Fibroblast in Medical News

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

... a combination of microRNAs and retrovirus-introduced genes to transform fibroblast cells -- found throughout the body of mice and humans -- into pluripotent ... a lipid, allowing them to pass through the cell membrane. By labeling the fibroblast cells, they showed that the treated cells could be incorporated into a ...

UCSF team closer to creating safe embryonic-like stem cells

... a combination of microRNAs and retrovirus-introduced genes to transform fibroblast cells -- found throughout the body of mice and humans -- into pluripotent ... a lipid, allowing them to pass through the cell membrane. By labeling the fibroblast cells, they showed that the treated cells could be incorporated into a ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... a disintegrin and metalloproteinase domain 17 (ADAM17), TACE; acidic fibroblast growth factor (aFGF); activin receptor IIA (ActrIIA); adenosine deaminase; ... factor 4E (EIF4E); exonuclease III; farnesyl transferase (FTase); fibroblast growth factor 2 (FGF-2); FGFr; focal adhesion kinase (FAK); folate ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... inhibitor that simultaneously inhibits vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR) and fibroblast growth factor receptors (FGFR). The data presented at the conference come from a Phase II study investigating the efficacy and safety of the ...

Researchers Discover the Tale Behind Short Dogs

... 20 short-legged dog breeds, including dachshunds, corgis and basset hounds, have two copies of a gene that play a role in production of the protein fibroblast growth factor 4 (FGF4). The copies are not identical, though, as one lacks some essential parts of the DNA code, according to the study published ...

New Longevinex Advantage(R) Designed for Americans Who Want to Live Longer and Look Younger

... thick hair and extra-flexible joints - the visible signs of youthfulness. A unique source of pure oral hyaluronan is provided which stimulates fibroblast cells in the body to produce more hyaluronan, along with molecules like resveratrol, quercetin, anthocyanins, catechin and ferulic acid (all known as ...

Important Data Presented on Independent Predictors of Mortality in Patients With Idiopathic Pulmonary Fibrosis

... Pirfenidone Prior in-vitro evidence has shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Data presented from one Phase 3 study and four Phase 2 clinical trials in more than 400 patients suggest that pirfenidone may ...

URI scientists reveal mechanism that regulates cancer-causing gene

... and respond to oxidation. This sensing system was found to uniquely apply to two families of proteins implicated in numerous cancers: the Src and fibroblast Growth Factor Receptor families of tyrosine kinases. Their results were published online March 9 in the Proceedings of the National Academy of ...

Master molecular switch may prevent the spread of cancer cells to distant sites in the body

... there can be more than one messenger RNA (mRNA) produced from the same gene. These mRNAs then go on to make different proteins. The mRNA for fibroblast Growth Factor Receptor 2 (FGFR2) is the focus of the Molecular Cell study. FGFR2 mRNA has two forms, one called IIIb, which is expressed in ...

Discovery provides hope for sufferers of disfiguring bone disease

... the UEA scientists focused on Apert Syndrome - the most severe of the craniosynostosis range of diseases that is caused by mutations in a gene called fibroblast Growth Factor Receptor 2 (FGFR2). They identified a key offending molecule FGF10 and demonstrated for the first time that 'dampening down' the ...

New test may help to ensure that dengue vaccines do no harm

... the new test will capture enhancement that the older test misses. To construct the new test of cross-neutralization, researchers took CV-1 fibroblast cells, which share some traits with macrophages, and genetically engineered them to include a gene that directs for the building of an FC receptor on ...

Fibroblasts invade at a snail's pace

... during wound healing and tissue remodeling. The team thinks that in addition to its role in EMT, Snail1 also acts as a master regulator of fibroblast function. In cancer cells, says author Grant Rowe, sustained Snail1 expression may not only cause a loss of epithelial markers but also promote tumor ...

Amira Pharmaceuticals, Inc. Expands its Scientific Advisory Board and Appoints Dr. Paul Anderson, Professor Jerold Chun and Professor Andrew Tager

... laboratory published a seminal paper demonstrating that the lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. The results suggested that lysophosphatidic acid is the chemoattractant predominantly responsible for recruiting ...

