Metastasis in Medical News

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

... cells and thereby extend the period during which metastasis may emerge after the diagnosis and removal of a ... signal that was abundantly expressed in bone metastasis tissue. These results demonstrate that Src ... cell survival provides mechanistic insights into metastasis latency, and suggests strategies to hasten the ...

Lab Study Finds Protein That May Inhibit Cancer Spread

... is no approved therapy for inhibiting or treating metastasis -- the migration of cancer cells from the original cancer site to other parts of the body. metastasis is one of the leading causes of cancer death. ... secrete a protein called prosaposin that inhibits metastasis by promoting production of factors that block the ...

Potent metastasis inhibitor identified

... Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially ... a protein called prosaposin -- which inhibits metastasis by causing production of factors that block the ... at Children's, encouraged him to focus on the metastasis inhibitor -- prosaposin. "You might have a drug ...

Joan Massagué wins BBVA Foundation Frontiers of Knowledge Award in Biomedicine

... research into the genetic and cellular bases of metastasis and remains an acknowledged leader in this field. ... Research into the genes involved in cerebral metastasis and their mode of action, "is still very much at ... stage", says Massagu. "These are the first brain metastasis genes to be identified, with clinical data". ...

Where tumor cells boldly go: Weill Cornell cancer biologists shed light on the metastatic niche

... far from the primary tumor, well before full metastasis takes hold. "In cancer, it is metastatic ... players that mediate changes at future sites of metastasis such as liver, lung, brain or bone, and thereby ... future when we'll be able to prevent metastasis through a new approach for early detection and ...

Tips from the American Journal of Pathology

... 174: 1921-1930 TIP30 Inhibits Lung Cancer metastasis Researchers in Shanghai, China suggest that ... of TIP30 expression promoted lung cancer metastasis and angiogenesis in mice, Tong et al conclude ... roles in suppressing the progression and metastasis of lung cancer." These findings highlight TIP30 ...

Instead of fighting breast cancer, immune cell promotes its spread

... as a promoting factor in breast cancer metastasis and provides a potentially good marker for breast ... pathway downstream of RANKL blocks primary metastasis and can potentially be developed as a treatment ... and immune response, we can also reduce tumor metastasis and are very likely to develop a therapy that is ...

M. D. Anderson launches graduate program in cancer metastasis

... Texas System. The Graduate Program in Cancer metastasis Research: Bench to Bedside, will concentrate on ... program is the first to treat the study of metastasis as a separate discipline," said program organizer ... faculty. UT System allocated $485,250 to the metastasis program over three years, one of only seven ...

Master molecular switch may prevent the spread of cancer cells to distant sites in the body

... one day lead to a drug that controls cancer cell metastasis and tissue fibrosis. This change in cell ... physiological consequences, leading to cancer metastasis as well as other disease processes such as tissue ... cells, then it might be possible to prevent metastasis or control fibrosis," notes corresponding author ...

New findings measure precise impact of fat on cancer spread

... implanted in the mice. However, the rate of metastasis rose a dramatic 300 percent in the mice fed a ... supported the other results showing increased metastasis in animals fed a high-fat diet. The researches ... work will focus on not only how obesity increases metastasis but also how it might play a direct role in ...

Protein predicts liver cancer recurrence and after transplantation

... is associated with liver cancer recurrence and metastasis after liver transplantation. Capn4 could ... molecule associated with hepatocellular carcinoma metastasis and recurrence. "It was dramatically ... of Capn4 associated with tumor invasion and metastasis after liver transplantation for hepatocellular ...

PET/CT may improve prognosis for patients with inflammatory breast cancer

... to identify the precise location and extent of metastasis (spread of disease), offering the potential for a ... cancer, and 90 percent had no symptoms of distant metastasis (disease spread beyond the breast). Each ... sensitivity, however, allows us to pinpoint metastasis in other parts of the body; for example, behind ...

Gene plays dual role in breast cancers with poor prognosis

... gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy. The research, ... University. "Resistance to chemotherapy and metastasis remain major challenges to curative therapy." ... and eventually preventing, breast cancer metastasis and chemoresistance. To further unravel the ...

