Oncogene in Medical News

Cancer-Causing Gene Discovery Suggests New Therapies

... paper with Barna. "The ability of the Myc oncogene to directly alter this process may well explain ... in DNA activity in the cell nucleus. But how the oncogene affected the subsequent production of proteins, a ... that was cancer-prone and overexpressed the Myc oncogene and one that was newly engineered to lower ...

Cancer drug works by overactivating cancer gene

... melanoma tumor cells because it causes the c-MYC oncogene to overproduce a cell-death promoter called NOXA. ... treatment could be to actually exacerbate oncogene function, to promote such a dysregulation of cell ... cell death, surprisingly turned out to be the oncogene c-MYC. The discovery of the oncogenes role in ...

Gene Connections Key to Brain Tumor Growth

... genes. The hub gene is the EGFR (epidermal growth factor receptor) oncogene on chromosome 7, according to the study. It is amplified in about 45 ... researchers reported. A decrease in the function of ANXA7 shoots the EGFR oncogene into overdrive, contributing to the development and progression of ...

Study pinpoints novel cancer gene and biomarker

... as this finding was, it was hardly enough to prove that GOLPH3 is an oncogene -- a contributor to cancer when overexpressed within a cell. Demonstrating ... Medical School. In addition to identifying GOLPH3 as a bona fide oncogene and an indicator of whether rapamycin is likely to be effective against ...

NYU Langone Medical Center's tip sheet to the 45th Annual Meeting of ASCO

... # 11034, Sunday, May 31, 2009, 2 p.m. to 6 p.m. Overexpression of an oncogene linked to worse melanoma prognosis Iman Osman, M.D., associate ... Institute present preliminary evidence that overabundant expression of an oncogene called Skp2 was associated with a worse melanoma prognosis. The activity ...

Blocking Oncogene Can Stop Spread of Ovarian Cancer

... MONDAY, Dec. 15 (HealthDay News) -- Blocking proteins produced by the oncogene MYC can stop the spread of ovarian cancer, researchers say. An oncogene is a gene that has the potential to help cause cancer. In up to 60 ...

Cellular senescence a double-edged sword

... For example, normal cells that acquired a highly active version of the RAS oncogene became senescent and secreted higher levels of SASP components. This very ... or cancer cells that have lost the p53 tumor suppressor gene, or gained an oncogene such as RAS, promote cancer so efficiently," Campisi said. These ...

Colon Cancer Oncogene Discovered

... important work," Brooks said. "They have identified what apparently is an oncogene associated with some colorectal cancers." Dr. William Hahn, of the ... beginning of that pathway," Brooks added. "All they have shown is this oncogene seems to be associated with a significant number of cancer ... ...

Research Uncovers Clues to Lymphoma

... the B-cell receptor on the surface of B-cells can cooperate with the MYC oncogene to accelerate the development of lymphomas. They also found that ... are genes thought to encourage cancer. It was already known that the oncogene MYC played an important role in the development of lymphomas. It wasn't ...

Crucial factors in lymphoma development and survival discovered

... The B-cell receptor on the surface of B cells can cooperate with the MYC oncogene to accelerate the development of lymphomas. The research team, led by ... , and about 19,000 people die of it. It has long been known that the oncogene MYC plays a crucial role in the development of lymphomas. One unanswered ...

Gene Plays 'Jekyll-and-Hyde' Role in Deadly Brain Cancer

... little over decades. Previous research has shown that STAT3 is an oncogene in several types of glioblastoma. An oncogene is a gene whose normal functions are disrupted and, as a result, helps ...

Natural secretion marks difference between mole and melanoma

... School. It might also be used to treat other cancers with mutations in the oncogene known as BRAF. "This is a natural mechanism by which cells try to ... senescence and cease dividing. "How, then, does an activated BRAF oncogene induce uncontrolled proliferation in melanoma and senescence in benign ...

Gene plays 'Jekyll and Hyde' in brain cancer

... has found that STAT3 isnt always the villain. While it does behave as an oncogene in certain types of glioblastoma, in others it becomes whats called a ... human glioblastoma tumors as well. The belief that STAT3 can only be an oncogene has been a pretty entrenched dogma in the field, says Bonni, so we ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

... family of cancer-promoting oncogenes, which include KRAS and NRAS , are implicated in several cancers, including colorectal cancer. BRAF is an oncogene of RAF, which is a family of proteins typically activated by RAS and which influence cellular activity. About Quest Diagnostics Quest ...

