mediated in Medical News

Bariatric Surgery Cuts Cancer Risk for Women

... bariatric surgery could not be demonstrated to be mediated by weight loss or reduced energy intake." New ... women. If the favorable effect in women is not mediated by weight loss or reduced energy intake, it must be mediated by something else," he said. Andrew G. ...

JCI table of contents: June 20, 2008

... Cigarette smokeinduced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 ... tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins AUTHOR ... analysis revealed that the HDAC inhibitors mediated their effects by inducing DCs to express more of ...

The immune system's role in hepatitis C recurrence after liver transplantation

... the model that a genetic component contributes to natural killer cell mediated control of virus as well natural killer cell mediated hepatic injury in the setting of liver transplantation for HCV." ...

UCLA Art/Sci Center to host symposium on sound and science

... day of the symposium will feature presentations related to technologically mediated forms of listening from the nanoscale of cells to the macroscale of solar winds and similarly mediated modes of musical expression. The field of acoustic ecology will also be ...

2 immune-system proteins linked to colitis-associated cancer

... during CAC development, and that its molecular effects are largely mediated by the transcription factor STAT3 in cancer cells. Their latest study ... Karin said. The proliferative and survival effects of IL-6 are largely mediated by the transcription factor STAT3, first suggested to have a ...

Novel Photoconductive Cellular Depolarization Technology Reveals Insight Into Neuronal Growth, Guidance, and Regeneration

... this, researchers have sought to better understand how axon guidance is mediated in order to potentially aid in recovery following injury. Focusing ... axon guidance in which growth guidance both spatial and temporal is mediated by neuronal activity. Further under experimental conditions simulating ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... is a p-glycoprotein substrate, but does not inhibit p-glycoprotein mediated transport of digoxin. Based on these results, sitagliptin is considered ... sitagliptin to be involved in clinically meaningful drug-drug interactions mediated by plasma protein binding displacement is very low. Vivo ...

Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage

... Salutary Effects on Keratinocytes following Trauma-Hemorrhage Are mediated by Estrogen Receptor (ER)- and ER-”. ... Salutary Effects on Keratinocytes following Trauma-Hemorrhage Are mediated by Estrogen Receptor (ER)-± and ER-². Fariba Moeinpour, Irshad ...

Duska Therapeutics Receives Comments From FDA on Phase 3 ATPace(TM) Protocol Synopsis

... adenosine triphosphate is believed to have dual inhibitory action; one mediated by adenosine, the product of its rapid enzymatic degradation, and the ... in terminating PSVT, ATP is believed to have dual inhibitory action; one mediated by adenosine, the product of its rapid enzymatic degradation, and the ...

Some like it hot! Structure of receptor for hot chili pepper and pain revealed

... to flux in and out. Any time you feel a burn or pain sensation, it is mediated by a TRPV1 channel. Different levels of heat are mediated by different TRP channels, said Dr. Vera Moiseenkova-Bell, a postdoctoral ...

Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals

... extracellular ATP on improving sperm motility and fertilization potency is mediated by P2 receptors and increased level of intracellular calcium. The data ... extracellular ATP on improving sperm motility and fertilization potency is mediated by P2 receptors and increased level of intracellular calcium and that the ...

Latona Announces the Acquistion of Patent Rights and Orphan Drug Status to Novel Late Stage Drug Compound for Juvenile and Adult Rheumatoid Arthritis

... Oralgam - Oralgam is a late Phase II drug used for the treatment of immune mediated diseases. A novel product, Oralgam has shown efficacy in the treatment of ... company dedicated to development and commercialization of immune mediated diseases. About Research Corporation Technologies (RCT) - RCT ( ...

JCI online early table of contents: March 13, 2008

... The ability of DA to inhibit EPC mobilization from the bone marrow was mediated via the DA D2 receptor expressed by the EPCs. These data led the authors ... TITLE: The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin AUTHOR CONTACT: Ernst ...

FOXO factor promotes survival of oxygen-deprived cancer cells

... enable cells to adapt to the oxygen deficit. This response is primarily mediated by the hypoxia-inducible transcription factors, HIF1 and HIF2. HIF ... research findings have also revealed an anti-cancer role for HIF1 that is mediated by the initiation of programmed cell death, called apoptosis, in response ...

