Mouse in Medical News

Finding key to cancer drug Gleevec's limitations

... toward CML are able to resist the drug. "The mouse model we have developed for CML allows us to ... U-M and senior author of the study. Developing a mouse model that closely reproduces the progression of ... testing several two-drug combinations using their mouse model. Imatinib is being combined either with ...

Scientists Track Impact of DNA Damage in the Developing Brain

... DNA strands in an organ system, in this case the mouse brain and nervous system. While the results ... a way to switch off Xrcc1 production in the mouse brain and nervous system as development began. ... system. St. Jude researchers then developed a mouse that carried an Xrcc1 gene outfitted with ...

Scientists Use Non-Embryonic Stem Cells to Create Healthy Mice

... THURSDAY, July 23 (HealthDay News) -- The mouse may be named "Tiny," but what it represents in ... team injected some of the iPS cell lines into mouse embryonic material, a complex technique known as ... resulted in the production of dozens of healthy mouse pups. What's more, the iPS-generated pups were ...

Scientists Use Adult Stem Cells to Create Healthy Mice

... THURSDAY, July 23 (HealthDay News) -- The mouse may be named "Tiny," but what it represents in ... team injected some of the iPS cell lines into mouse embryonic material, a complex technique known as ... resulted in the production of dozens of healthy mouse pups. What's more, the iPS-generated pups were ...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

... Increases Brain Beta Amyloid in Alzheimer's mouse Models Recent evidence suggests that ... series of experiments in cells and in Alzheimer's mouse models to assess the effects of dimebolin on beta ... Immunotherapy Against Tau Tangles in Alzheimer's mouse Models Immunotherapy (treatment by ...

New technique could sustain cancer patients' fertility

... on earlier efforts by the research team, who grew mouse follicles in culture, induced the eggs they contained to mature, fertilized them with mouse sperm, and implanted them into female mice to ... in culture. The ability to do research on mouse and monkey follicles might lead to advances that ...

Study pinpoints novel cancer gene and biomarker

... human cancer cells, laboratory cell cultures, and mouse models - to demonstrate that a surplus of a gene ... a non-cancerous cell cancerous. It did in both mouse and human cells. "All these results enabled us ... mechanistic relationship we'd identified in the mouse system is also at work in human tumors," says ...

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

... successfully generated a novel kinase-dead mutant mouse of the CaMKII alpha gene that completely and ... generated a novel CaMKII alpha (K42R) knock-in mouse that completely lacks the kinase activity of ... protein was preserved. In addition, the K42R mouse showed a severe deficit in inhibitory avoidance ...

Scripps Florida scientists devise accelerated method to determine infectious prion strains

... among various strains combines a transgenic mouse model with a rapid and sensitive cell-based ... "There are about 20 prion strains known in mouse models," Lasmzas said. "We still don't understand ... varieties of prion strains are identified in mouse models according to incubation time, clinical ...

Why do people with Down syndrome have less cancer?

... tissues from people with Down syndrome and in a mouse model of the disease. Further study confirmed ... vascular endothelial growth factor (VEGF). In a mouse model of Down syndrome, endothelial cells (which ... Ryeom and her group next validated the mouse findings in human cells. In collaboration with ...

JCI online early table of contents: May 1, 2009

... have now determined that Fog2 regulates adult mouse heart function and the growth of new coronary ... heart and coronary vessel function in the adult mouse heart. TITLE: Fog2 is critical for cardiac ... maintenance of coronary vasculature in the adult mouse heart AUTHOR CONTACT: William T. Pu ...

Popular gaming system may offer radiologists an alternative way to view patient images

... a fun, alternative method to using a standard mouse and keyboard to navigate through patient images, ... repetitive motion injuries as a result of using a mouse and keyboard. "We have developed a new fun ... hand movements instead of basic keyboard and mouse clicks," said Cliff Yeh, MD, Matthew Amans, MD, ...

AAI honors Chen Dong for breakthrough T lymphocyte research

... these crucial receptors from their T cells to a mouse model of rheumatoid arthritis. There was plenty ... in their inner lining. Blocking IL-17 in a mouse model of multiple sclerosis greatly reduced the ... would be very beneficial." Preliminary data in a mouse model of autoimmunity against cancer are "very ...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

... molecules called microRNAs to help turn adult mouse cells back to their embryonic state. These ... molecules called microRNAs to help turn adult mouse cells back to their embryonic state. These ... the treated cells could be incorporated into a mouse embryo and become every cell type in the adult ...

