Homeostasis in Medical News

Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells

... drugs worked by reprogramming the innate protein homeostasis machinery of the cell to repair the mutant ... calcium channel blockers restore partial enzyme homeostasis in cell lines derived from patients suffering ... also partially restored lysosomal enzyme homeostasis in cell lines derived from patients suffering ...

Millennium and Harvard Medical School Sign Cooperative Agreement for Research in Novel Field of Cancer Biology

... Pioneers Invest in Evolving Field of Protein homeostasis - CAMBRIDGE, Mass., Jan. 31 ... scientific progress in the field of protein homeostasis makes this agreement a natural fit for our ... in, and commitment to the field of protein homeostasis at Millennium. VELCADE(R) (bortezomib) for ...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

... Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves Glucose homeostasis in Diet-Induced Obese Mice" (Wong, K, Zhang, L-N, Vincelette, J, ... obese individuals to diabetes. -- "Improvement of Glucose homeostasis by AR9281, a Novel Inhibitor of Soluble Epoxide Hydrolase, in ...

Scientists Create Mice Resistant to Obesity

... people. They also shed light on the brain circuitry that controls energy homeostasis -- the balance between how much energy (i.e., food) an animal takes in and ... According to lead study author Qingchun Tong, most research into energy homeostasis has involved what scientists call genetically encoded neuropeptides, ...

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

... of AP1903, a small-molecule dimerizer agent developed by ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA ). In this way, the immune system's innate homeostasis is overridden and a potent and durable antigen-specific T cell response may be generated. The dose-escalation trial will evaluate the safety ...

Study aims to induce recovery from ankylosing spondylitis

... different species of pathogenic bacteria has been implicated in dozens of chronic disease states. ARF has discovered how to restore nuclear receptor homeostasis so that the body's own immune system can fight these pathogenic bacteria. The East-West partnership, which will eventually include subjects ...

Six Scientists Receive Awards for Contributions to Alzheimer's Disease Research

... winner of the 2009 Best Paper in Alzheimer's Disease Neuroimaging Award for his article entitled Ab Plaques Lead to Aberrant Regulation of Calcium homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks. Dr. Backsai will receive $5,000. Jennifer Whitwell, PhD, ...

6 scientists receive awards for contributions to Alzheimer's disease research

... winner of the 2009 Best Paper in Alzheimer's Disease Neuroimaging Award for his article entitled Ab Plaques Lead to Aberrant Regulation of Calcium homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks. Dr. Backsai will receive $5,000. Jennifer Whitwell, PhD, of the ...

Study further expands understanding of leptin's role in brain neurocircuitry

... of novel anti-diabetic drug targets." First identified in 1994 as an appetite and weight-regulation hormone, leptin plays a key role in energy homeostasis through its effects on the central nervous system. Over the years, investigators have pinpointed a region of the brain's hypothalamus known as the ...

AGA Institute presents cutting-edge research during DDW

... members. S. Ohashi et al. (8:22 a.m.) Microbial-innate Immune Interactions at the Epithelial Cell Interface. D. Polk (8:39 a.m.) Changes in Mucosal homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 Knockout Mice. D. Laubitz et al. (9:04 a.m.) Colitis-associated variant of TLR2 causes ...

Sodium channel blocker shows promise as a potential treatment for cystic fibrosis

... with normal respiration. One of the mechanisms causing airways to not clear mucous correctly in these patients involves the body's natural homeostasis of sodium which, when absorbed too quickly from the surface of the airway, causes moisture to become absorbed too quickly. "Cystic fibrosis ...

Study Results Published in CUTIS Demonstrate Long-Term Safety and Efficacy of Vectical(TM) (calcitriol) Ointment 3 mcg/g in the Management of Mild-to-Moderate Plaque Psoriasis

... abnormal urinalysis, skin irritation and psoriasis. Additionally, Vectical(TM) Ointment demonstrated no significant clinical effect on calcium homeostasis when used continuously over one year by 116 people who were evaluated. Also during the study, patients reported a noticeable improvement in ...

Beating a Global Killer: HIV/AIDS

... IPF, like other natural autoantibody based fractionated proteins, has an affinity to pathogenic binding and simultaneously produces effects of immune homeostasis in the presence of replacativly competent HIV. IPF has shown significant antiretroviral activity via immune stimulatory pathways in vitro, notably ...