JCI table of contents: Nov. 21, 2007

... the effects of PAHs on the number of follicles in female offspring were mediated through the aryl hydrocarbon receptor (Ahr), which upregulated expression ... resulted in increased bleeding time. Further analysis revealed that BSDL mediated its effects on platelets in vitro and in vivo by binding a protein on the ...

JCI table of contents: Nov. 8, 2007

... of mice engineered to express human SHGB. Decreased production of SHGB was mediated by decreased expression of a protein that stimulates the gene that makes ... are used to treat individuals with inflammatory and autoimmune diseases mediated by immune cells known as T cells, e.g. rheumatoid arthritis. Despite this ...

JCI table of contents: Oct. 25, 2007

... As further analysis indicated that the inhibitor of TGF-beta signaling mediated its effects in the CNS, the authors concluded that early production of ... were associated with increased incidence and severity of BOS and were mediated by immune cells known as CD4+ T cells and the soluble factors IL-17, ...

Reprints Desk Makes Pharmaceutical ePrint Procurement Service Available Through FIZ AutoDoc Document Delivery System

... industry." FIZ AutoDoc is the document delivery system of choice for many of Europe's largest corporations, supporting unmediated and mediated ordering for single journal articles, patent documents, reports, conference papers, proceedings or other publications. Reprints Desk offers ePrint ...

A Curse or Two Might Quell the Pain

... even more than men's. "Swearing may raise levels of aggression, downplaying feebleness in favor of a more pain-tolerant machismo, most likely mediated by classic fight-or-flight mechanisms," said the study's lead author, Richard Stephens, a lecturer in psychology at Keele University. "Swearing ...

New role discovered for molecule important in development of the pancreas

... Pdx1 binds directly to the Ngn3 gene, controlling its expression; it does this by forming a molecular complex with the protein Hnf6, which is mediated by the Pdx1 C terminus. Pdx1 also binds directly to and controls the expression of two additional endocrine cell genes, Hnf1b and Foxa2. "Pdx1 ...

Pharmacyclics Sets Record Date for Rights Offering

... is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the Company is to create a profitable business by generating income from products it develops, licenses and ...

Gene's novel role may provide key to treating liver and neurodegenerative diseases

... model to study the role of FAIM in detail. FAIM triggers a mechanism that ultimately impedes an important pathway to apoptosis, which is mediated by a key protein called Fas. Using their mouse model, the scientists elucidated part of the sequence of molecular events that regulates Fas-mediated ...

Risk of cancer

... which activates pathways that are central to the development of cancer. The impacts of this altered genetic regulation on cell division are probably mediated via the MYC cancer gene, which is one of the best known accelerator genes in cancer. Single-base changes are the most common type of variation ...

AUA Foundation announces 2009 Research Scholar Program award winners

... Homeodomain Transcription Factor and the Mammalian Lower Urinary Tract Jared Whitson, MD, San Francisco VA Medical Center Double Stranded-RNA mediated Gene Activation and Regulation Jun Yan, PhD, Columbia University Analyses of Early Stage Prostate Carcinogenesis: Targeting the NF-κ-B ...

Atrial fibrillation in endurance athletes still poses problems for sports cardiologists

... the heart fibrosis induced by endurance exercise. The anti-fibrotic effect of losartan, an angiotensin type-II receptor antagonist, appears to be mediated suppression of angiotensin II-induced proliferation of fibroblasts. Again, markers of fibrosis were reduced by administration of losartan. ...

Study shows promise for new cancer-stopping therapy

... gene replacement in HCC has potential for applicability to other types of cancers, as well. The delivery and restoration of miRNA expression via AAV mediated gene transfer of the miRNA may be beneficial to a large number of cancer subtypes. "This concept of replacing microRNAs that are expressed in ...

Jazz Pharmaceuticals to Present Data From First Phase III Study of Sodium Oxybate in Patients With Fibromyalgia

... of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the ...

Prometheus Presents Proprietary Oncology Diagnostic Platform at ASCO Annual Meeting

... presentation entitled "Profiling of Receptor Tyrosine Kinases (RTK) Activation in Circulating Tumor Cells (CTCs) in Metastatic Tumors Using Proximity mediated Microarray Immunoassay," Prometheus demonstrated that its novel microarray platform can successfully detect the activation of key cancer pathways ...

Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting

... proceeds in an ordered sequence of events that includes control of injury and inflammation, followed by repair and remodeling. These events are mediated by the complex interactions of specific growth factors and cytokines. In the diabetic patient, this wound healing process is often impaired, in part ...

Targeting the more lethal form of the cancer rhabdomyosarcoma

... whereas it suppresses the growth of ERMS cells. The team, led by David Malkin and Gregory Hannigan, determined that the signaling protein JNK mediated these differing effects of ILK. Knocking down expression of ILK in ERMS cells induced activation of JNK and promoted tumor cell growth both in vitro ...

Light Sciences Oncology Announces Results of Study on Immunotherapeutic Mechanism of Aptocine(TM), a Novel Light-Activated Drug Therapy for Cancer

... with tumor 40 days after transferring immune cells from an Aptocine-treated animal still conferred immune protection. The systemic effect is mediated at least in part by CD8+ T-cells; enrichment in T-cell transfer increased effect and depletion eliminated effect. ASCO Poster ...

Recent developments at Burnham Institute for Medical Research, May 2009

... the energy of the nerve cell is compromised and connections to other nerve cells are lost and eventually the nerve cells die. The chemical reaction mediated by free radicals (in this case a form of nitric oxide or NO) is called S-nitrosylation. Dr. Stuart Lipton and Dr. Adam Godzik found that ...

Even modest exercise can reduce negative effects of belly fat

... (CRP), less belly fat, and improved general fitness than the 'flex' group," said Ph.D. candidate Vieira. "The lower CRP levels were partially mediated by the reduction in trunk fat," she explained. ...

Johnson & Johnson Reports 2009 First-Quarter Results:

... CONCERTA, a treatment for attention deficit hyperactivity disorder; REMICADE in the U.S., a biologic approved for the treatment of a number of immune mediated inflammatory diseases; INVEGA and RISPERDAL CONSTA, both antipsychotic medications; and VELCADE, a treatment for multiple myeloma, had strong sales ...

Colon cancer shuts down receptor that could shut it down

... relationship between butyrate and GPR109A. Research teams at GlaxoSmithKline and the University of Heidelberg, Germany in 2003 showed cloned GPR109A mediated the protective cardiovascular effect of niacin, but was activated only if niacin levels in the blood were 1,000 times normal levels. That got the ...

Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimer's disease

... disease dementia. These findings are very exciting, and for the first time tentatively link type-2 diabetic metabolic defects to increasing dementia mediated by β-amyloid production." The discovery in Dr. Pasinetti's laboratory has staggering societal implications: there are currently more than 5 ...

The Healy Law Firm Represents Plaintiff in $12 Million Settlement with Clark USA Over Fatal Illinois Oil Refinery Accident

... as Administrator of the Estate of Michael F. Forsythe, deceased v. Clark USA, Inc. (Court No. 2007 L 009909), former presiding Judge Donald O'Connell mediated a settlement between the parties. The settlement was approved by Illinois Circuit Court Judge Thomas Quinn. Michael Forsythe and Gary Szabla ...

NYU study finds new risk factor for melanoma in younger women

... age of 50, melanoma incidence skews markedly toward men. Polsky and his co-authors suspect the difference may be linked to the activity of estrogen, mediated in part by a genetic variant in a gene called MDM2. When estrogen binds to this gene, it turns on production of MDM2, a potential oncogene ...

New target for heart failure therapy identified

... The findings, which will be published online this week in Proceedings of the National Academy of Sciences , show that aldosterone production is mediated by a protein called beta-arrestin-1. Beta-arrestin-1 binds to angiotensin II receptors when they are activated by angiotensin II. Aldosterone is ...

Brain tumor treatment may increase number of cancer stem-like cells

... and isolate "side population" (SP) cells from mouse and human glioblastomas. "Because the SP phenotype in glioma cancer stem-like cells is mainly mediated by ABCG2, as shown by the almost complete abolition of this phenotype when ABCG2 activity is blocked, we subsequently studied the oncogenic potential ...