Plasmid in Medical News

Bacterial 'battle for survival' leads to new antibiotic

... Streptomyces. A logical conclusion is that the plasmid carries the gene for rhodostreptomycin, but the researchers have sequenced more than half of the plasmid and found no genes that correlate to the antibiotic. Another theory is that the plasmid itself served as the insult that provoked ...

Researchers solve first structure of a key to intact DNA inheritance

... and often lethal staph infection. "The plasmid segregation system we are working on, called ... and segregation, Schumacher says, because plasmid segregation is relatively simple: two proteins ... grow, literally pushing the two replicated plasmid segrosomes apart, resulting in two copies of ...

Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009

... in previous pivotal large scale trials of other non-analgesic approaches for diabetic neuropathy." About SB-509 SB-509 is an injectable plasmid encoding a DNA-binding Zinc Finger DNA-binding Protein (ZFP) Transcription Factor (ZFP TF(TM)) designed to upregulate the endogenous expression of ...

Five UCSF Scientists Elected to National Academy of Sciences

... tolerance-inducing cells in the thymus that express the beta-cell specific insulin gene. As a graduate student, Hanahan developed high efficiency plasmid transformation methods and E. coli strains that have facilitated DNA cloning procedures; his work on E. coli transformation (the production of ...

iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

... 2008, Dr. Yamanaka's group reported for the first time a virus-free method for inducing pluripotency in differentiated cells by using a pair of plasmid vectors to introduce the four iPS genes into embryonic mouse fibroblasts as part of CiRA's efforts to establish safe and efficient methods to ...

Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate

... About SNS-01 Senesco's SNS-01 consists of three components: an eIF5A plasmid, an siRNA against eIF5A and polyethyleneiminie (PEI). The eIF5A plasmid upregulates the apoptotic pathways within cancer cells. The siRNA downregulates proinflammatory cytokines, NF-kB and ICAM, which are proliferation ...

Rockefeller University's Center for Clinical and Translational Science funds 18 new pilot studies

... to a novel vaccine against pancreatic cancer. Investigators will administer a monoclonal antibody, which targets dendritic cells, followed by a DNA plasmid that works as a booster. Ype de Jong, M.D., Ph.D., visiting fellow, Charles M. Rice's Laboratory of Virology and Infectious Disease, to define ...

Therapeutic DNA Vaccine Company Inovio Biomedical Reports Second Quarter 2008 Financial Results

... T-cell responses to the hepatitis C virus was recorded in conjunction with the viral load reductions. Pre-clinical results from two proprietary plasmid DNA-based universal influenza vaccine candidates using the company's proprietary electroporation delivery technology and, specifically, a new ...

Vical to Present Phase 1 Data for Vaxfectin(R)-Formulated Pandemic Influenza DNA Vaccines

... and to evaluate monovalent and trivalent Vaxfectin(R)-formulated DNA vaccines at various doses. Vical's monovalent vaccine contains a plasmid (a closed loop of DNA) encoding the hemagglutinin (HA) surface protein from the H5N1 influenza virus strain, A/Vietnam/1203/04. It is designed ...

New Roche Chlamydia Test Approved for Use in European Union

... It is designed with a dual target approach to help ensure reliability of test results even when mutations occur in the bacteria's cryptic plasmid DNA. According to Eurosurveillance, a leading independent scientific journal, Chlamydia trachomatis is the most commonly reported sexually ...

Senesco Expands on Preclinical Multiple Myeloma Findings

... preclinical testing and its recent expanded studies, the Company has used a combination therapy of its siRNA against Factor 5A, as well as a plasmid of the Factor 5A gene encapsulated in a nanoparticle. Whether the combination therapy was injected intratumorally or systemically, human multiple ...

What is the more suitable for early detection of low abundant lamivudine-resistant mutants?

... samples. LDR was able to detect as low as 0.01% (100 copies/mL) of YIDD plasmid, while real-time PCR only detected 0.1% (1000 copies/mL) of YIDD plasmid in the background of YMDD plasmid. In addition, the cost of LDR is slightly lower than that of real-time PCR. However, real-time PCR is much more ...

Vical Expands Clinical Testing of DNA Vaccine Against H5N1 Pandemic Influenza

... -- Vical Incorporated (Nasdaq: VICL) today announced the expansion as planned of Phase 1 testing of the company's Vaxfectin(TM)-formulated plasmid DNA (pDNA) pandemic influenza vaccine to allow comparison of vaccination with needle and syringe to vaccination with the Biojector(R) 2000 ...

SuperArray Bioscience Corporation Licenses RNA Interference Patent From The Carnegie Institution

... Institution," said Dr. Paul Nisson, Senior Director of Technology Development at SuperArray Bioscience Inc. "Our combination of a multi-purpose plasmid backbone and a rigorously experimentally verified design algorithm to produce gene-specific RNA Interference for every gene in human, rat and ...

Malaria Truths Discovered By Einstein Researchers

... to introduce any gene of interest into P. falciparum. So they fashioned a plasmid (circular loop of DNA) containing several elements: the gene for the Bronx Bomber enzyme; a section of DNA that would bind the plasmid to a complementary section of DNA inside P. falciparum; and a marker gene ...

New Transgenic Mushrooms Raise Hope for Mass Production of Human Drugs

... flask containing the altered bacterium. Over the course of several days, as the bacterium went through its lifecycle, it transferred a portion of its plasmid into the mushroom cell, and integrated the introduced gene into the chromosome of the mushroom. The researchers then exposed the mushroom ...

Dual Gene Therapy Suppresses Lung Cancer in Preclinical Test

... then confirmed these findings in the mouse studies. The nanoparticle delivery system, which the researchers have used for years, consists of a plasmid gene expression cassette loaded with DNA that encodes either the p53 or the FUS1 protein. This is wrapped tightly in a form of cholesterol to protect ...

Impotent? No Problem – Have An Injectio

... response without transfer-related side effects." “The subjects were given a single injection ranging from 500 to 7500 micrograms of the hSlo plasmid into the corpus cavernosum of the penis and monitored for 24 weeks.” Patients who were given the two highest doses showed sustained improvement ...

Faster way of producing Bird flu vaccine using Reverse Genetics

... reduced number of plasmids which would increase the adaptability of the virus DNA in the tissue culture cells. Researchers feel that by reducing the plasmid number the effect of the vaccine can be increased. Experts View: Chief Medical Officer Sir Liam Donaldson said, “120 million doses ...

Artificially made protein to inhibit angiogenesis

... potentials. Researchers have used an approach used in gene therapy by putting the manmade gene that makes the interceptors in a carrier called plasmid that will get the interceptors inside the cells concerned. This will not only stop blood vessels formation but also help in eliminating existing ...