Amgen Highlights Data to Be Presented at ASCO
... neutropenia (neutropenia with fever) based on clinical practice. Another study compares the effectiveness of prophylactic versus delayed use of granulocyte
colony-stimulating factors (G-CSFs), including NEUPOGEN(R) (filgrastim) and Neulasta, on neutropenia-related hospitalizations based on clinical ...
Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells
... expressed genes for all three embryonic germ layers (the tissues from which all other tissue types in the body develop) and also produced myeloid and granulocyte
colonies (types of white blood cells).
The group confirmed that the reprogrammed cells had acquired ES cell characteristics by injecting the ...
Human Heart Can Make New Cells
... they slowed the degradation of SDF-1, the main chemical that guides stem cells to damaged heart tissue. They also treated the mouse hearts with granulocyte
colony stimulating factor, a drug that mobilizes stem cells from various places such as the bone marrow and blood. This two-pronged approach led to ...
Scientists uncover indicator that warns leukemia is progressing to more dangerous form
... cells that carry BCR-ABL to the blast crisis stage. This stage is characterized by the over-production of beta-catenin in white blood cells called granulocyte
macrophage progenitors (GMP) in effect, leukemia stem cells.
According to Jamieson, a major roadblock in predicting and stopping the conversion ...
Landmark Rh Immune Globulin Celebrates 40 Years of Saving Babies' Lives
... in any Rh-negative person after incompatible transfusion of Rh-positive blood or blood products (e.g., red blood cells, platelet concentrates, granulocyte
The use of RhoGAM and MICRhoGAM is contraindicated in Rh-positive individuals.
Scientists identify new congenital neutropenia syndrome and causative gene mutation
... fighting infection. Children born with SCN suffer from frequent bacterial infections, and until the introduction of treatment with recombinant human granulocyte
colony-stimulating factor (GCSF) in the 1990s, about three-fourths of affected children would die before 3 years of age. Treatment with GCSF usually ...
Single microRNA fine-tunes innate immune response
... and dampening their activation.
The study indicated that microRNA-223 targets Mefc2, a transcription factor that promotes the expansion of granulocyte
cell progenitors. (Transcription factors are proteins that regulate gene expression.) By knocking out Mefc2, the authors found that some of the ...
IDM Pharma Announces Data Presentation From Mifamurtide (L-MTP-PE) Compassionate Use Program
... (2 mg/m2 IV over 1 hour) was administered twice a week for 12
weeks followed by once a week for 24 weeks in combination with aerosol
monocyte colony stimulating factor (GM-CSF), an
immune stimulating agent. In addition, some patients in the program were
also treated with ...
Their immune cells, fighting your cancer
... Academy of Sciences, DOI: 10.1073/pnas.0602382103).
Cui hopes to begin human trials next summer in the US, when the immune systems of potential granulocyte
donors will be at their peak.
The concept of using immune cells from one person to fight cancer in another person is a very hot topic right now, ...
White Blood Cell Booster May Help Cancer Patients Avoid Deadly Complications
... or halted when a patient's white blood cell count is too low, potentially leading to poorer outcomes, she added.
"Patients taking a drug known as granulocyte
colony-stimulating factor early in their chemotherapy were about half as likely to develop dangerously low white blood cell counts with fever, and ...
Maxygen Initiates Phase IIa Clinical Trial of MAXY-G34 in Breast Cancer Patients
... to evaluate the efficacy, safety and tolerability of MAXY-G34 in the treatment of chemotherapy-induced neutropenia . MAXY-G34 is a novel pegylated granulocyte
colony stimulating factor (PEG-GCSF) shown in preclinical and Phase I studies to have novel and potentially superior properties compared to the ...
Growth Factors Given With Chemotherapy may Increase Risk of Blood Diseases
... of the conditions is very small, but that risk should still be taken into consideration when making treatment decisions.
The growth factors granulocyte
or granulocyte-macrophage colony-stimulating factor (G-CSF or GM-CSF) have been used to reduce the risk of infections from neutropenia, an abnormally ...
Are mature cells better than stem cells for cloning?
... advantage in using adult stem cells over mature fully differentiated cells. We can say with near certainty that a fully differentiated cell such as a granulocyte
retains the genetic capacity for becoming like a seed that can give rise to all cell types necessary for the development of an entire organism." ...
Scientists Isolate Leukemia Stem Cells in Mouse Model
... an abnormal gene, MLL-AF9, which causes a type of acute myelogenous leukemia (AML) in humans, into partially committed mouse blood cells known as granulocyte
macrophage progenitors, or GMPs. These genetically altered cells were injected into mice, which subsequently developed AML.
Through several ...
Stem Cell Therapy For Heart Attack Found To Be Ineffective
... new blood vessels after a heart attack. Mobilization of bone marrow stem cells can be achieved through stimulation of a growth factor protein, called granulocyte
colony-stimulating factor (G-CSF).
The researchers conducted a randomized, double blind, placebo-controlled study (REVIVAL-2) to assess effect ...
Protective regimen for acute Graft-versus-host disease
... plus antithymocyte globulin, followed by an infusion of HLA-matched peripheral-blood mononuclear cells from related or unrelated donors who received granulocyte
Of the 37 transplant recipients, only 2 had acute GVHD after hematopoietic-cell transplantation. Potent antitumor ...
High-Dosage of Epirubicin and Cyclophosphamide may cause AML
... Both the cumulative doses of epirubicin and cyclophosphamide had independent risk factors for AML/MDS. Other factors such as age, radiotherapy, granulocyte
colony stimulating factor and tamoxifen were not independently associated with AML/MDS.
Patients taking more than the standard cumulative dose ...
Therapy Boosts Chemotherapy Effects
... 640 patients with previously untreated AML to receive either standard chemotherapy or chemotherapy and treatment with a growth factor known as granulocyte
colony-stimulating factor, or G-CSF. While patients in the two groups initially showed similar response rates, a long-term follow up showed those in ...