Arthritis Hand Pain Relief: Infrared Heat Therapy Ergonomic Computer Workstation

... low-priced infrared heated mouse, heated mouse pad, heated keyboard pad and mouse hand warmer blanket. IGMproducts.com is the ... the following USB items: ValueRays® Warm mouse ValueRays® ...

Stem Cell Breakthrough May Lead to MS Treatments

... assuming that because you can do something with a mouse cell, that a human cell is going to behave in the ... question: What's the difference between mouse and man? It's not as silly as it sounds. ... out to be wrong. For years, researchers using mouse embryonic stem cells (ESCs) knew that if they ...

Also in the April 7 JNCI

... Signaling Promotes Gastric Cancer Growth in mouse Models Disruption of transforming growth ... in gastric cancer cells promotes tumor growth in mouse models. TGF- is a cytokine that ... that disruption of TGF- signaling in a mouse model of diffuse-type gastric carcinoma, which ...

JCI online early table of contents: April 6, 2009

... that have spread to other sites) and spontaneous mouse melanomas. The team, led by Francesco Colucci ... Consistent with these data from human cell lines, mouse spontaneous melanomas and melanoma cell lines ... reduced NK cellmediated killing of human and mouse melanoma cells lines in vitro and in vivo. The ...

CSHL neuroscientists propose project to comprehensively map mammalian brain circuits

... complete a first-draft circuit map of the entire mouse brain within two to three years, as a first step ... are proposing to map the circuit in the mouse brain at what they call a "mesoscopic scale." ... with the basic architectural organization of the mouse brain, in terms of its observed cellular, ...

JCI table of contents: March 23, 2009

... from licorice) blocks COX-2 activity in human and mouse colorectal tumor cells, inhibiting their growth ... type of viral vector, LVs, in a tumor-prone mouse model, a team of researchers, at San ... vector design and integration site selection in a mouse model of HSC gene therapy AUTHOR CONTACT: ...

JCI online early table of contents: March 9, 2009

... factor, not only restored RA sensitivity of mouse and human melanomas, but remarkably stopped tumor ... of SOX9 inhibits the growth of human and mouse melanoma and restores their sensitivity to ... the effects of CaMKII inhibition in the mouse heart after a heart attack. They found that ...

Penn vet researchers identify a critical growth factor that stimulates sperm stem cells to thrive

... the first time a specific "niche factor" in the mouse testes called colony stimulating factor 1, Csf1, ... that the niche in the testis of a newborn male mouse supported stem cells and their ability to produce ... looked at what happened to SSCs as the male mouse aged and became infertile, which occurs at about ...

Genetic evidence points to potential therapeutic bypass for autoimmune process

... With this approach, the researchers identified a mouse that almost completely lacked Treg cells. The ... Carma1-deficient mice and infected them with a mouse variant of human cytomegalovirus which is ... new insight into the way pathogens, in this case mouse CMV, hijack the host immune system by ...

Study sheds light on angiogenesis inhibitors, points to limitations, solutions

... affect tumors in patients as they do in their mouse models of human cancers. They call for ... to become more invasive. We hypothesize from the mouse models that if you cut off the tumor's blood ... drug sunitinib (manufactured as Sutent) in mouse models of both pancreatic neuroendocrine cancer ...

JCI online early table of contents: Feb. 16, 2009

... Glasgow, United Kingdom, have now shown that both mouse and human GM1-specific antibodies can damage live mouse nerve cells. In the study, initial analysis indicated that only some mouse GM1-specific antibodies could bind and damage ...

Team led by Scripps Scientists increases understanding of two types of blindness

... Though based on mouse studies, the research bolsters the idea that ... better treatments, the research team examined a mouse model of these human diseases. The particular "knockout" mouse the team focused on has been used by other ...

New insights into growth factor's role in brain development

... proBDNF and mature BDNF were being made in a mouse model. They found that proBDNF is most highly ... hippocampus during the postnatal period of the mouse at about days 3 to 21, when large numbers of ... levels of both molecules seen in the young mouse brain, and lower and more localized levels ...

