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glioma in Medical News

Delivering Chemo Directly Into Brain Tumors Shows Promise

... 3 percent of patients diagnosed with a malignant glioma survive five years or more, according to ... Even when there's no tumor visible, microscopic glioma cells usually remain that eventually regrow, ... been shown to be effective in killing malignant glioma cells, but delivering enough of it through the ...

Brain tumor treatment may increase number of cancer stem-like cells

... ABCG2, a protein linked with drug resistance, in glioma cancer stem-like cells. "ABC proteins are ... human glioblastomas. "Because the SP phenotype in glioma cancer stem-like cells is mainly mediated by ... although not by itself oncogenic, is a marker for glioma stem-like cells. Further, the researchers ...

Avastin and Other Emerging Agents Will Drive the Glioma Drug Market to More Than $1.8 Billion in 2017

... The new Pharmacor report entitled glioma finds that sales of Avastin, which is already used off-label to treat relapsed glioma and is in development for treating both relapsed ... Temodar/Temodal, the current leading agent for glioma in both patient share and market share, will fall ...

Cancer-killing viruses influence tumor blood-vessel growth

... study, Kaur and her colleagues implanted human glioma cells into rodents with a working immune system, ... in CYR61 gene activity using several different glioma cell lines and glioma cells from patients, and several strains of ...

RTOG Study Likely Treatment Option for Brain Tumor Patients like Sen. Kennedy

... patients with newly diagnosed malignant glioma is a possible consideration for Sen. Edward ... (ACR), is enrolling approximately 1153 malignant glioma patients at 217 sites throughout the United ... practice) will improve the outcome for malignant glioma patients and what effects, if any, the longer ...

Ted Kennedy Released From Hospital

... the cause of the seizure as a malignant glioma in the left parietal lobe. The usual course of ... not possible or not desirable. "But malignant glioma are infiltrative tumors," added Friedman, who's ... The National Library of Medicine has more on glioma . SOURCES: Deepa ...

Ted Kennedy Has a Brain Tumor

... Doctors find malignant glioma in tests after seizure TUESDAY, May ... the cause of the seizure as a malignant glioma in the left parietal lobe. The usual course of ... The National Library of Medicine has more on glioma . SOURCES: May 20, 2008, ...

Cedars-Sinai Medical Center opens patient trial of virus that attacks brain cancer cells

... induced cell death . Although not every glioma cell line has an activated Ras pathway, Ras ... killing was seen in 19 of 24 established human glioma cell lines tested. Reovirus also infected and killed all nine of nine primary glioma cultures taken from brain tumor surgical ...

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

... two groups with results as follows: Malignant glioma N Evaluable Partial Stable ... 0 2 (14%) 2 (14%) Anaplastic glioma 9 6 2* (33%) 2 (33%) ... (PFS) and Overall Survival (OS) in the Anaplastic glioma group was 9 wks (range 2 - 50 wks) and 49 ...

Other highlights in the Oct. 30 JNCI

... and colleagues discuss current therapies for glioma that affect communication between tumor cells and ... they are less likely to develop resistance than glioma cells. A better understanding of the ... genetically stable normal cells that surround the glioma rather than the genetically unstable tumor cells ...

Surveyed Oncologists Expect to Prescribe Provenge to about Half of Their Prostate Cancer Patients if the Vaccine is Approved

... Toward Emerging Cancer Vaccines for Prostate Cancer, Lung Cancer, and glioma finds that clinicians are willing to prescribe Provenge to patients in ... Toward Emerging Cancer Vaccines for Prostate Cancer, Lung Cancer, and glioma is based on a U.S. survey of 70 oncologists, 71 urologists and 20 MCO ...

Most common brain cancer may start in neural stem cells

... scientists show that the expression of mutant p53 protein is a marker for glioma cells in all stages of the disease. "Now, if we believe that the SVZ ... supports the idea that mutant p53 can be a useful marker to trace the glioma cells at all stages. What's next: Before any treatments based on ...

Most common brain cancer may originate in neural stem cells

... scientists show that the expression of mutant p53 protein is a marker for glioma cells in all stages of the disease. "Now, if we believe that the SVZ ... supports the idea that mutant p53 can be a useful marker to trace the glioma cells at all stages. What's next: Before any treatments based on ...

