Platelet in Medical News

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

... monitor complete blood count (including platelet count), at least prior to each dose of DOXIL ... Kaposi's sarcoma, hematologic toxicity (based on platelet count or absolute neutrophil count) may require ... multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil count, hemoglobin ...

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

... A Functional Pool of P2Y12 Receptors Exposed Upon platelet Activation Persists in Mice Treated with High ... p.m. Location: Poster Area, platelet Biology New Directions in Antithrombotic ... Elinogrel (PRT060128) in Patients with High platelet Reactivity During Clopidogrel Therapy ...

Experts reach consensus on diagnosis and treatment of bleeding disorders in women

... factor (VWF), a protein necessary for normal platelet adhesion and protection of factor VIII (FVIII) ... A hematologic evaluation of the patient's platelet number and function and her coagulation factor ... such as VWD, rare bleeding disorders and platelet disorders, which remain underdiagnosed in women ...

3SBio Inc. Files for SFDA Approval for TPIAO Label Extension for the Treatment of ITP

... of chemotherapy induced thrombocytopenia, or platelet deficiency. The aim of this filing is to extend ... potentially resulting in dangerously low platelet counts. There are today approximately eighty ... increasing platelet production to outpace platelet destruction by the immune system. ...

Bioreactors might solve blood-platelet supply problems

... critical blood components. About 13 million platelet concentrates are collected annually in the United ... only five days. As a result, 20 to 40 percent of platelet concentrates are discarded. Red blood cells, by ... to the other arm. The method yields four to six platelet units per donor. For this study, Lasky and his ...

Ad de Waard Appointed Vice President of International Sales and Marketing at Accumetrics, Inc.

... products, including products in the area of platelet function analysis. Prior to Accumetrics, ... committed to advancing medical understanding of platelet function and enhancing quality of care for ... and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' ...

Novel therapeutic approaches may improve patient outcomes in several platelet disorders

... oral treatment for chronic ITP, a low-dose platelet transfusion strategy for patients with hypoproliferative thrombocytopenia, and a new therapeutic platelet transfusion approach following high-dose ... to minimize bleeding episodes in patients with platelet disorders," said press conference moderator ...

Eisai Inc. Supports Acting Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism

... non steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, or other anticoagulants. The risk ... up to 6 months in the FRAGMIN(R) treatment arm, platelet counts of <100,000/mm3 occurred in 13.6% of ... with bleeding diathesis, thrombocytopenia or platelet defects; severe liver or kidney insufficiency, ...

PROMACTA(R) (eltrombopag) RECEIVES UNANIMOUS RECOMMENDATION BY FDA ADVISORY PANEL

... and discussed that support eltrombopag increased platelet counts and reduced bleeding. "Chronic ITP is a ... are crucial to managing this disease -- improved platelet counts and decreased bleeding. If approved, this ... patients with chronic ITP to increase platelet counts and reduce or prevent bleeding. In the ...

Ashwell receptor reduces mortality during sepsis

... made a breakthrough when they discovered that platelet counts and vWF that are reduced during ... contradicts the prevailing notion that the low platelet count of sepsis is due to the consumption of ... therefore harmful, said Marth. Rather, this low platelet count is due an adaptive response by the Ashwell ...

Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting

... Lymphoid Malignancies -- Reduction in platelet Counts as a Mechanistic Biomarker and Guide for ... without any sign of bleeding. Reductions in platelet counts were analyzed in the three ongoing Phase I ... via inhibition of Bcl- XL, without decreasing platelet production, confirming on-target activity. At 315 ...

Naturally-occuring protein may be effective in limiting heart attack injury and restoring function

... being developed as a pharmaceutical to increase platelet count in cancer patients during chemotherapy, can ... treatment with TPO did not increase platelet count. This novel finding suggests the ... of TPO are separate from its ability to increase platelet count. Dr. Baker has submitted a US and ...

Fugitive cancer cells can be blocked by stopping blood cells that aid them

... the scientists report that a combination of two platelet inhibitors reduced the number and size of breast ... the drugs was aspirin, a widely used inhibitor of platelet clotting. The other was an experimental drug, APT102, which also prevents platelet clotting, but by a different mechanism. Both ...

Smith & Nephew Introduces New Biologic to Speed Healing

... the U.S. launch of the CAPTION(TM) Disposable platelet Concentration System. The CAPTION system simplifies and expedites the collection of platelet rich concentrate (PRC) and eliminates cross- ... The PRC made by the CAPTION system consists of platelet cells suspended in a proprietary solution. ...

