Erythropoietin in Medical News

Retrospective Analysis Finds Treatment of Cancer Chemotherapy Patients With Epoetin Alfa Associated With Lower Drug Cost Than Darbepoetin Alfa

... associated with neutralizing antibodies to erythropoietin have been reported in patients treated with ... for binding and neutralizing antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT ... Treatment of patients with grossly elevated serum erythropoietin levels (e.g., >200 mUnits/mL) is not ...

Gene Variant Boosts Risk of Severe Diabetic Eye, Kidney Diseases

... THURSDAY, May 8 (HealthDay News) -- A gene called erythropoietin (EPO) is linked to severe diabetic eye and kidney ... failure or chemotherapy. In the United States, erythropoietin represents one of the largest single drug ... need to consider blunting the effects of erythropoietin in addition, or as an alternative, to an ...

Drugs used for cancer-associated anemia linked with increased risk of blood clots, death

... in the February 27 issue of JAMA. The ESAs erythropoietin and darbepoetin are widely used to treat anemia ... in conjunction with basic science reports on erythropoietin and erythropoietin receptors in solid cancers, raise concern about ...

Drug for anemic cancer patients raises risk of death

... a significant effect when he added an ESA called erythropoietin to head and neck cancer cells in tissue culture. ... of a growing body of studies that demonstrate erythropoietin expression and function in a variety of human ... at a National Cancer Institute workshop on erythropoietin and tumor progression December 2007 in Bethesda, ...

Anemia treatment may be a double-edged sword

... erythropoietin has so far been known to doctors as a hormone ... causing blindness. The researchers measured erythropoietin produced in the retina as the disease progressed. ... into the retina. The researchers concluded that erythropoietin helps blood vessels survive and grow in the ...

New study examines the validity of epo testing

... BETHESDA, Md. (June 26, 2008)Recombinant human erythropoietin (rHuEpo) is a genetically engineered hormone sometimes misused by ... The Study The study is entitled, "Testing for Recombinant Human erythropoietin in Urine: Problems Associated with Current Anti-Doping Testing," and was ...

Anemia Drugs May Speed Tumor Growth in Some Cancer Patients

... a patient is susceptible to having their tumor progress if treated with erythropoietin and, alternatively, we may be able to predict patients it would be safe to ... phase III trial of erythropoietin. Scientists measured levels of erythropoietin receptor (EpoR) messenger RNA (mRNA). High levels of EpoR mRNA in ...

JCI table of contents: Jan. 24, 2008

... OPHTHALMOLOGY: I can see clearly now Epo has come and gone erythropoietin (Epo) is a hormone that stimulates red blood cell production and that is ... timing must be carefully regulated to prevent adverse effects. TITLE: erythropoietin deficiency decreases vascular stability in mice AUTHOR CONTACT: Lois ....

Modeling Simulation Predicts Potential Negative Impact on U.S. Blood Supply if ESA Use Limited for Chemotherapy-Induced Anemia

... without other cytopenias, associated with neutralizing antibodies to erythropoietin have been reported in patients with chronic renal failure receiving ... to perform assays for binding and neutralizing antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently ...

Updated Analysis of 2001 Epoetin Alfa Study Posted

... without other cytopenias, associated with neutralizing antibodies to erythropoietin have been reported in patients with chronic renal failure receiving ... to perform assays for binding and neutralizing antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently ...

FDA Approves MIRCERA(R): First Renal Anemia Treatment with Monthly Maintenance Dosing

... and legal manner." In contrast to erythropoietin, MIRCERA is an erythropoietin receptor activator with greater activity in vivo as well as increased ... have been associated with the development of neutralizing antibodies to erythropoietin in patients treated with ESAs. PRCA was not observed with MIRCERA in ...

New anemia measure predicts risk of death in dialysis patients

... and a common cause of death in dialysis patients. Treatment including erythropoietin and intravenous iron has been a major advance in the management of kidney ... of anemiafor example, the type, dose, and timing of treatment with erythropoietin and ironthat might improve outcomes among hemodialysis patients." ...

Ortho Biotech to Submit Official Request for Reconsideration to CMS Regarding ESA Coverage Policy

... without other cytopenias, associated with neutralizing antibodies to erythropoietin have been reported in patients with chronic renal failure receiving ... to perform assays for binding and neutralizing antibodies. If erythropoietin antibody-mediated anemia is confirmed, PROCRIT should be permanently ...