Also in the Nov. 11 JNCI

... also tested the effects of overexpression of OLC1 in tissue culture and in a mouse model of lung cancer. OLC1 overexpression transformed human fibroblast cells in culture and induced tumor formation in mice. The protein was overexpressed in the majority of human lung cancer samples tested, and the gene ...

Monitoring Hormone May Improve Kidney Failure Outcomes

... early-stage patients who don't yet need dialysis, study says WEDNESDAY, Aug. 6 (HealthDay News) -- Monitoring levels of a hormone called fibroblast growth factor 23 (FGF-23) may help improve treatment of kidney failure patients, say Massachusetts General Hospital researchers. Their analysis ...

Patch Helps Mend Damaged Hearts

... on the animal studies Wednesday at an American Heart Association meeting in Keystone, Colo. "The mesh is grown in a bioreactor with human dermal fibroblast cells," Lancaster said. When the patch is placed on the heart, it delivers cells that grow to strengthen the heart muscle. "We evaluated this ...

Why some treatments rescue aging skin

... shot, says John J. Voorhees, M.D., F.R.C.P., chair of the Department of Dermatology at the U-M Medical School and the articles senior author. fibroblast cells in the skin are the key producers of collagen. We have shown that if you make more collagen go in, it provides an environment in which ...

Scientists identify novel way to prevent cardiac fibrosis

... Epac expression may provide a novel way to do this, especially in cardiac fibroblasts, Insel added. To test this possibility, the scientists treated fibroblast cells in culture in ways that altered Epac expression, increasing Epac expression using an adenoviral construct. Using this strategy to ...

Mayo Clinic identifies treatment target for liver cancer recurrence and survival

... to bind to cells, thus inhibiting growth. The investigators found that SULF2 did the opposite -- it increased binding of a specific growth factor, fibroblast growth factor 2 (FGF2), to tumor cells, and also increased expression of the heparan sulfate proteoglycan glypican 3 (GPC3), which plays an important ...

New Study Shows the Use of MEDIHONEY(TM) Wound & Burn Dressing is Associated With Reduction in Wound Size

... treatment for lowering wound pH, but the duration of the effect is unknown. Lowering wound pH can potentially reduce protease activity, increase fibroblast activity and increase oxygen release, consequently aiding wound healing." After two weeks of treatment with the dressings, the authors ...

FSU researcher's 'mutant' proteins could lead to new treatment for heart disease

... like a death sentence. A new approach to the problem called therapeutic coronary angiogenesis is creating hope through the injection of human fibroblast growth factor protein into affected areas. Improvements with the procedure may arise from the use of mutant forms with increased stability. Blaber ...

JCI online early table of contents: Jan. 10 2008

... factor TGF-beta-1, produced by inflammatory cells known as eosinophils, has been shown to drive the processes that result in airway fibrosis, notably fibroblast proliferation and extracellular matrix deposition. Now, James Malter and colleagues at the University of Wisconsin School of Medicine and Public ...

Pharmion to Present Clinical Data on Key Hematology Products at American Society of Hematology (ASH) Annual Meeting

... Leukemia (Abstract #2122). -- Poster Board No. 402-III: Up-Regulation of miR-195 Expression Leads to Decreased Expression of Basic fibroblast Growth Factor in CLL Patients Treated with DNA Methylation Inhibitors (Abstract #3183). Date / Time / Location: December 10, 2007; 1:30-3:00 ....

JCI table of contents: Nov. 21, 2007

... of renal fibrosis. Following tPA treatment of rat kidney fibroblasts, collagen was secreted by the cells along with a protein marker of fibroblast activation, alpha-SMA. This protein deposition was independent of the blood clotting effects of tPA, but it did require presence of the protein LRP-1 ...

Research Reveals Nutrient's Impact on the Embryo

... become too high, an enzyme called cyp26a1 degrades the excess retinoic acid in order to restore normal levels. If levels are too low, proteins called fibroblast growth factors (FGFs) slow retinoic acid degradation. "Those two things work together to keep the whole system adjusted to the right level. ...