Motorcycle Cancer Risk: Motorcycle Cop Cancer Concern from ELF EMFs Penetrating Motorcycle Seats

... is another concern. Also, various ELF EMF exposures are suspect of interfering with breast cancer medication. For cancer survivors electromagnetic homeostasis is essential in restoring natural defense immune and lymph systems, melatonin, etc.," Chipkar says. "Motorcycle police officers deserve our ...

Experimental Biology 2009 meets April 18-22

... and analysis of metabolites, such as sugars and fats) in the search for biomarkers for human diseases. One symposium on alteration of epigenetic homeostasis through exposure to environmental agents includes an overview on epigenetics, the new genetics of disease susceptibility, and specific presentations ...

Tweaking Hormones Might Ease Chronic Stress

... pituitary, adrenal (HPA) axis, one of the body's major control systems. The HPA axis uses hormone feedback regulatory loops to help maintain body homeostasis (balance of systems). A team led by Amos Ben-Zvi, of the University of Alberta, Edmonton, say that when the HPA axis is pushed far from its ...

Motorcycle Seats NOT The Cause of Impotence or Erectile Dysfunction for Bikers

... can disrupt zinc ions which are linked to impotence and erectile dysfunction. Furthermore, excessive ELF EMF invasion compromises electromagnetic homeostasis involving neuron function, hormone imbalance and adrenal fatigue all linked to impotence and libido loss," Chipkar says. "I discovered up to 500 ...

Vitamin K linked to insulin resistance in older men

... but did receive the multivitamin and the calcium and vitamin D supplement. For the present study, insulin resistance was assessed by the homeostasis model (HOMA-IR). Additionally, participants' blood glucose and blood insulin levels were measured following a minimum 10-hour fast. In addition to ...

Economic Stress Takes Toll on Health

... essential amino acids. Taken together, Sun Eleuthero and Sun Chlorella work synergistically. When the body is clean, it allows the body to maintain homeostasis and the anti-stress and calming effects of an adaptogen like Sun Eleuthero are enhanced. For more information about Sun Chlorella USA, visit the ...

Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting

... Kelly, et al. Abstract: http://ash.confex.com/ash/2008/webprogram/Paper11166.html -- "Effect of Reducing Intravascular Hemolysis on Ferritin homeostasis in Eculizumab Treated Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients," Dr. Alexander Roeth, et al. Abstract: ...

Maternal obesity can program fetal brain to induce adult-onset obesity

... the first time that the metabolic programming occurs in the fetal hypothalamus, the area of the brain responsible for maintaining the body's energy homeostasis (body weight) throughout life. Levels of the hormones insulin and leptin also were elevated in fetuses of these obese mother rats, abnormalities ...

Protein 'switch' suppresses skin cancer development

... maintaining skin homeostasis, or stability, and preventing skin cancer. "This study has revealed the importance of IKKα in maintaining skin homeostasis and in preventing skin cancer, as well as the mechanism of how IKKα acts in these processes," Hu said. "We will further investigate how ...

Dr. Ajrawat's Air-Pulse Autonomic Meditation Therapy, a Revolutionary, Scientific, Meditation Therapy, Receives Patent Trademark

... into an effective scientific therapy where the primary focus is on the body and mind; organs, organ systems and their functioning; and restoration of homeostasis – a new paradigm. Hence, with Dr. Ajrawat's Air-Pulse Autonomic Meditation Therapy and Dr. Ajrawat's Image Therapy, an individual receives ...

New Research Shows Chronic Stress Worsens Neurodegenerative and Inflammatory Illnesses

... essential amino acids. Taken together, Sun Eleuthero and Sun Chlorella work synergistically. When the body is clean, it allows the body to maintain homeostasis and the anti-stress and calming effects of an adaptogen like Sun Eleuthero are enhanced. For more information about Sun Chlorella USA, visit the ...

Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program

... that the R-spondin family of proteins activate the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. The R-spondin proteins also amplified the activity of Wnt proteins, and modulated the Wnt pathway by a common mechanism. The study, ...