3SBio Inc. Announces Unaudited First Quarter 2009 Results

... year's presentation basis. First Quarter 2009 Business Highlights: -- EPIAO, the Company's flagship injectable recombinant human erythropoietin ("EPO") products, demonstrated resilient growth despite a challenging environment, with net revenue from EPIAO rising 21.0% over the ...

Anemia Drugs May Raise Death Risk in Cancer Patients

... drugs would still be made available for people for whom transfusion isn't a good option -- but those are very limited circumstances." ESAs include erythropoietin (Epogen, Procrit) and darbepoetin (Aranesp). They work by stimulating the bone marrow to produce new red blood cells, according to the U.S. National ...

The Walter and Eliza Hall Institute Announces the Next Director

... Lodish. During this time, he worked on trying to understand how the dedicated receptor on the surface of red blood cells recognizes the hormone erythropoietin (also known as EPO), famous for its clinical use in patients with renal failure and infamous for its illicit use by some sports people. Since ...

Nephros, Inc. Receives the 2009 Frost & Sullivan Medical Device Patient Care Company of the Year Award

... inflammation-related parameters, better nutritional indices, reduced beta-2-microglobulin levels, and improved anemia management achieved with less erythropoietin stimulating agents when hemodialysis patients are treated with ultrapure dialysate, in comparison with standard dialysate. Studies have ...

Monash wins $32m for health and medical research

... University researchers will share in a total of $32M for 62 individual projects, including: $1.8 million for research into the effect of erythropoietin (EPO) on traumatic brain injury; $491,250 to research testicular development and disease; $312,500 to explore novel treatment strategies for ...

Story ideas for health reporters covering the summer Olympic Games

... Creating reliable tests for these illegal compounds has been difficult. Several recent studies show that testing in humans for both steroids and erythropoietin (EPO), a hormone that induces red blood cell production, is very difficult. In testing for EPO, for example, a study suggests the tests are ...

Naturally-occuring protein may be effective in limiting heart attack injury and restoring function

... in clinical use to treat anemia in end-stage kidney disease, protects the rat heart against injury during a heart attack. They found that although erythropoietin and TPO have separate functional roles, there were similarities in the structures of the two proteins that suggested TPO may have protective ...

Mice Can Sense Oxygen Through Their Skin

... a new study that showed the skin plays a major role in sensing oxygen levels in the environment and in stimulating kidney production of the hormone erythropoietin (EPO) when oxygen levels decline. EPO boosts production of red blood cells that carry and deliver oxygen throughout the body. If this finding is ...

Twin findings raise hopes of improved anemia treatments

... a big impact and so the possibility of modulating this gene to generate new treatments is significant. As a number of patients don't respond to erythropoietin (EPO) the current form of hormone therapy for anaemias this new knowledge will hopefully lead to alternative treatments. The research being ...

Anemia Drugs for Cancer Patients Increase Death Risk

... author, Dr. Charles Bennett, the A.C. Beuhler professor of geriatric medicine at Northwestern University's Feinberg School of Medicine. ESAs -- erythropoietin (Epogen, Procrit) and darbepoetin (Aranesp) -- work by stimulating the bone marrow to produce new red blood cells, according to the U.S. National ...

Standard test for blood sugar control not accurate in diabetic dialysis patients

... Freedman said that until it is available, doctors and patients should be aware that the HbA1c underestimates glucose control and is affected by both erythropoietin administration and the hemoglobin concentration. ...

JCI online early table of contents: Jan. 10 2008

... in red blood cells (rbcs) caused by their insufficient production, excessive destruction, or excessive loss is administration of recombinant erythropoietin (Epo), a hormone that stimulates the production of rbc precursors by the bone marrow. Unfortunately, many patients with anemia do not respond to ...

Natural human hormone as the next antidepressant?

... regenerated as fast as normal or suffering from toxic effects of stress and stress hormones. This led the researchers to evaluate the effects of erythropoietin (Epo), a hormone naturally produced by the kidneys that stimulates the formation of red blood cells and is known as a treatment for anemia. The ...

Study questions impact of hemoglobin variations on mortality in dialysis patients

... one of the most frequent complications of kidney failure and is associated with an increased risk of death in dialysis patients. Treatment including erythropoietin and intravenous iron has been a major advance in the management of kidney failure-related anemia, yet low blood counts and variation in hemoglobin ...

