Ischemia in Medical News

Depression, Anxiety Bad for the Heart

... a much more multi-modal approach to chest pain. ischemia is not the only or most important cause of what ... and similar measures are properly used to assess ischemia in people with angina, Sullivan said. "But in ... and his colleagues studied 191 people with known ischemia who underwent stress testing and heart imaging. ...

Promising Three-year Data: Saving Limbs With Drug-Eluting Stents

... Disease (PAD) Patients With Critical Limb ischemia Avoid Amputation SAN DIEGO, March 10 ... -- Attempts to treat critical limb ischemia in peripheral arterial disease (PAD) patients ... prospective registry who had critical limb ischemia and who underwent infrapopliteal ...

Tamaris Announces Foot and Leg Ulcers Pose Significant Health Threat

... At this stage of PAD, called Critical Limb ischemia (CLI), the health threat is serious. The ... are the facts: PAD at the stage of Critical Limb ischemia presents the likelihood of amputation or even ... study for PAD at the stage of Critical Limb ischemia with foot and/or leg ulcers. It is anticipated ...

Mini heart attacks lessen damage from major ones

... system attacks the cardiac tissue damaged by ischemia and reperfusion, causing inflammation which can ... the following protective mechanism: temporary ischemia causes the generation of nitrated lipids inside ... ability of isolated rat heart cells to survive ischemia using a dye that the live cells keep out, but ...

Quintet of proteins forms new, early-warning blood test before heart attack strikes

... before and after a period of medically induced ischemia lasting as long as 45 minutes. All had ischemia induced through accelerated pacing of the heart's ... present in significantly increased amounts after ischemia occurred, with at least a doubling in the blood ...

Quark Pharmaceuticals Receives FDA Approval of IND for Kidney Transplant siRNA Drug DGFi

... in renal transplantation is a syndrome caused by ischemia and reperfusion injury. ischemia reperfusion injury occurs frequently in kidneys ... in protecting kidneys from injury due to cold ischemia or lack of oxygen during organ preservation and ...

Older Diabetics' Risk of Cardiac Ischemia Lower Than Thought

... "We found that silent myocardial ischemia -- restriction of blood flow to the heart -- ... also concluded that this lower prevalence of ischemia did not justify putting all people with type 2 ... patients likely had an equal prevalence of ischemia to those who were screened, standard clinical ...

OmniSonics Medical Technologies Announces First Patient Enrolled in SONIC II REGISTRY

... mechanical thrombectomy for acute limb ischemia (ALI). All patients enrolled in the SONIC ... healthcare professionals treating acute limb ischemia to bring innovative treatments to patients ... deep vein thrombosis (DVT) and acute limb ischemia (ALI). DVT affects approximately 2 million people ...

Adult stem cell application effective in treatment of peripheric vascular disease

... in blood flow. If it is not treated in time, the ischemia can cause various complications; the worst ... limb. In any case, the basic effect of peripheric ischemia is an important loss of vascularisation in the ... cell populations in the treatment of peripheric ischemia given that the use of marrowbone cells for ...

JCI online early table of contents: Jan. 2, 2008

... blood and oxygen flow in the limbs (critical limb ischemia [CLI]) that can result in tissue injury or death. ... ischemia. When injected into mice with a moderate ischemia similar to IC in humans, mouse MAPC-Us restored ... restored blood flow in mice with a severe limb ischemia similar to CLI in humans. From these results, the ...

Different anticoagulant regimens yield equal results

... effect of bivalirudin monotherapy on composite ischemia and death are unknown. In the short term, the ... in which the 1-year estimated rate of composite ischemia was 15.4 percent, composite ischemia occurred in 16.0 percent of patients assigned to ...

COURAGE Sub-study: PCI Outperforms Drugs-Only

... showed that patients with moderate to severe ischemia benefited most from PCI when compared with those ... only optimal medical therapy. In fact, when ischemia was reduced, the risk of death was also reduced. ... of heart disease -- that significant ischemia is not in a patient's best long- term interests. ...

Cell transplantation and cardiac repair

... in Germany who used bone marrow stem cell transplants to repair limb ischemia with a goal of preventing amputations. Two delivery techniques for ... Bone marrow cell transplants for limb ischemia Bone marrow cell transplantation has been shown to induce new blood ...

