Peptide in Medical News

Photos: Lumixyl(TM) Enters the Market to Improve the Appearance of Hyperpigmentation without Irritation and Side Effects

... a non-toxic, non-irritating, synthetic peptide technology shown to significantly help improve ... Lumixyl's ground-breaking technology is the only peptide shown to measurably promote healthy skin function ... skin that was treated with the Lumixyl peptide expressed a reduced production of melanin by as ...

Tips from the journals of the American Society for Microbiology

... antibodies that target a gastrin-releasing peptide which is known to play a key role in cancer ... and Vaccine Immunology . Gastrin-releasing peptide (GRP) is an important human peptide that regulates gastric acid secretion and motor ...

Caltech chemists say antibody surrogates are just a 'click' away

... group at one end. The alkyne group on the added peptide can potentially chemically react with the azide group of the library's peptides, to create a new peptide that is now two segments long. However, the reaction can only occur when the second peptide comes into close contact with the first on the ...

Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure

... Clinic cardiology researchers have found a peptide that helps preserve and improve kidney function ... blood pressure. Earlier variations of this peptide caused blood pressure to drop limiting the ... and keep you out of the hospital." This new peptide (a unique link of amino acids) has been tested in ...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

... symposia focused on the potential of peptide therapy treatment approaches for type 2 diabetes, ... SYMPOSIA "Effective Use of peptide Therapies for Optimal Glucose and Weight Control ... healthcare providers understand the potential of peptide therapy treatment approaches for diabetes. The ...

Study reveals current multi-component vaccines may need reworking

... when exposed to high enough levels of the peptide representing it. Andrea Sant, Ph.D., ... the quality that confers immunodominance on a peptide to be the strength and lifespan (kinetic ... pockets on the MHC class II molecule for a given peptide to fit into it before the complex heads to the ...

Researchers identify potential therapeutic target in osteosarcoma

... with circulating particles that display a peptide mimic of the natural ligand that binds IL-11Ra. ... particles called phages equipped with a peptide that mimics IL-11, the receptor's natural ligand. ... is defined as BMTP-11 (Bone Metastasis Targeting peptide 11). The first clinical trial, in which BMTP-11 ...

Genes That Control Body's Salt Levels Are Identified

... genes for these peptides -- atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). They found three variants clearly related ... and, therefore, to lower blood pressure. Higher peptide levels lead to lower blood pressure because ...

Targeted nanospheres find, penetrate, then fuel burning of melanoma

... Hollow gold nanospheres equipped with a targeting peptide find melanoma cells, penetrate them deeply, and ... hollow, spherical gold nanospheres with a peptide - a small compound composed of amino acids - that ... hollow gold nanospheres without the targeting peptide were not. The targeted nanospheres were actively ...

Enzyme with a sugar antenna

... amino acid at a time is much too complex for long peptide chains and sometimes doesn't work at all because ... chemical ligation". In this technique, one peptide fragment is attached to the terminal cysteine group (sulfur-containing amino acid) of a second peptide fragment by means of a thioester groupa selective ...

Process found to play role in rheumatoid arthritis could lead to new treatment

... In addition, the researchers identified a novel peptide to inhibit PlGF action. When injected into arthritic mice, this peptide reduced the severity of arthritis and prevented ... of antibody-induced arthritis. The peptide they identified inhibits binding of PIGF to its ...

Peptimmune Grants Major Pharmaceutical Company Exclusive Option to License PI-2301 for Multiple Sclerosis

... "Peptimmune and its world-leading expertise in peptide copolymers represent an attractive investment opportunity." About PI-2301 PI-2301 is a peptide copolymer developed using Peptimmune's novel platform peptide chemistry. PI-2301 is designed to enhance the ...

Merck Serono and Apitope Announce Licensing Agreement on Novel Peptide Therapeutics for the Treatment of Multiple Sclerosis

... and Commercialization of ATX-MS-1467, Apitope's peptide Therapeutic for the Treatment of Multiple ... commercialize Apitope's product ATX-MS-1467. This peptide therapeutic has completed an initial clinical ... and allergic disorders. Apitope's therapeutic peptide technology platform is based on established ...

