Genes in Medical News

Carnegie Mellon develops innovative method to detect genetic causes of complex diseases

... underlying an entire regulatory network of genes or traits that are responsible for complex ... we can look for associations between networks of genes and clinical traits." Severe asthma, for ... diseases," Xing said, "so we can identify the genes that underlie disease processes, understand the ...

Silenced genes as a warning sign of blood cancer

... Such labels are found particularly often in genes which act as important inhibitors of pathogenic ... believe that the first chemically deactivated genes trigger whole cascades of changes in the genetic ... by regulating the activity of their respective genes very specifically. Although every single gene is ...

TGen-led team is 1 of 7 selected for $1 million skin-cancer grants

... study: Identification of Novel Melanoma Risk genes Using High-throughput Genomics. "The ... efforts,'' Dr. Brown said. "Identifying the genes that mediate development of melanoma will give ... the best form of cure. Characterization of the genes influencing melanoma risk is critical towards ...

Genes key to staph disease severity, drug resistance found hitchhiking together

... horizontal gene transfer, whereby resistance genes move from one bacterium to another. Staph bacteria also can exchange virulence genes using the same mechanism, but this was previously ... of New Jersey. "The discovery that bundled genes determine virulence and antimicrobial resistance ...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

... St. Jude scientists identify new genes implicated in childhood acute myeloid leukemia ... also performed DNA re-sequencing of 25 genes that are commonly mutated in adult AML. Point ... less than one point mutation per patient in the genes sequenced. The scientists also reported just 21 ...

Scientists discover key event in prostate cancer progression

... androgens bind with these receptors to activate genes that control cell growth. The researchers show ... receptors are reprogrammed to regulate a group of genes involved in a different, later, phase of cell ... how they become active in that disease and what genes they regulate to promote tumor growth." The ...

Immune System Gene Discovery Sheds Light on Staph Infections

... Southwestern Medical Center have figured what genes turn on and off in a person's immune system when ... published in the online journal PLoS One , the genes in children's innate immune system, which ... overactive when S. aureus hits. Meanwhile, the genes in the children's adaptive immune systems, which ...

Studies Show Genetic Activity of Antioxidants

... are reporting studies describing the range of genes that are affected by curcumin, the active ... at the Centre de Clermont-Ferrand/Thiex in Saint genes Champanelle, who described the turmeric study. "We have slides with samples of all the genes and we compared the expression of each gene to ...

Study Shows a Link Between Schizophrenia & Genetic Mutations

... schizophrenia and ultra-rare variants in microRNA genes on the X-chromosome has been identified. Mutations in a subset of these regulatory RNA genes may strongly predispose to schizophrenia. The ... that down-regulate the expression of a variety of genes and are scattered over the genome. Components ...

Male Sex Chromosome on Its Way Out: Study

... of the Y chromosome has led to a dramatic loss of genes on the chromosome. "Today, the human Y ... from Penn State. "We know that a few of the genes on the Y chromosome are important, such as the ... of sperm, but we also know that most of the genes were not important for survival because they were ...

Gene Connections Key to Brain Tumor Growth

... Researchers have identified a network of mutated genes and gene processes that, together, contribute to ... Association . "It's the concert of those genes and the interaction of those genes that ultimately determine the progression of ...

Researchers map how staph infections alter immune system

... a process that summarizes how individual genes are being activated or suppressed in response to ... probes the entire human genome to determine which genes are turned on or off. They found that in children with invasive staphylococcal infections, the genes involved in the body's innate immune response are ...

Variants of 'umami' taste receptor contribute to our individualized flavor worlds

... They further report that variations in the genes that code for this receptor correspond to ... 87 individuals to look for variations in the genes that code for T1R1 and T1R3, two protein subunits ... to further understand the degree to which these genes account for umami taste perception," said ....