JCI online early table of contents: March 3, 2008

... HEMATOLOGY: Role for the serotonin transporter in platelet aggregation New data, generated by Randy ... the protein SERT (the serotonin transporter) in platelet aggregation, a key event in blood clotting. In ... increased SERT expression on the surface of the platelet and thereby increased SERT function. Alterations ...

Serum fibrosis markers correlate with liver fibrosis stage in patients with advanced chronic hep C

... fibrosis markers, including serum HA, TIMP-1 and platelet count, could identify cirrhosis with better ... created a model that included TIMP-1, log HA and platelet count. The 3-variable model was significantly ... a 3-variable model consisting of TIMP-1, HA, and platelet count distinguished patients with non-cirrhotic ...

Half of patients undergoing cerebrovascular stent placement respond poorly to clopidogrel

... (re-stenosis). Given the importance of platelet inhibition in the prevention of in-stent ... stenosis. Researchers used the VerifyNow rapid platelet function assay-aspirin (RPFA-ASA) to calculate ... to calculate P2Y12 reaction units and percentage platelet inhibition immediately before the endovascular ...

Drug-based on MGH discovery may significantly improve treatment of dangerous blood disorder

... (Nplate) show that it significantly improved platelet levels in patients with chronic immune ... platelets, ITP also may be due to reduced platelet production. Currently available treatments for ... the spleen (splenectomy) are designed to reduce platelet destruction and may be ineffective in many ...

GlaxoSmithKline Files for FDA Approval of PROMACTA(TM) (eltrombopag) to be the First Oral Platelet Growth Factor for Rare Blood Disorder

... Data Show PROMACTA Significantly Raised platelet Counts and Lowered Bleeding Risk in Clinical ... If approved, eltrombopag would be the first oral platelet growth factor therapy for the short-term ... purpura (ITP) to increase platelet counts and reduce or prevent bleeding. Chronic ...

Research Highlights New Approaches to Management of Blood Clotting and Bleeding Disorders

... purpura (ITP) per ASH guidelines and baseline platelet counts <30,000/µL. Chronic ITP is an autoimmune ... platelets in the bone marrow) causing defective platelet production. These result in a low blood ... is a novel "peptibody" that acts by stimulating platelet production at the thrombopoietin receptor. ...

Eltrombopag studied in Idiopathic Thrombocytopenic Purpura

... Center demonstrate that an investigational oral platelet growth factor called eltrombopag successfully increased platelet counts and decreased bleeding in patients with ... eltrombopag doses of 50 and 75 mg daily elevated platelet counts to a safe level (= 50,000 per cubic ...

Drug May Help Reverse Clotting Deficiency

... were able to use the medication to boost their platelet levels and cut their risk for bleeding. In a ... their condition after eltrombopag raised their platelet counts. "Eltrombopag is not just used in one ... "This is a condition in which there's a low platelet count, and if it drops very low, usually below ...

Rigel R788 Raises Platelet Counts in Immune Thrombocytopenic Purpura (ITP) Patients in Phase 2 Study

... the primary efficacy marker being the measure of platelet counts compared to each patient's baseline ... favorably to R788 treatment with higher stable platelet counts; six of these had peak platelet counts of ... receiving weekly IV gammaglobulin, maintained platelet counts while on only R788 for 20 weeks of the ...

Diesel exhaust associated with higher heart attack, stroke risk in men

... diesel exhaust increased clot formation and blood platelet activity in healthy volunteers which could lead ... They measured clot formation, coagulation, platelet activation and inflammatory markers after each ... The researchers also found an increase in platelet activation, assessed by measuring the number of ...

In Landmark Phase III Head-to-Head Study, Prasugrel Statistically Superior to Clopidogrel in Reducing Risk of Heart Attack

... for both acute and maintenance therapy to inhibit platelet activation and subsequent aggregation that occur ... undergoing PCI. Prasugrel works by inhibiting platelet activation and subsequent aggregation by blocking ... adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets ...

Daiichi Sankyo, Lilly Announce New Prasugrel Head-to-Head Phase III Study Against Clopidogrel

... attacks(1). The study, TRILOGY ACS (TaRgeted platelet Inhibition to cLarify the Optimal strateGy to ... undergoing PCI. Prasugrel works by inhibiting platelet activation and subsequent aggregation by blocking ... adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets ...