Surveyed Oncologists Indicate that Avastin has Advantages over Temodar/Temodal in Increasing Overall Survival of High-Grade Glioma

... Decision Resources' proprietary clinical gold standard for high-grade glioma was Avastin. Although Avastin is not formally approved for the treatment ... Analyst Ramya Kollipara, Ph.D. "Because the prognosis for high-grade glioma patients is so poor, interviewed thought leaders welcome Avastin's entry ...

Chemo Alone Effective in Treating Kids' Brain Tumors

... be effective in treating children with inoperable or progressive low-grade glioma brain tumors, according to a multi-institutional study. Low-grade glioma is the most common brain tumor in children. If surgery can be performed, ...

Sen. Kennedy Up and Walking After Brain Tumor Surgery

... treatments for what doctors say is a life-threatening malignant glioma TUESDAY, June 3 (HealthDay News) -- Sen. Edward M. Kennedy ... More information The U.S. National Library of Medicine has more on glioma . SOURCES: Leonard Lichtenfeld, M.D., Deputy Chief ...

Sen. Kennedy's Brain Tumor Surgery Called a 'Success'

... chemotherapy treatments for what doctors call a life-threatening malignant glioma MONDAY, June 2 (HealthDay News) -- Sen. Edward M. Kennedy's ... More information The U.S. National Library of Medicine has more on glioma . SOURCES: Leonard Lichtenfeld, M.D., Deputy Chief ...

Sen. Kennedy Undergoing Surgery for Brain Tumor

... circumstances, that's not possible or not desirable. "But malignant glioma are infiltrative tumors," added Friedman, who's also an assistant ... More information The National Library of Medicine has more on glioma . SOURCES: Deepa Subramaniam, M.D., director, ...

St. Jude finds young age may give survival advantage to children with certain brain tumors

... children under 3 years old who have a brain tumor called diffuse pontine glioma (DPG) appear to have a better outcome than older children with the same ... chemotherapy. The researchers point to a similar finding with a type of glioma that originates in the cerebrum: Young children with high-grade gliomas ...

YM BIOSCIENCES REPORTS FIRST QUARTER 2008 OPERATIONAL AND FINANCIAL RESULTS

... a 44-patient clinical trial in children with diffuse, intrinsic pontine glioma (DIPG), an inoperable progressive brain cancer." "More recently our ... late-stage trials designed to be supportive of registration in adult glioma and pancreatic cancer. - Subsequent to the end of the quarter: - YM ...

Customized virus kills brain tumor stem cells that drive lethal cancer

... surgery almost never eliminates it. Patients suffering from this malignant glioma live on average for about 14 months with treatment. Fueyo and ... after surgery," Fueyo said. "So we decided to test Delta-24-RGD against glioma stem cells and tumors grown from them." The research team led by Fueyo, ...

Molecular probe 'paints' cancer cells in living animals, Stanford researchers find

... They are now testing the probe's ability to reveal the presence of glioma tumor cells during brain surgery in mice. "Because glioma tumor tissue looks nearly identical to normal tissue, it's very difficult ...

Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program

... #: 150240 Publication No.: 445 Abstract Title: Dosimetry of phase I interstitial 131I-chTNT-1/B MAb (Cotara) for the treatment of recurrent glioma Accepted to: ISRTRD Integrated Session (Oral) Session Info: Dosimetry/Radiobiology IV: Targeted, Diagnostic and Therapeutic Agents Tuesday, ...

USC researchers develop new drug to target tumor cells and blood vessels

... of the DMC compound by isolating endothelial cellsthe cells that line the interior surface of blood vesselsfrom human nonmalignant brain and glioma tissues and treating them with DMC. They found that the drug was cytotoxic to tumor-associated endothelial cells and suppressed cell ...

Neurosurgeons from around the world gather at PLA 301 Hospital in China

... procedures in the first week of operation. In the six weeks since installation of the IMRISneuro suite, the team treated 43 patients suffering with glioma or epilepsy. While PLA 301 is widely-recognized for performing at the highest of global clinical standards, Dr. Xu Bainan, Chairman of Neurosurgery, ...

Avastin effective at delaying brain tumor progression in recurrent disease

... to a retrospective study of 22 patients conducted by a researcher at the Seattle Cancer Care Alliance. The patients all had a recurrent malignant glioma known as alkylator-refractory anaplastic oligodendroglioma (AO), for which there is no existing standard therapy. Oligodendrogliomas begin in brain ...