Genes Linked to Cholesterol in Cells Are Identified

... TUESDAY, July 7 (HealthDay News) -- Twenty genes that play major roles in controlling cholesterol ... by German researchers, who said that some of the genes may play a role in heart disease risk and offer new targets for drug treatment. The 20 genes are likely to be "immediately relevant" for ...

Moles and melanoma -- researchers find genetic links to skin cancer

... subjects' genetic make-up, to pinpoint which genes were most significant in developing melanoma a ... found to be much more likely to be carrying the genes most closely associated with red hair and ... In this study we found a clear link between some genes on chromosomes 9 and 22 and increased risk of ...

Australian researchers identify genes that cause melanoma

... of Medical Research (QIMR) have found two new genes that together double a person's risk of ... Nick Hayward and Grant Montgomery, studied the genes of almost 6,000 people together with their mole count. Specific changes in two genes were found to make people more susceptible to ...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

... snippets of DNA, while myocardin turns on the genes to which SRF sticks. Most of the genes turned on by myocardin/SRF in VSMC are needed for ... is the process where information encoded in genes is converted into proteins, the workhorse ...

Prometheus Launches MyCeliacID(TM), the First Do it Yourself, Saliva-Based Genetic Test Dedicated to Celiac Disease

... indicates that the individual does not have the genes associated with celiac disease and is highly ... indicates that the individual has one or more genes that predispose to celiac disease, however it is ... quickly find out if you or a loved one has the genes for celiac disease." MyCeliacID is available ...

Hundreds of Genes Could Be Linked to ADHD

... identified by U.S. researchers. Many of these genes were known to be involved in learning, behavior, ... study in 2003, we expected to find a handful of genes that predispose a child to ADHD," study co-leader ... release. "Instead, there may be hundreds of genes involved, only some of which are changed in each ...

Study pinpoints novel cancer gene and biomarker

... molecular biology are needed to determine which genes are involved in cancer and which are mere ... MD, of Dana-Farber. "To narrow that group to the genes that actually drive cancer growth and metastasis, ... studies, which focus on what individual genes do to turn a cell cancerous, and mechanistic ...

Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle

... known that the relationships between fruit fly genes change over time, but existing experimental ... database that measured the activity of 4,028 genes at 66 intervals spanning the embryonic, larval, ... with microarrays, provided a snapshot of which genes were active at the time in the large, evolving ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

... called X-inactivation, which turns off all genes on an entire chromosome. His work may provide ... the process that turns the information in our genes into proteins. Misregulation of protein ... Cambridge, Massachusetts, is working to identify genes that are necessary to ensure accurate and ...

Targeting tumor behavior may lead to new liver cancer drugs

... of tumor behavior. The agents target multiple genes associated with that behavior at one time. The ... block tumor progression by striking multiple genes that are associated with a particular ... effect on these changes," Patel says. "If genes 'A, B and C' were increased in our tumor cells, ...

Joan Massagué wins BBVA Foundation Frontiers of Knowledge Award in Biomedicine

... harmful substances. Massagu has identified three genes that intervene in the process, but the list will ... in each type of cancer. Research into the genes involved in cerebral metastasis and their mode of ... Massagu. "These are the first brain metastasis genes to be identified, with clinical data". Dr. ...

Study Refutes Depression Gene Finding

... of Mental Health. "We're learning more about how genes can control the different biologic pathways in ... have had an unusually tough time linking specific genes with different psychiatric illnesses, such as ... to Merikangas, there may be as many as 40 genes governing serotonin activity. The 2003 ...

Lifestyle May Counter Blood Pressure Genes

... June 16 (HealthDay News) --Being born with genes that predispose you to high blood pressure ... that they interact, and that the effect of those genes varies among individuals who have different ... a socioeconomic factor. The study found that genes for high blood pressure have a greater effect in ...

Dad's Genes May Play Greater Role Than Thought

... Cairns said. "The vast majority of their genes are tightly packed in material that is not ... randomly distributed but is located at important genes for embryonic development." The discovery was ... and sequenced it," Cairns said. "We found genes that are important in guiding the development of ...

