Intramuscular in Medical News

Landmark Rh Immune Globulin Celebrates 40 Years of Saving Babies' Lives

... micro grams) (250 IU) Rx Only For intramuscular Injection Only Prefilled syringes, ... DOSAGE AND ADMINISTRATION For intramuscular use only, do not administer intravenously. ... PRECAUTIONS Warnings For intramuscular use only, do not inject intravenously. In ...

BioCryst Reports Positive Results From a Phase 2 Study of Intravenous Peramivir for Outpatient Influenza

... and outpatient influenza, utilizing either an intramuscular or intravenous formulation. A Phase 2 trial in ... subjects in a previous Phase 2 clinical trial of intramuscular peramivir did not receive adequate dosing by intramuscular injection may not be correct, that HHS and the ...

Tattooing Best Way to Deliver DNA Vaccines

... Showed stronger antibody, cellular responses than intramuscular injection, study says THURSDAY, Feb. ... effective method for delivering DNA vaccines than intramuscular injection, a new German study finds. ... on mice, the researchers compared tattooing and intramuscular injection, with and without the adjuvants that ...

New Approach to Progesterone Supplementation in ART Revealed in Recently Published White Paper

... ART and that vaginal progesterone provides improved patient comfort over intramuscular (IM) progesterone without compromising pregnancy rates. The objective ... The vaginal progesterone formulations that were compared with intramuscular progesterone included: Crinone(R), Prometrium(R) oral tablets, compounded ...

Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial in Chennai India

... equally into two treatment groups. Group 1 received forty (40) 1 mL intramuscular injections in the ischemic regions below the knee and Group 2 received twenty (20) 1 mL intramuscular injections below the knee and an intra-arterial infusion of 20 mL down the ...

Strativa Pharmaceuticals Acquires Worldwide Rights to Nascobal(R) (Cyanocobalamin, USP) Nasal Spray From QOL Medical

... status in pernicious anemia patients who are in remission following intramuscular vitamin B12 therapy and who have no nervous system involvement. Nascobal ... If a patient is not properly maintained with Nascobal Nasal Spray, intramuscular vitamin B12 is necessary. Vitamin B12 concentrations must be monitored. ...

Limit sucrose as painkiller for newborns

... blood taken (venipuncture) for the newborn screening test but not for intramuscular injections, write Dr. Anna Taddio and co-authors. In this ... However, "unexpectedly, we did not observe analgesic effects during either intramuscular injection of vitamin K in either group [newborns of diabetic and ...

Clarity for Consumers on Botox Complication and Death Reports

... of Botox(R) to treat the medical disorders is often ten-fold the number of intramuscular units (i.u.'s) injected to treat the cosmetic patient," said Coalition ... glabella, or furrows between the brows consists of 20 to 35 units (i.u. or intramuscular units), whereas a patient treated for a neuromuscular disorder may receive ...

FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... Technology. Using this technology increases the rate of dissolution and enables the formulation of an aqueous suspension for once-monthly intramuscular administration. INVEGA SUSTENNA is manufactured by Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc, in the U.S. About ...

Tips from the journals of the American Society for Microbiology

... DNA vaccine including various immunoadjuvants (substances to improve the immune response) and monitored anti-GRP antibody levels in vaccinated mice. intramuscular injections induced high levels of specific antibodies against GRP as well as suppressed the growth of melanoma cells. Additionally, researchers ...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

... pcDNA"3.1D/V5-His-TOPO and purified these using Qiagen Endo-Free Giga Prep Kit. Eight groups of 6 week-old female BALB/c mice (13/group) received intramuscular injections of 100 micrograms of the vaccination preparation at days 2 and 9. At day 16, mice were induced with experimental SLE. Serum samples were ...

New Data Demonstrate RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment May Improve Health Outcomes and Reduce Hospitalizations in Patients with Schizophrenia

... is encapsulated in microspheres made of a biodegradable polymer, which are suspended in a water-based solution and administered to patients by intramuscular injection once every two weeks. RLAT is manufactured by Alkermes, Inc. and marketed by Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, ....

FDA Grants Approval for Use of RISPERDAL(R) CONSTA(R) as Both a Monotherapy and Adjunctive Therapy in the Maintenance Treatment of Bipolar I Disorder

... is encapsulated in microspheres made of a biodegradable polymer, which are suspended in a water-based solution and administered to patients by intramuscular injection once every two weeks. RLAT is manufactured by Alkermes, Inc. and marketed by Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, ....

Henry Ford Hospital: Unique Patient Study -- No Informed Consent

... of the seizure is unknown, but some causes include previous trauma, stroke, tumor, or infection. The study, called RAMPART, will compare an intramuscular injection of midazolam (Versed) to an intravenous (IV) dose of lorazepam (Ativan). Both drugs are better than the most common current prehospital ...