Cancer cells need normal, nonmutated genes to survive

... tumor, which deprives cells of oxygen. Survival requires a complete kit of stress response tools. "Researchers often characterize cancer cells as oncogene addicts, but they're just as reliant on normal genes that alleviate stress," explains senior author Stephen Elledge, a professor at HMS and Brigham ...

Reminder: Top Physician-Scientists Discuss State of Cancer Research at Damon Runyon Cancer Research Foundation Symposium

... Dr. Weinberg is one of the nation's most distinguished cancer researchers, most widely known for his pioneering discovery of the first human oncogene (Ras). Scott Hensley , award-winning healthcare writer and editor, will moderate a panel discussion titled "Moving from Discovery ...

New oncogene gives valuable insight into hepatocellular tumors in humans

... Recently, somatic mutations were identified that activated GP130 in 60% of IHCA (Rebouissou et al, Nature, 2009), thus defining GP130 as a new oncogene in human tumours. This study aimed to evaluate frequency of GP130 mutations in a wide series of tumours. Dr Jessica Zucman-Rossi of Inserm U674, ...

New alternative to biopsy detects subtle changes in cancer cells, Stanford study shows

... to identify the relative amounts and positions of the various proteins. The scientists found that not only was the technique able to identify oncogene activation in cultured tumor cells, but it also worked well in small lymphoma samples drawn from laboratory mice with small, hollow needles. ...

Top Physician-Scientists Discuss State of Cancer Research at Damon Runyon Cancer Research Foundation Symposium

... Dr. Weinberg is one of the nation's most distinguished cancer researchers, most widely known for his pioneering discovery of the first human oncogene (Ras). A panel discussion titled "Moving from Discovery through Development - The Evolving Relationship between Academia and Industry." ...

Also in the March 24 JNCI

... Overexpression of Fatty Acid Synthase Promotes Prostate Cancer in Mouse Models Fatty acid synthase (FASN) can act as a prostate cancer oncogene in mouse models. FASN, a key enzyme in the synthesis of long-chain fatty acids, is overexpressed in prostate cancer, relative to its expression in ...

NYU study finds new risk factor for melanoma in younger women

... mediated in part by a genetic variant in a gene called MDM2. When estrogen binds to this gene, it turns on production of MDM2, a potential oncogene (cancer promoting gene) in cells. In the presence of the genetic variation in MDM2, originally identified by the laboratory of Dr. Arnold Levine at ...

International Panel of Experts Gather for Roundtable Consensus Regarding Multiple Myeloma Related Disease

... Clinical Oncology, Science, Proceedings of the National Academy of Sciences, Cancer, Clinical Cancer Research, Clinical Lymphoma and Myeloma, Nature, oncogene and the British Journal of Haematology. www.imbcr.org Available Topic Expert(s): For information on the listed expert(s), click appropriate ...

Festschrift Issue honoring Judah Folkman, M.D., in Lymphatic Research and Biology

... Lymphangiogenesis?," Yihai Cao explains the processes behind increased lymphatic supply to cancerous lesions. Dean Felsher explores the phenomena of oncogene addiction, cellular senescence, and the angiogenic switch in a report entitled, "Reversing Cancer From Inside and Out." In a forward-looking review, ...

New insight into aggressive childhood cancer

... screen of nearly 200 genes that are dependent on amplified MYCN in human neuroblastoma or are direct targets of Myc. The researchers found that the oncogene AURKA is required for growth of MYCN-amplified neuroblastoma cells, but not cells lacking amplified MYCN. AURKA encodes the kinase Aurora A which ...

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

... may put them at high risk for squamous cell carcinomas linked to human papillomavirus (HPV), according to a study posted online ahead of print by oncogene . Researchers led by Cincinnati Children's Hospital Medical Center report the breakdown of a cell signaling pathway for the FA (Fanconi Anemia) ...

Escape cancer, but age sooner? The dark side of the tumor suppressing process

... or cancer cells, and further defines a new mechanism by which precancerous or cancer cells that have lost the p53 tumor suppressor, or gained an oncogene such as Ras, promote cancer so efficiently. "This study defines a new paradigm for how oncogenes promote, and how tumor suppressor genes suppress ...