DecisionBase 2009 Now Available from Decision Resources

... Oncology Breast Cancer (HER2-Positive) Breast Cancer (Metastatic Triple Negative) glioma (High Grade) Malignant Melanoma (Stage IV) Chronic Lymphocytic Leukemia (Relapsed/Refractory) Prostate Cancer (Metastatic, ...

Also in the March 24 JNCI

... activity, Dawei Xu, M.D., Ph.D., of the Karolinska Institute in Stockholm, Sweden, and colleagues infected normal diploid fibroblasts and malignant glioma cells with HCMV or introduced a copy of the viral immediate early antigen 72 (IE-72) gene into the cells. Infection with HCMV induced telomerase ...

Also in the Feb. 24 JNCI

... Frank Pajonk, M.D., Ph.D. of the David Geffen School of Medicine at the University of California, Los Angeles and colleagues engineered breast and glioma cell lines to express a fluorescent protein that was a target for degradation by the 26S proteasome, which normally disposes of unwanted cellular ...

Genetic Mutations Linked to Deadly Brain Cancer

... Yan said. "Two tumors may look like a duck and walk like a duck, but the two tumors may be quite different." Once a test determines the type of a glioma in a patient, doctors could conceivably choose from an array of treatments. "You can give one kind of patients one kind of drug, and others another ...

Prayers From Maria - Children's Glioma Cancer Foundation Hosts Sunflower Soiree

... funding global research into the causes, prevention, treatments and cure for childhood brain tumors known as gliomas, Prayers From Maria - Children's glioma Cancer Foundation, was founded in 2006 by Ed and Megan McNamara. The foundation receives considerable support from the community-at-large. The ...

Mayo Clinic identifies best treatments for long-term survival in brain tumor patients

... radiation therapy, while those who had radiation therapy survived an average of six years. "This study is exciting because it shows how well glioma patients can do after surgery," says Dr. Laack. "An average of 15 years tumor-free is better than any previously published results. It is also ...

Mayo Clinic Identifies Best Treatments for Long-Term Survival in Brain Tumor Patients

... therapy, while those who had radiation therapy survived an average of six years. "This study is exciting because it shows how well glioma patients can do after surgery," says Dr. Laack. "An average of 15 years tumor-free is better than any previously published results. It is also ...

The miseries of allergies just may help prevent some cancers, study finds

... noted. However, on closer examination, these "outliers were illuminating." Studies show that allergies are correlated with lower incidences of glioma and pancreatic cancer, which affect internal tissues. However, both glia (which participate in signal transmission in the nervous system, and whose ...

Cleveland Clinic Physicians to Present at Medical Conference in Panama, July 11-12

... 2008 8:30 a.m. - 9:15 a.m.: Key Note Conference: Treatment Options for Brain Metastases, Dr. Lilyana Angelov 9:30 a.m. - 10:00 a.m.: Advances in glioma Treatment, Dr. John Suh 10:00 a.m. - 10:30 a.m.: Current Surgical Management of Spine Metastases, Dr. Edward Benzel 10:30 a.m. - 11:00 a.m.: ...

Kennedy Faced Brain Surgeon's Knife While Awake

... Kennedy's age with such a tumor is about 12 to 14 months," she said. More information The U.S. National Library of Medicine has more on glioma . SOURCES: Eugene S. Flamm, M.D., professor and chairman, department of neurosurgery, Montefiore Medical Center and Albert ...

Measuring medicine: How new technologies could help doctors predict patient outcomes

... different types of tissues or tumors. In this study, researchers assessed brain tumor response by diffusion MRI in 60 patients with high grade glioma who were undergoing radiation therapy. The patients were assessed at one, three and 10 weeks after the start of radiation treatment. Researchers ...

Forever young: Differentiation blocked in tumor stem cells

... an early stage of development. The research, published by Cell Press in the January issue of Cancer Cell, significantly advances the understanding of glioma pathophysiology and provides new directions for design of therapeutic strategies that are targeted to specific types of tumors. Tumor-initiating ...

Blood-vessel blocker aids cancer-killing virus

... the blood vessels in a brain-tumor model. Kazuhiko Kurozumi, a visiting research scholar from Japan in Kaurs laboratory, first implanted rat glioma cells into the brains of several groups of rats. Seven days later, he injected a cancer-killing virus, called hrR3, into the growing tumors. This ...
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