Farm moms may help children beat allergies

... exposure affects her babys T regulatory cells. These cells, it is now believed, act to suppress immune responses and thereby maintain immune system homeostasis to contribute to healthy immune development. We found that the babies of mothers exposed to farms have more and better functioning regulatory T ...

Thyroid Hormone Could One Day Treat Osteoporosis

... "We found that TSH, which is a hormone that was thought to be exclusively involved in the release of thyroid hormones, which are essential for the homeostasis of the body, can directly affect bone remodeling," said lead researcher Dr. Mone Zaidi, a professor of medicine and physiology and director of the ...

Notch controls bone formation and strength

... at the possiblity that loss of Notch interferes with the natural signal between osteoblasts and osteoclasts (bone resorbing cells) and prevents the homeostasis or natural balance between the two. That means the protein Notch and the cellular pathways that express and control it might be targets for drugs ...

New cataract gene discovered

... molecule that is carried by this new transporter across the membrane has now begun. The researchers suspect that this genetic defect interferes with homeostasis in the lens as well as in the kidney. Since the known environmental risk factors for age-related cataract point to physiological and oxidative ...

Study: Brain connections strengthen during waking hours, weaken during sleep

... sustainable baseline, says Cirelli. The theory she and collaborator Dr. Giulio Tononi, professor of psychiatry, have developed, called the synaptic homeostasis hypothesis, runs against the grain of what many scientists currently think about how sleep affects learning. The most popular notion these days, says ...

Novel Compounds May Battle Diseases of Aging

... plasma glucose levels, and increased the function of mitochondria (the powerhouse of cells). In rats, the compounds improved whole body glucose homeostasis and insulin sensitivity in fat tissue, skeletal muscle, and the liver. The experimental compounds were developed and tested by Sirtris ...

How 'IAP antagonist' chemicals kill tumors

... in deciding the life-or-death balance. Apoptosis or programmed cell death is a cell suicide mechanism with a major role in development and homeostasis in all animals, Vucic explained. It is now accepted that apoptosis is also an extremely important defense against tumors, Silke added. Scientists ...

Journal of Alzheimer's Disease special issue explores multifaceted aspects of AD

... Mocchegiani and Marco Malavolta from INRCA (National Institute of Research and Cure for the Elderly) of Ancona (Italy) write about the role of zinc homeostasis in different conditions of brain dysfunction, including brain inflammatory status, aging brain and neurodegeneration They also discuss the role ...

JCI table of contents: Nov. 8, 2007

... and serum levels of PTH. Because PTH modulates serum calcium levels, and FGF23 affects vitamin D and phosphate levels, the authors suggest a mineral homeostasis feedback loop connecting the bone, kidney, and parathyroid. TITLE: The parathyroid is a target organ for FGF23 in rats AUTHOR CONTACT: Justin ...

New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs

... 2007 LRI Novel Research Grant Recipients Lupus Research Institute 2007 Grant Recipients Jennifer Anolik, MD, PhD University of Rochester B cell homeostasis during B cell depletion therapy in mice Gregory Barton, PhD University of California, Berkeley The role of ubiquitin-mediated downregulation of ...

JCI table of contents: Oct. 18, 2007

... obesity and glucose intolerance. TITLE: Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice AUTHOR CONTACT: David Y. Hui University of Cincinnati, Cincinnati, Ohio, USA. Phone: (513) 558-9152; Fax: (513) 558-1312; E-mail: ...

JCI table of contents: Sept. 4, 2007

... in the genes encoding the RR subunits. TITLE: Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis AUTHOR CONTACT: Gerald S. Shadel Yale University School of Medicine, New Haven, Connecticut, USA. Phone: (203) 785-2475; Fax: (203) ...

Insulin Sensitizer- Energy Conserving Signal to Brain

... its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation. Energy homeostasis may be mediated by both short-term regulators, such as gut hormones, and long-term regulators, said Takashi Kadowaki of the University of Tokyo. In ...

Cause of Gender Differences in Blood Pressure, Kidney Damage Under Study

... much of their life, work that led to her selection for the 2007 New Investigator Award of the American Physiological Societys Water and Electrolyte homeostasis Section. She presented her work May 1 during the Experimental Biology Meeting Annual Meeting in Washington, D.C. Female hormones cant ...