Gene Therapy Improves Diabetic Neuropathy in Study

... a disorder that commonly affects diabetics who've had the disease for many years, a new study finds. Researchers in Boston found that intramuscular injections of vascular endothelial growth factor (VEGF) gene may help patients with diabetic polyneuropathy. The study included 39 patients who ...

Testosterone Undecanoate Achieves and Maintains Normal Testosterone Levels in Hypogonadal Men With Five Injections Per Year, New Data Show

... This open-label study enrolled 130 hypogonadal men with serum testosterone levels below 300 ng/dL at study entry. NEBIDO was dosed as an intramuscular injection (750 mg) at baseline, at week four, and then every 10 weeks throughout the remainder of the 21-month study. Approximately 70 percent of ...

Surveyed Specialists Foresee Greater Use of Parenteral Outpatient Therapy for the Treatment of Osteomyelitis

... of methicillin-resistant Staphylococcus aureus (MRSA) will increase, they foresee greater use of parenteral outpatient therapy (intravenous or intramuscular injection) for the treatment of osteomyelitis. Osteomyelitis is an infection of bone or bone marrow caused by bacterial infections. ...

Seaweed and fireflies brew may guide stem cell treatment for peripheral artery disease

... In a preliminary "proof of concept" study in rabbits, Johns Hopkins scientists safely and successfully delivered therapeutic stem cells via intramuscular injections and then monitored the stem cells' viability once they reached their targets. A report of the study by Johns Hopkins radiologists is ...

Ferring Pharmaceuticals Announces Immediate Availability of Degarelix for the Treatment of Advanced Prostate Cancer

... or leuprolide: a degarelix subcutaneous (under the skin) injection of 240 mg for one month with monthly maintenance doses of 80 mg (n=207) or monthly intramuscular (into the muscle) injections of leuprolide depot 7.5 mg (n=201). The primary endpoint was testosterone suppression to less than or equal to 50 ...

ROXRO Announces FDA Accepts for Review NDA for ROX-888 for the Management of Acute Moderate to Severe Pain

... be used at home. Formulated as an easy-to-use spray, ROX-888 is rapidly absorbed through the nasal mucosa, achieving peak blood levels as fast as an intramuscular injection. The pharmacokinetic properties of ROX-888 have been demonstrated in clinical trials to provide rapid relief of acute moderate to severe ...

BioCryst to Present at the 11th Annual BIO CEO & Investor Conference

... statements contained herein include that our belief that many subjects in the Phase 2 clinical trials of peramivir did not receive adequate dosing by intramuscular injection may not be correct, that HHS and the Food & Drug Administration (FDA) may not agree with our analysis, that HHS may further condition, ...

BioCryst Pharmaceuticals to Announce Fourth Quarter and Year End 2008 Financial Results on February 6, 2009

... statements contained herein include that our belief that many subjects in the Phase 2 clinical trials of peramivir did not receive adequate dosing by intramuscular injection may not be correct, that HHS and the Food & Drug Administration (FDA) may not agree with our analysis, that HHS may further condition, ...

Half-Dose Flu Shot Works Well in Young Adults

... antibodies against influenza and the volunteers reported any flu-like symptoms they experienced during this time period. "Antibody responses to intramuscular half-dose trivalent inactivated influenza vaccine in healthy, previously immunized adults were not substantially inferior to the full-dose vaccine, ...

Research Identifies Predictors for Successful IVF

... for Reproductive Medicine (ASRM) in San Francisco, November 8-12, 2008. Four studies compared ENDOMETRIN(R) (progesterone) Vaginal Insert, 100 mg, to intramuscular (IM) progesterone-in-oil (PIO) for luteal support. Additional studies assessed the benefits of once-daily combined gonadotropin dosing compared with ...

Fertility experts present the latest research at reproductive medicine meeting

... final oocyte (egg cell) maturation for IVF. For ease of administration and improved patient tolerance, use of subcutaneous (SC) Ovidrel instead of intramuscular (IM) u-hCG has been used in women undergoing egg retrieval for oocyte donation. However, a decrease in serum hCG levels, a measure of patient ...

Sanofi-aventis Q3 2008 Adjusted EPS Excluding Selected Items(1):

... intended for Type 2 diabetes) and of surinabant (a CB-1 receptor antagonist for smoking cessation). Results from a Phase III trial of a high-dose intramuscular influenza vaccine, announced at the ICAAC/IDSA conference in the United States, demonstrated increased immune responses among adults 65 years of age ...

