Expression in Medical News

Covance to Acquire Seattle-Based Gene Expression Laboratory from Merck & Co., Inc.

... Covance will acquire Merck's Seattle-based Gene expression Laboratory that performs genomics services such as genotyping, gene sequencing and gene expression profiling. "The acquisition of this ... occupancy of the site and operation of the Gene expression Laboratory on August 17, 2009. "The ...

MEK4, genistein and invasion of human prostate cancer cells

... by assessing cell invasion and gene and protein expression of mitogen-activated protein kinase 4 (MEK4) and ... Overexpression of MEK4 increased MMP-2 expression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling showed ...

Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research

... bone marrow. MCL is characterized by over expression of the gene cyclin D1 due to a chromosomal ... Dr. Fu and his co-workers have found that higher expression of miR-17~92 is directly correlated with poorer ... These findings indicate that higher miR-17~92 expression induces abnormal activation of a pathway in tumor ...

Smoking increases potential for metastatic pancreatic cancer

... Related Cancers Center. Nicotine promotes the expression osteopontin, and high levels of osteopontin have ... behavior. The researchers correlated OPNc expression with the patients' smoking history. OPNc expression was found on 87 percent of the invasive PDA ...

Bcl6 gene sculpts helper T cell to boost antibody production

... HOUSTON - expression of a single gene programs an immune system helper ... the team reported that that IL-6 and IL-21 induce expression of Bcl6 in the absence of transforming growth ... Another set of experiments showed that Bcl6 expression inhibits a T cell from differentiating into Th17, ...

Study Shows a Link Between Schizophrenia & Genetic Mutations

... of small, non-coding RNAs that down-regulate the expression of a variety of genes and are scattered over the ... demonstrated alterations in miRNA function or expression levels. The overwhelming majority of ... be feasible to treat schizophrenia by restoring expression of normal microRNAs in the central nervous system ...

Carbohydrate acts as tumor suppressor

... cancer cells and metastasis. An increase in expression of the enzyme that produces these glycans, ... Using antibodies, the team investigated the expression of both α-DG and its associated glycans in ... found that when they knocked down β3GnT1 expression by RNA interference, which reduces protein ...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

... control VSMC differentiation and growth. Gene expression is the process where information encoded in genes ... muscle cells. miR-143 was found to block the expression of factors that promote proliferation by VSMC precursors. Surprisingly, miR-145 activated the expression of myocardin, which maintains VSMC in their ...

Study shows PET can measure effectiveness of novel breast cancer treatment

... "Obtaining an accurate assessment of the HER2 expression levels in breast cancer tumors is absolutely ... of imaging can be used to monitor changes in HER2 expression after treatment. Researchers then intravenously ... each dose. The researchers found that HER2 expression was reduced by 71 percent in mice bearing tumors ...

A new take on growth factor signaling in tamoxifen resistance

... a new computational method of analysis of gene expression data called gene set enrichment analysis (GSEA) ... increased growth factor activation from the gene expression profiles of nearly 100 luminal-B breast cancers ... given conditions. Dr Loi said, "Although gene expression data has demonstrated its ability to identify ...

Mapping gene expression with Gene Expression Atlas

... (EMBL-EBI) launch a new database, the Gene expression Atlas, which allows scientists to search and compare gene expression data at unprecedented detail and scope. Observing how gene expression varies in different cell types, tissues and under ...

Study shows promise for new cancer-stopping therapy

... in normal tissues and are critical in gene expression and in maintaining normal cell development and ... autism and cancer. "The pattern of expression of miRNAs has emerged as critically useful ... as well. The delivery and restoration of miRNA expression via AAV mediated gene transfer of the miRNA may ...

First-Ever Standardized Scales to Measure the Skin's Aging Process Are Presented at THE Aesthetic Show

... present at rest and deep lines with facial expression , 3 for fine wrinkles present at rest and deeper lines with facial expression and 4 for deeper wrinkles at rest and deeper furrows with facial expression . Every participant graded the scales ...

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

... A further element of the study looked into the expression patterns of certain genes in mice with arthritis. ... regulatory gene CRY was found to up-regulate expression of a gene which promotes the activation of ... was induced in mice with the CRY gene removed. expression of the genes responsible for regulation of the ...