New Experts Help New England Peptide Combat Global Acetonitrile Shortage; Company Integrating Cost-Effective Chemical Solvent Alternatives

... strategic usage of new solutions are two leading peptide experts, Dr. Robert Hammer and Dr. Robert Hodges. ... recent months, NEP has added a globally-renowned peptide researcher, Dr. Robert Hodges, to its Scientific Advisory Board (SAB) and named a peptide chemistry expert, Dr. Robert Hammer, as its new ...

Vigorous Treadmill Workout Curbs Appetite Hormones

... hormones: ghrelin (which stimulates appetite) and peptide YY (which suppresses appetite). During the ... (aerobic exercise), ghrelin levels dropped and peptide YY levels increased, indicating that the hormones ... decreased, but there was no significant change in peptide YY levels. The appetite hormone effects of both ...

Sigma-Aldrich Enters Distribution Agreement With AlphaGenix, Inc.

... its components; and HydroMatrix(TM), a synthetic peptide scaffold that offers the precision and control of ... natural 3-D architecture of a highly crosslinked peptide hydrogel. Over the past decade, researchers ... comprised of extracellular matrix components and peptide nanofibers that have cell culture and ...

Peptimmune Announces the Second Close of Series D Private Financing

... About PI-2301 PI-2301 is a second generation peptide copolymer from a similar compound class as ... been optimized using Peptimmune's novel platform peptide chemistry and in pre-clinical studies, has shown ... focused on the development of peptide therapies to improve the management of chronic ...

Novel hydrogel systems for dentin regeneration

... generation of delivery systems are synthetic peptide hydrogels, which provide a nanostructured matrix ... the results of studies on hydrogels made of peptide amphiphiles, where a short peptide sequence is ... design concept, where the self-assembly of peptide chains is achieved without attaching a ...

Breast Cancer Vaccines Look Promising

... human telomerase reverse transcriptase (hTERT) peptide to vaccinate 19 women with breast cancer that had spread. The peptide is nearly universally overexpressed in human ... vaccine using nanoparticles loaded with the HER2 peptide that carry an immune system-stimulating peptide, ...

Brown chemists create cancer-detecting nanoparticles

... the nanoparticle's size and the thickness of the peptide coating, which ensures the nanoparticle attaches ... their nanoparticles with a two-nanometer thick peptide coating 10 times thinner than the coating ... of the team's work is discovering that the RGD peptide coating binds almost seamlessly to the U87MG ...

JCI table of contents: May 22, 2008

... antibody that recognizes DNGR-1 was linked to a peptide it delivered the peptide specifically to DCs expressing CD8-alpha. CTL responses directed to the peptide were induced in mice vaccinated with the ...

Heart Hormones Beat Back Cancers in Mice

... treatment with any of four human cardiac peptide hormones, mice engineered to develop human ... of four cardiac hormones: long acting natriuretic peptide (LANP), vessel dilator (VDL), kaliruretic peptide (KP), or atrial ...

Peptide discovered in scorpion venom may hold key to secretory diseases

... Researchers have discovered a peptide in scorpion venom that may hold the key to ... and Cystic Fibrosis Foundation. peptide toxins from scorpions, snakes, snails and spiders ... chromatography (HPLC) to extract the novel GaTx1 peptide from the complex venom of the Giant Israeli ...

NuView Radiopharmaceuticals, Inc. Secures Exclusive Rights From Thomas Jefferson University for a Tumor-Specific Imaging Agent for the Diagnosis of Breast and Prostate Cancers

... human tumors over-express vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors known as VPAC1, VPAC2 and PAC1. ... evaluations are currently under way for specific peptide analogues for PET imaging of these cancers. ...

Protein Nasal Spray Revives Sleep-Deprived Monkeys

... all night, at least in monkeys. Orexin-A is a peptide (a kind of protein) made in the brain to regulate ... sleep, the brain attempts to make more of the peptide to preserve alertness but often fails to fight ... same pattern of activity when they were given the peptide as when they had not lost any sleep. Orexin-A ...

Xenome Enters Into Joint Research Collaboration to Discover Novel Peptide Therapeutics with Amylin Pharmaceuticals

... focus on the discovery and development of novel peptide therapeutics for a range of metabolic and ... the peptides from Xenome's proprietary bioactive peptide library derived from natural sources. Amylin will ... has successfully created several peptide therapies for the treatment of diabetes and ...

