Hypoxia in Medical News

$16.8 million study will breathe new life into cancer battle

... state that is common to all solid tumours. hypoxia causes a huge problem in cancer therapy because ... respond less well to treatment. Furthermore, hypoxia also appears to increase the chance that a tumour ... of the process of metastasis and why hypoxia plays such a key role. The researchers in this ...

JCI table of contents: March 23, 2009

... examine how human lung tumors without regions of hypoxia develop and found that tumors rely on hypoxia to promote their own expansion. In the study, ... hypoxia, leading the authors to conclude that hypoxia seems to be a key factor driving tumor ...

Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack

... the body tends to correlate with their degree of hypoxia resistance." Crowder says it may be possible ... inhibiting translation likely protects cells from hypoxia by reducing energy consumption because making ... were surprised by the degree of resistance to hypoxia when the translation rate was cut. They wanted to ...

Sleep disordered breathing and obesity: Independent effects, causes

... Clinic found that the chronic intermittent hypoxia that often characterizes OSA, a common form of ... "We have developed a mouse model of intermittent hypoxia and have demonstrated that a combination of a high-fat diet and intermittent hypoxia leads to liver disease in those mice. We plan on ...

Study of Everest Climbers Questions Oxygen Use

... low levels would work for ER patients with hypoxia remains unclear WEDNESDAY, Jan. 7 ... could lead to a change in the treatment of the hypoxia often seen in people in emergency rooms, like ... he said. More Information What hypoxia can do to the brain is described by the U.S. ...

The mental health dangers of birth hypoxia

... during pregnancy and birth, such as birth hypoxia - the shortage of oxygen in the body - are ... for schizophrenia. However, it is not clear why hypoxia increases the risk for schizophrenia. The ... a specific indicator of fetal distress following hypoxia was more likely to be present among people who ...

Researchers identify unusual molecular switch for common form of advanced breast cancer

... orchestrate angiogenesis, the tumor response to hypoxia and progression of tumors to form large locally ... observed that elevated levels of 4E-BP1 trigger hypoxia inhibition of conventional protein synthesis in ... and angiogenesis, thereby functioning as a hypoxia controlled switch for tumor growth and survival. ...

Breaking Studies - Masimo's Technologies the Focus of Multiple Clinical Studies at Last Week's American Society of Anesthesiologists' Annual Meeting

... be involved in the physiopathological process of hypoxia of acute CO poisoning patients." The application ... especially Masimo ear sensor, can detect hypoxia as soon as or even sooner than finger," adding ... and ear) can also sense recovery state from hypoxia sooner than finger." (5) In addition, a study ...

Long-term study shows low oxygen levels in prostate tumors can predict recurrence

... as tumor grade, PSA level, and tumor size, the team determined that hypoxia was a significant independent predictor of an increase in PSA levels. ... score, tumor size, age, and other prostate cancer risk factors, tumor hypoxia alone could predict the likelihood of increased PSA levels, and ...

U of I study shows benefits of hormone found in fat tissue

... plays a key role in regulating the immune system. When we exposed mice to hypoxia (simulating an event, such as a heart attack, in which a part of the body ... another group was fed a normal diet. The obese mice recovered from acute hypoxia five times faster than the mice fed normal diets. In a second ...

Smoking during pregnancy increases risk of SIDS

... cigarette smoke exposure can contribute to the destabilizing effects of hypoxia and thermal stress on neonatal breathing, said Dr. Hasan. To ... exposed to cigarette smoked prenatally. Under hyperthermic conditions, hypoxia induced gasping in both groups, but only the cigarette smoke-exposed ...

Anemia Triples Risk of Local Recurrence in Breast Cancer Patients

... oncologic research. Anemia is associated with a high likelihood of tumor hypoxia [too little oxygen in the blood]." The chemotherapy used in the study ... context, we should start discussing anemia more in the context of tumor hypoxia and look for targets that are distinct from erythropoiesis." More ...

Another way to grow blood vessels

... observed before. The response is regulated by a group of proteins known as hypoxia Inducible Factors (HIF) that detect hypoxia and activate the production of VEGF (vascular endothelial growth factor). ...