Analysis Sheds Light on Protein's Role in Cancer

... and healthy tissue. When they blocked the expression of PHD2, researchers at Stanford University ... Further investigation revealed that blocking PHD2 expression increased levels of two other proteins -- IL-8 ... colleagues will study whether mice that lack PHD2 expression develop more aggressive tumors, and whether ...

Ingenuity and Integromics Offer Integration for Comprehensive Genomics Analysis

... normalize, and interpret raw microarray gene expression data, directly into IPA for better modeling, ... to use tools for researchers to analyze their expression data for statistical and biological ... that help them best understand their gene expression data," said Tuan Nguyen, VP, Partner and ...

Ceregene Presents Additional Clinical Data from Phase 2 Trial of CERE-120 for Parkinson's Disease

... procedure, the gene therapy vector, or the expression of neurturin in the Parkinson's disease brain. ... the results of analyses of neurturin gene expression in the brains from two CERE-120 treated subjects ... CERE-120 produced clear evidence of neurturin expression in the targeted putamen but no evidence for ...

John P. Cogswell, Ph.D., receives 2009 Alzheimer Award

... Dr. Cogswell's work examines changes in microRNA expression and their role in the sporadic form of the ... are best known for regulating RNA and protein expression in pathways and networks due to the combinatorial ... technology this paper demonstrates altered expression of specific microRNAs in the brain of Alzheimer's ...

A potential drug for liver carcinoma

... (PPARγ), NF-κB, Bcl-2 and Bax protein expression of HepG2 cells were analyzed by Western blotting. ... μmol/L ADFMChR, PPARγ and Bax protein expression increased but Bcl-2 and NF-κB expression decreased in HepG2 cells; however, pre-incubation ...

A novel marker of colorectal carcinoma

... TSPAN1. The correlation between TSPAN1 expression and the clinicopathological factors and the ... tissue. The light density of TSPAN1 mRNA expression levels was 0.89 0.30 in adenocarcinoma by gel-image system. TSPAN1 protein expression was detected in 78.41 %( 69/88) and weakly ...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

... AUGUSTA, Ga. A protein that helps regulate expression of androgen receptors could prove a new focal ... cancer cells than in normal prostate cells while expression of testosterone-fed androgen receptors is higher, ... initiation and progression may be regulated by expression or non-expression of these co-factors," says Dr. ...

WaferGen Appoints Seasoned Industry Executives to Board of Directors and Scientific Advisory Board

... developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip is being ... as the first whole genome, high throughput gene expression real-time PCR platform. This innovative system, ... and cost advantages to researchers in the gene expression and genotyping markets. Based on collaborations ...

Genomic Health's Oncotype DX(R) Colon Cancer Test Predicts Individualized Recurrence Risk for Stage II Colon Cancer Patients

... Score is calculated from the quantitated expression of 7 recurrence genes and 5 reference genes in ... stage II colon cancer. Detailed analysis of gene expression and colon cancer recurrence was performed to ... cancer test are from the United Kingdom. Gene expression was quantified by RT-PCR from manually ...

Farnesoid X receptor regulates cystathionase

... The expression and activity of Cystathionase is reduced in ... and CHIP assay. In the normal liver the CSE expression was significantly increased when mice were fed a ... the FXR ligand failed to up-regulate CSE mRNA expression in FXR knock-out mice. Contraction of ...

Novel gene predicts local recurrence in early onset breast cancer

... disease. Of these, 56 percent lacked DEAR1 expression in their tumors, which was associated with 58 ... no lymph node involvement at diagnosis. Low expression associated with triple-negative breast cancer While the researchers found that loss of DEAR1 expression correlated significantly with local recurrence, ...

Novel gene predicts local recurrence in early-onset breast cancer

... disease. Of these, 56 percent lacked DEAR1 expression in their tumors, which was associated with 58 ... no lymph node involvement at diagnosis. Low expression associated with triple-negative breast cancer While the researchers found that loss of DEAR1 expression correlated significantly with local recurrence, ...

First-Ever Standardized Scales to Measure the Skin's Aging Process Are Introduced at the American Society for Aesthetic Plastic Surgery's Annual Meeting

... present at rest and deep lines with facial expression , 3 for fine wrinkles present at rest and deeper lines with facial expression and 4 for deeper wrinkles at rest and deeper furrows with facial expression . Every participant graded the scales ...