Stem Cells May Offer New Way to Treat Blocked Arteries

... with partial benefits. "The most important thing is that the amount of ischemia [artery blockage] was halved" in those given the marrow cells, Atsma said. "The amount of tissue with ischemia was reduced, heart function improved significantly in a small way and ...

A new light on the mechanisms of early stage liver reperfusion injury

... in the rat liver. The authors examined the effects of 60 min lobar ischemia followed by different periods of 5, 10, 30, 45, 60 and 120 min ... focal hepatitis were the most important changes induced by in vivo lobar ischemia in the rat liver. However, during reperfusion not only some changes ...

Stem cell therapy grows new blood vessels

... how these stem cells have a natural ability to hone in on the area of ischemia to induce blood vessel repair and improve blood flow. Hess says this ... cells from the patient's own bone marrow and put them back in the area of ischemia to allow these cells to coordinate the formation of new blood vessels." ...

Drug-Eluting Stents Show Promise for Leg Arteries

... and sometimes leads to severe obstructions, known as critical limb ischemia (CLI), a condition in which the decreased blood flow causes pain and skin ... the integral value of below-the-knee drug-eluting stents in critical limb ischemia treatment," Karnabatidis said. Garratt added that "the real value of ...

Society of Interventional Radiology Hosts 34th Annual Scientific Meeting

... Seeing the Promise of Drug-Eluting Stents for Critical Limb ischemia Interventional radiologists are helping peripheral arterial disease (PAD) patients with critical limb ischemia avoid amputation by exploring the treatment of the smaller blood vessels ...

Efficacy of stents is improved when their placement is determined by arterial blood flow measurement

... in these results is that placing stents in lesions not responsible for ischemia is not only unnecessary, but may cause worse outcomes. Commenting on ... be used in patients with stable symptoms and without documentation of ischemia by another method. In patients with multivessel disease in particular, FFR ...

Transplanted fatty livers associated with worse prognosis for patients with HCV

... to have fatty livers. These organs are highly susceptible to cold or warm ischemia injury, leading researchers to hypothesize that liver steatosis may be ... with severe reperfusion injury. "We strongly suggest that cold ischemia time should be limited when the donor graft contains greater than 30 ...

A potential drug for ischemia/reperfusion related liver injury

... for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 minutes; (4) I-R/Resveratrol ... against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury ...

New System Devised To Guide Doctors Treating Patients With Symptomatic Myocardial Bridging

... 62 were in class B - Having clinical symptoms and objective signs of ischemia by non-invasive stress tests. 37 were in class C - Having clinical ... based on angiography and intracoronary Doppler - with or without signs of ischemia by noninvasive stress tests. Based on initial observations and ...

New system devised to guide doctors treating patients with symptomatic myocardial bridging

... 62 were in class B Having clinical symptoms and objective signs of ischemia by non-invasive stress tests. 37 were in class C Having clinical ... based on angiography and intracoronary Doppler with or without signs of ischemia by non-invasive stress tests. Based on initial observations and ...

A rare case of ischemic colitis caused by chronic venous insufficiency

... by obstruction of macrovascular mesenteric vein rarely causes ischemia of the bowel. This report describes the first case of ischemic colitis ... A possible breakage of this balance may cause venous stasis and relative ischemia of the gastrointestinal tract. Long-term follow-up is needed, as there ...

Gene Variant Boosts Risk for Stress-Related Ischemia

... attack, heart rhythm abnormalities or sudden death. Mental stress-related ischemia occurs in about 10 percent of all patients with heart disease. ... More information The American Heart Association has more about ischemia . -- Robert Preidt ...

Cardium Reports on Recent Highlights and Financial Results

... Generx is being evaluated as a potential treatment for myocardial ischemia (insufficient blood flow within the heart muscle) which gives rise to ... (FDA) has granted Fast Track designation to Generx for myocardial ischemia in view of the large unmet medical need for effective new therapies ...

GSK Revises US Labeling for Avandia(R)

... based on an extensive and thorough review by the FDA of myocardial ischemia data on Avandia, the most widely studied oral anti-diabetic medicine ... The box will state that the available data on the risk of myocardial ischemia are inconclusive. The FDA has also concluded there is insufficient ...