Nastech Pharmaceutical Company Announces Promotion of Rick Costantino, Ph.D., to Chief Scientific Officer of Delivery

... development of new drug delivery technologies for peptide and protein therapeutics. Paul Johnson, Ph.D., ... of non-invasive delivery options for peptide and protein therapeutics," stated Steven C. Quay, ... of new drugs and delivery systems for peptide and protein drugs." Dr. Quay added, "I would ...

M.D. Anderson-led team reports possible key to autoimmune disease

... HOUSTON A human peptide that acts as a natural antibiotic against ... publication in Nature. This combination of the peptide and self-DNA activates the same immune response ... tissue that activates the dendritic cells. The peptide is a member of a family of antimicrobial peptides ...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... in several solid tumors including pancreatic cancer. YSA, a small peptide ligand that binds the EphA2R with high affinity, was inserted into the HI ... reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells ...

Synthetech Announces Fiscal 2009 Results

... also impact our contract drug synthesis market where our traditional peptide building block products are sold. Despite potential adverse effects on ... We develop and manufacture amino acid derivatives, specialty amino acids, peptide fragments and proprietary custom chiral intermediates and specialty ...

Estrogen linked to lowered immunity in fish

... researchers also suspect that hepcidin may act as an antimicrobial peptide in mammals, fish and frogs. Antimicrobial peptides are the first line of ... in two ways. "First," said Robertson, "hepcidin could be an antimicrobial peptide that actually kills pathogens. Or it could be more complex. To live, a ...

4-in-1

... iron oxide particles with a fluorescence dye, RNA fragments, and a special peptide attached. The peptide is present to specifically identify the cancer cells; the RNA fragments ...

Rheumatoid Arthritis Therapeutics in Thailand

... history, blood tests, rheumatoid factor (RF), anti-cyclic citrullinated peptide (Anti-CCP), and X-ray. (Logo: ... factor (RF). The other supporting tests are: anticyclic citrullinated peptide (Anti-CCP), erythrocyte sedimentation rate (ESR), and X-ray." "Recent ...

Gold Nanospheres Show Promise in 'Boiling' Out Cancer

... directly to the melanoma cells by a special protein fragment called a peptide placed inside the nanosphere. Using a technique known as photoablation ... eight times more effective in killing the cancer than those without the peptide guidance system, according to researchers who were to present the findings ...

Alzheimer's Drug May Someday Help Head Trauma Victims

... showed that brain injury in mice resulted in substantially more amyloid peptide than normal. They then found that amyloid peptide production after brain injury was reduced in mice that received an ...

Takeda Receives New Information on Alogliptin (SYR-322) NDA

... (DPP-4), which metabolizes the insulin-increasing hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). By maintaining the blood levels of GLP-1 and GIP, DPP-4 inhibitors ...

GSK Initiates Phase III Programme for Novel Type 2 Diabetes Medication, Syncria(R) (albiglutide)

... safety and tolerability of the investigational GLP-1 (Glucagon-like peptide 1) agonist Syncria(R) (albiglutide) in men and women with type 2 diabetes. ... is an investigational biological, injectable form of human GLP-1 -- a peptide that acts throughout the body to help maintain normal blood-sugar levels ...

Nile Therapeutics to Present at the 27th Annual J.P. Morgan Healthcare Conference

... development programs for its lead compound, CD-NP, a novel chimeric peptide for the treatment of acute heart failure. About Nile Therapeutics ... developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure; 2NTX-99, a small ...

CEL-SCI Launches Study to Determine Long Lasting Beneficial Effects of its Rheumatoid Arthritis Vaccine

... epitope linked to a T-cell binding ligand (TCBL) can be manufactured by peptide synthesis or by covalently linking the two peptides. Depending upon the ... it would appear that the L.E.A.P.S. construct represents a chimeric peptide with bi-functional behavior. CEL-SCI Corporation is developing ...

Nile Therapeutics, Inc. Reports 2008 Third Quarter Financial Results

... Development Update CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for the treatment of ADHF. CD-NP was designed to ... developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure; 2NTX-99, a small ...