JCI online early table of contents: Feb. 7, 2008

... the Harvard Institutes of Medicine, Boston, have reported that a state of hypoxia (that is, low oxygen levels) can induce expression of D3 and lead to local ... rat model of hypertrophic heart failure a disease that is associated with hypoxia in the heart muscle D3 was induced at the site of hypoxia, causing a ...

Link between chronic kidney disease and oxygen-deprived tissue

... diseased kidneys in mice, shows that HIF-1 is the molecular link between hypoxia and CKD in humans as well as rodents," says Haase. The next step is to ... can promote fibrosis. We also hope to study the inflammatory response to hypoxia in the diseased kidney, concludes Haase. We already know that some ...

A new chemotherapeutic target for hepatocellular carcinoma

... protein concentration in HCC cells increased with a combination of hypoxia and anti cancer drugs. With TACE, the conditions of hypoxia are maintained by embolisation over a long period of time. Therefore, this ...

VivoMetrics' LifeShirt Going to South Pole to Uncover Clues to High-Altitude Illness

... in Antarctica to understand the body's response in chronic diseases where hypoxia (low oxygen) is a factor, such as chronic heart failure or chronic ... failure, lung disease, and obstructive sleep apnea all have ties with hypoxia and thus research on predictors of high altitude illness may be helpful ...

Severe COPD may lead to cognitive impairment

... COPD may experience periods of hypoxialow oxygen levelsthat might lead to brain abnormalities that could reduce cognitive capacity. Alternatively, hypoxia may cause or exacerbate diseases that are characterized by cognitive impairment, such as Alzheimer's disease. Although past studies have observed a ...

Sleep Disorders Linked to Arrhythmias

... odds of clinically significant arrhythmias independent of self-reported heart failure and cardiovascular disease." The study also found that hypoxia (deficiency in the amount of oxygen reaching body tissues) may trigger ventricular arrhythmia in older men. In addition, the "strong associations ...

Why some prostate cancer returns

... perpetuates the free radicals. That's why Dr. Movsas began his work nearly a decade ago to investigate low oxygen levels also known as tumor hypoxia in prostate cancer tumors while working at Fox Chase. To measure the amount of oxygen being delivered to the tumors and surrounding areas, Dr. ...

Compounds Found to Protect Rabbits From Cerebral Palsy

... in the fetus that can result in cerebral palsy, Silverman said. "This can happen right at the end of pregnancy," he explained. Common causes of hypoxia include a pinched umbilical cord or a cord wrapped around the fetus's neck or shoulder. The report was published online Wednesday in the Annals ...

Stanford study prevents pancreatic tumor growth in mice by inhibiting key protein

... cells undergo a process of programmed cell death when oxygen levels drop too far. Overcoming this response to low oxygen levels a condition called hypoxia is a critical step in tumor progression. The researchers wondered if CCN2 played a role in keeping tumor cells alive in hypoxic conditions. If ...

'Relocation' plan of metastatic cancer cells uncovered by Stanford researchers

... are components of the extracellular matrix surrounding many organs. LOX expression increases in cancer cells deprived of oxygen a condition called hypoxia that begins to occur when blood vessels fail to reach the inner cells of a growing tumor mass. Inhibiting LOX expression decreases tumor cell ...

Doctors' questions about end-of-life legalities may result in patient pain

... shock to the heart to restore normal rhythm. Terminally-ill patients may be at increased risk of ICD shocks due to electrolyte disturbances, hypoxia and heart failure. It is estimated that more than 3 million people in North America are now eligible for an ICD. With a growing elderly population in ...

Journal CHEST: Nov. highlights

... the change in CO level, which was defined as a gap between the presleep and postsleep CO levels, correlated with apnea-hypopnea index and hypoxia duration as a percentage of total sleep time, which showed that the higher the CO level, the more severe the OSA. Treatment with continuous positive ...

HPV virus helps cervical and head and neck cancers resist treatment and grow and spread

... step for Rettig and his team is to confirm the findings in additional animal models to gain broader understanding of the potential correlation of hypoxia and activation of the cell signaling pathway in humans. He hopes to have a drug to test in human clinical studies in about five years. HPV is the ...

Fall Risk Higher in Older Women Who Sleep Less

... and objective measures of sleep should examine the interrelationships between specific sleep characteristics (e.g., sleep-related breathing disorder, hypoxia and measures of sleep duration and fragmentation) to determine if these disorders contribute independently toward risk of falls." More ...

