Germline in Medical News

Human sperm created from embryonic stem cells

... with XY chromosomes (male) were developed into germline stem cells which were then prompted to complete ... on this technique, the cells differentiated into germline stem cells. These expressed a protein which ... further differentiation, these in vitro derived germline stem cells expressed markers which are specific ...

Testes stem cell can change into other body tissues, Stanford/UCSF study shows

... by many types of adult stem cells. They termed the cells "multipotent germline stem cells." Germ cells are those cells in the body that differentiate to ... not yet possible to completely re-create human embryonic stem cells from germline cells," said Reijo-Pera, "These cells differ in gene expression, ...

Researchers Create Embryonic-Like Stem Cells From Human Testes

... is a big leap forward in efficiency with which these people get these germline stem cells," he said. But besides the obvious fact that women can't ... make an iPS cell than to have a testicular biopsy to give rise to an adult germline stem cell," he said. More information For more on stem cells, ...

Penn Veterinary Medicine report new strategy to create genetically modified animals

... Vet, and her colleagues introduced adeno-associated virus, AAV, to male germline stem cells in both goats and mice. The study showed that AAV stably ... approach to germ line genetic modification. It also demonstrates that germline transduction and germ cell transplantation in large animals provides an ...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

... cells, they showed that the treated cells could be incorporated into a mouse embryo and become every cell type in the adult animal -- including germline cells that would produce the next generation of mice. "These are transient, non-coding molecules that do not incorporate into the genome, ...

UCSF team closer to creating safe embryonic-like stem cells

... cells, they showed that the treated cells could be incorporated into a mouse embryo and become every cell type in the adult animal -- including germline cells that would produce the next generation of mice. "These are transient, non-coding molecules that do not incorporate into the genome, but ...

Stem Cells Spur New Eggs in Ovaries of Adult Mice

... and adult mice. The presence of these germ cells could indicate reproductive capability. Still, researchers disagreed as to whether female germline stem cells (FGSCs) do exist in mammalian ovaries after birth. So, the Chinese team isolated active female FGSCs from adult and five-day-old mice. ...

Family history of colorectal cancer linked with reduced risk of cancer recurrence

... colorectal cancer. Should this be the case, genome-wide association studies and tumor gene expression profiling studies will be warranted to identify germline and tumor-specific genetic features associated with a family history of colorectal cancer and favorable outcome following adjuvant chemotherapy. ...

CSHL scientists are part of consortium that sequences platypus genome

... of small RNAs called piwi-, or piRNAs. In platypus, in contrast to other mammals studied to date, the piRNA system appears to play an active role in germline defense, within the mature testis. In sum, Dr. Hannon noted, the small RNA complement of the platypus has highlighted both unique and conserved ...

USC study finds evidence of gender-related differences in development of colon cancer

... Research, found that specific gene variants linked to the development of colon cancer resulted in opposite survival outcomes for men and women. germline variations in the epidermal growth factor receptor (EGFR) DNA -- a gene widely expressed in colonic tissue -- has been linked with poor prognosis ...

Identical Genes From Parents May Raise Cancer Risk

... suggest that more than 5 percent of all cancers are linked to heredity, the researchers said. Previously, Eng had noticed that a high level of germline cells (those containing genetic material that can be passed on to children) were homogenous, meaning that two copies of the same gene were identical. ...

Other Highlights in the Nov. 27 JNCI

... mutation carriers. Such risk estimates are important for determining appropriate risk management strategies for the male members of families with germline mutations in BRCA1 or BRCA2, the authors write. Contact: Tim Parsons or Kenna Lowe, public affairs office, Johns Hopkins School of Public Health, ...

Scientists, physicians present latest findings in 'personalized' cancer treatment and prevention

... our knowledge of tumor biology and signaling pathways advances, so too does our ability to molecularly characterize individual tumors and identify germline determinants of patient prognosis and response, said David Sidransky, M.D., meeting chairperson and professor of Otolaryngology - Head and Neck ...

Cigarette Smoke Alters DNA in Sperm, Genetic Damage Could Pass to Offspring

... Association for Cancer Research. 'Here we are looking at male germline mutations, which are mutations in the DNA of sperm. If inherited, these ... Among the next steps in gaining a better understanding of the germline genetic health conse-quences of smoking, Yauk and her colleagues plan to ...

Fruit Crop Fungicide Induces Permanent Changes in Mating Behavior

... out of the gene pool.” Vinclozolin causes changes in the male rats’ germline cells (for example, sperm). The fungicide does not directly alter DNA, but ... to vinclozolin was passed down generation to generation through the germline of the males. For the first time, Crews and Gore show the inherited ...

Researchers Identify Genetic Mutations for Hereditary Diffuse Gastric Cancer

... family history of gastric cancer and more than 50 percent of families with 2 diffuse gastric cancer cases diagnosed prior to age 50 years will carry germline mutations in the CDH1 gene," the researchers write. "This extended family with the 2398delC founder mutation is a useful resource for ...

Gene Therapy for Hereditary Immunodeficiency Diseases

... using a vector – a kind of vehicle that carries the gene. Somatic gene transfer only targets body cells (somatic cells). Introducing genes into the germline is illegal in Germany. The first well-documented gene therapy studies were launched in the early 1990s. By 2005 it was estimated that more than ...

Feedback Loop Governing Ovarian Development Unraveled

... its amount of stem cell precursors, called primordial germ cells (PGCs). Primordial germ cells are important cells. Some of them develop into germline stem cells, which have regenerative powers and others will differentiate into eggs. Signals, sensors, feedback A fruit fly takes ten ...

Human Testicular Cells Would Help In Stem Cell Research

... adult mice. Under certain culture conditions these cells grew into colonies much like embryonic stem cells. They called these cells multipotent adult germline stem cells (maGSCs). Certain features of maGSCs are that it can spontaneously differentiate into the three basic tissue layers of the embryo and ...

H-ras gene mutation linked to Costello Syndrome

... team from DuPont Hospital studied genetic mutations in H-ras gene which lead to Costello Syndrome, scientists found that the gene mutation occured in germline cells //though it was not observed in the genotype of the parents of the affected patients. The researchers have published the results of their study ...