histones

Novel method conceived, to achieve genome-wide gene silencing.

... showed that a protein called SUMO holds on to the histones and acts to repress transcription of genes, and it...rger, "In our experiments, we saw SUMO binding to histones across the genome, suggesting that if this mechanism went wrong, it could have a dramatic effect. We...

Researchers Purify Protein That Could Regulate Male Hormones

... Lineberger Comprehensive Cancer Center. Because histones are so intimately associated with DNA, even slight chemical alterations of these proteins can have profound effects on nearby genes. Depending on their precise location and how many methyl groups are added, the presence of alterations can either turn...

Cell Survival Depends on Chromosome Integrity

...ust be copied exactly and repackaged properly with histones to form chromosomes in the new cell. During the copying process, new chromosomes often have breaks in them that need to be sealed before the chromosome is considered “finished” and the cell is ready to divide into two. All cells have damage control...

Mouse Gene With Gene Stutter Will Help Leukemia Research

... activity, were being altered. “We show that the histones are being modified in ways that can increase the activity of the HoxA9 gene,” says first author Adrienne M. Dorrance, a graduate student in Caligiuri’s laboratory and the recipient of the Lady Tata Memorial Trust Award for her work on this gene. “We ...

Recurrent Gliomas: Vorinostat Shows Anti-cancer Activity

...h DNA in cells. By inhibiting the deacetylation of histones -- proteins that help organize the structure of DNA -- vorinostat alters the expression of several important genes and proteins resulting in tumor cell death and stopping tumor growth. Dr. Galanis says that study findings indicate that vorinostat b...

RNA Play a Vital Role in Gene Activity

...l regions are tightly wound around proteins called histones and cannot be copied into RNA. Loss of HOTAIR in s...ed the Polycomb Repressive Complex 2 that modifies histones and helps them wind up the DNA. The researchers' interest is more than just theoretical. Polycomb ...