JNCI April 28 tip sheet

... Gene in Mouse Models of Neuroblastoma Reduced expression of clusterin in a mouse model of neuroblastoma ... used molecular techniques to increase or decrease expression of clusterin, MYCN, and a group of microRNAs ... in animal models of neuroblastoma. Increased expression of MYCN and miR-17-19 appeared to decrease ...

WaferGen and Leading Academic Medical Center Establish Genotyping Research Collaboration to Validate SNPs in Breast Cancer Using SmartChip(TM) Real-Time PCR System

... as the first whole genome, high-throughput gene expression real-time polymerase chain reaction (PCR) ... is expected to be the ability to conduct gene expression and genotyping research at a fraction of the time ... genetic analysis market alone (comprised of gene expression and genotyping analysis) had approximately $2.4 ...

Tips from the American Journal of Pathology

... dependent. Neuwirt et al identified SOCS-1 expression in multiple prostate cancer cell lines as well as ... cancer cells and that inhibition of SOCS-1 expression stimulated tumor cell growth. SOCS-1, ... is a putative tumor suppressor with decreased expression in numerous cancers including melanoma, breast ...

New biomarker may predict leukemia aggressiveness

... "The question was, could the level of PDE7B expression provide evidence for the clinical stage and ... really had worse disease and showed that PDE7B expression had predictive value relative to other currently ... Insel said. "In some cases, the level of PDE7B expression provided prognostic information that was additive ...

Chemo Combo Shows Promise Against Ovarian Cancer

... on this study. "By examining gene expression data, we determined that the combination of the ... effective in cell lines with higher levels of SRC expression and SRC pathway deregulation," Teoh said. ... a targeted therapy like dasatinib based on gene expression pathways in select ovarian cancers," she said. ...

Addition of dasatinib to standard chemo cocktail may enhance effect in certain ovarian cancers

... investigator on this study. "By examining gene expression data, we determined that the combination of the ... effective in cell lines with higher levels of SRC expression and SRC pathway deregulation." That ... each other's efficacy, was absent when low SRC expression and low SRC pathway deregulation were present, ...

Also in the April 7 JNCI

... proliferation in a variety of tissues and its expression has been associated with progression of ... in mice injected with these cells. expression of the dominant-negative receptor did not ... identify and validate biomarkers and gene expression patterns associated with each disease, and ...

Biomarker associated with poor outcome in aggressive childhood cancer

... of growth and differentiation. RA mediates gene expression by interacting with retinoic acid receptors ... some of these aggressive tumors exhibit increased expression of the MYCN oncogene, little is known about the ... cofactor of RA-induced differentiation. Reduced expression of ZNF423 was led to a growth advantage and ...

Gene helps protect tumor suppressor in breast cancer

... and grade. For example, complete loss of PTEN expression is found more frequently in metastatic cancer ... analyzed cells from 42 breast cancers. Rak expression showed a strong positive correlation with PTEN. They also investigated the effect of Rak expression by injecting mice with cells that over-expressed ...

WaferGen's Chief Scientific Officer to Deliver Executive Talk at Malaysian Ministry of Science, Technology and Innovation's PCR Conference

... world's first whole genome, high throughput gene expression real-time PCR platform. Dr. Gelfand is ... developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip is being ... as the first whole genome, high throughput gene expression real-time polymerase chain reaction (PCR) ...

Pathwork Tissue of Origin Test Validation Study Published in Journal of Clinical Oncology

... entitled, "Multicenter Validation of a 1,550-Gene expression Profile for Identification of Tumor Tissue of ... uses microarray technology to measure the gene expression pattern, comprising more than 1,500 genes, in a tumor with an uncertain origin and compare it to expression patterns of a panel of 15 known tumor types, ...

Also in the March 24 JNCI

... with human cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) ... cells. Infection with HCMV induced telomerase expression in both normal and malignant human cells. ... overexpressed in prostate cancer, relative to its expression in adjacent normal tissue. Additionally, previous ...

Catching Ovarian Cancer Early May Miss Aggressive Tumors

... currently detected at an early stage have gene expression profiles that correlate with favorable outcomes, ... release. He and his colleagues analyzed gene expression patterns in 166 ovarian cancer tissue samples, ... at an early stage almost always shared gene expression characteristics with advanced stage cases that ...