Living with females extends the reproductive life of the male mouse, says Penn veterinary researcher

... PHILADELPHIA - Living with a female mouse can extend the reproductive life of a male mouse by as much as 20 percent, according to a study ... "It appears that housing females with a male mouse delays the decline of reproductive processes at ...

Penn researchers unlock molecular origin of blood stem cells

... a majority of bone marrow stem cells form in the mouse embryo. The findings, appearing online this week ... for the protein Runx1 in the endothelial cells of mouse embryos. During development, some endothelial ... Next, Speck's team shut off Runx1 expression in mouse embryos at day 11.5 of gestation -- a time when ...

Old, Fat Mice Blamed for Virus Transmission

... was how the hantavirus is most often spread from mouse to mouse. With the aid of fluorescent talcum ... 15-day periods. The number of contacts that a mouse had with other mice did not affect its likelihood ... of the Royal Society B . Knowing where deer mouse populations thrive -- where mice grow older and ...

Rockefeller University's Center for Clinical and Translational Science funds 18 new pilot studies

... of antigens to T helper cells work in mouse glial cells, and to identify substrates in ... aureus. This trial also aims to develop a skin mouse model to be used to ascertain the safety and ... Neuroendocrinology, to measure lead levels in a mouse model of chronic lead exposure. Lisa Zaba, ....

Decreased activity of basal ganglia is the main cause of abnormal muscle constrictions in dystonia

... abnormal muscle constrictions of dystonia using a mouse model. They report their findings in Journal of ... activity in the basal ganglia of a dystonia mouse model, which was generated by transferring human ... in normal state. However, in the dystonia mouse model, the neuronal activity is decreased so that ...

Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds

... may one day be repaired. First, they grew mouse esophageal cells they suspected were adult stem ... formed epithelial structures. Additionally, in a mouse model of injury of the esophagus in a normal ... researchers will develop genetically engineered mouse models to be able to track molecular markers of ...

Mutant proteins result in infectious prion disease in mice

... has created an infectious prion disease in a mouse model, in a step that may help unravel the ... gene, the researchers developed a transgenic mouse model that expressed the mutant prion protein. ... and unlike the flexible "loop" found in normal mouse or human prion proteins. Aging mice with the ...

Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder

... In this study, researchers worked with a mouse model of RDEB-infused bone marrow cells to ... of anchoring fibrils, and improve survival in the mouse recipients. The research team used bone marrow ... cells can connect the epidermis and dermis in a mouse model of the disease and offer a potentially ...

Bone marrow-derived stem cells may offer novel therapeutic option for skin disorder

... In this study, researchers worked with a mouse model of RDEB-infused bone marrow cells to ... of anchoring fibrils, and improve survival in the mouse recipients. The research team used bone marrow ... cells can connect the epidermis and dermis in a mouse model of the disease and offer a potentially ...

Dormant stem cells for emergencies

... life. These processes have best been studied in mouse bone marrow. Up to now, scientists have ... have now discovered a group of stem cells in mouse bone marrow that remain in a kind of dormancy ... scientists labeled the genetic material of all mouse blood cells and subsequently investigated how ...

JCI online early table of contents: Dec. 1, 2008

... T cells. Sadelain and colleagues engineered mouse bone marrow cells to express therapeutic genes ... of fluid and HCO3 by epithelial cells in the mouse pancreatic duct, data that they hope will have ... and HCO3 secretion by epithelial cells in the mouse pancreatic duct through its ability to activate ...

Introducing The Hot Tooth Keyboard, the Cleanable, Hygienic, Wireless Keyboard for Dental Practitioners and Laboratories

... 1 year warranty. U-Cool Keyboard - Mighty mouse 5 - a waterproof optical scrolling mouse designed for easy cleaning with standard disinfectants. Mighty mouse 5 - Cool Drape - Silicone sheets that can be ...

Cold Spring Harbor science teams identify 13 new tumor-suppressor genes in liver cancer

... but combining it with functional screening in mouse models is a notable step forward." The usual ... a gene's function is to mutate it in mouse embryos and then create lines of mice that can ... by engineering mutations into the genome of adult mouse cells and then re-injecting these cells into ...