Lung cancer cells activate inflammation to induce metastasis

... by cancerous lung epithelial cells that enhances metastasis by stimulating the activity of inflammatory ... The discovery could lead to a therapy to limit metastasis of this most common lethal form of cancer. The ... versican as the major macrophage activator and metastasis enhancing factor. Versican is also found in very ...

Exciting discovery could 'stop cancer from killing people'

... metastasis is the ability of cancer cells to spread from a ... role. Essential to our understanding of how metastasis develops is identification of the molecules, and ... Cγ1 (PLCγ1) plays a crucial role in metastasis formation, but that down regulation of PLCγ1 ...

If metastasectomy should be performed before other treatments

... extrahepatic spread to the lung, so called lung metastasis from liver cancer is a dilemma, because it may be ... partly true that most of the patients with lung metastasis from liver cancer did not survive for more than 1 ... results after collaborative treatments for lung metastasis from liver cancers were achieved. A research ...

Nanoparticle Stops Cancer From Spreading

... 'Smart bomb' curbs metastasis with fewer side effects, study finds ... little impact on primary tumors, it halted the metastasis of pancreatic and kidney cancers throughout the bodies of mice. Cancer metastasis normally is much harder to treat than the primary ...

Also in the July 8 JNCI

... Cyclin A1 promotes prostate cancer invasion and metastasis by increasing the expression of key signaling ... cyclin A1 expression in tumor invasion and metastasis in a mouse model of prostate cancer. The ... (MMPs) and promotes tumor cell invasion and metastasis in part through MMPs and [urokinase-type ...

'Smart bomb' nanoparticle strategy impacts metastasis

... strategy using molecular "smart bombs" to target metastasis with anti-cancer drugs leads to good results ... chemotherapy to achieve a profound impact on metastasis in pancreatic and kidney cancer in mice. In a ... signs of toxicity in the patient." Cancer metastasis is traditionally much more difficult to treat ...

Identification of 5 genes involved in the metastasis of breast tumors to the lung

... The identification of five genes involve in the metastasis of breast tumours to the lung is the principal ... which presented a greater tendency for developing metastasis was employed. The increase in what is known as ... new discovery in the complex network that is the metastasis process of tumours provides key data on the ...

Stabilizing cancer-fighting p53 can also shield a metastasis-promoter

... only the p53 mutation. The frequency of metastasis went from zero in the p53 H/H with normal Mdm2, ... copy of Mdm2 to 17 percent in mice with no Mdm2. metastasis - the invasive spread of cancer to other organs - ... raises the possibility of suppressing cancer metastasis by eliminating mutant p53 stability, which the ...

Which is accurate, CT or MRI?

... Paraaortic lymph node metastasis in patients with pancreatico-biliary carcinoma ... carcinoma, paraaortic lymph node metastasis has a crucial impact on surgical indication or ... MRI in the evaluation of paraaortic lymph node metastasis in patients with pancreatico-biliary carcinoma. ...

Scientists at Yale provide explanation for how cancer spreads

... a white blood cell as the initiating event for metastasis suggests that metastasis is virtually another disease imposed on the ... that white blood cell fusion accounts for cancer metastasis in humans. To date, the fusion theory and the ...

Researchers learn how signaling molecule orchestrates breast cancer's spread

... use a particular type of molecule to promote metastasis -- the spread of cancer cells. metastasis is the cause of approximately 90 percent of all ... shows that TGF-a enhances human breast cancer metastasis and reveals how tumor cells learn to exploit ...

Molecular Cause of Breast Cancer Metastasis Discovered

... correlation between TGF-beta signaling and metastasis in breast cancers that also express the estrogen ... to lung. No similar correlation was found for metastasis to the bone, liver or brain. When the team ... signaling, or ANGPTL4 expression, and lung metastasis is disrupted, the researchers found. Enhance that ...

Soy compound may halt spread of prostate cancer

... University found that genistein decreased metastasis of prostate cancer to the lungs by 96 percent ... to demonstrate genistein can stop prostate cancer metastasis in a living organism. These impressive ... developed within the prostate, it stopped lung metastasis almost completely. They repeated the experiment ...

A protein that triggers aggressive breast cancer

... cancer cells need SATB1 to become metastatic; metastasis -- the stage when cells break away from the ... SATB1 from metastatic cells not only abolishes metastasis and tumor growth in mice but also returns cells ... activity. "SATB1 is a key player in the metastasis of breast cancer cells, controlling expression of ...