National Patient Advocate Foundation (NPAF) Statement Regarding New FDA Label on Erythropoietin Stimulating Agents (ESAs)

... affiliate Patient Advocate Foundation (PAF), continues to routinely receive inquiries from patients wanting to know more about the use of erythropoietin Stimulating Agents (ESA). These patients, with life-threatening, debilitating and chronic conditions, continue to seek information about ...

Simpler Anemia Treatment May Help Kidney Patients

... and colleagues. The findings are published in the Oct. 20 issue of The Lancet . Conventional therapy with epoetin (a synthetic form of human erythropoietin that promotes red blood cell production) requires frequent administrations (at least once weekly), changes of dose, and close monitoring of ...

Cancer Doctors Across America 'Stunned' at Government's Ruling Restricting Anemia Management Protocols for Cancer Patients, Call Ruling 'Interference' in Practice of Medicine

... addressed to the American Society of Hematology, US Oncology and the American Society of Clinical Oncology, and outlined limitations on coverage of erythropoietin stimulating agents (ESAs) for cancer patients. CMS stated that they would only reconsider amending the cancer National Coverage Determination (NCD) ...

New discovery leaves blood-doping athletes scratching their heads

... of The FASEB Journal ( www.fasebj.org ), researchers show that the estimated 100,000 hair follicles on each persons head have the potential to become erythropoietin (EPO) factories. EPO, the hormone primarily responsible for the creation of red blood cells, is used illegally to enhance athletic performance and is ...

New discovery leaves blood-doping athletes scratching their heads

... of The FASEB Journal ( www.fasebj.org ), researchers show that the estimated 100,000 hair follicles on each persons head have the potential to become erythropoietin (EPO) factories. EPO, the hormone primarily responsible for the creation of red blood cells, is used illegally to enhance athletic performance and is ...

Anemia Drug Overused and Could Hasten Death in Some, Say Experts

... some athletes to boost endurance). In 1993, erythropoietin use was expanded to include cancer patients who ... several clinical experiments in which high-dose erythropoietin appeared to shorten the lives of some patients ... lymphoid, and throat cancers - suggesting that erythropoietin caused "tumor promotion" and shorter survival in ...

Anemia Treatment for Cancer Patients Might Not be a Good Idea.

... treating anemia in cancer patients with the drug erythropoietin (epoetin beta) may actually interfere with cancer ... study involved 351 patients who received either erythropoietin or a placebo about two weeks before undergoing ... cancer control or survival. On the contrary, erythropoietin might impair disease control when manifest cancer ...

Anemia Treatment for Cancer Patients

... treating anemia in cancer patients with the drug erythropoietin (epoetin beta) may actually interfere with cancer ... study involved 351 patients who received either erythropoietin or a placebo about two weeks before undergoing ... cancer control or survival. On the contrary, erythropoietin might impair disease control when manifest cancer ...

Anemia Treatment for Cancer Patients

... treating anemia in cancer patients with the drug erythropoietin (epoetin beta) may actually interfere with cancer ... study involved 351 patients who received either erythropoietin or a placebo about two weeks before undergoing ... cancer control or survival. On the contrary, erythropoietin might impair disease control when manifest cancer ...

‘For-profit Dialysis Centers’ in the Spotlight Over Anti-anemia Drug Overdoe

... their lives. Abnormally high hemoglobin increases the risk of heart attacks, strokes and blood clots. Healthy kidneys secrete a hormone called erythropoietin which is the catalyst behind the production of red blood cells in the bone marrow. Those patients suffering kidney disease do not produce adequate ...

Anemia Drugs to Be Taken With Caution

... fact// that such drugs should be prescribed in restricted conditions only. The mode of action of Aranesp is based on the natural protein called erythropoietin (EPO) which augments the production of red blood corpuscles in the body. This drug is the major product of Amgen Inc and has also been permitted to ...

Vitamin E-Coated Dialysis Filters Help Fight Anemia in Hemodialysis Patients

... without anemia—had increased from about 50 to 80 percent. The patients also had a significant reduction in their required dose of the hormone erythropoietin (EPO). Normally produced by the kidneys, EPO fights anemia by inducing the bone marrow to make red blood cells and prolonging the life span of ...