Mapping gene expression with Gene Expression Atlas

... and functions, largely because different genes are active in these cells. The Gene Expression ... my particular gene of interest expressed? which genes are expressed in a particular condition? For example, what genes are specifically active in kidney cells, or how ...

LSUHSC research finds single gene controls growth of some cancers

... the role it plays in the activation of the EBV genes responsible for the indiscriminate growth of ... stress change EBNA1's ability to activate EBV genes responsible for indiscriminate tumor cell ... S. Scott Cancer Center. "As a consequence, EBV genes required for proliferation are no longer ...

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

... Copenhagen, Denmark, Wednesday 10 June 2009: The genes that regulate human circadian rhythm, or 'the ... as responsible for interactions between the genes that regulate the body clock and those that may ... looked into the expression patterns of certain genes in mice with arthritis. Here, researchers ...

Interleukin Genetics Launches Inherent Health Brand of Genetic Tests Offering Clear and Personalized Insights to Wellness

... to lose weight and keep it off. "The genes analyzed in the Inherent Health Weight Management ... Genetic Test that identifies DNA variations in genes crucial to B-vitamin metabolism and the ability ... Individuals that show suboptimal results for the genes can be at increased risk for ineffective ...

UT Southwestern's Olson wins prestigious French award for heart research

... important is his demonstration that many of the genes that control heart formation are called into play ... He and his team have discovered networks of genes that orchestrate the formation of the heart and have shown how inherited genetic mutations in these genes cause congenital heart disease, the most frequent ...

Most common brain cancer may start in neural stem cells

... new insights to an unfolding picture of how genes go awry to result in brain cancer. Scientists recently learned that certain genes and pathways of cell action are altered in ... of these key alterations involves mutations in genes that are players in the p53 pathway. But until ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

... 12, 13 and 61 of both the KRAS and NRAS genes and mutations in exons 11, 12, and 15 of the ... For more information on the interplay of genes and pathways, please refer below to "About ... of patients with wild-type (normal) KRAS genes respond to anti-EGFR therapy, suggesting that ...

Most common brain cancer may originate in neural stem cells

... new insights to an unfolding picture of how genes go awry to result in brain cancer. Scientists recently learned that certain genes and pathways of cell action are altered in ... of these key alterations involves mutations in genes that are players in the p53 pathway. But until ...

Pitt melanoma researchers present novel findings at ASCO

... Cancer Institute (UPCI) have identified eight genes that help predict a melanoma patient's response ... Neural Network Analysis to survey over 25,000 genes and the regulators that turn the genes on and off to see if they could identify ones ...

Cancer cells need normal, nonmutated genes to survive

... survival. "Cancer cells actually leverage many genes that don't harbor mutations to maintain their ... author and postdoctoral researcher Ji Luo. "These genes probably help them deal with the problems that ... addicts, but they're just as reliant on normal genes that alleviate stress," explains senior author ...

The vulnerable cancer cell

... by targeting a largely hidden network of normal genes that cancer cells rely on for survival. ... (RNAi) technology to identify a host of genes that cancer cells depend on for survival. The ... use the powerful RNAi technology to seek out genes that KRAS-mutant cancer cells need for survival. ...

Viable Swine Flu Shot Closer to Reality

... The strain was created by "combining the genes of the novel H1N1 virus with other parts from ... released on Friday suggests that many of the genes that make up the new H1N1 swine flu virus have ... also found that the new H1N1 strain lacks genes that -- in other influenza A strains -- confer ...

U.S. Closer to Viable Swine Flu Shot

... The strain was created by "combining the genes of the novel H1N1 virus with other parts from ... released on Friday suggests that many of the genes that make up the new H1N1 swine flu virus have ... also found that the new H1N1 strain lacks genes that -- in other influenza A strains -- confer ...