New blood marker may predict prostate cancer spread

... help identify patients at risk for lymph nodes metastasis who should undergo pelvic lymphadenectomy. In ... it may spare patients at low risk of lymph node metastasis the potential morbidity of an unnecessary ... of endoglin as a marker for predicting lymph node metastasis in patients with clinically localized prostate ...

A new significance of LVD and angiogenic MVD is identified in human primary SCRC

... higher in the cases of colorectal carcinoma with metastasis than in cases without metastasis. For each one ... there was a 1.45-fold increase in the risk of metastasis in SCRC, and for each one microvessel increased, ... specificity and sensitivity of LVD in predicting metastasis or non-metastasis in SCRC were both higher than ...

Small RNAs can prevent spread of breast cancer

... likelihood that breast tumors will metastasize. metastasis of breast cancer is the leading cause of death from the disease. metastasis occurs when cells from a primary tumor break off ... distinct genetic signatures associated with metastasis to the bone and the lungs. They decided to ...

Survival shortened when ER/PR negative breast cancer spreads to the brain

... in systemic therapy prolong survival, brain metastasis in breast cancer patients is becoming more ... with ER/PR- disease tend to develop brain metastasis even if the cancer has not spread anywhere else, and this metastasis develops sooner and survival is shorter compared ...

JCI online early table of contents: Dec. 6, 2007

... ONCOLOGY: The molecule GPC1 facilitates tumor metastasis The prognosis for individuals diagnosed with ... indicating that the importance of GPC1 to tumor metastasis is not restricted to PDAC. TITLE: Glypican-1 ... strategies to prevent colorectal cancer metastasis to the liver. In the study, in vitro analysis ...

Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer

... candidate for controlling tumor growth, metastasis to bone and bone disorders, such as osteolysis ... as a therapeutic agent to target primary tumors, metastasis to bone and tumor-induced osteolysis. There ... Targeting metastatic tumors at sites of metastasis would be of great benefit for patients who have ...

Transparent zebrafish help researchers track breast cancer

... discovery of how two proteins interact in the metastasis of breast cancer. The study led by Richard ... tumor cells to complete the most critical step of metastasis entering the blood vessels, said Konstantin ... how RhoC and VEGF cooperate to facilitate cell metastasis in living tissues. The transparency of the fish ...

UC San Diego researchers improve accuracy of breast cancer prognoses

... approach for predicting the risk of breast cancer metastasis in individual patients. This work will be ... offer new mechanistic insights into breast cancer metastasis and are more accurate and reproducible than two ... chemotherapy, due to our inability to predict metastasis risks with high accuracy. One of our goals is to ...

18F-DG PET/CT can highly increase the detection of colorectal cancer

... of PET/CT in detection of the recurrence and metastasis of colorectal cancer (CRC) was recently confirmed ... 2006. After PET/CT imaging, recurrence and/or metastasis were confirmed in 82.4% (56/68) of the patients, ... means of CRC management, but recurrence and/or metastasis occurs in 30 to 50 percent of patients after ...

Cancer stem cell subpopulation drives metastasis of human pancreatic cancer

... cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. The ... of CSCs in cancer initiation, progression, and metastasis and suggests new directions for development of ... development, identifying them as CSCs. Cancer metastasis was abolished by inhibiting CXCR4 or by ...

Chicago team uses artificial intelligence to diagnose metastatic cancer

... could potentially predict with promising accuracy which patients had metastasis and which did not," says Drukker. Next they plan to start an observer ... use the computer program to see if it enhances their ability to diagnose metastasis -- again, based on retrospective cases for which the answer can later be ...

RNA snippet suppresses spread of aggressive breast cancer

... breast cancer in humans, may more accurately predict the likelihood of metastasis (which accounts for 90% of cancer-related deaths) and ultimately help ... to possess lower levels of miR-31. The functional role of miR-31 in metastasis regulation was then confirmed in mice. When Valastyan removed miR-31 from ...

JCI table of contents: March 23, 2009

... in human and mouse colorectal tumor cells, inhibiting their growth and metastasis in experimental models of colorectal cancer. Importantly, long-term ... expression in human tumor cells promotes differentiation and inhibits metastasis AUTHOR CONTACT: Paolo Michieli University of Turin Medical School, ...