MU research team makes progress toward 'printing' organs

... of determining where specific cells need to be. For example, an artery has three specific types of cells endothelial cells, smooth muscle cells and fibroblast cells, each type needing to be in a specific location in the artery. As thousands and thousands of cells are added to the bio-paper under controlled ...

Emory researchers identify signaling protein for multiple myeloma

... myeloma patients harbor a genetic abnormality called t(4;14) chromosomal translocation that causes over-expression of a tyrosine kinase called fibroblast growth factor receptor 3 (FGFR3). Tyrosine kinases are molecules that act as biological switches inside cells, regulating processes including cell ...

New Treatment Offers Hope for Systemic Sclerosis

... treatment of leukemia. Through skin biopsies, researchers obtained fibroblast cultures from the lesions of five patients with SSc, and six healthy sex- ... fibrosis compared with non-diseased controls. On the experimental fibroblast cultures from SSc patients, imatinib mesylate strongly reduced the ...

Only A Few Differentiating Factors Between Adult And Stem Cells

... demonstrated that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors," Yamanaka said. ... factors, known as Oct3/4, Sox2, c-Myc, and Klf4, could lend differentiated fibroblast cells taken from embryonic or adult mice the pluripotency normally ...

Targeting Sugar on Blood Vessels may Inhibit Cancer Growth

... in the tumor environment. An example would be developing small-molecule inhibitors of Ndst1. By affecting a broad array of molecules such as VEGF, fibroblast growth factor, platelet-derived growth factor, or others that impact angiogenesis in a variety of carcinomas this therapy could be used to inhibit ...

Researchers Identify the Gene Mutation That Raises Breast Cancer Risk

... was observed in one out of six women during the study. The researchers say that the newly identified gene variant, in the gene called fibroblast growth factor receptor 2 (FGFR2), is the most important genetic risk factor for breast cancer identified in about a decade, due to its widespread ...

A Single Biological Mechanism Behind Several Autoimmune Disorders

... T cells express IGF-1R in patients with Graves’ disease. The results support a potential role for IGF-1R as a determinant of immune responses through fibroblast and lymphocyte activation and expansion. This further implicates IGF-1R in the pathogenesis of patients with Graves’ disease. Graves' disease, ...

Growth Factor Aids in Regeneration of Heart Blood Vessel

... clogged arteries and damaged tissue. // Unfortunately, clinical trials, which were carried out for two important blood vessel growth factors, fibroblast growth factor- 2 (FGF2) and vascular endothelial growth factor (VEGF), have not yielded sterling outcomes. Now researchers at Washington ...

Digestive acid production dependent on newly found hormone

... signals to the liver//. The bile acids play a very important role in the emulsification of fats that enables absorption. The hormone is called fibroblast growth factor (FGF 15), the secretion of which depends on the level of bile acid secretion. FGF15 in turn limits further production of bile acid by ...

Simple Urine Test Can Help To Monitor Disfiguring Birthmarks

... with vascular malformations, but in only 22 percent of controls. Vascular anomalies were also associated with elevated urine levels of basic fibroblast growth factor (bFGF), another compound that promotes angiogenesis. Increased urine levels of MMPs and bFGF correlated with both the extent and ...

Mutant sperm beat out healthy brethren in study

... with Apert syndrome but 15 of the men did. The two mutations that cause most cases of Apert syndrome affect a gene and the protein it controls called fibroblast growth-factor receptor-2. Men over 60 were three times as likely as men under 30 to have sperm with at least one of these changes. The mutations ...

Genetic indicates memory

... one hour after the task, six hours later, and then 24 hours later. They say learning affected 140 different genes. They found a gene called fibroblast growth factor (FGF-18) increased at all times during the learning process. By injecting FGF-18 directly into the rat's brain they were able to ...

Pain Killers Keep the Virus Away

... Shenk and his colleagues tried to prevent HCMV replication in human connective tissue cells with a cox-2 inhibitor. When infected with the virus the fibroblast cells temporarily boosted their production of prostaglandin E2 more than 50-fold. But when treated with the cox-2 inhibitor, the number of virus ...