Pall launches new products to increase supply of safe blood

... to ensure patients receive the safest possible platelet transfusion -- no matter what type of system ... collection and filtration system for whole-blood platelet collection. The new Acrodose PLus System ... them to use any collection system for whole blood platelet preparation -- ultimately giving more patients ...

Possible safer target for anti-clotting drugs found

... to find an enzyme whose inhibition lessened platelet aggregation without abnormal bleeding, and we ... found that mice lacking calpain-1 had reduced platelet aggregation but did not have any abnormal ... mice were given a PTP1B inhibitor, the reduced platelet aggregation was restored. When calpain-1 knockout ...

Critical blood shortages eased by new technology

... of the four million whole blood-derived platelet concentrates are discarded. Many blood banks are ... readily available. The resulting AcrodoseSM platelet is an innovative product that can provide ... platelets and other whole blood-derived platelet products. Acrodose Platelets are leukocyte (white ...

Falling Platelet Counts May Signal HIV-Linked Dementia

... -- HIV-infected patients with declining blood platelet counts may be at increased risk for ... dementia. The researchers found that a decline in platelet count from baseline at the start of the study was ... analyses indicated that decline from baseline platelet levels was associated with a five- to sixfold ...

Accumetrics' VerifyNow(R) P2Y12 Test Provides Physicians With Information to Assess a Patient's Response to Newly-Approved Prasugrel (Effient(R))

... ) Accumetrics is committed to advancing medical understanding of platelet function and enhancing quality of care for patients receiving antiplatelet ... industry-leading and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' VerifyNow System is the first ...

Miami Physician Sentenced to 97 Months in Prison for Role in $10 Million Medicare Fraud Scheme

... to the plea documents, none of Midway's patients actually had low blood platelet counts. Rodriguez admitted that to make it appear that the patients actually had low platelet levels, he and his co-conspirators used chemists to manipulate the blood ...

Children's National Medical Center Dedicates New Blood Donor Center

... has an additional donor bed, enabling Children's to increase the number of platelet donations each month. The center is designed to enable staff to see every ... throughout the entire donation process. "The demand for blood and platelet donations has grown more than ever, as we treat more patients with many ...

Accumetrics, Inc. Announces Distribution Channels in Israel and Cyprus

... ) Accumetrics is committed to advancing medical understanding of platelet function and enhancing quality of care for patients receiving antiplatelet ... industry-leading and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' VerifyNow System is the first rapid ...

Four Miami-Area Residents Sentenced In $10 Million Medicare Fraud Scheme

... platelets in the blood. None of Midway's patients actually had low blood platelet counts. Dagnesses' admitted role at Midway was to manipulate the ... would make it appear that the patients actually had dangerously low blood platelet counts. Specifically, Dagnesses would obtain vials of blood drawn from ...

Accumetrics, Inc. Announces 1000th Patient Enrolled in GRAVITAS Trial

... ) Accumetrics is committed to advancing medical understanding of platelet function and enhancing quality of care for patients receiving antiplatelet ... industry-leading and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' VerifyNow System is the first rapid ...

Accumetrics, Inc. Announces United Kingdom Distribution Agreement With ELITech UK Limited

... ) Accumetrics is committed to advancing medical understanding of platelet function and enhancing quality of care for patients receiving antiplatelet ... industry-leading and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' VerifyNow System is the first rapid ...

Miami Doctor and Chemist Plead Guilty in HIV Infusion Fraud Scheme

... to court documents, none of Midway's patients actually had low blood platelet counts. To make it appear that the patients actually had low platelet levels, Del Cueto admitted that she and her co-conspirators used chemists, ...

Two Doctors and Two Medical Assistants Plead Guilty in $10 Million Medicare Fraud Scheme

... to the plea documents, none of Midway's patients actually had low blood platelet counts. Rodriguez admitted that to make it appear that the patients actually had low platelet levels, he and his co-conspirators used chemists to manipulate the blood ...

Gregory J. Tibbitts Appointed Chief Financial Officer at Accumetrics, Inc.

... ) Accumetrics is committed to advancing medical understanding of platelet response and enhancing quality of care for patients receiving antiplatelet ... industry-leading and widely accessible diagnostic tests for rapid platelet function assessment. Accumetrics' VerifyNow System is the first rapid ...