Cancer research highlights

... in New York, is the lead researcher. She explains the significance of the team's work this way: "Our results are able to visualize variable levels of hypoxia within tumors, which is potentially important for future therapies because it suggests this is a feasible approach to locating pockets of resistance ...

NOAA and Louisiana scientists predict largest Gulf of Mexico 'dead zone' on record

... The forecast is based on a mathematical model developed by LSU through NOAA's long-term research investment by CSCOR's Gulf of Mexico Ecosystems and hypoxia Assessment. The model incorporates U.S. Geological Survey data on the amount of nitrogen reaching the Gulf of Mexico in May. NOAA has been funding ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... hepatocyte growth factor/scatter factor (HGF/SF); highly upregulated in liver cancer (HULC); human chorionic gonadotropin (hCG); hyaluronan (HA); hypoxia inducible factor 1 alpha (HIF-1alpha); interleukin 13 (IL-13); IL-13 receptor alpha2 (IL-13ralpha2); inosine monophosphate dehydrogenase (IMPDH); ...

Solid tumor cells not killed by radiation and chemotherapy become stronger

... opinion that the whole tumor grows more aggressively because of this pulsation of oxygen at low levels," Dewhirst said. "Most people thought cycling hypoxia was caused by temporary stoppage of blood flow in single blood vessel in tumors. In fact, however, oxygen levels cycle up and down virtually ...

Green Tea May Help Brain Cope With Sleep Disorders

... drinking water laced with GTP to rats intermittently deprived of oxygen during 12-hour "night" cycles -- a condition that mimics the intermittent hypoxia (IH) that humans with OSA experience. The rats that drank green tea-treated water performed significantly better in a maze than rats that consumed ...

WaferGen Launches SmartSlide 200 Micro-Incubation System for Stem Cell Research and Cell Biology Applications

... to precisely control and vary these parameters helps researchers closely mimic physiological growth conditions, allowing them to create anoxia and hypoxia conditions which are critical for growth and differentiation of stem cells. "We are very excited to launch our SmartSlide 200 ...

Oceans, coasts and your health: Reducing risks and reaping rewards

... the Future, recently released by the Joint Subcommittee on Ocean Science and Technology (JSOST), Interagency Working Group on Harmful Algal Blooms, hypoxia and Human Health, and other related Federal activities. ...

FOXO factor promotes survival of oxygen-deprived cancer cells

... Dr. Tak W. Mak from the Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital in Toronto and colleagues found that hypoxia stimulates an HIF1-dependent increase in a protein called FOXO3a. FOXO transcription factors are evolutionarily conserved proteins that are critical ...

Who is the arch-criminal in the development of hepatopulmonary syndrome?

... is intra-pulmonary vascular dilatation. The intra-pulmonary vascular dilatation severely affects pulmonary gas exchange, and consequently leads to hypoxia and raised mortality of cirrhotic patients. The present research hotspots focus mainly on clarifying the pathogenesis of HPS, particularly in ...

Exercise may play role in reducing inflammation in damaged skin tissue

... and macrophages are attracted to that. So one potential thing that exercise might be doing, although we would need to test this, is reducing hypoxia within the wounds. And its known that hyperbaric oxygen therapy which has been used with burn patients speeds wound healing in some people. The ...

JCI table of contents: Nov. 21, 2007

... authors to suggest that therapies aiming to maintain adequate oxygen levels in the kidney might halt the progression of kidney fibrosis. TITLE: hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition AUTHOR CONTACT: Volker H. Haase University of ...

Combination targets: some drugs may work best when they work together

... findings support further development of AZD6244 and radiotherapy as combined regimen, and indicate a novel role for AZD6244 in inhibiting the tumor hypoxia response. It is possible that the effect of AZD6244 on HIF as well as tumor blood vessel growth induced by HIF contributed towards the ...

How vitamin C stops the big 'C'

... free radicals. Antioxidants remove these free radicals and stop HIF-1, and the tumor, in its tracks. The authors confirmed the importance of this hypoxia protein by creating cancer cells with a genetic variant of HIF-1 that did not require free radicals to be stable. In these cells, antioxidants no ...