research results

... commercial mycoplasma tests. McCT results are reproducible to 99.6 percent. The method is based on multiplication of specific DNA sequences by polymerase chain reaction and subsequent detection of the multiplied DNA regions. A special advantage of the new test is that it can be carried out on a ...

Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Earnings Growth Outlook for 2009

... Abbott's broad-based hepatitis C program includes our partnership with Enanta Pharmaceuticals to develop protease inhibitors, as well as our internal polymerase inhibitor program. Our compounds in development have the potential to shorten treatment duration, improve tolerability and increase cure rates. ...

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

... from two series of purine analogs for the treatment of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary nucleotide analog polymerase inhibitor of HCV that is being advanced into studies required for submission of an Investigational New Drug (IND) application with the FDA or ...

New Cancer Drug Fights Tumors in Those With BRCA Mutations

... risk for prostate cancer, the British researchers noted. Olaparib works differently than other cancer drugs in that it blocks Poly(ADP-ribose) polymerase (PARP), a protein involved in DNA repair. Healthy cells use PARP to repair themselves, but cancer cells do the same, the scientists explained. ...

Fears About Pregnancy and cats Should not stop Those who want to Adopt a cat

... are positive for the parasite as are about one-third of humans, she said. Not all cats or humans who test positive will develop symptoms. The polymerase chain reaction test, a type of DNA testing, is the most accurate diagnostic test, particularly when the eyes are affected, Chauvet said. Treatment ...

Cepheid Announces European Release of Improved Test for BCR-ABL Chromosomal Translocation Associated With Chronic Myelogenous Leukemia (CML)

... The Europe Against Cancer Program practice guidelines, for management of patients with CML, call for use of quantitative Reverse Transcription polymerase Chain Reaction (RT-PCR) assays during the initial workup of patients with chronic phase CML, and in monitoring for minimal residual disease. Patients ...

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

... CRY gene removed. Expression of the genes responsible for regulation of the human body clock were determined by immunohistochemistry and quantitative polymerase Chain Reaction. TNF-alpha levels were measured by ELISA, and transactivation of TNF-alpha gene was examined by reporter assay. ...

New accurate diagnostic test for swine H1N1 influenza using RT-PCR technology

... laboratories. The molecular strategy described in the article in Vector-Borne and Zoonotic Diseases is based on proven and widely used Real-Time, polymerase Chain Reaction (RT-PCR) technology. The authors of the report entitled "A Simple Method for Molecular Detection of Swine-Origin and Human-Origin ...

DxNA Submits its Rapid Detection Platform Test for H1N1 to FDA

... is developing a number of follow-on tests to detect pathogens that may affect people and agriculture. Through its rapid, precise, on-site polymerase chain reaction (PCR) genetic testing capabilities, GeneSTAT technology facilitates the rapid detection of pathogens and viruses. The World Health ...

Anadys Pharmaceuticals, Inc. Announces Pricing of Common Stock and Warrant Offering

... improvements in treatment outcomes may be attainable with the introduction of new medicines. The Company is developing ANA598, a non-nucleoside polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous ...

BD and HandyLab Announce Exclusive Collaboration to Commercialize Molecular Assays

... system to provide hands-off operation. The system incorporates clinical sample preparation, nucleic acid extraction, and microfluidic real-time polymerase chain reaction (PCR) amplification and detection. The self-contained workstation is designed to accommodate on-demand and batch workflows. It ...

Diatherix Laboratories Releases First Clinically Available Test For Confirmation of The Swine Flu Virus

... This test has been added to the company's viral respiratory panel, which uses proprietary molecular technology called Target Enriched Multiplex polymerase Chain Reaction (Tem-PCR). Samples from confirmed patients, provided by the Centers for Disease Control and Prevention (CDC) and local hospitals, ...

Aethlon Medical Discloses New HIV/AIDS Treatment Data

... There were no observed adverse events reported by the principal investigator. All viral load measurements were performed with real-time quantitative polymerase chain reaction (RT-PCR), with treatment samples being measured in duplicate. The outcome of the study fulfilled the challenge underlying a ...

DxNA to Use its Rapid Detection Platform to Simplify Testing for Swine Flu (H1N1 Virus)

... to health agencies around the world and offered our assistance in helping to rapidly diagnose this virus." Through its rapid, precise, on-site polymerase chain reaction (PCR) genetic testing capabilities, GeneSTAT technology facilitates the rapid detection of pathogens and viruses. The World Health ...

WaferGen and Leading Academic Medical Center Establish Genotyping Research Collaboration to Validate SNPs in Breast Cancer Using SmartChip(TM) Real-Time PCR System

... Real-Time PCR System The SmartChip Real-Time PCR System(TM) is designed as the first whole genome, high-throughput gene expression real-time polymerase chain reaction (PCR) platform. WaferGen believes the SmartChip Real-Time PCR System will be the first platform to combine the high-throughput ...

Abbott Reports 16 Percent Earnings Growth in First Quarter; Confirms Double-Digit Earnings Growth Outlook for 2009

... Abbott's broad-based hepatitis C program includes our partnership with Enanta Pharmaceuticals to develop protease inhibitors as well as our internal polymerase inhibitor program. Abbott has three HCV compounds in clinical development. Vascular Devices XIENCE PRIME - ...

PGD Technology Offers More Than Designer Babies

... defects where the DNA mutation is limited to a specific location on a gene, PGD can diagnose affected embryos. After the biopsy of one or two cells, polymerase chain reaction (PCR) is used to amplify the DNA sequence of interest. The normal and abnormal genetic sequences in the DNA can be amplified and ...

Microfluidic Systems (MFSI) is Granted a Microfluidic Cartridge Patent for DNA Separation

... the identity of a rape perpetrator, it is imperative that the DNA from the victim and perpetrator be separated prior to analysis such as with the polymerase chain reaction (PCR) technique and/or DNA sequencing. Currently, the laboratory procedure to perform this tedious DNA processing technique, referred ...

Anadys Pharmaceuticals to Present at the Citi Biotech Day

... C and oncology. For the treatment of chronic hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the ...

Anadys Pharmaceuticals to Report Fourth Quarter and Year End 2008 Financial Results

... C and oncology. For the treatment of chronic hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral TLR7 agonist prodrug. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

2 gene mutations linked to most common brain cancers -- and longer survival

... Hughes Medical Institute investigator. Mutations were found by a standard technique of amplifying sections of the IDH1 and IDH2 genes through polymerase chain reaction (PCR), a process that replicates bits of DNA to levels that can be detected by sensitive computer equipment. ...

ViroPharma Reports Results of Phase 3 Clinical Trial for Maribavir in Bone Marrow Transplant Patients

... included weekly testing at a central laboratory for the presence of CMV pp65 antigenemia and for the presence of CMV DNA in plasma using a polymerase chain reaction (PCR). If CMV infection was detected during the study drug administration period (or if CMV organ disease was diagnosed), study drug ...

Anadys Pharmaceuticals to Present at the BIO CEO & Investor Conference

... C and oncology. For the treatment of chronic hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral TLR7 agonist prodrug. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...
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