A simple blood test for colon cancer

... argument for patients to undergo the colonoscopy, and then polyp removal, if necessary. The novel invention is based on testing CD24, the oncogene for colorectal cancer. It utilizes the fact that polyps in the colon emit biomarkers, which can be detected in the blood at very low levels. Recent ...

UNC researchers find clue to stopping breast-cancer metastasis

... "It's a useful model system that mimics what happens in the body." The study results appeared in the Nov. 3, 2008, online edition of the journal oncogene . Most women would never die from breast cancer if the cancer cells couldn't metastasize to the brain and bone marrow, Otey said. "To really make ...

Recipe for cell reprogramming adds protein

... DNA anywhere in a cell's genome, thereby potentially triggering the expression of cancer-causing genes, or oncogenes. Second, c-Myc is a known oncogene whose overexpression can also cause cancer. For IPS cells to be employed to treat human diseases such as Parkinson's, researchers must find safe ...

Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis

... DACH1 to Ras-induced breast cancer cells, for example, they saw a greater than 75 percent reduction in cell migration. Cells turned cancerous by the oncogene ErbB2 showed a 50 percent drop in migration. Cells made cancerous by Myc also had 50 percent less migration. The researchers performed a proteomic ...

Identification of 5 genes involved in the metastasis of breast tumors to the lung

... Hospital. The study made up a significant part of Mr Ral Catena's PhD thesis. For this research, recently published in the scientific journal oncogene , a transgenic mouse model which presented a greater tendency for developing metastasis was employed. The increase in what is known as the Vascular ...

Gene mutation improves leukemia drug's effect

... AML patients should receive high-dose cytarabine as their post-remission therapy. "This appears to be the first example in AML of a mutation in an oncogene that favorably modifies a patient's response to the dose of a routinely used chemotherapeutic drug," Bloomfield says. "If confirmed, AML patients ...

MicroRNA controls expression of oncogenes

... and some acute lymphoblastic leukemias. The researchers went on to show that transcriptional silencing of miR-203 lead to upregulation of the oncogene ABL1 and the BCR-ABL1 oncogenic fusion protein in various mouse and human hematopoietic malignancies. Further, restoration of miR-203 resulted in a ...

Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?

... sites. CKAP4-similar protein has high homogeneity with Np63, and the characteristic expression of agrNp63 alpha that is considered a potential oncogene in the isoforms of p63 is similar to Ca-Hb3. Np63 is an isoform of the p63 family. A number of studies have highlighted the oncogenic potential ...

Scientists discover a mechanism that can send cells on the road to cancer

... molecular biologists from Stony Brook University in New York. Using a Tumor Virus to Illuminate Function The team focused on an adenoviral oncogene called E1A, and a protein that it codes for with the same name. Both have received a great deal of attention over the years, said Dr. Tansey, and to ...

Molecule Disrupts DNA Sequence in Ewing's Sarcoma

... yield first targeted therapy for the rare disease, researchers say MONDAY, April 14 (HealthDay News) -- A molecule that disrupts the oncogene that causes Ewing's sarcoma has been identified by Georgetown University Medical Center researchers. Ewing's sarcoma is a rare cancer that ...

2 microRNAs promote spread of tumor cells

... Molecular and Cellular Oncogenesis Program and lead author and co-corresponding author on the study. In 2006, miR-373 was identified as a possible oncogene a modified gene that causes cancer in testicular cancer. According to Huang, miR-520c is a new miRNA whose function has not been known until now. ...

Top Scientists to Receive Prestigious Awards From the American Society of Hematology

... Medical Center. "It is my honor to recognize these outstanding individuals for their achievements." With his discovery of the workings of the MYC oncogene in Burkitt lymphoma, Dr. Croce was one of the first to make a case for the genetic basis of cancer. A prolific researcher, he later identified ...

JCI table of contents: Nov. 15, 2007

... conclude that FOXP3 is a suppressor of tumor development induced by SKP2. TITLE: FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2 AUTHOR CONTACT: Yang Liu University of Michigan, Ann Arbor, Michigan, USA. Phone: (734) 615-3158; Fax: (734) 763-2162; E-mail: ...

M. D. Anderson researchers identify tumor-suppressor gene for lung cancer

... in cancer development. The team also found that the tumors generated in the mice without the genes lacked mutations to the K-Ras gene, a common oncogene that fuels cancer growth. "This may be important because the carcinogenesis pathway observed in our model may be relevant to the more than 65 percent ...