Mitochondria send death signal to cardiac cells, study shows

... In experiments, cardiac cell mitochondria were isolated and subjected to ischemia and reperfusion the blockage and restart of blood flow. The researchers ... they saw that after the mitochrondria were subjected to ischemia followed by reoxygenation, a boost of calcium occurred in the ....

FDA to Review Clotting Drug After Trial Suggests Death Risk

... authors, Dr. Dennis T. Mangano, said at the time. Mangano, director of the ischemia Research and Education Foundation, a California-based nonprofit group, ... U.S. Food and Drug Adminstration; Dennis T. Mangano, M.D., Ph.D, director, ischemia Research and Education Foundation, San Bruno, Calif.; T. Bruce Ferguson ....

Blood Rush to the Brain When Angry Is a Good Sign

... vasoconstriction, or lack of dilation in response to mental stress in stable coronary heart disease, contributes to the genesis of myocardial ischemia and confers an increased risk in patients with coronary artery disease," researcher Tasneem Naqvi said in a news release. "It will be interesting to ...

Study examines liver transplantation after drug induced acute liver failure

... Interestingly, these patients were least likely to be listed as status 1 and spent the most time waiting for an organ. Also, the warm and cold ischemia times were longest for this group of patients. "The relatively low survival probability persisted after controlling for these variables in ...

AlphaRx and Gaia BioPharma Report Positive Efficacy Results in a Pre-Clinical Trial of GAI-122 Injectable Nano-emulsion for Post-operative Delirium

... of AlphaRx. In rat model studies, injected GAI-122 ameliorates learning and memory disturbances produced by cerebral embolization, cerebral ischemia or lesions in the basal forebrain, the area of origin of the acetylcholine neuron system projecting into the cerebral cortex, hippocampus and ...

Jackson's Death Puts Spotlight on Sudden Cardiac Arrest

... Heart and Vascular Institute of Lenox Hill Hospital in New York City. "Most cardiac arrest is related to ischemic heart disease," Garratt said. ischemia is blockage of an artery. "Most of the time, ventricular fibrillation takes place when an artery is blocked off. When that happens, if you don't get ...

Sofinnova Partners Leads Investment Round in CoAxia

... is a venture-backed, privately held, clinical-stage company providing perfusion augmentation therapies to improve outcomes for patients with cerebral ischemia resulting from stroke, vasospasm and other conditions. In addition to the SENTIS, Flo24 and FASTFlo trials for ischemic stroke, CoAxia's ...

New findings encourage more vigilant monitoring of seizure activity among intensive care patients

... was found to detect small seizures occurring within the patient's brain that the continuous EEG could not detect. ICE was also helpful in detecting ischemia (inadequate blood flow) and bleeding as soon as they occurred, and prior to detection by clinical exam or other monitoring methods. Dr. Allen Waziri, ...

Stroke Damage Is Less in Rats Given Opioids

... abnormalities," they wrote. "The observation that this substance, previously shown to induce hibernation, attenuated deficits inherent in cerebral ischemia provides a new pharmacological target for stroke therapy." The study appears online in the journal BMC Biology . More information The ...

New Anticoagulant Pill Works Well in Trial

... bleeding events, with a trend towards a reduction in the primary efficacy endpoint of death, myocardial infarction, stroke or severe recurrent ischemia requiring revascularization," Mega and colleagues wrote. "Regarding the main secondary efficacy endpoint, rivaroxaban reduced the rate of death, ...

Study: Women with hard to diagnose chest pain symptoms at higher risk for cardiovascular events

... heart disease," said C. Noel Bairey Merz, MD, director of the Women's Heart Center at the Cedars-Sinai Heart Institute and the chair of the Women's ischemia Syndrome Evaluation (WISE). Sponsored by the National Heart Lung and Blood Institute, the WISE studies began in 1997 and have pointed out how ...

Different treatment options in chronic coronary artery disease

... complementary data. Thus PCI or ACB is advisable in those patients who still suffer from angina pectoris under drug treatment or for whom relevant ischemia has been demonstrated by non-invasive methods. According to the authors, the main indication for aortocoronary bypass surgery is when the proportion ...

Heart screening unnecessary in type 2 diabetes patients with no symptoms

... diabetic patients without a history of heart problems helped identify those at higher cardiac risk. The team spearheaded the Detection of ischemia in Asymptomatic Diabetics study in which 1,123 participants were randomly assigned to either a screening stress test that looks at the blood flow to ...