macrophage

Molecule aids fight E. Coli Infections

...ecific genes, Ezekowitz and his team identified 36 macrophage proteins essential to the phagocytosis process. One, called PGRP-LC, is a cell surface receptor that sits on the outer membrane and receives chemical signals. When the scientists deactivated PGRP-LC, the macrophages lost their ability to detect and d...

Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression

...searchers are confident that blocking the molecule macrophage migration inhibitory factor it will be possible for treatment of Multiple Sclerosis. Experts View: Professor Caroline Whitacre said, "Our results suggest that MIF may be less important for initiating MS, but that it may be necessary for MS prog...

Study Would Pave Way for the Development of New Drugs That Targets TB Proteasome

...kills or disables most of the bacteria. Inside the macrophage the immune cells damages and destroys the bacterial proteins. These accumulated proteins have to be removed otherwise it will in turn destroy the cell. But the TB bacteria remove the damaged proteins with the help of a protein-cleaving complex know...

Nanotechnology Could Revolutionize Cardiac Treatment

...which forms of the particles bind to the different macrophage receptors,’ Uhrich said. ‘The significant finding of our study is that the nanoscale organization matters tremendously for blockage of oxidized LDL, which opens new avenues for more specific targeting of receptors.’ Mogue said that if this method p...

Scientists Isolate Leukemia Stem Cells in Mouse Model

...y committed mouse blood cells known as granulocyte macrophage progenitors, or GMPs. These genetically altered cells were injected into mice, which subsequently developed AML. Through several steps of purification, the researchers winnowed down the leukemia cells from the mice to a small population that contai...

Nano-sized inhaled particles traverse quickly from nose to brain

...stress response, such as tumor necrosis factor and macrophage inflammatory protein, increased significantly in the brain, according to gene and protein analyses. "We suggest that despite differences between human and rodent olfactory systems, this pathway is likely to be operative in humans," the authors con...

Salmonella Bacteria Are Deceptive

...so--including STM3117--responded specifically to a macrophage protein associated with resistance to microbial infection. A standard assay called Western blot confirmed the abundance increases of that small group of proteins during infection. Source-Eurekalert RAS...

An Infectious Agent of Deception, Exposed Through Proteomics

...r so—including STM3117—responded specifically to a macrophage protein associated with resistance to microbial infection. A standard assay called Western blot confirmed the abundance increases of that small group of proteins during infection. Source-Newswis SRM...

Inhibiting Blood to Save the Brain

...S, but an active participant. Fibrinogen activates macrophage cells in the brain called microglia, causing inflammation which damages myelin. The scientists sought to design a therapeutic strategy that would block the damaging effects of fibrinogen without affecting its beneficial blood coagulation. Studying ...

CT Imaging With Novel Contrast Agent May Predict Heart Attack in Waiting

...y plaques. Researchers compared the enhancement of macrophage rich plaque after the injection of N1177 and a con...entional CT contrast agent. The enhancement of the macrophage rich plaque after the injection of N1177 was significantly higher and specific inside of the vessel ...

Macrophages may Help Prevent Obesity

...esearch has recently shown the same differences in macrophage activation in humans," said Justin Odegaard, an MD student in Chawla's lab. He says that the fat reserves of obese people have been found to contain inflammatory macrophages, while those of lean people contain anti-inflammatory macrophages, replica...

Immune System Protein Could Be the Key Infertility

...ey have found that the level of a substance called macrophage migration inhibitory factor (MIF) in semen could be the key. The finding, detailed in the latest issue of the journal Molecular Medicine, could lead to fertility tests for males or new types of male contraception, Yousef Al-Abed and his colleague...

Immune Substance in Semen may Help Determine Male Fertility

... Dr. Yousef Al-Abed says that the substance called macrophage migration inhibitory factor (MIF) is the key to helping sperm mature, which is necessary for its union with an egg. The findings, published in Molecular Medicine, attain significance as they may lead to a diagnostic test to determine fertility sta...

Cigarette Smoking Delays Ligament Healing

...educed. "Our studies also have shown a decreased macrophage response that may help explain why we see this delayed or decreased healing response," Wright says. Between 20 and 25 percent of the U.S. population smokes. Wright and Sandell say that although the prevalence of smoking among athletes is slightly l...

Smoking Hampers Healing of the Ligament

...educed. "Our studies also have shown a decreased macrophage response that may help explain why we see this delayed or decreased healing response," Wright says. Sandell and Wright say their findings point to yet another reason smokers would do well to quit. "Many patients don't want to hear it, but these re...