New intranasal influenza vaccine triggers robust immunity with significantly less antigen

... influenza vaccine (n=12 ferrets/dose). All three doses produced antibody responses substantially higher than those triggered by the standard intramuscular vaccine. The ferrets, which represent the most relevant influenza animal model for humans, were then challenged with live influenza virus, and all ...

Nanoemulsion-Based Intranasal Influenza Vaccine Adjuvant Triggers Robust Immunity Using Significantly Less Antigen

... influenza vaccine (n=12 ferrets/dose). All three doses produced antibody responses substantially higher than those triggered by the standard intramuscular vaccine. The ferrets, which represent the most relevant influenza animal model for humans, were then challenged with live influenza virus, and all ...

Wyeth v. Levine: Preemption and The Facts

... Levine again sought treatment. She was again prescribed Phenergan to treat her nausea, this time via intravenous injection (or "IV push") rather than intramuscular injection, to provide relief more quickly. However, the product was improperly administered by a physician assistant at a dose twice the labeled ...

Stallergenes Partners With Catalent and the Medical House for Commercialization of Adrenaline Autoinjector in Europe

... and hypotension. Mediator release results in smooth muscle contraction, vasodilatation, increased vascular permeability. intramuscular adrenaline is a vasoconstrictor, the first line treatment for anaphylactic shock, for patient self administration. Any patient with a severe systemic ...

Eisai Inc. Supports Acting Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism

... an increased risk of bleeding associated with the dosage of FRAGMIN(R) recommended for these indications. FRAGMIN(R) Injection is not intended for intramuscular administration. FRAGMIN(R) cannot be used interchangeably (unit for unit) with unfractionated heparin or other low-molecular-weight heparins. ...

Positive Findings Published on Emergent Technology for Treating Chronic Pain

... PHILADELPHIA, Aug. 20 /PRNewswire/ -- Peer-reviewed safety and efficacy data on Electrical Twitch Obtaining intramuscular Stimulation (eToims(R)), successfully applied to patients suffering from treatment-resistant chronic pain appeared in the August/September issue of ...

Vical to Present Phase 1 Data for Vaxfectin(R)-Formulated Pandemic Influenza DNA Vaccines

... approximately 100 healthy volunteers age 18 to 45 at three U.S. clinical sites. The trial was designed to assess safety and immunogenicity following intramuscular vaccination with needle and syringe or with the Biojector(R) 2000 needle-free injection system in different cohorts, and to evaluate monovalent and ...

The Vitamin B12 Craze - Super Nutrient or Super Hype?

... B12 deficient. Treatment options for vitamin B12 deficiency were once limited to oral supplements for those with normal digestive tracts and painful intramuscular injections for patients whose digestive systems cannot absorb B12 through food or oral supplements. Recently, the availability of nasal sprays have ...

Phase 3 data Re: Anti-RSV antibody to be presented at Pediatric Academic Societies Annual Meeting

... involving 1,410 full-term healthy infants less than six months of age in some Southwest Native American populations was designed to compare monthly intramuscular injections of motavizumab against placebo. In previous epidemiologic studies these populations were shown to have high rates of hospitalization due ...

BioCryst Pharmaceuticals to Announce First Quarter 2008 Financial Results on May 8, 2008

... contained herein include that our belief that many subjects in the Phase II clinical trials of peramivir did not receive adequate dosing by intramuscular injection may not be correct, that HHS and the Food & Drug Administration (FDA) may not agree with our analysis, that HHS may further condition, ...

Study shows that high-dose, high-frequency interferon produces no additional benefit

... CAMBRIDGE, MA April 15, 2008 -- Results of a phase IV, open label, head-to-head study of intramuscular AVONEX and high-dose, high-frequency subcutaneous Rebif (interferon beta-1a) provide clinical evidence that the two drugs show similar efficacy over ...

Antibiotic Use in Dementia Patients Questioned

... those, 42 percent were on antibiotic therapy during the last two weeks of their lives. Many were given antibiotics through an intravenous line or by intramuscular injection. The next step, according to D'Agata, is to figure out whether these patients benefit from antibiotic therapy, and what are the ...

1st EMEA application filed for product using innovative intradermal microinjection system BD Soluvia

... than 7000 subjects to evaluate safety and the ability to generate an immune response of the novel intradermal (ID) influenza vaccine. Compared with intramuscular (IM) injection, ID delivery was shown to be especially effective in enhancing the immune response in the elderly1,2. Independently, BD conducted ...

Sanofi-aventis Announces 2007 Earnings Ahead of Guidance Sharp Rise in Proposed Dividend

... is scheduled for 2009. A number of other influenza vaccine R&D programs made significant progress during 2007: -- The improved formulation intramuscular vaccine program, designed to vaccinate the elderly against seasonal influenza. Filing for approval in the United States is scheduled for the ...